CN109528541A - A kind of cleaning compositions of the polynary yeast complexing polypeptide containing five mines - Google Patents
A kind of cleaning compositions of the polynary yeast complexing polypeptide containing five mines Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
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Abstract
The present invention relates to daily chemicals field, a kind of cleaning compositions of polynary yeast complexing polypeptide containing five mines are disclosed, including the polynary yeast of five mines is complexed polypeptide extract: 0.01 ~ 28%；Fatty acid 15 ~ 40%；Alkali 3 ~ 20%；Auxiliary dispersants: 3 ~ 35%；Emulsifier 0.1 ~ 5%；Thickening stabilizing agent 0.2 ~ 10%；Cosurfactant 0.1 ~ 25%；Humectants and emollients 0 ~ 15%；Deionized water surplus.The present invention analyzes the skin clinical symptoms that surfactant starts with may cause after skin contact, and by composition system framework rationally build and limitation to raw material key parameter, so that composition irritation is low, antiphlogistic effects are obvious, moistening effect is obvious, and then provides good skin nursing effect.
Description
Technical field
The present invention relates to daily chemicals fields, and in particular to a kind of cleaning compositions of the polynary yeast complexing polypeptide containing five mines.
Background technique
Surfactant is most common a kind of raw material in cosmetic formulations, for example, for cleaning, emulsifying, soak, solubilization
With dispersion etc..Their characteristics in structure and in the solution influence the interaction of they and skin and hair.Surface is living
Property agent and skin interaction be various.Surfactant and cuticula surface action first, then penetrate into cuticula.?
The target area of cuticula is attachment between the keratin in extracellular lipid and keratocyte and desmosome keratocyte.If seeped
Through cuticula, surfactant may influence the metabolism of the living cells in epidermis, or possibly even generate the work of cytokine
With.Inflammatory response may be generated by penetrating into corium by epidermis living.During clean, surfactant starts to connect with skin
After touching, in fact it could happen that various clinic skin symptoms.It is most common that symptom is caused to be pachylosis, continue with surfactant
After contact, skin abnormality is peeled off and drying.If contacted with accumulation of surfactant, Skin barrier destruction will lead to, make skin
Skin is damaged.It is easy to induce inflammatory response, shows as red swelling of the skin and swelling.Since skin of face is than other positions sensitivity, make
For instant response, tightens feeling and be easy to occur in face.
The product classification of face cleaning product on the market mainly has conventional surfactants type, amino acid pattern and soap base type clean
Face product.Soap base type face cleaning product is that fatty acid soaps are obtained after saponification by fatty bronsted lowry acids and bases bronsted lowry, is daily use chemicals in recent years
Popular one of the product that washes one's face of line, main feature have easily sprawl, foaming power it is good, foaming abundancy is fine and smooth, and decontamination is clean thorough
Bottom is easy to rinse well after, gives skin clean salubrious sense.But disadvantage is also very prominent, mainly have due to face cleaning product compared with
It is dry, tight to will lead to face skin under drying, the lower weather condition of temperature by strong degreasing and higher pH after use
It is taut, or even keep skin impaired.
In cleaning product at this stage, some technologies can be added some anti-inflammatory agents and go to alleviate the inflammation of skin, some skills
Art may go alleviation washing class product to wash rear bring tight feeling using some moisturizer of addition or emollient.In Chinese patent Shen
It please disclose in number 108085196.A by being added cationic polymer 1 ~ 10%, polyalcohol 35 ~ 55%, water-soluble emollients 35 ~
64% so a kind of composition goes the skins senses such as mild sense, moisture feeling when promoting face cleaning, and increases substantially the guarantor after face cleaning
Wet ability, to solve the problems, such as that face cleaning class product is dry and astringent in face cleaning rear face.In Chinese Patent Application No. 106109310.A
In to disclose 12 parts of Baical Skullcap root P.E of addition, 5 parts of stearic acid, 4 parts of potassium hydroxide, 8 parts of palmitinic acid, 2 parts of lanolin, glycerol list hard
The suitable collocation of 2 parts of resin acid ester, chelating agent achievees the effect that mildly cleaning, anti-inflammatory are anti-inflammatory.
But these disclosed technologies are not started with from material to alleviate the unhealthy situation of skin, the prior art is useful
Traditional Chinese medicine extraction and plant extracts alleviate the unhealthy situation of skin, but the dosage of surfactant of its chemical industry synthesis remains unchanged
In high levels, therefore it is unfavorable for reducing the irritation of detergent itself.These technologies are by the way that a large amount of protect is added mostly
The anti-or scorching agent of humectant goes to achieve the purpose that make skin not tight not red and swollen, not by the network of Cucumber and surfactant
Cooperation removes to reduce cleaning compositions after washing to skin bring stimulation with to go to reduce their possible stimulations,
To play the role of delaying inflammation, improve skin appearance.
