CN107349115A - A kind of plant alcohol plastid pilatory for preventing trichomadesis and preparation method thereof and application method - Google Patents

A kind of plant alcohol plastid pilatory for preventing trichomadesis and preparation method thereof and application method Download PDF

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Publication number
CN107349115A
CN107349115A CN201710503209.3A CN201710503209A CN107349115A CN 107349115 A CN107349115 A CN 107349115A CN 201710503209 A CN201710503209 A CN 201710503209A CN 107349115 A CN107349115 A CN 107349115A
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plant
plastid
pilatory
alcohol
alcohol plastid
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CN107349115B (en
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张学记
董海峰
穆惠芳
党海涛
王昌涛
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Zhongjian Taike Biotechnology Co.,Ltd.
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张学记
董海峰
穆惠芳
党海涛
王昌涛
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/81—Preparation or application process involves irradiation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
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  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides a kind of plant alcohol plastid pilatory for preventing trichomadesis and preparation method thereof and application method, and plant alcohol plastid pilatory for preventing trichomadesis includes plant alcohol plastid, plant penetrant, other auxiliary materials.Enemy long effective plant extracts and alcohol plastid is made by the present invention occurs, because the imitated vesicle structure that alcohol plastid is formed has preferably flexible and film mobility, active ingredient can be carried and be directed through cuticula, transdermal efficiency significantly improves, add plant penetrant simultaneously, it is preferable that the plant molecular for helping not encapsulate completely penetrates into the performance trichogenous effect of plant molecular, preventing baldness effect in hair follicle cell.

Description

A kind of plant alcohol plastid pilatory for preventing trichomadesis and preparation method thereof and application method
Technical field
The invention belongs to cosmetic technical field, more particularly to a kind of plant alcohol plastid pilatory for preventing trichomadesis and its preparation side Method and application method.
Background technology
Alopecia is clinical frequently-occurring disease, common disease, can be judged as that pathologic takes off more than more than 100 when losing hair daily Hair, mainly including androgenetic alopecia, alopecia areata, pseudopelade and growth period alopecia etc..Alopecia for a long time is always to perplex people Major issue, affect daily life, its cause of disease is more complicated, especially as people's life, operating pressure Increase, the incidence of disease is very high, has a strong impact on attractive in appearance.
At present, in the market loss preventing plant hair product for improving hair-growing is mostly the mixed liquor of water extraction solution or Aqueous extracts and alcohol extract, Its application method is mostly shampoo or conditioner, is used in hair washing；Shampoo or conditioner stop on hair during because of hair washing Time is only a few minutes, and the time is too short, does not have permeation enhancers or application nanometer technology to help plant point in plant extraction liquid in addition Son enters hair follicle and activation hair follicle, and therefore, its Anti-hair loss and hair tonic to hair does not have positive effect.
Number of patent application provides a kind of preparation for baldness for 201210395803.2 patent of invention, and the preparation for baldness is with humic acid Sodium salt and/or sylvite are essential component, and with promoting blood circulation and removing blood stasis, tonic hair follicle, hair tonic profit hair, Anti-hair loss effect；Institute of the present invention Sodium humate (potassium) salt stated can stimulate circulation, and have facilitation to the hair growth for the mouse that loses hair or feathers, to injecting ring phosphinylidyne The mouse hair obscission of amine has certain inhibitory action.By regarding sodium humate (potassium) salt as principle active component, carry Supplied with it is good promote hair growth, Anti-hair loss effect and it is natural, have no irritating odor, have no toxic side effect, be safe and reliable Preparation for baldness and hair growth method, but the Anti-hair loss of the invention and hair-growing effects unobvious.
The content of the invention
In order to overcome above problems of the prior art, the present invention is improved and planted using nanometer technology and rush infiltration technology Thing active ingredient enters hair follicle deep layer.The plant alcohol plastid pilatory for preventing trichomadesis of the present invention uses plant alcohol plastid and plant osmosis Agent, active ingredient can be promoted to penetrate into hair follicle, meanwhile, allow product to be stayed for some time on scalp in use, And application far-infrared heater heats, and further promotes the infiltration and effect of effective molecule, reaches promotion natural on-off cycles of hair growth, prevent head The purpose of falling out.
