CN114533596A - Cosmetic composition for improving acne and preparation process thereof - Google Patents
Cosmetic composition for improving acne and preparation process thereof Download PDFInfo
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- CN114533596A CN114533596A CN202111238773.XA CN202111238773A CN114533596A CN 114533596 A CN114533596 A CN 114533596A CN 202111238773 A CN202111238773 A CN 202111238773A CN 114533596 A CN114533596 A CN 114533596A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses a cosmetic composition for improving closed acne and a preparation process thereof, wherein the composition comprises the following components: butanediol, betaine salicylate, ethoxy diglycol, 1, 2-pentanediol, 1, 3-propanediol, trehalose, hydroxyethyl urea, caprylyl glycine, caprylyl salicylic acid, acne-removing essential oil, glyceryl caprylate, allantoin, dipotassium glycyrrhizinate, disodium ethylenediamine tetraacetate, sodium hyaluronate, hydroxyphenyl propionamide benzoic acid and deionized water. The active components for improving the closed comedo comprise caprylyl glycine, betaine salicylate, caprylyl salicylic acid and acne-removing essential oil, the reproduction of propionibacterium acnes is directly inhibited for solving the problem of the closed comedo, and the salicylic acid derivatives of caprylyl salicylic acid, betaine salicylic acid and caprylyl glycine are combined to inhibit the reproduction of the propionibacterium acnes together, so that a very good antibacterial effect is achieved.
Description
Technical Field
The invention relates to the technical field of cosmetics processing in daily chemical industry, in particular to a cosmetic composition for improving closed acne and a preparation process thereof.
Background
The skin care product is good for beauty, along with the continuous expansion of the skin care product market, the market demand of searching targeted functional skin care products for problem skin is greater and greater, and among the demand of a plurality of problems, the demand of acne removal skin care products is in leaderby.
The mechanism of the production of the pox is that because the grease is excessively secreted, waste keratinocytes are accumulated to block pores, and the anaerobic bacterium propionibacterium acnes in the pores is propagated and activated in large quantities to stimulate the inflammation of hair follicle sebaceous glands, so that the pox is produced. The types of pox include closed comedones, nodular pox, papular pox, cystic pox, pustular pox, nodular/cystic pox, papular/pustular pox, and polymeric pox. Acne-type pox can be further worsened if not properly treated, turning into nodular acne; nodular acne may be worsened to cystic acne if it is infected again.
The salicylic acid can inhibit the reproduction of Propionibacterium acnes, and can penetrate into pores to dissolve comedones. Due to the excellent anti-acne ability of "salicylic acid", it is often found in anti-acne products as "anti-acne seniors". The same principle is also utilized in the prior market for acid brushing and acne removing which are relatively exploded, but the situations of acid brushing and face rotting and acid brushing and acne removing can occur if the acne removing cream is improperly used. In the literature of the ' scientific understanding ' acid brushing ' beauty treatment published by the State drug administration in recent years, the addition of certain ' acid ' in cosmetics is definitely proposed, for example, the use limit and the technical requirement of fruit acid, salicylic acid and the like are strict, and the content of the salicylic acid in the cosmetics is not more than 3.0 percent. It can be seen that the allowable concentration of "acid" in the cosmetic is relatively low. Therefore, the development of a product which is safer, mild in components and non-irritant and can effectively improve the closed acne is urgently needed.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defects of the prior art and discloses a cosmetic composition capable of improving closed acne and a preparation process thereof.
The scheme adopted by the invention is as follows:
a cosmetic composition for improving closed acne, which comprises: butanediol, betaine salicylate, ethoxy diglycol, 1, 2-pentanediol, 1, 3-propanediol, trehalose, hydroxyethyl urea, caprylyl glycine, caprylyl salicylic acid, acne-removing essential oil, glycerol caprylate, allantoin, dipotassium glycyrrhizinate, ethylene diamine tetraacetic acid disodium, sodium hyaluronate, hydroxyphenylpropionamide benzoic acid and deionized water.