Proteins and peptides class in cosmetics using more and more extensive, but most protein derivative is come
It says, substance of the molecular mass greater than 300u can penetrate through this saying of stratum corneum barrier and receive dispute greatly.Some small molecules
Polypeptide shows their physiological activity but possibly into skin.These proteins and peptides substances are used in cosmetics,
The complexing of itself and surfactant will reduce their possible stimulations, be applied in cosmetic formulations with this kind of method
It can protect skin.Needed by human body wants less but indispensable minerals, has a great impact to the health of human body, mineral
Matter is the important element for maintaining human health, it has a series of important physiological functions to human body.It is more that yeast is prepared at this stage
The research that peptide chelates a variety of mine elements is very few, and polypeptide chelate mine element is that one or more peptide groups and mine element ion occur
The compound with cyclic structure that complex reaction is formed, good biochemical stability are easily absorbed by the body, side effect
It is small, biological value is high, can reach not only supplemented polypeptide but also supplement minerals double effects.
Summary of the invention
It is an object of the invention to alleviate in the prior art because the dosage of surfactant of chemical industry synthesis it is big caused by it is various
Skin problem, it is intended that a kind of extractive technique of the polynary yeast complexing polypeptide containing five mines and the washing combination containing the complexing polypeptide are provided
Object, extractive technique disclosed by the invention can make polypeptide while 5 kinds of mineral elements are complexed, while it is anti-to save extract moisturizing
Scorching and anti-wrinkle ability, the application of polypeptide extract is complexed by the yeast, and by the reasonable of composition system framework
It builds and the limitation to raw material key parameter, so that composition irritation itself is low, antiphlogistic effects are obvious, and moistening effect is bright
It is aobvious, and then good skin nursing effect is provided.
Technical scheme is as follows:
A kind of cleaning compositions of the polynary yeast complexing polypeptide containing five mines, including following mass percent component:
The polynary yeast complexing polypeptide extract of five mines: 0.01 ~ 28%；
Fatty acid 15 ~ 40%；
Alkali 3 ~ 20%；
Auxiliary dispersants: 3 ~ 35%；
Emulsifier 0.1 ~ 5%；
Thickening stabilizing agent 0.2 ~ 10%；
Cosurfactant 0.1 ~ 25%；
Humectants and emollients 0 ~ 15%；
Deionized water surplus.
Further, which includes following mass percent component:
Fatty acid 15 ~ 40%, preferably 20 ~ 40%, more preferable 25 ~ 38%；
Auxiliary dispersants: 3 ~ 35%；It is preferred that 5 ~ 30%, more preferable 8 ~ 25%；
Alkali 3 ~ 20%, preferably 3 ~ 20%, more preferably 3 ~ 15%, most preferably 4 ~ 10%；
Emulsifier 0.1 ~ 5%, preferably 0.3 ~ 3%, more preferable 0.3 ~ 2.5%；
Thickening stabilizing agent 0.2 ~ 10%, preferably 0.5 ~ 6%, more preferable 0.5 ~ 4%；
Cosurfactant 0.1 ~ 25%, preferably 0.5 ~ 20%, more preferable 0.5 ~ 15%；
Humectants and emollients 0 ~ 15%, preferably 0.1 ~ 12%, more preferably 0.1 ~ 6%；
Or mixtures thereof auxiliary dispersants include but is not limited to: polyalcohol, and molecular weight is lower than 20,000 polyethylene glycol,.Suitable for this
The polyalcohol of the auxiliary dispersants of invention includes but are not limited to: glycerol, sorbierite, pentaerythrite, propylene glycol, 1,3- fourth two
Alcohol, diglycerol, dipropylene glycol, polyglycereol class, with its two or more mixture；Preferably glycerine, sorbierite, propylene glycol, 1,3-
Butanediol, polyglycereol or their two or more mixtures.The basic component of polyalcohol and cleaning compositions that the present invention limits
It is compatible in physical property and chemical property, the viscosity of product can be adjusted, can be obviously improved and wash rear skin sense, and
It has no adverse effects to the pearl effect of product.
Deionized water surplus.In addition to the above-mentioned raw material that must be added to, auxiliary material, example can also be added according to actual needs
Such as water-soluble polymer rheology control agent, ion chelating agent, preservative, essence, other active components (fungicide, vitamin
And its derivative) etc. ingredients.
