CN107349115B - Plant ethosome anti-hair loss pilatory as well as preparation method and using method thereof - Google Patents
Plant ethosome anti-hair loss pilatory as well as preparation method and using method thereof Download PDFInfo
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- CN107349115B CN107349115B CN201710503209.3A CN201710503209A CN107349115B CN 107349115 B CN107349115 B CN 107349115B CN 201710503209 A CN201710503209 A CN 201710503209A CN 107349115 B CN107349115 B CN 107349115B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Abstract
The invention provides a plant ethosome anti-hair loss pilatory and a preparation method and a using method thereof. The plant extract effective for hair growth is prepared into the ethosome, and the vesicle structure formed by the ethosome has better flexibility and membrane fluidity, can carry effective components to directly penetrate through the cuticle, obviously improves the transdermal efficiency, and simultaneously is added with the plant penetrant to help the incompletely encapsulated plant molecules to penetrate into hair follicle cells to play the role of the plant molecules in promoting hair growth, so that the hair loss prevention and hair growth effect is better.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a plant ethosome anti-hair loss pilatory as well as a preparation method and a use method thereof.
Background
The alopecia is a clinical frequently-occurring disease and a common disease, and can be judged as pathological alopecia when more than one hundred hairs fall every day, and mainly comprises androgenetic alopecia, alopecia areata, pseudoalopecia areata, anagen alopecia and the like. Alopecia has been an important problem troubling people for a long time, influences the daily life of people, has complex etiology, and has high morbidity and serious influence on the appearance particularly along with the increase of the life and working pressure of people.
At present, most of plant anti-hair loss and hair growth products in the market are water extract solutions or mixed solutions of water extract solutions and alcohol extract solutions, and the application methods of the plant anti-hair loss and hair growth products are shampoo or hair care agents and are used during hair washing; the hair washing agent or the hair care agent stays on the hair for only a few minutes during hair washing, the time is too short, and in addition, no penetration enhancer is arranged in the plant extracting solution or the nanometer technology is applied to help plant molecules to enter hair follicles and activate the hair follicles, so the hair washing agent or the hair care agent has no obvious effect on preventing and growing the hair.
The invention patent with the patent application number of 201210395803.2 provides a hair restorer which takes humic acid sodium salt and/or potassium salt as an essential component and has the effects of promoting blood circulation, removing blood stasis, nourishing hair follicles, growing and moistening hair and preventing alopecia; the sodium (potassium) humate can promote blood circulation, promote hair growth of unhairing mice, and inhibit hair loss of mice injected with cyclophosphamide. The hair growth agent and the hair growth method which have good hair growth promoting and hair loss preventing effects, are natural, have no pungent smell, have no toxic or side effect, and are safe and reliable are provided by taking the sodium (potassium) humate as the main effective component, but the hair loss preventing and hair growth effects of the invention are not obvious.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention applies nanotechnology and permeation-promoting technology to improve the penetration of effective components of plants into the deep layer of hair follicles. The plant ethosome anti-hair loss pilatory adopts the plant ethosome and the plant penetrant, can promote effective components to permeate into hair follicles, meanwhile, the product stays on the scalp for a period of time in the using process, and is heated by the far infrared heater, so that the permeation and the action of effective molecules are further promoted, and the purposes of promoting the growth of hairs and preventing the hairs from falling off are achieved.
The plant ethosome anti-hair loss pilatory of the invention is prepared from a plurality of components, and comprises the following components by weight percent: 20-80% of plant ethosome, 10-20% of plant penetrant and the balance of auxiliary materials.
Preferably, the composition comprises the following components in percentage by weight: 30-70% of plant ethosome, 13-17% of plant penetrant and the balance of auxiliary materials.
In any of the above schemes, the composition preferably comprises the following components in percentage by weight: 30% of plant ethosome, 20% of plant penetrant and 50% of auxiliary material.
In any of the above schemes, the composition preferably comprises the following components in percentage by weight: 40% of plant ethosome, 15% of plant penetrant and 45% of auxiliary material.
In any of the above schemes, the composition preferably comprises the following components in percentage by weight: 50% of plant ethosome, 12% of plant penetrant and 38% of auxiliary material.
