CN102988262A - Bee venom composition with acne removing function - Google Patents
Bee venom composition with acne removing function Download PDFInfo
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- CN102988262A CN102988262A CN201210563008XA CN201210563008A CN102988262A CN 102988262 A CN102988262 A CN 102988262A CN 201210563008X A CN201210563008X A CN 201210563008XA CN 201210563008 A CN201210563008 A CN 201210563008A CN 102988262 A CN102988262 A CN 102988262A
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- venenum apis
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- apis
- polysaccharide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
The invention discloses a bee venom composition with an acne removing function. The bee venom composition comprises an acne removing cosmetic matrix component and also comprises bee venom. The invention solves the problems of serious irritation and easy causing of allergy of skin of the existing acne removing cosmetic and easy remaining of deep scars, unpleasant smell and the like of the Chinese medicine acne removing cosmetic. The bee venom is firstly applied to the acne removing cosmetic to play a role in dredging hair follicle, balancing grease secretion, inhibiting bacteria, diminishing inflammation, promoting wound healing, inhibiting hyperpigmentation, recovering scars, removing acne marks and the like. The bee venom composition with the acne removing function comprises multiple kinds of a cream, an emulsion, a water solution, a gel, a jelly and a mask, is remarkable and long-lasting in acne removing effect without irritation to the skin, and is suitable for people with various types of skin, suffering from whelk, adult acne or scar, acne scars and the like. The whelk cannot be easily relapsed after the bee venom composition is not used.
Description
Technical field:
The invention belongs to cosmetic field, be specifically related to a kind of Venenum apis compositions with acne-removing.
Background technology:
With the quickening pace of modern life, the increase of work and life stress, add environmental pollution and food-safety problem takes place frequently, the sickness rate of comedo rises year by year.Comedo is a kind of common chronic pilosebaceous unit diseases associated with inflammation, be apt to occur in the vigorous positions of sebum secretion such as face, shirtfront and upper back, long, the easily recurrence of the course of disease often shows as hoary hair's acne, blackhead or inflammatory pimple, serious pustule, tuberosity, cyst or the cicatrix of having.If inflammation is obvious, more can cause pain or tactile painful, and with seborrhea, even the Pericarpium Citri Reticulatae face appears.Comedo incidence rate in the youth of both sexes crowd is high, it not only has a strong impact on the attractive in appearance of face, and affect the social and psychological of people, make the patient occur not self-confident, awkward, lose, the negative emotions such as anxiety, anxiety, irritability and depression, thereby affect quality of life.
At present, the cosmetics for the treatment of comedo have added chemical bactericide, hormone, astringent and antiinflammatory etc. more on the market, though can sterilize at short notice or antiinflammatory, but large to skin irritation, life-time service can increase the burden of skin, and causes the allergic symptoms such as red swelling of the skin, suppuration or pain, and because pathogen very easily produces drug resistance, comedo will soon recur, and forms cicatrix or pigmentation.Antibiotic and hormonal substance are now forbidden by " cosmetics health standard " (version in 2007) because the life-time service side effect is large.In addition, the Chinese medicine acne-eliminating cosmetic also can stay black or Red Sigil because onset is slow, treatment cycle is long, niff and color are arranged more after the healing, also is not subjected to the welcome of consumer.Therefore, research and develop a kind of safer, lasting and the comprehensive acne-eliminating cosmetic of effect is particularly urgent.
Summary of the invention:
The object of the invention is to, the skin problems such as easily allergy, Chinese medicine acne-eliminating cosmetic easily stay the dark marking, the smell is awful large for existing removing acne cosmetics zest, a kind of safer, lasting Venenum apis compositions with acne-removing is provided, this Venenum apis compositions functional component is clear and definite, steady quality, have no side effect, can not cause skin allergy, preventing from scar or pigmentation after comedo is cured also are difficult for recurrence after stopping using.
Venenum apis compositions with acne-removing of the present invention comprises acne-eliminating cosmetic substrate composition, it is characterized in that, also contains Venenum apis.
Preferably, described Venenum apis prepares by the following method, gets thick Venenum apis water dissolution, and then after the ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
This Venenum apis purification process is being simplified the Venenum apis purifying process, provides cost savings simultaneously, can also to melittin, the effective enrichment of apamin isoreactivity material and concentrated with remarkable beautifying skin-protection function, remove hyaluronidase, phospholipase A
2Deng the material that easily causes skin allergy, inflammation and pain, guarantee safety, without skin irritation and irritated in, acne-removing is significantly strengthened.This purification process has solved the not yet effective problem such as enrichment of active substance that has the beauty and skin care effect in the prior art in the Venenum apis, has filled up the blank that Venenum apis is used in acne-eliminating cosmetic, and has given full play to its acne-removing.
Preferably, described Venenum apis, its content accounts for 0.00001% ~ 2% of Venenum apis compositions gross mass.
Described Venenum apis preferably prepares by the following method: get thick Venenum apis and add 10-30 times of volume water and fully dissolve, the centrifugal 10-30min of 5000-10000g, after the ultrafilter membrane of supernatant by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
For strengthening the effects such as antiinflammatory, sun-proof, moisturizing, acne removing seal, Venenum apis compositions with acne-removing of the present invention preferably also contains Sargassum polysaccharides and Margarita powder, the content of Sargassum polysaccharides accounts for the 0.01%-5% of Venenum apis compositions gross mass, and the content of Margarita powder accounts for the 0.2%-15% of Venenum apis compositions gross mass.