Further, fatty acid is including in octanoic acid, capric acid, lauric acid, myristic acid, palmitinic acid, stearic acid, behenic acid
Two or more any mixture, preferably lauric acid, myristic acid, palmitinic acid, stearic acid, in behenic acid
At least one, further preferably lauric acid, myristic acid, palmitinic acid, stearic mixture.Fatty acid mixt is preferred
Weight ratio is lauric acid: myristic acid: palmitinic acid: stearic acid=0 ~ 12:1 ~ 15:0 ~ 12:1 ~ 15, further preferably 0 ~ 10:1 ~
12:0 ~ 10:1 ~ 12, most preferably 2 ~ 8:3 ~ 10:2 ~ 8:3 ~ 10.Lauric purity preferably 80 ~ 100%, further preferred 90 ~
100%, most preferably 95 ~ 100%；The purity of myristic acid preferably 80 ~ 100%, further preferred 90 ~ 100%, most preferably 95 ~
100%；The purity of palmitinic acid preferably 80 ~ 100%, further preferred 90 ~ 100%, most preferably 95 ~ 100%；Stearic acid is conventional city
Sell product, the generally composition of hexadecylic acid and stearic acid, preferably C16Acid: C18The ratio of acid is 10 ~ 80:90 ~ 20, more preferably
For 40 ~ 80:60 ~ 20, most preferably 55 ~ 80:45 ~ 20.
Fatty acid can assign foam, appearance, viscosity, cleaning force and skin sense of face cleaning class rich choice of products etc.；Fatty acid is produced
Raw foam is more and more tiny with the increase of relative molecular mass, and foam is also more and more stable；Degreasing power is with fatty acid
The increase of total amount enhances therewith；When content of fatty acid is very few, the stability of sample is poor；When the content of fatty acid is excessive, operated
The problems such as journey will appear the difficult dispersion of soap group, bubble is more, cause sample spreadability and stability undesirable.Myristic acid and ten
The pearl effect of eight sour (stearic acid) is most strong；What stearic acid generated is strong flash of light shape pearly-lustre, the pearly-lustre that myristic acid generates
It is a kind of sub-translucent, the milky pearly-lustre of similar ceramic surface.
Further, alkali includes KOH, NaOH, NH4At least one of OH, triethanolamine, preferably KOH, triethanolamine,
Or their mixture, most preferably KOH.The dosage of alkali, it is related with the purity of degree of neutralization and alkali.Such as the soap of soap base face cleaning class product
Base component is reacted to obtain by fatty acid with alkali, meets following reaction formula (I):
Wherein, MOH is alkali.Degree of neutralization control of the invention is 70 ~ 90%, preferably 72 ~ 88%, most preferably 76 ~ 85%, described
The purity of alkali preferred > 80%, more preferably greater than 88%, most there is choosing to be greater than 91%.The computation formula of the specific dosage of required alkali
(II) as follows:
The degree of neutralization of soap base face cleaning class product illustrates that some fatty acid is not neutralized in system, therefore soap base is less than 100%
As composed by fatty acid soaps and free fatty acid.Particularly, pH value is another key index for judging soap base component, with alkali
Dosage, degree of neutralization and neutralize whether completely it is directly related, when being face cleaning class production quality control important judgement refer to
One of mark.The pH value for being suitable for the present composition is preferably 8.0 ~ 11.0, more preferably 9.0 ~ 11.0, particularly preferably 9.5 ~
10.5。
Further, it is C that emulsifier, which includes hydrophobic group,8~C22Carbochain, it is independent or mixing or it is branched, it is hydrophilic
Base be light base (- OH), ether (- O-), phosphate radical, sulfate radical, sulfonate radical, carboxylate radical nonionic surfactant or anion
Surfactant, newborn chain length are preferably C8~C18Carbochain, more preferably C14~C18Carbochain；Hydrophilic group be light base (- OH),
Ether (- O-), phosphate radical, sulfate radical, sulfonate radical, carboxylate radical nonionic surfactant or anionic surfactant, it is excellent
It is selected as fatty alcohol polyoxyethylene ether, fatty glyceride, polyglycerol ester, monoalkyl phosphoric acid esters, monoalkyl phosphate, more preferably
Peregal, stearic acid monoglyceride, self-emulsifying monoglyceride, Phosphoric acid monohexadecyl ester, cetanol potassium phosphate, particularly preferred stearic acid list are sweet
Rouge, self-emulsifying monoglyceride, cetanol potassium phosphate.Emulsifier is to solve a system stability in the most important effect of face cleaning product
The problem of, it should be exactly auxiliary stabilization, adding suitable emulsifier can be with effective solution face cleaning product in height
Temperature stability, and the phenomenon for preventing product system coarse after restoring room temperature, this in face cleaning product compounding system of emulsifier
Kind effect is also indispensable.Emulsifier can will be formulated the complete fatty acid of unreacted and be emulsified, wrapped up, be suspended, and can make
Product is more stable.