Preferably, the composition comprises the following components in parts by weight: 1-8 parts of butanediol, 2-5 parts of betaine salicylate, 1-5 parts of ethoxy diglycol, 0.5-5 parts of 1, 2-pentanediol, 0.5-5 parts of 1, 3-propanediol, 0.5-1 part of trehalose, 0.2-5 parts of hydroxyethyl urea, 0.1-1 part of caprylyl glycine, 0.1-1 part of caprylyl salicylic acid, 0.05-0.5 part of acne-removing essential oil, 0.1-1.5 parts of glyceryl caprylate, 0.1-0.5 part of allantoin, 0.05-0.25 part of dipotassium glycyrrhizinate, 0.05-0.2 part of disodium ethylenediamine tetraacetic acid, 0.01-0.05 part of sodium hyaluronate, 0.05-0.5 part of hydroxyphenylpropionamide benzoic acid and 60.5-93.69 parts of deionized water.
Preferably, the composition comprises the following components in parts by weight: 2 parts of butanediol, 4 parts of betaine salicylate, 2 parts of ethoxy diglycol, 3 parts of 1, 2-pentanediol, 3 parts of 1, 3-propanediol, 1 part of trehalose, 1 part of hydroxyethyl urea, 0.5 part of caprylyl glycine, 0.2 part of caprylyl salicylic acid, 0.05 part of acne-removing essential oil, 1 part of glyceryl caprylate, 0.2 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, 0.05 part of disodium ethylenediamine tetraacetic acid, 0.05 part of sodium hyaluronate, 0.05 part of hydroxyphenylpropionamide benzoic acid and 81.7 parts of deionized water.
Preferably, the acne-removing essential oil comprises the following components in parts by weight: 10-20% of lavender oil, 10-20% of juniper oil, 10-20% of melaleuca alternifolia leaf oil, 5-10% of oregano leaf oil, 5-10% of vetiver root oil, 4-10% of frankincense oil, 5-10% of patchouli oil, 5-10% of peppermint oil, 4-10% of thyme oil, 5-20% of pomegranate seed oil, 5-10% of chrysanthemum morifolium oil and 5-20% of dipropylene glycol.
Preferably, the acne-removing essential oil comprises the following components in parts by weight: 10% of lavender oil, 12% of juniper oil, 11% of melaleuca alternifolia leaf oil, 8% of origanum vulgaris leaf oil, 6% of vetiver root oil, 4% of frankincense oil, 5% of patchouli oil, 5% of mint oil, 4% of thyme oil, 20% of pomegranate seed oil, 10% of chamomile oil and 5% of dipropylene glycol.
Further, the invention also discloses a preparation process of the cosmetic composition for improving the acne, which comprises the following steps:
(1) mixing and heating butanediol, betaine salicylate, ethoxy diglycol, 1, 2-pentanediol, 1, 3-propanediol, caprylyl glycine, caprylyl salicylic acid, glyceryl caprylate and hydroxyphenyl propionamide benzoic acid according to the proportion, stirring to completely dissolve the mixture, cooling to 40-60 ℃, adding acne-removing essential oil, and stirring to be uniform;
(2) mixing and heating trehalose, hydroxyethyl urea, allantoin, dipotassium glycyrrhizinate, disodium ethylene diamine tetraacetate, sodium hyaluronate and deionized water according to the proportion, stirring to completely dissolve the mixture, and preserving the temperature for 20-40 minutes for later use;
(3) and (3) cooling the liquid prepared in the step (2), adding the liquid prepared in the step (1), stirring uniformly, cooling to 38-40 ℃, filtering and discharging to obtain the cosmetic composition for improving the acne.
Preferably, the mixing in the step (1) is heated to 75-80 ℃, and the temperature in the step (1) is reduced to 50 ℃.
Preferably, the mixing in the step (2) is heated to 75-80 ℃.
Preferably, the incubation time in step (2) is 30 minutes.
Preferably, the temperature of the liquid prepared in the step (2) in the step (3) is reduced to 50 ℃.
The action principle is as follows: closed acne is also called closed acne, and the formation reasons of the closed acne are many, for example, cleansing oil is remained in pores due to improper use of a cleansing method, a skin fat film is completely damaged due to over-cleaning, water cannot be locked, a large amount of oil is discharged, skin grease is excessive due to incomplete cleaning, and the skin is too thick, so that the pores are blocked by the horny layer, and the oil cannot be normally discharged. The reasons can finally cause water and oil imbalance of skin, excessive oil is produced, pores cannot be secreted, the pores are blocked, and closed comedo is formed, so that the anaerobic propionibacterium acnes in the pores are propagated in a large quantity, and the pox is completely caused.