Described Sargassum polysaccharides refers to one or more the combination in sodium alginate, Porphyra Polysaccharide, Thallus Laminariae polysaccharide, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma gelatinae polysaccharide, Hijiki polysaccharide, laminarin, Sargassum polysaccharide, spirulina polysaccharide, sargassan, Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) polysaccharide, fucoidin, angle fork polysaccharides, Zostera marina polysaccharide and the chlorella polysaccharide.Commercially available, also can be according to existing method preparation.
Margarita powder of the present invention refers to one or more the combination in nanometer Margarita powder, water soluble Margarita ultrafine powder, the pearl hydrolysate liposome.Commercially available, also can be according to existing method preparation.
For strengthening the effects such as dredging pore, Bergamot Mint Extract, Venenum apis compositions with acne-removing of the present invention also can be preferably and contain PCA zinc and decoyl salicylic acid, the content of PCA zinc accounts for the 0.01%-1.5% of Venenum apis compositions gross mass, and the salicylic content of decoyl accounts for the 0.1%-2% of Venenum apis compositions gross mass.
PCA zinc of the present invention, decoyl salicylic acid and cosmetic base are commercial.
Described thick Venenum apis can be the thick Venenum apis of wasp and/or the thick Venenum apis of Apis, can own use the collector of bee venom collection, also can be from commercial.
Venenum apis compositions with acne-removing of the present invention prepares by the following method, with Venenum apis take powdery form or be mixed with in advance mass fraction and be the 10%-50% aqueous solution, with other composition homogenizing or mix, can according to the technique preparation of the acne-eliminating cosmetic kind of preparing according to routine, can make the acne-eliminating cosmetics such as cream frost, emulsion, water preparation, gel, gel or facial film.
Venenum apis composition stable with acne-removing of the present invention is good, coating evenly, spreadability is good.Zoopery and human body are tried out the results show; Venenum apis compositions safety with acne-removing of the present invention, to skin non-stimulated or photosensitization; can effectively prevent and reduce ultraviolet to the infringement of skin; can also sterilization, antiinflammatory, moisturizing, Bergamot Mint Extract, and improve the skin self-protection ability.
The function cosmetics that the Venenum apis compositions that the present invention has an acne-removing can be used as ordinary cosmetics or has an anti-acne effect use.
Solution of the present invention is based on the inventor to the comedo formation condition, pathogenesis, prevent and treat method, and to the understanding of functional activity material beauty and skin care effect, in conjunction with modern acne-eliminating cosmetic and pharmacological research achievement, comform to filter out in the multifunction activity material and have the metabolism of remarkable accelerator angle cell plastid, the dredging hair follicle, regulate fat secretion, antibacterial, sterilization, antiinflammatory, moisturizing, acne removing seal and cicatrix, antioxidation, the Venenum apis of the effect such as anti-ultraviolet damage, Sargassum polysaccharides, Margarita powder, PCA zinc and decoyl salicylic acid, by scientific composition, make its remarkable performance reach separately mutual synergistic function:
The Venenum apis that the present invention has in the Venenum apis compositions of acne-removing contains abundant melittin, apamin, catecholamine, free amino acid, vitamin, trace element and glycerol isoreactivity composition, molecular weight is little, immunogenicity is low, is difficult for producing anaphylaxis.
The propagation of the antibacterial such as Venenum apis Toplink establishment propionibacterium acnes, escherichia coli, bacillus pyocyaneus, streptococcus and staphylococcus aureus and fungus reduces skin to the comedo inflammatory reaction, and has the analgesic effect.It also has the effects such as significant antioxidation, anti-ultraviolet radiation.Apamin can improve microcirculation, promotes elastic fibers and collagen protein synthesis in the skin corium, recovers skin tension force and elasticity, and promotes that comedo closes up fast, repairs existing dark scar or prevents dark scar to form.Catecholamine has antiinflammation to the damaged skin that causes because of comedo, illumination etc., can reduce the pox scar and form.Free amino acid, vitamin and trace element isoreactivity substance provide nutrition for skin, effectively prevent ultraviolet from comedo is damaged and form pigmentation, can also improve the cutin metabolism, prevent the hair follicle hyperkeratosis, strengthen epidermal barrier function, reduce moisture loss, reduce air pollutants to skin infringement, regulation of skin permeability, have antioxidation and promote the effect such as skin self-regeneration.Glycerol can keep moisture of skin, with the minimizing smegma, and promotes other active component to penetrate into deep skin, the auxiliary skin self-repairing capability that improves.
The Sargassum polysaccharides that the present invention has in the Venenum apis compositions of acne-removing has extremely strong moisture retention, the energy horny layer softening, and play broad-spectrum bactericidal action by its dissolution of bacteria inner membrance, can also remove free radical, prevent the skin lipid peroxidating, the opposing ultraviolet causes skin injury, and can repair damaging cells, reduce pigmentation.Sargassum polysaccharides can also be accelerated the Transdermal absorption of anti-acne active component, thereby improves acne-removing.
The present invention has glycine, methionine etc. that Margarita powder in the Venenum apis compositions of acne-removing contains needed by human and promotes the trace element such as the aminoacid of skin collagen regeneration and Zn, very easily be absorbed by the body, have sterilization, antiinflammatory, toxin expelling, dispel the effects such as pox seal.Margarita powder can also promote reepithelialization and wound healing, impurity such as being blocked in the interior dust of skin pore, oil stain, antibacterial, decortication, dead cell are discharged smoothly, make skin become moist, pure white and moisten, the Venenum apis acne-removing is also had significant synergism.