Further, thickening stabilizing agent include Tego-stearate, double glycol stearates, rilanit special,
Monostearate and palm fibre put acid propylene glycol ester or its glyceride, higher aliphatic acid alkylolamide, fatty alcohol, fatty acid, polyethylene
Polymer, latex, zinc stearate, magnesium stearate, mica, superfine silicon dioxide, super fine zinc oxide, superfine titanic oxide, silicic acid
At least one of magnalium, preferably Tego-stearate, double glycol stearates, rilanit special are more preferably double hard
The mixture of resin acid glycol ester, rilanit special.Thickening stabilizing agent can make face cleaning product keep outer in high/low temperature and room temperature
Consistency is seen, preferred mixture can assist the stability and auxiliary pearl effect of face cleaning product high/low temperature.
Further, cosurfactant includes ethoxylated dodecyl alcohol sulfate, glycerine monofatty ester sulfuric acid
Salt, fatty alcohol ether sulfosuccinate ester salt, N- fatty acyl amino-acid salt, fatty acyl methyl tauride, monoalkyl sulfate are single
Alkyl carboxylate, at least one of alkylphosphonate preferably at least contain N- fatty acyl amino-acid salt, fatty acyl methyl
One or both of taurate；Being suitable for the invention amphoteric surfactant includes but is not limited to fatty acyl both sexes acetic acid
One or more of salt, fatty acyl propyl betaine, fatty acid amide hydroxypropyl sulfobetaines, particularly preferred fatty acyl both sexes
Or mixtures thereof acetate and fatty acyl propyl betaine,.Cosurfactant has high pH in face cleaning product body system
There is buffer function, to reduce irritation.Improve the foam property of product simultaneously, improves skin sense when using.
Further, humectants and emollients mineral oil, vegetable oil and its derivative, the lactic acid derivative of fatty acid are ultra-fine
Inorganic material powders, inorganic water-soluble polymer, cationic polymer, bionic phospholipid, PEG-7 olive grease, PEG-6 octanoic acid/
At least one of Triglyceride DDD, PEG-7 caprylic/capric triglyceride.Moisturizing moisturizer can be obviously improved face cleaning class
Product washes rear bring tight feeling, dry sensation, and emollient optional in this way or moisturizer should not viscosity to face cleaning class product, bubble
Foam, stability and appearance have a adverse impact.The dispersing agent as described in front is not also tight described in face cleaning product
It is not dry to wash that rear skin sense is helpful, therefore such emollient or moisturizer additive amount and without can excessively achieve the goal.
Further, the preparation method of the polynary yeast complexing polypeptide extract of five mines includes the following steps:
A. broken wall is carried out to yeast: beer waste yeast liquid is activated to itself enzyme system of yeast by three sections of alternating temperature techniques, with certainly
Molten method carries out the broken wall treatment of yeast；
B. prepared by solution: enzyme deactivation is living, and enzymolysis liquid of the enzyme deactivation after living is centrifuged 20 ~ 25min at 3000 ~ 5500r/min of revolving speed,
Supernatant liquor is taken, yeast polypeptides solution is made；
C. the pH value and temperature for adjusting yeast polypeptides solution, being added includes Zn+、Cu2+、Mg2+、Fe2+、Si4+Mineral ion and anti-
Oxidant carries out chelatropic reaction with saccharomyces cerevisiae respectively and obtains yeast polypeptides chelating liquid:
Zn+Chelating condition: pH5.8 ~ 6.3,60 ~ 70 DEG C of temperature, 45 ~ 60min of time, zinc salt additive amount be polypeptide solution quality
10 ~ 20%, antioxidant additive amount be zinc salt quality 20%；
Cu2+Chelating condition: pH6.5 ~ 7.5,58 ~ 68 DEG C of temperature, 3 ~ 5h of time, the additive amount of mantoquita is polypeptide solution quality
10 ~ 20%, antioxidant additive amount be mantoquita quality 20%；
Mg2+Chelating condition: pH6.5 ~ 7.5,40 ~ 58 DEG C of temperature, 1 ~ 4h of time, the additive amount of magnesium salts is polypeptide solution quality
15 ~ 28%, antioxidant additive amount be magnesium salts quality 15 ~ 25%；
Fe2+Chelating condition: pH6.3 ~ 7.3,25 ~ 38 DEG C of temperature, 30 ~ 70min of time, the additive amount of ferrous salt is that polypeptide is molten
The 15 ~ 25% of liquid quality, antioxidant additive amount are the 23% of ferrous salt quality；
Si4+Chelating condition: pH6.0 ~ 7.5,58 ~ 70 DEG C of temperature, 30 ~ 70min of time, the additive amount of silicon salt is polypeptide solution
