CN107049890A - A kind of skin care item with anti-acne effect of releiving - Google Patents
A kind of skin care item with anti-acne effect of releiving Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a kind of skin care item with anti-acne effect of releiving；Aim to provide that a kind of stability is good, excitant is small, it is adaptable to which the skin care item of the anti-acne of sensitive skin, the skin care item include active component and matrix, and the active component includes the component of following weight/mass percentage composition：Gellan gum 0.5 2%, shale oil sulphonic acid ester sodium 0.3 2.5%, phosphoglycerol inositol choline 0.1 1%, anti-acne element 0.5 3%, the anti-acne element is made up of decoyl glycine, decoyl salicylic acid, tocopherol phosphate, Flos Campsis extract, matrine, pyridoxine, and the decoyl glycine, decoyl salicylic acid, tocopherol phosphate, Flos Campsis extract, matrine, the mass ratio of pyridoxine are 1：1.5：1：2：1：1；Belong to cosmetic field.
Description
Technical field
It is a kind of skin care item with anti-acne effect of releiving, belonging to specifically the present invention relates to a kind of skin care item
Cosmetic field.
Background technology
As living environment deteriorates, sensibiligen increases, and cosmetics and chemicals are widely used so that sensitive
Crowd also gradually increasing.
At the same time, the change of sebum composition, the effect of local androgen, propionibacterium acnes cause point of inflammatory factor
Sebocyte cell disdifferentiation and hair follicle conduit hyperkeratinization can be caused by secreting etc..The hyperkeratinization of pilosebaceous duct is mainly
Because the keratinocyte hyperplasia of conduit and the cell detachment of conduit endothelium angling are reduced and caused, keratotic plug shape is ultimately resulted in
Into obstruction follicular canal finally induces acne.
Although there is the cosmetics for sensitive in the market, it is to play resistance to stimulate and eliminate scorching
The effect of disease, is seldom provided simultaneously with effect of anti-acne, it is difficult to meet consumer demand.
The content of the invention
In view of the above-mentioned problems, it is an object of the invention to provide a kind of stability is good, excitant is small, it is adaptable to sensitive skin
The skin care item of anti-acne.
To solve above technical problem, the technical scheme that the present invention is provided is such：
A kind of have the skin care item of anti-acne effect of releiving, including active component and matrix, the active component include with
The component of lower weight/mass percentage composition：
The anti-acne element is by decoyl glycine, decoyl salicylic acid, tocopherol phosphate, Flos Campsis extract, matrine, pyrrole
Tremble element composition, the decoyl glycine, decoyl salicylic acid, tocopherol phosphate, Flos Campsis extract, matrine, pyridoxine
Mass ratio is 1：1.5：1：2：1：1.
Also comprising compound fruit extract in the active component, the weight/mass percentage composition of the compound fruit extract is
Account for the 1-3% of skin care item gross mass.The compound fruit extract is made up of raspberry, sugarcane and sugar maple, the raspberry, sweet
Sugarcane and sugar maple mass ratio are 3：5：1.
Willow herb flower extract is also included in the skin care item, the weight/mass percentage composition of the willow herb flower extract is to account for skin care
The 1-3% of product gross mass.The willow herb flower extract is using the whole strain willow herb of fresh harvesting as raw material, through mashing, cellulase
After enzymolysis processing, add zymophyte bacterium solution, with the ultrasonication three times of 10-50W power, sealing and fermenting 3-4 days, most afterwards through from
The heart, decolouring, suction filtration, freeze-drying obtain finished product.