It is that wherein sodium ion is replaced to the zinc ion with bacteriostasis that the present invention has PCA zinc in the Venenum apis compositions of acne-removing, can establishment the propagation of the antibacterial such as propionibacterium acnes, escherichia coli, bacillus pyocyaneus, streptococcus and staphylococcus aureus and fungus, have simultaneously excellent moisture-keeping efficacy.Zinc can be regulated smegma, be prevented the hair follicle hyperkeratosis by the inhibition to the 5-alpha-reductase, thereby makes skin keep oil-water balance.DNA is synthetic, protein synthesis, cell division and keep that the plurality of enzymes activity all be unable to do without Zn in the tissue, therefore replenish Zn for skin, help to keep the eubolism of skin, can also promote epidermal growth and wound healing, and reduce skin allergy.
The decoyl salicylic acid that the present invention has in the Venenum apis compositions of acne-removing has the liposoluble characteristic, molecular weight is also larger, can be in the mode that merges with lipid, sebaceous gland by the secretion oils and fats is infiltrated horny layer and pore depths, and dissolution angular embolization, decomposition are blocked in keratin, the dead bark of sebaceous gland and pore, improves pore and blocks, the blocking-up comedo forms, alleviate or suppress the inflammation symptom, and remove blackhead in the pore, dwindle the pore that is stretched.It can be locked in horny layer with effect, and does not affect active epidermis cell and dermal tissue, good stability, low to skin irritation, and producing cumulative bad stimulates also low than general fruit acid with the probability of inflammation.Salicylic acid can also irritation cell new life and wound healing, and to improve the colour of skin, to eliminate the pox seal, it is bright and clean that skin is reappeared.
Compared with prior art, the present invention has following beneficial effect:
1, for the special physiology of skin structure and to the sensitivity of the used composition of cosmetics, it is primary raw material that the Venenum apis compositions with acne-removing among the present invention has been selected the Venenum apis of pure natural.Although it is very rare to add at present the cosmetics of Venenum apis, Venenum apis is included already in " international cosmetic raw material standard Chinese catalogue (2010 editions) ", and it is safe, feasible that this explanation is applied to cosmetics with Venenum apis.In addition, have in the Venenum apis compositions of acne-removing in the present invention, employed Venenum apis is through purification process, the material that easily causes skin allergy, inflammation and pain in the thick Venenum apis is effectively removed, and the compositions such as melittin, apamin is highly enriched, thereby given play to more significant acne-removing.Simultaneously, the Venenum apis compositions that the present invention has acne-removing can be absorbed by the skin rapidly, does not cause skin allergy, also can not bring any burden to skin.
2, the Venenum apis compositions of the present invention with acne-removing from Bergamot Mint Extract, dissolution angular embolization, anti-bacteria propagation, repair pigmentation after cicatrix, opposing ultraviolet, antiinflammatory, antiallergic, antioxidation, moisturizing, the anti-inflammatory, promote anti-acne composition percutaneous to absorb, promote the aspects such as comedo wound healing, bring into play comprehensive and significant anti-acne effect, make skin recover normal fine and smooth soft and smooth.After stopping using, the symptoms such as comedo are difficult for recurrence, and acne-removing is remarkable, lasting, safety.
3, the Venenum apis compositions of the present invention with acne-removing selected the Venenum apis of pure natural, has the good compatibility with skin, can be absorbed by the skin rapidly, and be safe, gentle, do not cause the reactions such as stimulation, allergy, and skin is burden not also.Venenum apis compositions with acne-removing of the present invention is by Venenum apis and Sargassum polysaccharides, Margarita powder, and Venenum apis and PCA zinc, the salicylic Synergistic of decoyl, can bring into play simultaneously dredging pore, Bergamot Mint Extract, sterilization, antiinflammatory, acne removing seal, moisturizing, the effect such as sun-proof, with the barrier function of comprehensive reparation and raising skin, thoroughly removing acne.When Venenum apis and Sargassum polysaccharides, when Margarita powder is composite, it is particularly remarkable that the Venenum apis compositions that the present invention has an acne-removing is cured effect to inflammatory damage, pustule and cyst comedo.When Venenum apis and PCA zinc, when the decoyl salicylic acid is composite, it is particularly remarkable that the Venenum apis compositions that the present invention has an acne-removing is cured effect to blackhead, hoary hair's acne, point-like sample, pimple and atrophic comedo.
4, the Venenum apis compositions with acne-removing of the present invention, it is numerous in variety, can satisfy comedo is arranged, different sexes, age and the skin quality crowd's of the problem puzzlements such as the pox of growing up, pox seal or cicatrix demand.
The specific embodiment:
Following examples are that the invention will be further described, but embodiments of the present invention are not limited to following embodiment introduction, all variation that is equal to or flexible categories that all should be considered as the present invention's protection of doing according to method of the present invention.
Below raw materials used, except special indicating, be commercially available.
Embodiment 1
Adopt collector of bee venom to gather the thick Venenum apis of wasp, add 25 times of volume water and fully dissolve, the centrifugal 15min of 8000g, supernatant is by the ultrafilter membrane ultrafiltration of molecular cut off 10000Da, and the filtrate lyophilization makes Venenum apis.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
A phase: carbomer 0.1%, NaCl0.8%, 1,3 butylene glycol 5%, propylene glycol 4%, EDTA-2Na0.1%, deionized water surplus.