The 15 ~ 25% of quality, antioxidant additive amount are the 5 ~ 8% of silicon salt quality；
D. after filtering to each yeast polypeptides chelating liquid, the filtrate respectively containing yeast polypeptides chelating mineral ion is obtained；
E. the resulting filtrate of Step d being mixed in pH6 ~ 7 and 25 ~ 45 DEG C of pure water and obtaining mixed liquor, mixed respectively contains yeast
The mass ratio of the filtrate of polypeptide chelate mineral ion is 1:1, respectively containing yeast polypeptides chelating mineral ion filtrate with it is pure
The gross mass ratio of water is 3 ~ 5:7 ~ 5；
F. leukonid/radish root ferment filtrate is added into mixed liquor, and supernatant liquid body is taken after filtering；20000 is below
Small molecule active object is conducive to skin and completely quickly absorbs.
G. separating molecular weight in 20000 small molecules below to the resulting supernatant liquid body of f step is extraction
Object finished product.
Traditional yeast broken wall method can all cause in yeast cells nutritional ingredient to be destroyed in various degree, active material loses
Effect, the disadvantages of product mouthfeel and bad use feeling, general autolysis method can also mild broken wall, but shell-broken effect is poor, this hair
The enzyme technology of three sections of changing temperature autolysis provided by bright, can make its shell-broken effect more preferable, and it is more to greatly increase yeast
The bioavilability of the nutriment of peptide.
Further, the design parameter of the technique of three sections of alternating temperatures includes: that the beer that mass concentration is 10 ~ 12% discards ferment
Mother liquor 4 ~ 5h of constant temperature at 38 ~ 42 DEG C, 1.5% dextranase of addition beer waste yeast liquid quality constant temperature at 52 ~ 57 DEG C
4 ~ 5h, using 4 ~ 5h of constant temperature at 60 ~ 65 DEG C；Technical process pH value remains 5.0 ~ 5.8.
The cleaning compositions of the present invention polynary yeast complexing polypeptide containing five mines, in addition to the above-mentioned raw material that must be added to, also
The rheology control agents such as auxiliary material, such as water-soluble polymer, ion chelating agent, preservative, perfume (or spice) can be added according to actual needs
The ingredients such as essence, other active components (fungicide, vitamin and its derivative).The polynary yeast complexing polypeptide extract of five mines adds
Skill routinely cold burden Adding Way is processed, the configuration method of composition is conventional configuration and hybrid technology, is not done herein in detail
Explanation.
After above-mentioned technical proposal, the invention has the following beneficial effects:
Polypeptide chelate mine element is that one or more peptide groups and having for mine element ion generation complex reaction formation are cyclic annular
The compound of structure, good biochemical stability are easily absorbed by the body, Small side effects, biological value height, can reach both
Supplement polypeptide supplements the double effects of minerals again.
The present invention starts with to alleviate the unhealthy situation of skin from material, and the useful traditional Chinese medicine extraction of the prior art and plant mention
Object is taken to alleviate the unhealthy situation of skin, but the dosage of surfactant of its chemical industry synthesis is still in high levels, therefore
It is unfavorable for reducing the irritation of detergent itself；The cleaning compositions of the polynary yeast complexing polypeptide containing five mines of the invention are to pass through
The complexing of yeast polypeptides and surfactant goes reduction cleaning compositions to exist to go to reduce their possible stimulations
Improve skin appearance to play the role of delaying inflammation to skin bring stimulation after washing.
Extractive technique disclosed by the invention can make polypeptide that 5 kinds of mineral elements be complexed, while can save extract moisturizing
Anti-inflammatory and anti-wrinkle ability, the application of polypeptide extract is complexed by the yeast, and passes through the conjunction to composition system framework
Reason is built and the limitation to raw material key parameter, so that composition irritation itself is low, antiphlogistic effects are obvious, and moistening effect is bright
It is aobvious, and then good skin nursing effect is provided.
Detailed description of the invention
Fig. 1 is the cuticula moisture content change rate chart of embodiment and comparative example.