In any of the above schemes, the composition preferably comprises the following components in percentage by weight: 60% of plant ethosome, 20% of plant penetrant and 20% of auxiliary material.
In any of the above schemes, the composition preferably comprises the following components in percentage by weight: 70% of plant ethosome, 15% of plant penetrant and 15% of auxiliary material.
Preferably in any of the above schemes, the plant ethosome comprises the following components in percentage by weight:
20 to 60 percent of plant alcohol extract;
1.0 to 6.0 percent of phospholipid;
0.0 to 2.0 percent of cholesterol;
0.1 to 0.8 percent of antioxidant;
38.5 to 80 percent of plant water extract.
Preferably in any of the above schemes, the plant ethosome comprises the following components in percentage by weight:
18.5 to 55 percent of plant alcohol extract;
1.0 to 6.0 percent of phospholipid;
0.0 to 2.0 percent of cholesterol;
0.1 to 0.8 percent of antioxidant;
38.5 to 75 percent of plant water extract.
Preferably in any of the above schemes, the plant ethosome comprises the following components in percentage by weight:
25% of plant alcohol extract;
2.0% of phospholipid;
0.5% of cholesterol;
0.2% of antioxidant;
72.8 percent of plant water extract.
Preferably in any of the above schemes, the plant ethosome comprises the following components in percentage by weight:
35% of plant alcohol extract;
3.0% of phospholipid;
1% of cholesterol;
0.4% of antioxidant;
60.6 percent of plant water extract.
Preferably in any of the above schemes, the plant ethosome comprises the following components in percentage by weight:
45 percent of plant alcohol extract;
4.0% of phospholipid;
1.5% of cholesterol;
0.5% of antioxidant;
49% of plant water extract.
Preferably in any of the above schemes, the plant ethosome comprises the following components in percentage by weight:
55% of plant alcohol extract;
5.0% of phospholipid;
1.8% of cholesterol;
0.7% of antioxidant;
37.5 percent of plant water extract.
In any of the above embodiments, preferably, the plant alcohol extract is an 80-100% low molecular weight alcohol extract extracted from a plant material.
In any of the above schemes, preferably, the plant alcohol extract is prepared by the following method: crushing plant raw materials, adding 80-100% of low molecular weight alcohol in an amount which is 10 times the weight of the plant raw materials by weight, soaking for 24 hours, carrying out ultrasonic extraction for 2 hours at the temperature of 60-90 ℃, filtering out medicine residues by using gauze, centrifuging the filtrate to remove precipitates to obtain plant alcohol extract;
preferably in any of the above embodiments, the low molecular weight alcohol is ethanol.
In any of the schemes, preferably, the plant raw material is one or more of cacumen biotae, ligusticum wallichii, polygonum multiflorum, loranthus parasiticus, fructus viticis, astragalus mongholicus, salvia miltiorrhiza, glossy privet fruit, radix sophorae flavescentis and mulberries.
In any of the schemes, preferably, the plant water extract is obtained by extracting camellia seed cake and radix ophiopogonis.
In any of the above schemes, preferably, the plant penetrant is obtained by extracting one or more of angelica, clove, mint and liquorice.
In any of the above embodiments, the formulation of the plant ethosome alopecia prevention and hair growth agent is any one of liquid, emulsion, gel and paste.
In any of the above embodiments, preferably, the phospholipid is at least one of soybean lecithin, egg yolk lecithin, hydrogenated soybean lecithin, and pegylated phospholipid.
In any of the above embodiments, preferably, the low molecular weight alcohol is at least one of absolute ethanol, isopropanol, and propylene glycol.
In any of the above embodiments, preferably, the antioxidant is at least one of vitamin E, vitamin C, and propyl gallate.
In any of the above embodiments, the plant ethosome has a particle size ranging from 50nm to 600 nm.
In any of the above embodiments, preferably, the plant ethosome has a particle size in the range of 100 nm.
In any of the above embodiments, preferably, the plant ethosome has a particle size in the range of 200 nm.
In any of the above embodiments, preferably, the plant ethosome has a particle size in the range of 300 nm.
In any of the above embodiments, preferably, the plant ethosome has a particle size in the range of 400 nm.