It is preferred that, the willow herb flower extract is obtained in accordance with the following methods：
(1) the whole strain willow herb using fresh harvesting is raw material, mashing, adds cellulase, and cellulase and slurries are matched somebody with somebody
Than for 1：10-20, hydrolysis temperature is 50-60 DEG C, and enzymolysis time is 2-3h, digests the enzyme that gone out after terminating；
(2) the willow herb slurries Jing Guo step (1) enzymolysis processing are placed in ultrasonic reaction kettle, then add the newborn bar of acidophilus
The proportioning of bacterium bacterium solution, lactobacillus acidophilus bacterium solution and slurries is 1：20-50, lactobacillus acidophilus bacterial concentration is 105-108CFU/ml,
After mixing, with the ultrasonication three times of 10-50W power, each 10-30s；
(3) the willow herb slurries Jing Guo step (2) ultrasonication are placed in fermentation tank, it is close under conditions of 25-35 DEG C
Seal ferment 3-4 days, daily stirring 1-2 times.
(4) zymotic fluid for obtaining step (3), 10-20min is centrifuged with rotating speed 4000-6000r/min, collects supernatant,
Supernatant is added in preprocessed good macroporous resin column, is first eluted to distilled water near colourless, then 50% is measured with 5 times
Ethanol elution, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and through 0.22 μm of miillpore filter suction filtration, freeze-drying is obtained
To finished product.
The weight/mass percentage composition of the matrix is the 77.5-95.8% for accounting for skin care item gross mass.The matrix is sweet by double third
Alcohol, carbomer, triethanolamine, Chlorphenesin, Phenoxyethanol/Sensiva SC50 and water composition, the quality percentage of each component contain
Amount sum is 77.5-95.8%.
Compared with prior art, the technical scheme that the present invention is provided has the advantages that：
The present invention is with gellan gum, shale oil sulphonic acid ester sodium, phosphoglycerol inositol choline, anti-acne element, compound fruit extract
Five kinds of compositions are active component, and by willow herb flower extract Synergistic made from special process, obtain scientific formulation it is rigorous,
Stability is good, excitant is small, it is adaptable to the skin care item of the anti-acne of sensitive skin.
Wherein：
Gellan gum is that a kind of molecular weight is up to 2 × 105-3×105U anion line style microbial polysaccharide, is also current property
Can one of the most excellent thickener, stabilizer, have the various good characteristics of xanthans, pectin and carragheen concurrently, be it is modern not
The hydrophilic colloid that can lack.The texture of different gellan gum concentration on gel has strong influence.When colloid concentration exists
When between 0.012-0.05%, the gellan gum aqueous solution forms a kind of network structure of pregel, similar to a kind of extremely weak gel,
With good suspendability.There is a yield stress in its pregel network structure, when shearing force exceedes yield stress,
Colloidal sol can become aqueous fluids under relatively low shear rate, can recover pregel structure when cancelling shearing force quickly again, its
Suspending power is independent of very high viscosity, therefore the suspendability good to product and satisfied texture.
Shale oil sulphonic acid ester sodium, has effects that dispel acne, anti-inflammatory anti-itch, after-sun restorative.
Phosphoglycerol inositol choline is a kind of active component obtained from sunflower lecithin, is phosphoglycerol inositol
Semi-synthetic derivative, is the natural component of cytolipin metabolism, available for after solarization and treatment of releiving, controls allergy and dermatitis skin
The symptom such as rubescent, itch, prevention light aging and inflammation occur after red seal.
Anti-acne element can effectively suppress epidermis gold-coloured staphylococci and propionibacterium acnes, suppress the superfluous secretion of sebum,
Epidermal cell tissue is recombinated, the metabolic processes of cell are stimulated, exfoliating simultaneously rebuilds corneocyte, accelerates answering for small pox
Original, makes skin emolliency, smooth, and improves the antibacterial action of skin.
Compound fruit extract, wherein the tartaric acid contained can be used for acne treatment, anti-aging and mitigate pigment, with light
Change microgroove, anti-aging, highlighting skin, the improvement colour of skin, the quality of skin and texture, there is provided a variety of work(such as the required nutrition of skin
Effect.