Specific embodiment
Below in conjunction with specific embodiment, present invention is further described in detail.
In these embodiments, unless stated otherwise, all concentration is all weight percent.Term " a small amount of object used
Those of the optionally substance that matter " refers to, such as preservative, essence, pigment, the selections of these a small amount of substances by with it is selected to
Prepare special component of the present invention physics and chemical characteristic and change.
It is prepared into the soap base class product containing the present composition, the following table 1 is 3 preferred embodiments of the present invention and 2
Comparative example.Wherein, comparative example 3 selects a kind of pin on the market is measured to releive with anti-inflammatory as the soap base facial cleanser of concept.
The extraction process of the polynary yeast complexing polypeptide of five mines selected by embodiment and comparative example is as follows:
A. mild broken wall: by beer waste yeast liquid by enzymes such as protease, the dextranases of three sections of alternating temperature techniques activation yeast
Itself enzyme system, based on autolysis method carry out yeast broken wall treatment；Suitable dextranase can be added to strengthen broken wall.To ferment
What female broken wall played a major role is temperature.The technology controlling and process of three sections of alternating temperatures is crucial: the beer that mass concentration is 10 ~ 12% discards ferment
Mother liquor 4 ~ 5h of constant temperature at 38 ~ 42 DEG C, 1.5% dextranase of addition beer waste yeast liquid quality constant temperature at 52 ~ 57 DEG C
4 ~ 5h, using 4 ~ 5h of constant temperature at 60 ~ 65 DEG C；Technical process pH value remains 5.0 ~ 5.8.
B. prepared by solution: enzyme deactivation is living, and by enzymolysis liquid of the enzyme deactivation after living in revolving speed be 3000 ~ 5500r/min centrifugation 20 ~
25min takes supernatant liquor, and yeast polypeptides solution is made.
C. it chelates: adjusting the pH value and temperature of yeast polypeptides solution, mineral ion (Zn is added+、Cu2+、Mg2+、Fe2+、Si4 +) and antioxidant respectively with saccharomyces cerevisiae carry out chelatropic reaction.
(1) Zn+Chelating condition: pH6.0, temperature 70 C, time 50min, the additive amount of zinc salt are polypeptide solution quality
10 ~ 20%, antioxidant additive amount be zinc salt quality 20%.
(2) Cu2+: pH7.0, temperature 60 C, time 4h, the additive amount of mantoquita are the 10 ~ 20% of polypeptide solution quality, antioxygen
Agent additive amount is the 20% of mantoquita quality.
(3) Mg2+: pH6.8,55 DEG C of temperature, time 2h, the additive amount of magnesium salts is the 15 ~ 28% of polypeptide solution quality, antioxygen
Agent additive amount is the 15 ~ 25% of magnesium salts quality.
(4) Fe2+: pH7.0,35 DEG C of temperature, time 40min, the additive amount of ferrous salt is the 15 ~ 25% of polypeptide solution quality,
Antioxidant additive amount is the 23% of ferrous salt quality.
(5) Si4+: pH6.2,65 DEG C of temperature, time 60min, the additive amount of silicon salt is the 15 ~ 25% of polypeptide solution quality, is resisted
Oxidant additive amount is the 5 ~ 8% of silicon salt quality.
D. after filtering to each yeast polypeptides chelating liquid, the filtrate respectively containing yeast polypeptides chelating mineral ion is obtained.
E. the resulting filtrate of Step d being mixed in pH6 ~ 7 and 25 ~ 45 DEG C of pure water and obtaining mixed liquor, mixed respectively contains
The mass ratio that yeast polypeptides chelate the filtrate of mineral ion is 1:1, the filtrate respectively containing yeast polypeptides chelating mineral ion
Gross mass ratio with pure water is 3 ~ 5:7 ~ 5
F. leukonid/radish root ferment filtrate addition, addition leukonid/radish root ferment filtrate amount are mixed liquor
The 2% of quality；
G. supernatant liquid body is filtered to obtain.
H. chromatography grading purification: by hollow fiber column, molecular weight is filtered out in 20000 small molecule actives below
Object.
The polynary yeast complexing polypeptide extract product yield of five mines made from this technique is 8%, and the chelation percent of each minerals can
Up to 89%, content of peptides 6.5%.