In any of the above embodiments, preferably, the plant ethosome has a particle size in the range of 500 nm.
The invention also provides a preparation method of the plant ethosome anti-hair loss pilatory, which comprises the following steps:
(1) preparing an alcohol phase from the plant alcohol extract, preparing a water phase from the plant water extract, and preparing a plant ethosome by an injection ultrasonic homogenization method;
(2) granulating the obtained plant ethosome by a mechanical method;
(3) uniformly mixing the whole plant ethosome, the plant penetrating agent and the auxiliary materials, and preparing to obtain the plant ethosome anti-hair loss pilatory.
Preferably, the alcohol phase in the step (1) is prepared by the following preparation method: adding soybean phospholipid and cholesterol into the plant alcohol extract, and ultrasonically stirring for dissolving to obtain an alcohol phase.
In any of the above embodiments, preferably, the plant alcohol extract: soybean lecithin: the weight ratio of cholesterol is 100: 1-6: 0.0 to 2.0.
In any of the above schemes, preferably, the plant water extract in step (1) is prepared by the following preparation method: weighing tea seed cake and radix ophiopogonis, crushing, adding 10 times of water by weight, soaking, carrying out ultrasonic extraction, filtering out medicine residues, and centrifuging to remove precipitates to obtain a plant water extract.
In any of the above embodiments, preferably, the aqueous phase in step (1) is obtained by adjusting the pH to 6.5 with a plant water extract.
In any of the above embodiments, the method for mechanically sizing plant ethosomes in the step (2) preferably comprises: homogenizing and stirring at 3000-4000 r/min with high speed dispersing homogenizer.
In any of the above embodiments, preferably, the plant penetrant in step (3) is prepared by the following preparation method: weighing at least one of angelica, clove, mint and liquorice, crushing, adding 10 times of 30-60% ethanol by weight, soaking, carrying out ultrasonic extraction, filtering out dregs, and centrifuging to remove precipitates to obtain the plant penetrant.
In any of the above schemes, preferably, the adjuvant in step (3) includes at least one of caprylic/capric triglyceride, jojoba oil, glycerol, butylene glycol, tween 80, mixed alcohol, monoglyceride, carbomer 940 gelling agent, and lanolin.
In any of the above schemes, preferably, a blank gel is further added to the plant ethosome in the step (3), and the preparation method of the blank gel comprises: weighing 2% of carbomer 940 gelling agent, uniformly dispersing in water, standing at room temperature, and fully swelling; adding 5% of glycerol, uniformly mixing with the fully swollen carbomer 940 gelling agent, and adjusting the pH to 5-7 by using triethanolamine to obtain the blank gel.
The invention also provides a use method of the plant ethosome alopecia-preventing pilatory, which comprises the following steps:
(1) uniformly coating the plant ethosome alopecia preventing and hair growing agent on the hair until the scalp is completely wet;
(2) wearing a shower cap, and heating for 10-100 minutes by using a far infrared heater;
(3) taking off the shower cap, combing the hair with a comb, massaging for 10 minutes, and washing the hair.
The plant ethosome hair loss preventing pilatory stays on scalp for a long time, and the effective components can fully play a role by using a far infrared heater.
The plant Ethosomes (Ethosomes) in the invention are novel flexible liposomes which are most concerned in the fields of medicine, pharmacy and cosmetology in recent years and are composed of low molecular weight alcohols (ethanol, propylene glycol, isopropanol), phospholipids, cholesterol and water; the ethosome is used as a carrier of a novel transdermal drug delivery system, and has the remarkable advantages of high encapsulation efficiency, large drug-loading rate, small particle size, good transdermal efficiency, large skin retention and capability of transferring intracellular drugs; there are two main mechanisms for promoting transdermal absorption, one is a penetration mechanism: the vesicle structure formed by the ethosomes carries effective components to directly penetrate through the stratum corneum, and due to the existence of alcohol in the phospholipid layer, the liposome has better flexibility and membrane fluidity, so that the penetration depth is high, and the transdermal efficiency is obviously improved; secondly, a fusion mechanism: the phospholipid of ethosome fuses with stratum corneum lipid, the compact and ordered structure of stratum corneum is disturbed, and simultaneously the effective components are released from the vesicle and independently permeate into the skin.