The plant alcohol plastid pilatory for preventing trichomadesis of the present invention, is made up of multiple components, includes the group of following percentage by weight Point：Plant alcohol plastid 20%~80%, plant penetrant 10~20%, remaining is auxiliary material.
Preferably, comprising following components in percentage by weight：Plant alcohol plastid 30%~70%, plant penetrant 13~ 17%, remaining is auxiliary material.
In any of the above-described scheme preferably, following components in percentage by weight is included：Plant alcohol plastid 30%, plant is oozed Saturating agent 20%, auxiliary material 50%.
In any of the above-described scheme preferably, following components in percentage by weight is included：Plant alcohol plastid 40%, plant is oozed Saturating agent 15%, auxiliary material 45%.
In any of the above-described scheme preferably, following components in percentage by weight is included：Plant alcohol plastid 50%, plant is oozed Saturating agent 12%, auxiliary material 38%.
In any of the above-described scheme preferably, following components in percentage by weight is included：Plant alcohol plastid 60%, plant is oozed Saturating agent 20%, auxiliary material 20%.
In any of the above-described scheme preferably, following components in percentage by weight is included：Plant alcohol plastid 70%, plant is oozed Saturating agent 15%, auxiliary material 15%.
In any of the above-described scheme preferably, the plant alcohol plastid includes following weight percent composition：
Plant alcohol extract 20%~60%；
Phosphatidase 1 .0%~6.0%；
Cholesterol 0.0%~2.0%；
Antioxidant 0.1%~0.8%；
Plant Aqueous extracts 38.5%~80%.
In any of the above-described scheme preferably, the plant alcohol plastid includes following weight percent composition：
Plant alcohol extract 18.5%~55%；
Phosphatidase 1 .0%~6.0%；
Cholesterol 0.0%~2.0%；
Antioxidant 0.1%~0.8%；
Plant Aqueous extracts 38.5%~75%.
In any of the above-described scheme preferably, the plant alcohol plastid includes following weight percent composition：
Plant alcohol extract 25%；
Phosphatidase 2 .0%；
Cholesterol 0.5%；
Antioxidant 0.2%；
Plant Aqueous extracts 72.8%.
In any of the above-described scheme preferably, the plant alcohol plastid includes following weight percent composition：
Plant alcohol extract 35%；
Phosphatidase 3 .0%；
Cholesterol 1%；
Antioxidant 0.4%；
Plant Aqueous extracts 60.6%.
In any of the above-described scheme preferably, the plant alcohol plastid includes following weight percent composition：
Plant alcohol extract 45%；
Phosphatidase 4 .0%；
Cholesterol 1.5%；
Antioxidant 0.5%；
Plant Aqueous extracts 49%.
In any of the above-described scheme preferably, the plant alcohol plastid includes following weight percent composition：
Plant alcohol extract 55%；
Phosphatidase 5 .0%；
Cholesterol 1.8%；
Antioxidant 0.7%；
Plant Aqueous extracts 37.5%.
In any of the above-described scheme preferably, the plant alcohol extract is that 80~100% extracted using plant material are low Molecular weight alcohol extract solution.
In any of the above-described scheme preferably, the plant alcohol extract is prepared using following methods：Plant material, crush, By weight, 10 times of 80%~100% low-molecular-weight alcohols of amount are added, are soaked 24 hours, 60 DEG C~90 DEG C ultrasonic extractions 2 hours, The dregs of a decoction are filtered out with gauze, filtrate centrifugation removes sediment, obtains plant alcohol extract；
In any of the above-described scheme preferably, the low-molecular-weight alcohol is ethanol.
In any of the above-described scheme preferably, the plant material is cacumen biotae, Ligusticum wallichii, the fleece-flower root, Ramulus Taxilli, wild pepper One or more in son, the Radix Astragali, the red sage root, the fruit of glossy privet, kuh-seng and mulberries.
In any of the above-described scheme preferably, the plant Aqueous extracts are obtained using after tea seed cake, tuber of dwarf lilyturf extraction.