B phase: fatty alcohol-polyoxyethylene ether 3%, C
12-C
15Alkyl benzoate 9%, dicaprylyl carbonate 2%, microwax 0.8%, azone/Cremophor RH40 0.2%, HANSHENGJIAO 0.5%.
C phase: Venenum apis 0.5%(adds with the form that deionized water is mixed with mass fraction 50% Venenum apis solution in advance).
D phase: butoben 0.5%, green tea essence 0.2%.
Technical process: heat respectively the A phase with B to 80 ℃, stir lower slowly B is added to A mutually in.Stirring is cooled to 55 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase, mix the anti-acne emulsion that the Venenum apis compositions with acne-removing that homogenizing makes present embodiment contains Venenum apis.
The emulsion feel of present embodiment preparation is fine and smooth, coating is even, profit does not separate, easily absorption.
Embodiment 2
Adopt collector of bee venom to gather the thick Venenum apis of Apis, add 10 times of volume water and fully dissolve, after the centrifugal 30min of 5000g, the supernatant ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
A phase: carbomer 0.2%, glycerol 4%, propylene glycol 3%, deionized water surplus.
B phase: ceteareth-212%, Jojoba oil 3%, cetearyl alcohol 2%, glyceryl monostearate 1%, caprylic/capric triglyceride 4%, ethylhexyl palmitate 3%, polydimethylsiloxane 2%, isopropyl myristate 3%, ethyl hydroxybenzoate 0.1%.
C phase: Venenum apis 0.00001%(adds with the form of powder).
D phase: azone/Cremophor RH40 1%, triethanolamine 0.2%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: heat respectively the A phase with B to 80 ℃, stir lower with B be added to A mutually in.Stirring is cooled to 45 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase, mix homogenizing and make the Venenum apis compositions with acne-removing of present embodiment-the contain Whelk-eliminating paste frost of Venenum apis.
The cream frost of present embodiment preparation is glossy, exquisite quality, be evenly distributed, profit do not separate mutually.
Embodiment 3
Buy the thick Venenum apis of wasp from Wuhan benefit people bee product company limited, add 30 times of volume water and fully dissolve, after the centrifugal 10min of 10000g, the supernatant ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made wasp aptoxin.
Adopt collector of bee venom to gather the thick Venenum apis of Apis, add 30 times of volume water and fully dissolve, after the centrifugal 10min of 10000g, the supernatant ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Apis Venenum apis.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
A phase: glycerol 5%, propylene glycol 3%, butanediol 2%, deionized water surplus.
The B phase: wasp aptoxin 1%, Apis Venenum apis 1%(Venenum apis are all added with the form of powder), deionized water 38%.
C phase: azone/Cremophor RH40 1%, triethanolamine 0.2%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: 30 ℃, mix first the A phase, again will be in advance the B of mixing be added to A mutually in, mix rear adding C phase component, mixing makes the Venenum apis compositions with acne-removing of present embodiment-the contain anti-acne water preparation of Venenum apis.
The water preparation of present embodiment preparation is without precipitation, high, the easily absorption, non-stimulated of transparency.
Embodiment 4
Buy the thick Venenum apis of Apis from the Shen Feng of Fujian Province scientific and technological development company limited, add 15 times of volume water and fully dissolve, after the centrifugal 20min of 6000g, the supernatant ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
A phase: HANSHENGJIAO 0.4%, acrylate/C
10-30Alkyl acrylate cross-linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, propylene glycol 5%, butanediol 5%, deionized water surplus.
B phase: Venenum apis 0.5%(adds with the form that distilled water is mixed with mass fraction 10% Venenum apis solution in advance), laminarin 0.01%, pearl hydrolysate liposome 3%, deionized water 20%.
C phase: Cremophor RH40 ester 1%, triethanolamine 0.2%, essence 0.1%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: mix the A phase component and be heated to 80 ℃ stirring, add when being cooled to 40 ℃ and be pre-mixed uniform B phase, stir 10min to transparent, the Venenum apis compositions with acne-removing that makes present embodiment behind the adding C phase stirring and evenly mixing contain-contains the anti-acne gel of Venenum apis.
The gel of present embodiment preparation is transparent, tissue is fine and smooth, without caking, under-10 ℃ and 40 ℃ of conditions, without paste separation.
Embodiment 5
Prepare the method for Venenum apis according to embodiment 1, make wasp aptoxin.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
A phase: HANSHENGJIAO 0.2%, acrylate/C
10-30Alkyl acrylate cross-linked polymer 0.6%, glycerol 5%, propylene glycol 3%, deionized water surplus.
B phase: Venenum apis 0.00001%(adds with the form that deionized water is mixed with mass fraction 10% Venenum apis solution in advance), sodium alginate 1%, Porphyra Polysaccharide 0.5%, Thallus Laminariae polysaccharide 0.5%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 0.5%, Eucheuma gelatinosum polysaccharide 0.5%, Eucheuma gelatinae polysaccharide 0.5%, Hijiki polysaccharide 0.5%, Sargassum polysaccharide 0.5%, sargassan 0.5%, water soluble Margarita ultrafine powder 0.2%, deionized water 30%.
C phase: azone/Cremophor RH40 1%, triethanolamine 0.3%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: mix the A phase component and be heated to 80 ℃ stirring, add when being cooled to 45 ℃ and be pre-mixed uniform B phase, stir homogenizing 3min, be sequentially added into mutually each component of C under the room temperature, the Venenum apis compositions with acne-removing that makes present embodiment of stirring contains the anti-acne jelly of Venenum apis.