Willow herb, also known as Canadian willow herb, are the non-sallows from Canadian northern prairie, and it can not only be
Survived under harsh weather, but also can be promptly in the area growth burnt by forest fire.Willow herb flower extract is included
Bioactive molecule, with anti-oxidant, anti-irritant, anti-acne and resist extraordinary 3male hormone secretion bioactivity.
Embodiment
With reference to embodiment, technical scheme is described in further detail, but not constituted pair
Any limitation of the present invention, the modification of anyone limited number of time made within the scope of the present invention, still the present invention's
Within protection domain.
And it should be noted that raw material employed in the technical scheme that provides of the present invention, unless otherwise specified, passes through
Conventional meanses are prepared or bought by commercial channel.
The preparation of the willow herb flower extract of embodiment 1
Whole strain willow herb is dried to water content 5-10% in the present embodiment, willow herb is then prepared in accordance with the following methods and is carried
Take thing：
(1) the whole strain willow herb using fresh harvesting is raw material, mashing, adds cellulase, and cellulase and slurries are matched somebody with somebody
Than for 1：15, hydrolysis temperature is 55 DEG C, and enzymolysis time is 3h, digests the enzyme that gone out after terminating；
(2) the willow herb slurries Jing Guo step (1) enzymolysis processing are placed in ultrasonic reaction kettle, then add the newborn bar of acidophilus
The proportioning of bacterium bacterium solution, lactobacillus acidophilus bacterium solution and slurries is 1：30, lactobacillus acidophilus bacterial concentration is 106CFU/ml, after mixing,
With the ultrasonication three times of 40W power, each 20s；
(3) the willow herb slurries Jing Guo step (2) ultrasonication are placed in fermentation tank, under conditions of 25 DEG C, sealing
Fermentation 3 days, daily stirring 2 times.
(4) zymotic fluid for obtaining step (3), 10min is centrifuged with rotating speed 4000r/min, supernatant is collected, by supernatant
It is added in preprocessed good macroporous resin column, is first eluted to distilled water near colourless, then measures 50% ethanol with 5 times and wash
It is de-, ethanol eluate is collected, and no alcohol taste is concentrated under reduced pressure into, through 0.22 μm of miillpore filter suction filtration, freeze-drying is obtained into
Product.
In order to better illustrate beneficial effects of the present invention, the present invention provides embodiment 2-4 and comparative example 1-4 Essence
Formula (being shown in Table 1), and to they carry out checking test：
Table 1
The preparation method of embodiment 2-4 and comparative example 1-4 Essence is according to this by the component in respective formula
The conventional Essence step of preparation process in field is made.
Matrix components in embodiment 4 and comparative example 1-4 Essence are completely the same, do not bring the effect of Synergistic
Really, illustrating the influence factor of the matrix components of the present invention can ignore in efficacy validation experiment.
First, stability test
Test sample：
Experimental group is Essence prepared by Example 2-4.
Blank group is that Essence normal temperature prepared by each Example 2-4 is preserved.
Control group is omits addition gellan gum, and remaining is same as Example 4.
1st, resistance to Thermal test
The heat resistant test is that the baking oven that the test sample for being respectively in room temperature is directly placed into 40 ± 1 DEG C keeps 24h, is recovered extremely
After room temperature, whether observation test sample is with testing preceding no significant difference.It the results are shown in Table shown in 2.
2nd, resist cold and test
The low temperature resistant test is that the cryogenic box that the test sample for being respectively in room temperature is directly placed into -10 DEG C keeps 24h, is recovered extremely
After room temperature, whether observation test sample is with testing preceding no significant difference.It the results are shown in Table shown in 2.
The stability test result of table 2
| Test sample | Resistance to Thermal test | Cold-resistant test | Blank group |
| Embodiment 2 | It is without exception | It is without exception | It is without exception |
| Embodiment 3 | It is without exception | It is without exception | It is without exception |
| Embodiment 4 | It is without exception | It is without exception | It is without exception |
| Control group | It is muddy | It is muddy | It is without exception |
As a result show, Essence prepared by 2-4 of the embodiment of the present invention is after resistance to Thermal test and cold-resistant test recover to room temperature
The situation without exception compared with blank group, illustrates that the Essence containing the present invention has good stability, can be with long-term storage.