In any of the above-described scheme preferably, the plant penetrant is using one in Radix Angelicae Sinensis, cloves, peppermint, radix glycyrrhizae Obtained after kind or several extractions.
In any of the above-described scheme preferably, the formulation of plant alcohol plastid pilatory for preventing trichomadesis is liquid, emulsion, gel Any one in agent, paste.
In any of the above-described scheme preferably, the phosphatide is soybean lecithin, egg yolk lecithin, hydrogenated soy phosphatidyl choline At least one of with PEGylation phosphatide.
In any of the above-described scheme preferably, the low-molecular-weight alcohol is absolute ethyl alcohol, isopropanol, at least the one of propane diols Kind.
In any of the above-described scheme preferably, the antioxidant is in vitamin E, vitamin C, propylgallate It is at least one.
In any of the above-described scheme preferably, the particle size range of the plant alcohol plastid is 50nm~600nm.
In any of the above-described scheme preferably, the particle size range of the plant alcohol plastid is 100nm.
In any of the above-described scheme preferably, the particle size range of the plant alcohol plastid is 200nm.
In any of the above-described scheme preferably, the particle size range of the plant alcohol plastid is 300nm.
In any of the above-described scheme preferably, the particle size range of the plant alcohol plastid is 400nm.
In any of the above-described scheme preferably, the particle size range of the plant alcohol plastid is 500nm.
The present invention also provides a kind of preparation method of above-mentioned plant alcohol plastid pilatory for preventing trichomadesis, comprises the following steps：
(1) prepares alcohol phase with plant alcohol extract, and aqueous phase is prepared with plant Aqueous extracts, is prepared using ultrasonic homogeneous method is injected Plant alcohol plastid；
(2) carries out whole grain using mechanical means to resulting plant alcohol plastid；
(3) the plant alcohol plastid that whole grain is crossed is well mixed, prepared by with plant penetrant, auxiliary material, obtains plant alcohol plastid and prevents Alopecia agent.
Preferably, alcohol phase is prepared using following preparation method in the step (1)：Soybean lecithin and cholesterol are added Into plant alcohol extract, ultrasonic agitation makes dissolving, obtains alcohol phase.
In any of the above-described scheme preferably, the plant alcohol extract：Soybean lecithin：The weight ratio of cholesterol is 100：1 ~6：0.0~2.0.
In any of the above-described scheme preferably, plant Aqueous extracts are prepared using following preparation method in the step (1)：Claim Tea seed cake, the tuber of dwarf lilyturf are taken, is crushed, by weight, adds the water of 10 times of amounts, immersion, ultrasonic extraction filters out the dregs of a decoction, and centrifugation removes precipitation Thing, obtain plant Aqueous extracts.
In any of the above-described scheme preferably, aqueous phase is to adjust pH value to 6.5 using plant Aqueous extracts in the step (1) After obtain.
In any of the above-described scheme preferably, whole grain is carried out to plant alcohol plastid using mechanical means in the step (2) Method be：Homogeneous stirring is carried out under 3000r/min-4000r/min rotating speed with high speed homogeneous dispersion machine.
In any of the above-described scheme preferably, plant penetrant is prepared using following preparation method in the step (3)：Claim At least one of Radix Angelicae Sinensis, cloves, peppermint, radix glycyrrhizae are taken, is crushed, by weight, adds 30%~60% ethanol of 10 times of amounts, leaching Bubble, ultrasonic extraction filter out the dregs of a decoction, and centrifugation removes sediment, obtains plant penetrant.
In any of the above-described scheme preferably, in the step (3) auxiliary material include pungent capric acid triglyceride, SIMMONDSIA CHINENSIS SEED OIL, At least one of glycerine, butanediol, Tween 80, mixed alcohol, monoglyceride, Acritamer 940 gelling agent, lanolin.
In any of the above-described scheme preferably, also need to add Blank gel in plant alcohol plastid in the step (3), it is empty The compound method of white gel is：Weigh 2% Acritamer 940 gelling agent to be dispersed in water, place, fill at ambient temperature Divide swelling；Add 5% glycerine, be well mixed with the Acritamer 940 gelling agent being fully swelled, pH to 5~7 is adjusted with triethanolamine, Obtain Blank gel.