The gel quality of preparing in the present embodiment is slim and graceful, and sensation is nice and cool.
Embodiment 6
Prepare the method for Venenum apis according to embodiment 2, make Apis Venenum apis.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
Venenum apis 2%(adds with the form of powder), spirulina polysaccharide 0.2%, Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) polysaccharide 0.2%, fucoidin 0.2%, angle fork polysaccharides 0.2%, Zostera marina polysaccharide 0.2%, chlorella polysaccharide 0.2%, nanometer Margarita powder 5%, water soluble Margarita ultrafine powder 10%, Semen Armeniacae Amarum powder 11%, Mel 5%, antiseptic 1%, deionized water surplus.Venenum apis, spirulina polysaccharide, Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) polysaccharide, fucoidin, angle fork polysaccharides, Zostera marina polysaccharide, chlorella polysaccharide, water soluble Margarita ultrafine powder are dissolved in the deionized water, after it is all dissolved, add in advance nanometer Margarita powder and the Semen Armeniacae Amarum powder of mixing under the room temperature, 50r/m stirring and evenly mixing 5min, add again Mel and antiseptic, stirring and evenly mixing 5min makes the Venenum apis compositions with acne-removing of present embodiment-the contain Deacne pack of Venenum apis.
Embodiment 7
Prepare the method for Venenum apis according to embodiment 3, make wasp aptoxin.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
A phase: carbomer 0.1%, glycerol 5%, propylene glycol 3%, deionized water surplus.
B phase: decoyl salicylic acid 1%, ceteareth-21.2%, ceteareth-211.5%, Parleam 3%, caprylic/capric triglyceride 3%, ethylhexyl palmitate 3%, polydimethylsiloxane 2%, ethyl hydroxybenzoate 0.1%.
C phase: Venenum apis 0.5%(adds with the form that deionized water is mixed with mass fraction 50% Venenum apis solution in advance), PCA zinc 0.5%, deionized water 20%.
D phase: azone/Cremophor RH40 1%, triethanolamine 0.1%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: heat respectively the A phase with B to 80 ℃, stir lower slowly B is added to A mutually in.Stirring is cooled to 55 ℃, C is added in the mixture of A, B phase, mix 10min after, add the D phase, mix homogenizing and make the Venenum apis compositions with acne-removing of present embodiment-the contain anti-acne emulsion of Venenum apis.
The emulsion feel of present embodiment preparation is fine and smooth, coating is even, profit does not separate, easily absorption.
Embodiment 8
Prepare the method for Venenum apis according to embodiment 1, make wasp aptoxin.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
A phase: glycerol 5%, propylene glycol 3%, butanediol 2%, deionized water surplus.
The B phase: Venenum apis 0.00001%(Venenum apis is all added with the form of powder), PCA zinc 1.5%, deionized water 30%.
C phase: decoyl salicylic acid 2%, azone/Cremophor RH40 1%, triethanolamine 0.2%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: 35 ℃, mix first the A phase, again will be in advance the B of mixing be added to A mutually in, mix rear adding C phase component, the Venenum apis compositions with acne-removing that mixing makes present embodiment contains the anti-acne water preparation of Venenum apis.
The water preparation of present embodiment preparation is without precipitation, high, the easily absorption, non-stimulated of transparency.
Embodiment 9
Prepare the method for Venenum apis according to embodiment 4, make Apis Venenum apis.
The Venenum apis compositions with acne-removing of present embodiment by gross mass percent 100%, is comprised of following component:
A phase: HANSHENGJIAO 0.4%, acrylate/C
10-30Alkyl acrylate cross-linked polymer 0.6%, EDTA-2Na0.1%, glycerol 5%, propylene glycol 5%, butanediol 5%, deionized water surplus.
B phase: Venenum apis 2%(adds with the form that distilled water is mixed with mass fraction 10% Venenum apis solution in advance), PCA zinc 0.01%, deionized water 20%.
C phase: decoyl salicylic acid 0.1%, Cremophor RH40 ester 1%, triethanolamine 0.2%, essence 0.1%, phenoxyethanol/methyl hydroxybenzoate/butyl hydroxybenzoate/ethyl hydroxybenzoate/propyl hydroxybenzoate/oxybenzene isobutyl ester 0.1%.
Technical process: mix the A phase component and be heated to 80 ℃ stirring, add when being cooled to 40 ℃ and be pre-mixed uniform B phase, stir 10min to transparent, add the Venenum apis compositions with acne-removing that makes present embodiment behind the C phase stirring and evenly mixing-the contain anti-acne gel of Venenum apis.
The gel of present embodiment preparation is transparent, tissue is fine and smooth, without caking, under-10 ℃ and 40 ℃ of conditions, without paste separation.
Embodiment 10
Following various samples are carried out animal experiment:
The percent of present embodiment refers to mass percent.
The wasp aptoxin of present embodiment and Apis Venenum apis are that the preparation method according to embodiment 3 prepares.
Normal saline (0.9%NaCl solution);
Contain thick Venenum apis compositions (be sample A, thick Venenum apis content is mass fraction 2%):
A1: the thick Venenum apis 2% of wasp, normal saline 98%;
A2: the thick Venenum apis 0.5% of wasp, the thick Venenum apis 1.5% of Apis, normal saline 98%.