According to the invention, under the condition of adding the plant ethosome, the plant penetration enhancer is added at the same time, so that the incompletely encapsulated plant molecules are helped to penetrate into hair follicles to play a role of promoting the growth of the hair by the plant molecules.
Advantageous effects
The invention provides a plant ethosome anti-hair loss pilatory and a preparation method and a using method thereof. The invention takes the plant which promotes the hair growth and the blood circulation as the raw material to prepare the plant ethosome, the plant penetrating agent is added to further promote each effective component to enter the hair follicle, the plant ethosome is prepared into liquid, emulsion, gel and paste, the special using method is adopted to lead the effective component to stay on the scalp for a long time, and the penetration and the action of the effective molecules are further promoted by the heating of far infrared rays. The plant extract effective for growth of the hair is prepared into the ethosome, and the vesicle structure formed by the ethosome has better flexibility and membrane fluidity, can carry effective components to directly penetrate through the cuticle, obviously improves the transdermal efficiency, and is added with the plant penetrant to help the incompletely encapsulated plant molecules to permeate into hair follicle cells to play the role of promoting the hair growth of the plant molecules. When the plant ethosome anti-hair loss pilatory is used, the plant ethosome anti-hair loss pilatory can be kept on the scalp for a long time, and the far infrared heater is used for heating to promote the blood circulation of hair and the penetration of effective components, so that the aims of preventing hair loss and promoting hair growth are fulfilled.
Detailed Description
In order to better understand the technical solutions and advantages of the present invention, the present invention is further described below by way of specific embodiments.
The plant alcohol extract used in the following examples is prepared by crushing cacumen biotae, ligusticum wallichii, polygonum multiflorum, parasitic loranthus, fructus viticis, astragalus mongholicus, salvia miltiorrhiza, glossy privet fruit, radix sophorae flavescentis and mulberries, adding 80-100% ethanol in an amount which is 10 times that of the crushed extract by weight, soaking for 24 hours, carrying out ultrasonic extraction at 60-90 ℃ for 2 hours, immediately filtering out medicine residues by using three layers of gauze, and centrifuging the filtrate to remove precipitates to obtain the plant alcohol extract;
the alcohol phase used in the following examples is as an alcohol extract: soybean lecithin: the weight ratio of the cholesterol is (80: 1-6: 0.0-2.0), the soybean phospholipid and the cholesterol are added into the alcohol extract, ultrasonic stirring is carried out to dissolve the soybean phospholipid and the cholesterol to obtain an alcohol phase, and the antioxidant is added according to the proportion of 0.1-0.8%.
The aqueous phase used in the following examples: weighing the tea seed cake and the dwarf lilyturf tuber as required, crushing, adding 10 times of water by weight, soaking for 24 hours, carrying out ultrasonic extraction at 60-90 ℃ for 2 hours, immediately filtering out medicine residues by using three layers of gauze, centrifuging the filtrate to remove precipitates to obtain a plant water extract, adding phosphate to adjust the pH value to 6.5, and obtaining a water phase;
plant penetrants used in the following examples: weighing angelica, clove, mint and liquorice according to the needs, crushing, adding 10 times of 30-60% ethanol by weight, soaking for 24 hours, carrying out ultrasonic extraction at 40-60 ℃ for 2 hours, immediately filtering out medicine residues by using three layers of gauze, centrifuging the filtrate to remove precipitates, and obtaining a plant penetrant solution;
example 1
The plant ethosome anti-hair loss and hair growth liquid and the preparation method thereof are as follows: heating the alcohol phase and the water phase to 50 deg.C respectively, keeping the temperature constant, adding one part of alcohol phase into three parts of water phase under stirring to obtain primary emulsion; homogenizing and stirring the primary emulsion at 3000r/min with a high-speed homogenizer to obtain suspension, stirring the ethosome suspension for 20 min, and performing secondary emulsification; placing the suspension at 0-4 ℃, cooling and solidifying to obtain a plant ethosome; adding 20% of plant penetrant into ethosome, adding 2% of caprylic capric triglyceride, 1% of jojoba oil, 3% of glycerol, 2% of butanediol and 5% of tween 80, and stirring for 20 minutes by a homogenizer to obtain the plant ethosome anti-hair loss hair-growing liquid.