The present invention also provides a kind of application method of plant alcohol plastid pilatory for preventing trichomadesis, comprises the following steps：
(1) is uniformly applied on hair and is spread pohytol plastid pilatory for preventing trichomadesis, to scalp complete wetting；
(2) puts on bathing cap, is heated 10~100 minutes with far infra-red heater；
(3) removes bathing cap, is massaged 10 minutes with combed, washes hair, and completes.
Plant alcohol plastid pilatory for preventing trichomadesis stops for a long time on scalp, is filled using far-infrared heater by active ingredient Divide and play a role.
Plant alcohol plastid (Ethosomes) in the present invention is most to be closed in recent years by medical science, pharmacy and aesthetic medicine field The novel flexible liposome of note, it is made up of low-molecular-weight alcohol (ethanol, propane diols, isopropanol), phosphatide, cholesterol and water；Alcohol Plastid as a kind of carrier of New Percutaneous delivery system, it is notable the advantages of be envelop rate height, drugloading rate is big, and particle diameter is smaller and can Deformation, transdermal excellent in efficiency, skin hold-up is big, and can carry out Intracellular drug transmission；It promotes the mechanism master of Transdermal absorption There are two kinds, first, penetrating mechanism：The imitated vesicle structure that alcohol plastid is formed carries active ingredient and is directed through cuticula, due to phosphatide The presence of alcohol in layer, there is preferably flexible and film mobility, therefore penetration depth is high, transdermal efficiency significantly improves；Second, Syncretizing mechanism：The phosphatide of alcohol plastid is merged with Stratum corneum lipids, and the structure of cuticula dense regular is disturbed, while active ingredient Discharged from vesica, penetrate skin alone.
The present invention, under conditions of plant alcohol plastid is added, while plant permeation enhancers are added, help what is do not encapsulated completely Plant molecular penetrates into the performance trichogenous effect of plant molecular in hair follicle.
Beneficial effect
The present invention provides a kind of plant alcohol plastid pilatory for preventing trichomadesis and preparation method thereof and application method, plant alcohol plastid Pilatory for preventing trichomadesis includes plant alcohol plastid, plant penetrant, other auxiliary materials.The present invention is to promote natural on-off cycles of hair growth and blood circulation Plant be raw material, be made plant alcohol plastid, add plant penetrant, further promote each active ingredient to enter hair follicle, will plant Thing alcohol plastid is prepared into liquid, emulsion, gel, paste, using special application method, stops the active ingredient long period On scalp, by the heating of far infrared, further promote the infiltration and effect of effective molecule.The present invention will be to natural on-off cycles of hair growth Alcohol plastid is made in effective plant extracts, because the imitated vesicle structure that alcohol plastid is formed has preferably flexible and film mobility, Active ingredient can be carried and be directed through cuticula, transdermal efficiency significantly improves, while adds plant penetrant, helps incomplete The plant molecular of encapsulating penetrates into the performance trichogenous effect of plant molecular in hair follicle cell.Use the plant of the present invention During alcohol plastid pilatory for preventing trichomadesis, allow it to retain the long period on scalp, heated with far infra-red heater and promote hair Blood circulation and active ingredient infiltration, realization prevent epilation, promote the purpose of natural on-off cycles of hair growth.
Embodiment
In order to be best understood from technical scheme and advantage, the present invention is done into one below by way of embodiment Walk explanation.
The plant alcohol extract used in following examples be cacumen biotae, Ligusticum wallichii, the fleece-flower root, Ramulus Taxilli, fructus viticis, the Radix Astragali, The red sage root, the fruit of glossy privet, kuh-seng, mulberries, crush, by weight, add 10 times of 80%~100% ethanol of amount, soak 24 hours, 60 DEG C ~90 DEG C of ultrasonic extractions 2 hours, filter out the dregs of a decoction with three layers of gauze immediately, and filtrate centrifugation removes sediment, obtains plant alcohol extract；
The alcohol phase used in following examples is by alcohol extract：Soybean lecithin：Cholesterol is (80：1~6：0.0~2.0) Weight ratio, first soybean lecithin and cholesterol are added in alcohol extract, ultrasonic agitation makes dissolving, obtains alcohol phase, by 0.1%~ 0.8% adds antioxidant.