And abnormal conditions occurs in control group, willow herb flower extract, the shale oil of gellan gum and Essence of the present invention are illustrated
Sulphonic acid ester sodium, phosphoglycerol inositol choline, anti-acne element, compound fruit extract synergy, the stability to Essence are played
Important effect.
2nd, excitant is tested
2-4 of the embodiment of the present invention Essences prepared are sent to third party testing agency detection skin irritation, to each
Essence is with the continuous skin irritation test of 6 chicken embryos, and to melt the time high for bleeding, blood coagulation and the blood vessel of the chicken embryo of test group
In 300 minutes.
As a result show, it is zero that Essence prepared by above-described embodiment, which calculates obtained stimulation scoring, illustrates the present invention
Essence prepared by embodiment 2-4 is nonirritant product.
3rd, anti-acne measure of merit
1. the crowd of experiment：Age 18-38 Sui is chosen, men and women does not limit, and previously to skin-care cosmetics without allergies, face has
The red and swollen subject of acne totally 160 people, is randomly divided into 8 groups, every group of 20 people.
2. test specimen：
Experimental group is Essence prepared by embodiment 2-4 and comparative example 1-4.
Control group is the facial mask from certain the cosmetics brand company bought on the market, and label, which is declared to have after product use, to be resisted
Acne effect.
3. test method：
Test specimen is used after the daily morning and evening face cleaning of above each group subject, after 28 days, subject is imitated to anti-acne
Fruit carries out use feeling evaluation, and evaluation result is counted, is specifically shown in Table 3 per capita.
Evaluation criterion：
(1) it is obviously improved：The disappearance of swelling and ache of erythema, acne disappear；
(2) it is slight to improve：The pain of erythema mitigates, acne partial remission or disappearance；
(3) it is invalid：Swelling and ache for erythema still exists, and acne are without improvement.
The anti-acne measure of merit result of table 3
As a result show, compared with comparative example 1-4 and control group, use the anti-acne effect of embodiment 2-4 Essence
Significantly, wherein anti-acne best results of embodiment 4, illustrate willow herb flower extract, gellan gum, shale oil sulphonic acid ester sodium, glycerine
Phosphoinositide choline, anti-acne element, six kinds of composition Synergistics of compound fruit extract, with good anti-acne effect.
In summary, the present invention is with gellan gum, shale oil sulphonic acid ester sodium, phosphoglycerol inositol choline, anti-acne element, Compound Water
Five kinds of compositions of fruit extract are active component, and by willow herb flower extract Synergistic made from special process, are formulated
Scientific and precise, stability are good, excitant is small, it is adaptable to the skin care item of the anti-acne of sensitive skin.
Claims (8)
1. a kind of skin care item with anti-acne effect of releiving, including active component and matrix, it is characterised in that the activearm
Subpackage contains the component of following weight/mass percentage composition：
The anti-acne element is by decoyl glycine, decoyl salicylic acid, tocopherol phosphate, Flos Campsis extract, matrine, pyridoxine
Composition, the decoyl glycine, decoyl salicylic acid, tocopherol phosphate, Flos Campsis extract, matrine, the quality of pyridoxine
Than for 1：1.5：1：2：1：1.
2. a kind of skin care item with anti-acne effect of releiving according to claim 1, it is characterised in that：The activearm
Also comprising compound fruit extract in point, the weight/mass percentage composition of the compound fruit extract is the 1- for accounting for skin care item gross mass
3%.
3. a kind of skin care item with anti-acne effect of releiving according to claim 2, it is characterised in that：The Compound Water
Fruit extract is made up of raspberry, sugarcane and sugar maple, and the raspberry, sugarcane and sugar maple mass ratio are 3：5：1.