Example 2
The plant ethosome anti-hair loss hair growth emulsion and the preparation method thereof are as follows: heating the alcohol phase and the water phase to 45 deg.C respectively, keeping the temperature constant, adding one part of alcohol phase into the two parts of water phase under stirring to obtain primary emulsion; homogenizing and stirring the primary emulsion at 4000r/min by a high-speed dispersion homogenizer under high pressure to obtain suspension, stirring the ethosome suspension for 30 minutes, and carrying out secondary emulsification; placing the suspension at 0-4 ℃, cooling and solidifying to obtain a plant ethosome; adding 15% of plant penetrating agent into ethosome, adding 5% of caprylic capric triglyceride, 2% of jojoba oil, 2% of mixed alcohol, 5% of monoglyceride, 5% of glycerol, 3% of butanediol and 6% of tween 80, and stirring for 20 minutes by a homogenizer to obtain the plant ethosome anti-hair loss hair-growing emulsion.
Example 3
The plant ethosome anti-hair loss hair-growing gel and the preparation method thereof are as follows: heating the alcohol phase and the water phase to 40 deg.C respectively, keeping the temperature constant, adding one part of alcohol phase into three parts of water phase under stirring to obtain primary emulsion; homogenizing and stirring the primary emulsion at 4000r/min by a high-speed dispersion homogenizer under high pressure to obtain suspension, stirring the ethosome suspension for 30 minutes, and carrying out secondary emulsification; placing the suspension at 0-4 ℃, cooling and solidifying to obtain a plant ethosome; adding 10% of plant penetrant into the ethosome;
the preparation method of the blank gel comprises the following steps: weighing 2% carbomer 940 gelling agent, uniformly dispersing in water, standing at room temperature for 24h, and fully swelling; adding 5% of glycerol, uniformly mixing with the fully swollen carbomer 940 gelling agent, and adjusting the pH of the mixture to 5-7 by using triethanolamine to obtain a blank gel;
mixing three parts of plant ethosome and one part of blank gel; adding 10% of plant penetrant, and stirring for 10 minutes to obtain the plant ethosome anti-hair loss hair-growing gel.
Example 4
The ethosome anti-hair loss and hair growth cream and the preparation method thereof are as follows: heating the alcohol phase and the water phase to 45 deg.C respectively, keeping the temperature constant, adding one part of alcohol phase into three parts of water phase under stirring to obtain primary emulsion; homogenizing and stirring the primary emulsion at 3000r/min with a high-speed dispersion homogenizer under high pressure to obtain suspension, stirring the ethosome suspension for 30 minutes, and performing secondary emulsification; placing the suspension at 0-4 ℃, cooling and solidifying to obtain a plant ethosome;
adding 10% of plant penetrant into the ethosome, and keeping the temperature at 50 ℃;
heating 12% mixed alcohol, 5% monoglyceride, 0.8% lanolin, 2% caprylic/capric triglyceride, 3% glycerol, 2% butanediol and 4% Tween-80 to 70 deg.C for melting to obtain oil;
adding 10% of plant penetrant into the ethosome, adding the oil phase into the ethosome under stirring by a homogenizer, and homogenizing for 20 minutes to obtain the plant ethosome anti-hair loss and hair growth cream.
Example 5
The application method of the plant ethosome anti-hair loss and hair growth emulsion comprises the following steps: uniformly smearing ethosome emulsion on hair until scalp is completely wetted, wearing a bath cap, heating for 2 hours by using a far infrared heater, taking off the bath cap, combing and massaging the hair for 10 minutes by using a comb, and washing the hair.
Example 6
The clinical observation treatment was performed on 360 patients, aged 24 to 70 years, wherein 289 male and 72 female patients suffered from alopecia due to various reasons. Groups were randomized into 9 groups of 40 people each.
The evaluation standard of curative effect is as follows:
the effect is shown: the clinical symptoms such as hair rarity, alopecia, baldness and the like basically or mostly disappear.
The method has the following advantages: the clinical symptoms such as hair rarity, alopecia, baldness and the like are obviously improved or improved.