1 embodiment 1-3 of table and comparative example 1-2 specific formula ratio table, comparative example 3 are conventional commercial product:
In order to further illustrate the present invention, embodiment and comparative example is tested:
6 sections of products are carried out with the test of cuticula moisture water content, test equipment is that Corneometer moisture measurement probe is surveyed
Examination.30 volunteers are selected, 0.2g sample are applied to sample area, cleaning of looping；Check plot is clear with same gimmick clear water
It washes.The timing since the time for smearing sample acquires data in 1h, 3h, 6h.The data of check plot and sample area are handled,
Data analysis is carried out after screening out exceptional value, moisture content change rate is bigger, illustrates that moistening effect is better.Its test data table is such as
Shown in following table and Fig. 1.
The cuticula moisture content change rate table of 2 embodiment of table and comparative example:
By the test of table 2 and the moisture content of skin of Fig. 1 it is found that being extracted in embodiment 1 ~ 3 containing the polynary yeast complexing polypeptide of five mines
The soap base face cleaning product of object and PQ-7 and glycerol are smaller for the damaged condition of skin barrier, the change rate of moisture content it is exhausted
It is also smaller to being worth, and its moisturizing recovery extent increasing with the polynary yeast complexing polypeptide extract dosage of five mines, to skin
The damaged condition of skin barrier is with regard to smaller.By comparative example 1 ~ 2 and embodiment 1 ~ 3 it is found that glycerol, PQ-7 and the polynary yeast complexing of five mines
After polypeptide extract compounding, it is better to repair to the moisturizing of skin.
In order to assess the antiphlogistic effects of the present composition, product made from embodiment 1 ~ 3 and comparative example 1 ~ 3 is being volunteered
Person tests with it, every group of 30 people, is used continuously 3 months, and daily using once, during using this product, test skin area is not
Using other skin care item, finally observation is used as a result, as shown in table 3.
It can be seen that composition of the invention effectively alleviates cleaning compositions tight feeling of skin, dry sensation after washing,
Reduce the appearance of scytitis, so that composition irritation is low, antiphlogistic effects are obvious, and moistening effect is obvious, and then can mention
For good skin nursing effect.
Although description of this invention combination embodiments above carries out, those skilled in the art
Member can carry out many replacements based on the above contents, modifications and variations, be obvious.Therefore, all such substitutions,
Improvements and changes are included in the spirit and scope of appended claims.
Claims (9)
1. a kind of cleaning compositions of the polynary yeast complexing polypeptide containing five mines, which is characterized in that including following mass percent group
Point:
The polynary yeast complexing polypeptide extract of five mines: 0.01 ~ 28%；
Fatty acid 15 ~ 40%；
Alkali 3 ~ 20%；
Auxiliary dispersants: 3 ~ 35%；
Emulsifier 0.1 ~ 5%；
Thickening stabilizing agent 0.2 ~ 10%；
Cosurfactant 0.1 ~ 25%；
Humectants and emollients 0 ~ 15%；
Deionized water surplus.
2. the cleaning compositions according to claim 1 for containing the polynary yeast complexing polypeptide of five mines, which is characterized in that described
Fatty acid includes octanoic acid, capric acid, lauric acid, myristic acid, palmitinic acid, stearic acid, any two kinds or two kinds in behenic acid
Above mixture.
3. the cleaning compositions according to claim 1 for containing the polynary yeast complexing polypeptide of five mines, which is characterized in that described
Alkali includes KOH, NaOH, NH4At least one of OH, triethanolamine.
4. the cleaning compositions according to claim 1 for containing the polynary yeast complexing polypeptide of five mines, which is characterized in that described
Emulsifier includes that hydrophobic group is C8~C22Carbochain, it is independent or mixing or it is branched, hydrophilic group be light base (- OH), ether
(- O-), phosphate radical, sulfate radical, sulfonate radical, carboxylate radical nonionic surfactant or anionic surfactant.
5. the cleaning compositions according to claim 1 for containing the polynary yeast complexing polypeptide of five mines, which is characterized in that described
Thickening stabilizing agent includes that Tego-stearate, double glycol stearates, rilanit special, monostearate and palm fibre put acid third
Diol ester or its glyceride, higher aliphatic acid alkylolamide, fatty alcohol, fatty acid, polyethylene polymer, latex, stearic acid
At least one of zinc, magnesium stearate, mica, superfine silicon dioxide, super fine zinc oxide, superfine titanic oxide, aluminum magnesium silicate.
6. the cleaning compositions according to claim 1 for containing the polynary yeast complexing polypeptide of five mines, which is characterized in that described
Cosurfactant includes ethoxylated dodecyl alcohol sulfate, glycerine monofatty ester sulfate, fatty alcohol ether sulfo group amber
Amber acid esters salt, N- fatty acyl amino-acid salt, fatty acyl methyl tauride, monoalkyl sulfate, monoalkyl carboxylate, monoalkyl
At least one of phosphate ester salt.