4. a kind of skin care item with anti-acne effect of releiving according to claim 1, it is characterised in that：The skin care item
In also include willow herb flower extract, the weight/mass percentage composition of the willow herb flower extract is the 1-3% for accounting for skin care item gross mass.
5. a kind of skin care item with anti-acne effect of releiving according to claim 4, it is characterised in that：The willow herb
Extract after mashing, cellulase degradation processing, adds zymophyte bacterium solution using the whole strain willow herb of fresh harvesting as raw material,
With the ultrasonication three times of 10-50W power, sealing and fermenting 3-4 days is most obtained through centrifugation, decolouring, suction filtration, freeze-drying afterwards
Finished product.
6. a kind of skin care item with anti-acne effect of releiving according to claim 5, it is characterised in that：The willow herb
Extract is obtained in accordance with the following methods：
(1) the whole strain willow herb using fresh harvesting is raw material, mashing, addition cellulase, and the proportioning of cellulase and slurries is
1：10-20, hydrolysis temperature is 50-60 DEG C, and enzymolysis time is 2-3h, digests the enzyme that gone out after terminating；
(2) the willow herb slurries Jing Guo step (1) enzymolysis processing are placed in ultrasonic reaction kettle, then add lactobacillus acidophilus bacterium
The proportioning of liquid, lactobacillus acidophilus bacterium solution and slurries is 1：20-50, lactobacillus acidophilus bacterial concentration is 105-108CFU/ml, is mixed
Afterwards, with the ultrasonication three times of 10-50W power, each 10-30s；
(3) the willow herb slurries Jing Guo step (2) ultrasonication are placed in fermentation tank, under conditions of 25-35 DEG C, sealing hair
Ferment 3-4 days, daily stirring 1-2 times.
(4) zymotic fluid for obtaining step (3), 10-20min is centrifuged with rotating speed 4000-6000r/min, collects supernatant, will be upper
Clear liquid is added in preprocessed good macroporous resin column, is first eluted to distilled water near colourless, then measures 50% ethanol with 5 times
Elution, collects ethanol eluate, and is concentrated under reduced pressure into no alcohol taste, and through 0.22 μm of miillpore filter suction filtration, freeze-drying is obtained into
Product.
7. a kind of skin care item with anti-acne effect of releiving according to claim 1, it is characterised in that：The matrix
Weight/mass percentage composition is the 77.5-95.8% for accounting for skin care item gross mass.
8. a kind of skin care item with anti-acne effect of releiving according to claim 7, it is characterised in that：The matrix by
Dipropylene glycol, carbomer, triethanolamine, Chlorphenesin, Phenoxyethanol/Sensiva SC50 and water composition, the quality of each component
Percentage composition sum is 77.5-95.8%.
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| CN201710501480.3A CN107049890B (en) | 2017-06-27 | 2017-06-27 | Skin care product with effects of relieving and resisting acne |
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|---|---|---|---|
| CN201710501480.3A CN107049890B (en) | 2017-06-27 | 2017-06-27 | Skin care product with effects of relieving and resisting acne |
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| CN107049890B CN107049890B (en) | 2020-04-03 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108938514A (en) * | 2017-11-03 | 2018-12-07 | 王明远 | A kind of clear skin acne-removing liquid of quantum and preparation method thereof |
| CN108938498A (en) * | 2018-09-25 | 2018-12-07 | 广州好润生物科技有限公司 | A kind of antiallergic remediation composition and its preparation method and application with inhibition histamine release |