Contain Venenum apis compositions (be sample B, Venenum apis content is mass fraction 2%):
B1: wasp aptoxin 2%, normal saline 98%;
B2: wasp aptoxin 0.5%, Apis Venenum apis 1.5%, normal saline 98%.
Contain Sargassum polysaccharides and Margarita powder compositions (be sample C, the total content of Sargassum polysaccharides, Margarita powder is mass fraction 2%):
C1: laminarin 1%, nanometer Margarita powder 1%, normal saline 98%;
C2: Hijiki polysaccharide 0.5%, sodium alginate 0.5%, water soluble Margarita ultrafine powder 1%, normal saline 98%;
C3: spirulina polysaccharide 0.5%, Zostera marina polysaccharide 0.5%, chlorella polysaccharide 0.5%, water soluble Margarita ultrafine powder 0.5%, normal saline 98%;
C4: Porphyra Polysaccharide 0.5%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 0.5%, sargassan 0.5%, pearl hydrolysate liposome 0.5%, normal saline 98%.
Contain Venenum apis, Sargassum polysaccharides and Margarita powder compositions (be sample D, the total content of Venenum apis, Sargassum polysaccharides, Margarita powder is mass fraction 2%):
D1: wasp aptoxin 0.5%, laminarin 0.5%, nanometer Margarita powder 1%, normal saline 98%;
D2: Apis Venenum apis 0.3%, wasp aptoxin 0.2%, Hijiki polysaccharide 0.3%, sodium alginate 0.2%, water soluble Margarita ultrafine powder 1%, normal saline 98%;
D3: Apis Venenum apis 0.1%, spirulina polysaccharide 0.4%, Zostera marina polysaccharide 0.5%, chlorella polysaccharide 0.5%, water soluble Margarita ultrafine powder 0.5%, normal saline 98%;
D4: wasp aptoxin 1%, Porphyra Polysaccharide 0.2%, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide 0.2%, sargassan 0.1%, pearl hydrolysate liposome 0.5%, normal saline 98%.
Contain PCA zinc and decoyl salicylic acid composition (be sample E, the salicylic total content of PCA zinc and decoyl is mass fraction 2%):
E1:PCA zinc 1%, decoyl salicylic acid 1%, normal saline 98%;
E2:PCA zinc 1.5%, decoyl salicylic acid 0.5%, normal saline 98%.
Contain Venenum apis, PCA zinc and decoyl salicylic acid composition (be sample F, Venenum apis, PCA zinc and the salicylic total content of decoyl are mass fraction 2%):
F1: wasp aptoxin 0.5%, PCA zinc 1%, decoyl salicylic acid 0.5%, normal saline 98%;
F2: Apis Venenum apis 0.4%, wasp aptoxin 0.4%, PCA zinc 1%, decoyl salicylic acid 0.2%, normal saline 98%.
Get 102 of rabbit, smear 1 time/d of dense liquor carbonis detergens at every rabbit ears medial surface syrinx opening part, application area is 3cm * 3cm, each 0.4mL, continuous 14d, make rabbit ear comedo model, and be divided at random 17 groups, it is the normal saline group, contain thick Venenum apis compositions group (sample A1-A2), contain Venenum apis compositions group (sample B1-B2), contain Sargassum polysaccharides and Margarita powder compositions group (sample C1-C4), contain Venenum apis, Sargassum polysaccharides and Margarita powder compositions group (sample D1-D4), contain PCA zinc and decoyl salicylic acid composition group (sample E1-E2), contain Venenum apis, PCA zinc and decoyl salicylic acid composition group (sample F 1-F2), 6 every group.
Be coated with corresponding sample respectively at each group rabbit ears affected part, each about 0.5mL, 3 times/d, continuous 7d.Day by day observe therapeutic effect, behind last coating 24h, get the auricle skin biopsy with the coating place of picking up the ears, the tissues observed pathological change behind the 7d.By its epidermis thicken and follicular orifice degrees of expansion and keratinization thing what are divided into 4 grades with the pathological change of specimen: " 0 " is for without comedo; "+" is the visible a small amount of fine and close keratinization thing of infundibulum of hair follicle section; " ++ " is infundibulum of hair follicle section visible moderate keratinization thing, and extends to sebaceous gland; " +++" in the hair follicle of expanding widely keratinization thing being arranged.Effective percentage=(the routine number of " 0 " level routine number+"+" level)/experimental example number * 100%.Experimental result is as shown in table 1:
Table 1: sample is on the impact of rabbit ear comedo model
Behind the normal saline coating 7d, comedo is without significant change, pachylosis, and it is obvious that hands touches granular sensation, the visible embolus of rabbit ear skin follicle mouth, visible inflammatory cell infiltration around the sebaceous gland, and with tuberosity.Compare with the normal saline group, sample A-F to rabbit ear comedo to improve effect comparatively obvious.
Owing to removed the sensitization source in the thick Venenum apis, therefore with contain thick Venenum apis compositions (being sample A) and compare, contain Venenum apis compositions (being sample B) skin is not had obvious irritation and sensitization, and since enrichment the effective ingredient in the Venenum apis, to contain thick Venenum apis compositions obvious to the effect ratio that improves of rabbit ear comedo to contain the Venenum apis compositions.
With contain Venenum apis compositions (being sample B), contain Sargassum polysaccharides and compare with Margarita powder compositions (being sample C), contain Venenum apis, Sargassum polysaccharides and Margarita powder compositions (being sample D) to rabbit ear comedo to improve effect more obvious, Sargassum polysaccharides, Margarita powder and Venenum apis among this explanation the present invention have significant synergistic function.