The aqueous phase used in following examples：Tea seed cake, the tuber of dwarf lilyturf are weighed on demand, are crushed, by weight, 10 times of amounts of addition Water, soak 24 hours, 60 DEG C~90 DEG C ultrasonic extractions 2 hours, filter out the dregs of a decoction with three layers of gauze immediately, filtrate centrifugation removes precipitation Thing, plant Aqueous extracts are obtained, add phosphate and adjust pH value to 6.5, obtain aqueous phase；
The plant penetrant used in following examples：Radix Angelicae Sinensis, cloves, peppermint, radix glycyrrhizae are weighed on demand, are crushed, by weight Meter, 30%~60% ethanol of 10 times of amounts are added, soaked 24 hours, 40 DEG C~60 DEG C ultrasonic extractions 2 hours, immediately with three layers of yarn Cloth filters out the dregs of a decoction, and filtrate centrifugation removes sediment, obtains plant osmosis agent solution；
Embodiment 1
Plant alcohol plastid preventing baldness liquid and preparation method thereof is：Alcohol phase and aqueous phase are separately heated to 50 DEG C, kept It is temperature-resistant, a alcohol is added in three parts of aqueous phases under agitation, colostrum is made；By colostrum high speed homogeneous dispersion machine The lower high pressure breast of 3000r/min homogeneous stirring is even to obtain suspension, stirring alcohol plastid suspension 20 minutes, carries out second emulsifying；Will Suspension is placed under the conditions of 0~4 DEG C, cooling and solidifying, plant alcohol plastid is made；20% plant penetrant is added to alcohol plastid In, add 2% pungent capric acid triglyceride, 1% SIMMONDSIA CHINENSIS SEED OIL, 3% glycerine, 2% butanediol, 5% Tween 80, homogenizer 20 minutes, produce plant alcohol plastid preventing baldness liquid.
Embodiment 2
Plant alcohol plastid preventing baldness breast and preparation method thereof is：Alcohol phase and aqueous phase are separately heated to 45 DEG C, kept It is temperature-resistant, a alcohol is added in two parts of aqueous phases under agitation, colostrum is made；By colostrum with high speed homogeneous dispersion machine The lower high pressure breast of 4000r/min homogeneous stirring is even to obtain suspension, stirring alcohol plastid suspension 30 minutes, carries out second emulsifying；Will Suspension is placed under the conditions of 0~4 DEG C, cooling and solidifying, plant alcohol plastid is made；15% plant penetrant is added to alcohol plastid In, add 5% pungent capric acid triglyceride, 2% SIMMONDSIA CHINENSIS SEED OIL, 2% mixed alcohol, 5% monoglyceride, 5% glycerine, 3% butanediol and 6% Tween 80, homogenizer 20 minutes, produce plant alcohol plastid preventing baldness breast.
Embodiment 3
Plant alcohol plastid preventing baldness gel and preparation method thereof is：Alcohol phase and aqueous phase are separately heated to 40 DEG C, protected Hold temperature-resistant, a alcohol is added in three parts of aqueous phases under agitation, colostrum is made；By colostrum with high speed homogeneous dispersion The lower high pressure breast of machine 4000r/min homogeneous stirring is even to obtain suspension, stirring alcohol plastid suspension 30 minutes, carries out second emulsifying； Under the conditions of suspension is placed in into 0~4 DEG C, cooling and solidifying, plant alcohol plastid is made；10% plant penetrant is added to alcohol plastid In；
The compound method of Blank gel：Weigh 2% Acritamer 940 gelling agent to be dispersed in water, in room temperature condition Lower placement 24h, fully swelling；Add 5% glycerine, be well mixed with the Acritamer 940 gelling agent being fully swelled, adjusted with triethanolamine Its pH to 5~7 is saved, obtains Blank gel；
Three parts of plant alcohol plastids are mixed with a Blank gel；The plant penetrant of addition 10%, stirring 10 minutes, i.e., Obtain plant alcohol plastid preventing baldness gel.