| CN108938513A (en) * | 2017-10-25 | 2018-12-07 | 游云利 | A kind of clear skin anti-acne face beautifying cream of quantum and preparation method thereof |
| CN109431873A (en) * | 2018-12-25 | 2019-03-08 | 广东润洁日化有限公司 | It is a kind of to repair the composition for soothing the skin inflammation |
| CN111317703A (en) * | 2020-04-15 | 2020-06-23 | 斑敏痘(广东)皮肤研究院 | Acne-removing skin-care preparation |
| CN111789807A (en) * | 2020-08-25 | 2020-10-20 | 浙江伊瑟奇医药科技有限公司 | Repair liquid for plant extract and preparation method thereof |
| CN114533596A (en) * | 2021-10-25 | 2022-05-27 | 陕西畅想制药有限公司 | Cosmetic composition for improving acne and preparation process thereof |
| IT202100020975A1 (en) * | 2021-08-03 | 2023-02-03 | Fb Dermo S R L | COMPOSITION FOR THE PREVENTION AND/OR TREATMENT OF ACNE. |
| CN116019731A (en) * | 2022-11-15 | 2023-04-28 | 广州好肌肤科技有限公司 | Herba centellae compound with safety acne removing effect for prepubertal period |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732205A (en) * | 2009-12-29 | 2010-06-16 | 北京工商大学 | Skin-care composition and preparation for relieving skin allergies and resisting inflammatory and irritation and preparation method thereof |
| CN102988262A (en) * | 2012-12-20 | 2013-03-27 | 中国科学院南海海洋研究所 | Bee venom composition with acne removing function |
| CN105395393A (en) * | 2015-11-25 | 2016-03-16 | 广州丹奇日用化工厂有限公司 | Skin care product composition with acne mark removing function and acne treatment cream |
| US20160367596A1 (en) * | 2015-06-17 | 2016-12-22 | Margaret Jean Profet | Topical and oral formulations comprising taurine and magnesium for the prevention and treatment of acne |
-
2017
- 2017-06-27 CN CN201710501480.3A patent/CN107049890B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732205A (en) * | 2009-12-29 | 2010-06-16 | 北京工商大学 | Skin-care composition and preparation for relieving skin allergies and resisting inflammatory and irritation and preparation method thereof |
| CN102988262A (en) * | 2012-12-20 | 2013-03-27 | 中国科学院南海海洋研究所 | Bee venom composition with acne removing function |
| US20160367596A1 (en) * | 2015-06-17 | 2016-12-22 | Margaret Jean Profet | Topical and oral formulations comprising taurine and magnesium for the prevention and treatment of acne |
| CN105395393A (en) * | 2015-11-25 | 2016-03-16 | 广州丹奇日用化工厂有限公司 | Skin care product composition with acne mark removing function and acne treatment cream |
Non-Patent Citations (3)
| Title |
|---|
| 王建新 主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
| 章苏宁 主编: "《化妆品工艺学》", 30 September 2007, 中国轻工业出版社 * |
| 马世昌 主编: "《化学物质辞典》", 30 April 1999, 陕西科学技术出版社 * |
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| CN108938514B (en) * | 2017-11-03 | 2021-08-24 | 王明远 | Skin-clearing acne-removing liquid and preparation method thereof |
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| CN111317703A (en) * | 2020-04-15 | 2020-06-23 | 斑敏痘(广东)皮肤研究院 | Acne-removing skin-care preparation |
| CN111789807A (en) * | 2020-08-25 | 2020-10-20 | 浙江伊瑟奇医药科技有限公司 | Repair liquid for plant extract and preparation method thereof |
| IT202100020975A1 (en) * | 2021-08-03 | 2023-02-03 | Fb Dermo S R L | COMPOSITION FOR THE PREVENTION AND/OR TREATMENT OF ACNE. |
| WO2023012616A1 (en) * | 2021-08-03 | 2023-02-09 | Fb Dermo S.R.L. | Composition for the prevention and/or treatment of acne |
| CN114533596A (en) * | 2021-10-25 | 2022-05-27 | 陕西畅想制药有限公司 | Cosmetic composition for improving acne and preparation process thereof |
| CN116019731A (en) * | 2022-11-15 | 2023-04-28 | 广州好肌肤科技有限公司 | Herba centellae compound with safety acne removing effect for prepubertal period |
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