And (4) invalidation: there was no improvement in clinical signs.
The treatment effect is as follows:
(1) experimental group 1: the plant ethosome alopecia preventing and hair growing solution prepared in example 1;
(2) experimental group 2: the plant ethosome alopecia preventing and hair growing cream prepared in example 2;
(3) experimental group 3: the plant ethosome alopecia preventing and hair growing gel prepared in example 3;
(4) experimental group 4: the plant ethosome alopecia-preventing and hair-growing cream prepared in example 4;
(5) blank control group 1: directly cleaning with clear water.
(6) Control group 2: control 2 differs from example 1 in that the alcohol phase is present as ethanol: soybean lecithin: cholesterol is 80: 1-6: 0.0-2.0 by weight, adding soybean phospholipids and cholesterol into ethanol, and ultrasonically stirring to dissolve the soybean phospholipids and the cholesterol to obtain an alcohol phase, wherein the other preparation methods are the same as those in example 1.
(7) Control group 3: control 3 differs from example 2 in that the alcohol phase is as an alcohol extract: soybean lecithin: cholesterol is 30: 1-6: 0.0-2.0 by weight, adding the soybean lecithin and the cholesterol into ethanol, and ultrasonically stirring to dissolve the soybean lecithin and the cholesterol to obtain an alcohol phase, wherein the other preparation methods are the same as the example 2.
(8) Control group 4: control 4 differs from example 3 in that the alcohol phase is present as ethanol: soybean lecithin: cholesterol is 90: 0.5: 2.0 weight ratio, adding soya lecithin and cholesterol into ethanol, and stirring with ultrasound to dissolve to obtain an alcohol phase, otherwise the preparation method is the same as that of example 3.
The use method comprises the following steps: uniformly smearing and smearing corresponding ethosome anti-hair loss hair growth promoting agent on hair until scalp is completely wet, wearing a bath cap, heating for 10-100 minutes by using a far infrared heater, taking off the bath cap, combing and massaging for 10 minutes by using a comb, and washing the hair. It is administered 2-3 times daily. Observations were made after three consecutive months.
(9) Control group 5: the hair restorer prepared in example 1 of the invention patent publication No. 200910231223.8, the method of use of which is described in example 1.
TABLE 1 therapeutic Condition
As can be seen from the data in table 1, after the plant ethosome anti-hair loss hair restorer of the present invention is used, the effects of the experimental group 1, the experimental group 2, the experimental group 3 and the experimental group 4 are obvious, wherein the effective rate is as high as 97.5% in the ineffective 1 cases in the experimental group 1, the experimental group 2 and the experimental group 4.
It should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (11)
1. A plant ethosome anti-hair loss pilatory is prepared from a plurality of components and is characterized in that: the composition is prepared from the following components in percentage by weight: 20-80% of plant ethosome, 10-20% of plant penetrant and the balance of auxiliary materials, wherein the plant ethosome is prepared from the following components in percentage by weight: 20 to 60 percent of plant alcohol extract and 1.0 to 6.0 percent of phospholipid; 0.0 to 2.0 percent of cholesterol; 0.1 to 0.8 percent of antioxidant, 38.5 to 80 percent of plant water extract and 100 percent of each component in the plant ethosome by weight percent; the plant alcohol extract is prepared by crushing plant raw materials, adding 80-100% ethanol in an amount which is 10 times the weight of the plant raw materials, soaking for 24 hours, carrying out ultrasonic extraction at the temperature of 60-90 ℃ for 2 hours, filtering out medicine residues by using gauze, and centrifuging the filtrate to remove precipitates; the plant raw materials comprise cacumen biotae, ligusticum wallichii, polygonum multiflorum, parasitic loranthus, fructus viticis, astragalus mongholicus, salvia miltiorrhiza, glossy privet fruit, radix sophorae flavescentis and mulberries; the antioxidant is at least one of vitamin E, vitamin C and propyl gallate; the plant water extract is obtained by extracting camellia seed cake and ophiopogon root; the plant penetrant is prepared by crushing at least one of Chinese angelica, clove, mint and liquorice, adding 10 times of 30-60% ethanol by weight, soaking, performing ultrasonic extraction, filtering out medicine residues, and centrifuging to remove precipitates.