Embodiment 4
Described alcohol plastid preventing baldness cream and preparation method thereof is：Alcohol phase and aqueous phase are separately heated to 45 DEG C, kept It is temperature-resistant, a alcohol is added in three parts of aqueous phases under agitation, colostrum is made；By colostrum with high speed homogeneous dispersion machine The lower high pressure breast of 3000r/min homogeneous stirring is even to obtain suspension, stirring alcohol plastid suspension 30 minutes, carries out second emulsifying；Will Suspension is placed under the conditions of 0~4 DEG C, cooling and solidifying, plant alcohol plastid is made；
The plant penetrant of addition 10% is into alcohol plastid, 50 DEG C of keeping temperature；
Take 12% mixed alcohol, 5% monoglyceride, 0.8% lanolin, 2% pungent capric acid triglyceride, 3% glycerine, 2% butanediol With 4% Tween 80, being heated to 70 DEG C makes thawing, as oily item；
The alcohol plastid for adding 10% plant penetrant adds oil phase under homogenizer, homogeneous 20 minutes, produces plant Thing alcohol plastid preventing baldness cream.
Embodiment 5
Plant alcohol plastid preventing baldness breast application method step be：Uniformly applied on hair and spread alcohol plastid breast, extremely Scalp complete wetting, puts on bathing cap, is heated 2 hours with far infra-red heater, removes bathing cap, and 10 points are massaged with combed Clock, wash hair, complete.
Embodiment 6
Clinical observation treatment is carried out to 360 patients, 24 to 70 years old ages, wherein male 289, women 72, is Alopecia caused by a variety of causes.9 groups are randomly divided into, every group of 40 people.
Efficacy assessment standard：
It is effective：The Clinical symptom and sign such as exiguous human hair, alopecia, bald is basic or big portion disappears.
Effectively：The clinical symptoms such as exiguous human hair, alopecia, bald are clearly better or taken a turn for the better.
It is invalid：Clinical symptom and sign is without improvement.
Therapeutic effect：
(1) experimental group 1：Plant alcohol plastid preventing baldness liquid prepared by embodiment 1；
(2) experimental group 2：Plant alcohol plastid preventing baldness breast prepared by embodiment 2；
(3) experimental group 3：Plant alcohol plastid preventing baldness gel prepared by embodiment 3；
(4) experimental group 4：Plant alcohol plastid preventing baldness cream prepared by embodiment 4；
(5) blank control group 1：Directly cleaned with clear water.
(6) control group 2：Alcohol phase unlike control group 2 and embodiment 1 is by ethanol：Soybean lecithin：Cholesterol is 80：1 ~6：0.0~2.0 weight ratio, soybean lecithin and cholesterol are added in ethanol, and ultrasonic agitation makes dissolving, obtains alcohol phase, Other preparation methods and embodiment 1 are identical.
(7) control group 3：Alcohol phase unlike control group 3 and embodiment 2 is by alcohol extract：Soybean lecithin：Cholesterol is 30：1~6：Soybean lecithin and cholesterol, are first added in ethanol by 0.0~2.0 weight ratio, and ultrasonic agitation makes dissolving, obtains Alcohol phase, other preparation methods and embodiment 2 are identical.
(8) control group 4：Alcohol phase unlike control group 4 and embodiment 3 is by ethanol：Soybean lecithin：Cholesterol is 90： 0.5：Soybean lecithin and cholesterol, are first added in ethanol by 2.0 weight ratio, and ultrasonic agitation makes dissolving, obtains alcohol phase, other Preparation method and embodiment 3 are identical.
Above-mentioned application method is：Uniformly apply to spread on hair and smear corresponding alcohol plastid pilatory for preventing trichomadesis, to head Skin complete wetting, puts on bathing cap, is heated 10~100 minutes with far infra-red heater, removes bathing cap, and 10 are massaged with combed Minute, wash hair, complete.Use 2-3 times daily.Observed after continuous three months.
(9) control group 5：Preparation for baldness prepared by the patent of invention disclosed embodiment 1 of Application No. 200910231223.8, It is described in application method embodiment 1.
The curative effect situation of table 1
Pass through data in table 1, after the plant alcohol plastid pilatory for preventing trichomadesis of the use present invention, experimental group 1, reality It is more obvious to test group 2, experimental group 3, the action effect of experimental group 4, wherein invalid 1 in experimental group 1, experimental group 2 and experimental group 4 Example, effective percentage is up to 97.5%.