With contain Venenum apis compositions (being sample B), contain PCA zinc and compare with decoyl salicylic acid composition (being sample E), contain Venenum apis, PCA zinc and decoyl salicylic acid composition (being sample F) to rabbit ear comedo to improve effect more obvious, PCA zinc, decoyl salicylic acid and Venenum apis among this explanation the present invention have remarkable synergistic function.
In a word, of the present invention have the Venenum apis compositions of acne-removing to the therapeutic effect highly significant of rabbit ear comedo model, and medication 4d can demonstrate obvious effect.
Embodiment 11
The Venenum apis compositions with acne-removing of embodiment 1-9 preparation is carried out human body experiment on probation, and sample 1-9 is the Venenum apis compositions with acne-removing of embodiment 1-9 preparation successively.
Choose totally 45 of light, the facial ordinary comedo volunteers of moderate, male 15 people wherein, women 30 people; Age 17-35 year, average 28.3 years old; Suffer from journey 4 week-7 year, average 3.5 years, 2 weeks before smearing cosmetics, do not use glucocorticosteroid hormone, tretinoin and antibiotics, unusual without hyperlipidemia and hepatic and renal function, forbid excessive drinking, avoid sunburst or ultraviolet excessively to shine.
45 volunteers are divided into 9 groups at random, every group of 5 people.The experimenter is with warm water cleaning pars affecta skin and after drying, smear every night counter sample 1 time, inactive other drug or cosmetics between the operating period, judges after 4 weeks that (the facial film using method that embodiment 6 prepares is warm water cleaning face to curative effect, facial film is applied to behind the pars affecta skin 10min cleans with clear water, 1 time every night, totally 4 weeks).Before treatment, reach the 4th week for the treatment of, respectively the facial inflammatory damage sum of volunteer (summation of inflammatory pimple and pustule), non-inflammatory lesions sum (summation of hoary hair's acne and blackhead) are counted, the untoward reaction after itemized record are used simultaneously.Criterion: base is healed: therapeutic index 〉=90%; Produce effects: 60%≤therapeutic index＜90%; Progressive: 20%≤therapeutic index＜60%; Invalid: therapeutic index＜20%.Total skin lesion number * 100% before therapeutic index=(the rear total skin lesion number of total skin lesion number-treatment before the treatment)/treatment.Effective percentage=(base heal routine number+produce effects example number)/whole routine numbers * 100%.
After 4 weeks, the Venenum apis compositions that respectively has acne-removing of embodiment 1-9 is as shown in table 2 to the therapeutic effect of comedo:
Table 2: have the Venenum apis compositions of acne-removing to the therapeutic effect of comedo
Venenum apis compositions and skin with acne-removing of the present invention has the good compatibility, can be absorbed by the skin rapidly, safe, gentle, do not cause the reactions such as stimulation, allergy, skin is burden not also, can also dissolution angular embolization, antiinflammatory, promotion wound heal rapidly, repair cicatrix, minimizing pigmentation.Use the Venenum apis compositions with acne-removing of the present invention after 4 weeks, it is normal fine and smooth soft and smooth that skin recovers, and the comedo symptom is difficult for recurrence after stopping using, its acne-removing safety, significantly, lasting, and comprehensively (table 2).
In above-mentioned 45 light, facial ordinary comedo volunteers of moderate, former facial inflammatory damage number amounts to 648, and the non-inflammatory lesions number amounts to 997.Be coated with the Venenum apis compositions that respectively has acne-removing with embodiment 1-9 after 4 weeks, facial inflammatory damage is cured 553 altogether, and non-inflammatory lesions is cured 834 altogether.Wherein, the Venenum apis compositions (Venenum apis is main anti-acne composition) of embodiment 1-3 preparation is cured 160 of facial inflammatory damages, 258 of non-inflammatory lesions altogether; The Venenum apis compositions (Venenum apis, Sargassum polysaccharides and Margarita powder are main anti-acne composition) of embodiment 4-6 preparation is cured 216 of facial inflammatory damages, 275 of non-inflammatory lesions altogether; The Venenum apis compositions (Venenum apis, PCA zinc and decoyl salicylic acid are main anti-acne composition) of embodiment 7-9 preparation is cured 177 of facial inflammatory damages, 301 of non-inflammatory lesions altogether.This shows that when Venenum apis and Sargassum polysaccharides, when Margarita powder is composite, the effects such as the Venenum apis compositions antiinflammatory with acne-removing of the present invention, sun-proof, moisturizing, acne removing seal significantly strengthen, and are obvious to curing inflammatory damage, pustule and cyst comedo effect.When Venenum apis and PCA zinc, when the decoyl salicylic acid is composite, the effects such as the Venenum apis compositions dredging pore with acne-removing of the present invention, Bergamot Mint Extract significantly strengthen, and are obvious to curing non-inflammatory lesions, point-like sample, pimple and atrophic comedo effect.
Generally speaking, the Venenum apis compositions with acne-removing of the present invention be applicable to comedo, the crowd of the different sexes of the problems puzzlements such as the pox of growing up, pox seal or cicatrix, age, skin quality.
Above-described embodiment is the better embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included in protection scope of the present invention.
Claims (10)
1. the Venenum apis compositions with acne-removing comprises acne-eliminating cosmetic substrate composition, it is characterized in that, also contains Venenum apis.