2. The plant ethosome alopecia preventing and hair growing agent as claimed in claim 1, which is characterized in that: comprises the following components in percentage by weight: 30-70% of plant ethosome, 13-17% of plant penetrant and the balance of auxiliary materials.
3. The plant ethosome alopecia preventing and hair growing agent as claimed in claim 1, which is characterized in that: the plant ethosome hair loss preventing and hair growing agent is in any one of liquid, emulsion, gel and paste.
4. The plant ethosome alopecia preventing and hair growing agent as claimed in claim 1, which is characterized in that: the grain size range of the plant ethosome is 100 nm-600 nm.
5. The method for producing the plant ethosome alopecia preventing and growing agent as set forth in any one of claims 1 to 4, wherein: the method comprises the following steps:
preparing an alcohol phase from the plant alcohol extract, preparing a water phase from the plant water extract, and preparing a plant ethosome by an injection ultrasonic homogenization method;
(2) granulating the obtained plant ethosome by a mechanical method;
(3) uniformly mixing the whole plant ethosome, the plant penetrating agent and the auxiliary materials, and preparing to obtain the plant ethosome anti-hair loss pilatory.
6. The method for preparing the plant ethosome alopecia preventing and hair growing agent according to claim 5, wherein the plant ethosome comprises the following steps: the alcohol phase in the step (1) is prepared by adopting the following preparation method: adding soybean phospholipid and cholesterol into the plant alcohol extract, and ultrasonically stirring for dissolving to obtain an alcohol phase.
7. The method for preparing the plant ethosome alopecia preventing and hair growing agent according to claim 5, wherein the plant ethosome comprises the following steps: the plant water extract in the step (1) is prepared by adopting the following preparation method: weighing tea seed cake and radix ophiopogonis, crushing, adding 10 times of water by weight, soaking, carrying out ultrasonic extraction, filtering out medicine residues, and centrifuging to remove precipitates to obtain a plant water extract.
8. The method for preparing the plant ethosome alopecia preventing and hair growing agent according to claim 5, wherein the plant ethosome comprises the following steps: the water phase in the step (1) is obtained by adjusting the pH value to 6.5 by using a plant water extract.
9. The method for preparing the plant ethosome alopecia preventing and hair growing agent according to claim 5, wherein the plant ethosome comprises the following steps: the method for straightening the plant ethosome by using a mechanical method in the step (2) comprises the following steps: homogenizing and stirring at 3000-4000 r/min with high speed dispersing homogenizer.
10. The method for preparing the plant ethosome alopecia preventing and hair growing agent according to claim 5, wherein the plant ethosome comprises the following steps: the auxiliary materials in the step (3) comprise at least one of caprylic/capric triglyceride, jojoba oil, glycerol, butanediol, tween 80, monoglyceride, carbomer 940 gelling agent and lanolin.
11. The method for preparing the plant ethosome alopecia preventing and hair growing agent according to claim 5, wherein the plant ethosome comprises the following steps: blank gel is also required to be added into the plant ethosome in the step (3), and the preparation method of the blank gel comprises the following steps: weighing 2% of carbomer 940 gelling agent, uniformly dispersing in water, standing at room temperature, and fully swelling; adding 5% of glycerol, uniformly mixing with the fully swollen carbomer 940 gelling agent, and adjusting the pH to 5-7 by using triethanolamine to obtain the blank gel.
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| CN102579323A (en) * | 2011-02-21 | 2012-07-18 | 舒泰神（北京）生物制药股份有限公司 | Paclitaxel ethosome gel and preparation method thereof |
| CN106075390A (en) * | 2016-07-28 | 2016-11-09 | 广东药科大学 | A kind of positively charged anticreep composite and flexible liposome and preparation method thereof |
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| CN102579323A (en) * | 2011-02-21 | 2012-07-18 | 舒泰神（北京）生物制药股份有限公司 | Paclitaxel ethosome gel and preparation method thereof |
| CN106075390A (en) * | 2016-07-28 | 2016-11-09 | 广东药科大学 | A kind of positively charged anticreep composite and flexible liposome and preparation method thereof |
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