It should be noted that various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；Although The present invention is described in detail with reference to foregoing embodiments, it will be understood by those within the art that：It is still Technical scheme described in foregoing embodiments can be modified, either which part or all technical characteristic are carried out Equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technical side The scope of case.

Claims (10)

1. a kind of plant alcohol plastid pilatory for preventing trichomadesis, is made up of multiple components, it is characterised in that：Include following percentage by weight Component：Plant alcohol plastid 20% ~ 80%, plant penetrant 10 ~ 20%, remaining is auxiliary material.
A kind of 2. plant alcohol plastid pilatory for preventing trichomadesis as claimed in claim 1, it is characterised in that：Include following weight percent The component of ratio：Plant alcohol plastid 30% ~ 70%, plant penetrant 13 ~ 17%, remaining is auxiliary material.
A kind of 3. plant alcohol plastid pilatory for preventing trichomadesis as claimed in claim 1, it is characterised in that：The plant alcohol plastid bag Containing following weight percent composition：
Plant alcohol extract 20%~60%；
Phosphatidase 1 .0%~6.0%；
Cholesterol 0.0%~2.0%；
Antioxidant 0.1%~0.8%；
Plant Aqueous extracts 38.5%~80%.
A kind of 4. plant alcohol plastid pilatory for preventing trichomadesis as claimed in claim 3, it is characterised in that：The plant alcohol extract is 80 ~ 100% low-molecular-weight alcohol extract solutions extracted using plant material.
A kind of 5. plant alcohol plastid pilatory for preventing trichomadesis as claimed in claim 4, it is characterised in that：The plant alcohol extract is adopted Prepare using the following method：Plant material, crush, by weight, add 10 times of 80% ~ 100% low-molecular-weight alcohols of amount, immersion 24 is small When, 60 DEG C~90 DEG C ultrasonic extractions 2 hours, the dregs of a decoction are filtered out with gauze, filtrate centrifugation removes sediment, obtains plant alcohol extract.
A kind of 6. plant alcohol plastid pilatory for preventing trichomadesis as claimed in claim 5, it is characterised in that：The low-molecular-weight alcohol is Ethanol.
A kind of 7. plant alcohol plastid pilatory for preventing trichomadesis as claimed in claim 5, it is characterised in that：The plant material is side One or more in CedarLeaves, Ligusticum wallichii, the fleece-flower root, Ramulus Taxilli, fructus viticis, the Radix Astragali, the red sage root, the fruit of glossy privet, kuh-seng and mulberries.
A kind of 8. plant alcohol plastid pilatory for preventing trichomadesis as claimed in claim 3, it is characterised in that：The plant Aqueous extracts are Obtained after being extracted using tea seed cake, the tuber of dwarf lilyturf.
9. the preparation method of the plant alcohol plastid pilatory for preventing trichomadesis as any one of claim 1-8, it is characterised in that： Comprise the following steps：
Alcohol phase is prepared with plant alcohol extract, aqueous phase is prepared with plant Aqueous extracts, pohytol matter is prepared using ultrasonic homogeneous method is injected Body；
（2）Whole grain is carried out to resulting plant alcohol plastid using mechanical means；
（3）The plant alcohol plastid that whole grain is crossed is well mixed with plant penetrant, auxiliary material, prepared, obtain plant alcohol plastid Anti-hair loss Preparation for baldness.
A kind of 10. application method of plant alcohol plastid pilatory for preventing trichomadesis as claimed in claim 1, it is characterised in that：Including Following steps：
（1）Uniformly applied on hair and spread pohytol plastid pilatory for preventing trichomadesis, to scalp complete wetting；
（2）Bathing cap is put on, is heated 10 ~ 100 minutes with far infra-red heater；
（3）Bathing cap is removed, is massaged 10 minutes with combed, is washed hair, is completed.
CN201710503209.3A 2017-06-27 2017-06-27 Plant ethosome anti-hair loss pilatory as well as preparation method and using method thereof Active CN107349115B (en)

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