2. Venenum apis compositions according to claim 1, it is characterized in that described Venenum apis prepares by the following method, get thick Venenum apis water dissolution, and then after the ultrafilter membrane by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
3. Venenum apis compositions according to claim 2, it is characterized in that, described Venenum apis is to prepare by the following method: get thick Venenum apis and add 10-30 times of volume water and fully dissolve, the centrifugal 10-30min of 5000-10000g, after the ultrafilter membrane of supernatant by molecular cut off 10000Da carries out ultrafiltration, the filtrate lyophilization is made Venenum apis.
4. according to claim 1 and 2 or 3 described Venenum apis compositionss, it is characterized in that, described Venenum apis, its content accounts for 0.00001% ~ 2% of Venenum apis compositions gross mass.
5. Venenum apis compositions according to claim 4, it is characterized in that, described Venenum apis compositions with acne-removing also contains Sargassum polysaccharides and Margarita powder, the content of Sargassum polysaccharides accounts for the 0.01%-5% of Venenum apis compositions gross mass, and the content of Margarita powder accounts for the 0.2%-15% of Venenum apis compositions gross mass.
6. Venenum apis compositions according to claim 5, it is characterized in that described Sargassum polysaccharides is one or more the combination in sodium alginate, Porphyra Polysaccharide, Thallus Laminariae polysaccharide, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) polysaccharide, Eucheuma gelatinosum polysaccharide, Eucheuma gelatinae polysaccharide, Hijiki polysaccharide, laminarin, Sargassum polysaccharide, spirulina polysaccharide, sargassan, Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) polysaccharide, fucoidin, angle fork polysaccharides, Zostera marina polysaccharide and the chlorella polysaccharide; Described Margarita powder is one or more the combination in nanometer Margarita powder, water soluble Margarita ultrafine powder, the pearl hydrolysate liposome.
7. Venenum apis compositions according to claim 4 is characterized in that, described Venenum apis compositions with acne-removing also contains PCA zinc and decoyl salicylic acid.
8. Venenum apis compositions according to claim 7 is characterized in that, the content of described PCA zinc accounts for the 0.01%-1.5% of Venenum apis compositions gross mass, and the salicylic content of described decoyl accounts for the 0.1%-2% of Venenum apis compositions gross mass.
9. Venenum apis compositions according to claim 2 is characterized in that, described thick Venenum apis is the thick Venenum apis of wasp and/or the thick Venenum apis of Apis.
10. Venenum apis compositions according to claim 1 is characterized in that, described Venenum apis compositions is cream frost, emulsion, water preparation, gel, Gel mile or facial film, and described Venenum apis compositions can or have the function cosmetics of anti-acne effect as ordinary cosmetics.
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| CN104906014A (en) * | 2015-05-18 | 2015-09-16 | 台山市互信生物科技有限公司 | Bee venom olive massage oil and application method thereof |
| CN105395407A (en) * | 2015-12-01 | 2016-03-16 | 青岛中皓生物工程有限公司 | Moisturizing and anti-aging essence and moisturizing and anti-aging cosmetic mainly containing ocean materials |
| CN106265283A (en) * | 2016-08-30 | 2017-01-04 | 广州君恒生物科技有限公司 | A kind of acne removing water |
| CN107049890A (en) * | 2017-06-27 | 2017-08-18 | 广东芭薇生物科技股份有限公司 | A kind of skin care item with anti-acne effect of releiving |
| CN110151631A (en) * | 2019-06-26 | 2019-08-23 | 广州三广生物科技有限公司 | A kind of natural oil control and acne removal composition |
| CN111249440A (en) * | 2020-03-06 | 2020-06-09 | 暨南大学 | Application of small molecule short peptide in preparation of product for treating acne |
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| CN112353745A (en) * | 2020-11-19 | 2021-02-12 | 李刚 | Bee cream and its preparing method |
| CN114867464A (en) * | 2019-08-06 | 2022-08-05 | 大自然化妆品股份有限公司 | Topical cosmetic composition, said composition and use for the facial administration of a tonic |
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| CN104906014A (en) * | 2015-05-18 | 2015-09-16 | 台山市互信生物科技有限公司 | Bee venom olive massage oil and application method thereof |
| CN105395407A (en) * | 2015-12-01 | 2016-03-16 | 青岛中皓生物工程有限公司 | Moisturizing and anti-aging essence and moisturizing and anti-aging cosmetic mainly containing ocean materials |
| CN105395407B (en) * | 2015-12-01 | 2019-03-05 | 青岛中皓生物工程有限公司 | The anti-aging Essence of crystal-clear profit and the crystal-clear anti-aging cosmetics of profit based on marine material |
| CN106265283A (en) * | 2016-08-30 | 2017-01-04 | 广州君恒生物科技有限公司 | A kind of acne removing water |
| CN107049890A (en) * | 2017-06-27 | 2017-08-18 | 广东芭薇生物科技股份有限公司 | A kind of skin care item with anti-acne effect of releiving |
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| CN111249440A (en) * | 2020-03-06 | 2020-06-09 | 暨南大学 | Application of small molecule short peptide in preparation of product for treating acne |
| CN111743830A (en) * | 2020-06-19 | 2020-10-09 | 广州天玺生物科技有限公司 | Acne-removing composition and application thereof |
| CN112353745A (en) * | 2020-11-19 | 2021-02-12 | 李刚 | Bee cream and its preparing method |
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| WO2014094375A1 (en) | 2014-06-26 |
| CN102988262B (en) | 2014-08-20 |
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