7. the cleaning compositions according to claim 1 for containing the polynary yeast complexing polypeptide of five mines, which is characterized in that described
Humectants and emollients mineral oil, vegetable oil and its derivative, the lactic acid derivative of fatty acid, ultra-fine inorganic material powders, inorganic water
Soluble polymer, cationic polymer, bionic phospholipid, PEG-7 olive grease, PEG-6 caprylic/capric triglyceride, PEG-7
At least one of caprylic/capric triglyceride.
8. the cleaning compositions according to claim 1 for containing the polynary yeast complexing polypeptide of five mines, which is characterized in that described
The preparation method of the polynary yeast complexing polypeptide extract of five mines includes the following steps:
A. broken wall is carried out to yeast: beer waste yeast liquid is activated to itself enzyme system of yeast by three sections of alternating temperature techniques, with certainly
Molten method carries out the broken wall treatment of yeast；
B. prepared by solution: enzyme deactivation is living, and enzymolysis liquid of the enzyme deactivation after living is centrifuged 20 ~ 25min at 3000 ~ 5500r/min of revolving speed,
Supernatant liquor is taken, yeast polypeptides solution is made；
C. the pH value and temperature for adjusting yeast polypeptides solution, being added includes Zn+、Cu2+、Mg2+、Fe2+、Si4+Mineral ion and anti-
Oxidant carries out chelatropic reaction with saccharomyces cerevisiae respectively and obtains yeast polypeptides chelating liquid:
Zn+Chelating condition: pH5.8 ~ 6.3,60 ~ 70 DEG C of temperature, 45 ~ 60min of time, zinc salt additive amount be polypeptide solution quality
10 ~ 20%, antioxidant additive amount be zinc salt quality 20%；
Cu2+Chelating condition: pH6.5 ~ 7.5,58 ~ 68 DEG C of temperature, 3 ~ 5h of time, the additive amount of mantoquita is polypeptide solution quality
10 ~ 20%, antioxidant additive amount is the 20% of mantoquita quality；
Mg2+Chelating condition: pH6.5 ~ 7.5,40 ~ 58 DEG C of temperature, 1 ~ 4h of time, the additive amount of magnesium salts is polypeptide solution quality
15 ~ 28%, antioxidant additive amount is the 15 ~ 25% of magnesium salts quality；
Fe2+Chelating condition: pH6.3 ~ 7.3,25 ~ 38 DEG C of temperature, 30 ~ 70min of time, the additive amount of ferrous salt is polypeptide solution
The 15 ~ 25% of quality, antioxidant additive amount are the 23% of ferrous salt quality；
Si4+Chelating condition: pH6.0 ~ 7.5,58 ~ 70 DEG C of temperature, 30 ~ 70min of time, the additive amount of silicon salt is polypeptide solution matter
The 15 ~ 25% of amount, antioxidant additive amount are the 5 ~ 8% of silicon salt quality；
D. after filtering to each yeast polypeptides chelating liquid, the filtrate respectively containing yeast polypeptides chelating mineral ion is obtained；
E. the resulting filtrate of Step d being mixed in pH6 ~ 7 and 25 ~ 45 DEG C of pure water and obtaining mixed liquor, mixed respectively contains yeast
The mass ratio of the filtrate of polypeptide chelate mineral ion is 1:1, respectively containing yeast polypeptides chelating mineral ion filtrate with it is pure
The gross mass ratio of water is 3 ~ 5:7 ~ 5；
F. leukonid/radish root ferment filtrate is added into mixed liquor, and supernatant liquid body is taken after filtering；
G. to the resulting supernatant liquid body of f step separate molecular weight 20000 small molecules below be extract at
Product.
9. the cleaning compositions according to claim 1 for containing the polynary yeast complexing polypeptide of five mines, which is characterized in that described
The design parameter of the technique of three sections of alternating temperatures include: mass concentration be 10 ~ 12% beer waste yeast liquid at 38 ~ 42 DEG C constant temperature 4
~ 5h, 1.5% dextranase of addition beer waste yeast liquid quality, 4 ~ 5h of constant temperature at 52 ~ 57 DEG C, using at 60 ~ 65 DEG C
4 ~ 5h of constant temperature；Technical process pH value remains 5.0 ~ 5.8.
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| CN113999549A (en) * | 2021-11-08 | 2022-02-01 | 惠乐丰(深圳)科技有限公司 | Composition for improving dispersion stability of powder material and preparation method thereof |
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