The octanoyl salicylic acid is a derivative of salicylic acid with one octanoyl group at five positions, and compared with salicylic acid and common AHA (acetyl-hydroxy-N-acetyl-L-acetyl-D-L-acetyl-L-acetyl-L-acetyl-L-acetyl-L-acetyl-L.
Betaine salicylate combines the effects of salicylic acid and betaine, and compared with salicylic acid, betaine salicylate can mildly dissolve cuticle, promote skin metabolism, exfoliate dead skin, and improve skin elasticity.
The caprylyl glycine has strong inhibiting effect on staphylococcus aureus, propionibacterium acnes and the like, and can clean the skin and resist the excessive secretion of sebum.
The acne-removing essential oil is compounded by a plurality of pure plant essential oils, and active factors of the essential oil supplement each other, quickly permeate hair follicles, disinfect and resist bacteria, promote cell regeneration and restore skin connective tissues.
The allantoin is added while removing closed acne, and can promote tissue growth, cell metabolism, soften cuticle protein and protect skin tissue obviously.
Advantageous effects
The active components for improving the closed comedo comprise caprylyl glycine, betaine salicylate, caprylyl salicylic acid and acne-removing essential oil, the reproduction of propionibacterium acnes is directly inhibited for solving the problem of the closed comedo, and the salicylic acid derivatives of caprylyl salicylic acid, betaine salicylic acid and caprylyl glycine are combined to inhibit the reproduction of the propionibacterium acnes together, so that a very good antibacterial effect is achieved.
Detailed Description
Example 1.
The cosmetic composition for improving the closed acne is prepared from the following raw materials in parts by weight: 10g of lavender oil, 12g of juniper oil in the ground, 11g of melaleuca alternifolia leaf oil, 8g of oregano leaf oil, 6g of vetiver root oil, 4g of frankincense oil, 5g of patchouli oil, 5g of peppermint oil, 4g of thyme oil, 20g of pomegranate seed oil, 10g of chamomile oil and 5g of dipropylene glycol.
The preparation process of the cosmetic composition for improving the closed acne specifically comprises the following steps:
(1) 2g of butanediol, 4g of betaine salicylate, 2g of ethoxydiglycol, 3g of 1, 2-pentanediol, 3g of 1, 3-propanediol, 0.5g of caprylylglycine, 0.2g of caprylylsalicylic acid, 1g of glyceryl caprylate and 0.05g of hydroxyphenylpropionamide benzoic acid were mixed and heated to 75 ℃ and stirred to be completely dissolved. Cooling to 50 ℃, adding 0.05g of acne-removing essential oil, and stirring uniformly.
(2) Mixing and heating 1g of trehalose, 1g of hydroxyethyl urea, 0.2g of allantoin, 0.2g of dipotassium glycyrrhizinate, 0.05g of disodium ethylenediamine tetraacetic acid, 0.05g of sodium hyaluronate and 81.7g of deionized water to 75-80 ℃, stirring to completely dissolve the mixture, and keeping the temperature for 30 minutes for later use.
(3) Cooling the liquid prepared in the step (2) to 50 ℃, adding the liquid prepared in the step (1), stirring to be uniform, cooling to 38 ℃, filtering and discharging to obtain the cosmetic composition for improving the acne.
Example 2.
The cosmetic composition for improving the closed acne is prepared from the following raw materials in parts by weight: 10g of lavender oil, 12g of juniper oil in the ground, 11g of melaleuca alternifolia leaf oil, 8g of oregano leaf oil, 6g of vetiver root oil, 4g of frankincense oil, 5g of patchouli oil, 5g of peppermint oil, 4g of thyme oil, 20g of pomegranate seed oil, 10g of chamomile oil and 5g of dipropylene glycol.
The preparation process of the cosmetic composition for improving the closed acne specifically comprises the following steps:
(1) 2g of butanediol, 3g of betaine salicylate, 2g of ethoxydiglycol, 3g of 1, 2-pentanediol, 3g of 1, 3-propanediol, 0.3g of caprylylglycine, 0.1g of caprylyl salicylic acid, 1g of glyceryl caprylate and 0.05g of hydroxyphenylpropionamide benzoic acid were mixed and heated to 75 ℃ and stirred to be completely dissolved. Cooling to 50 deg.C, adding 0.05g of acne-removing essential oil, and stirring.
(2) Mixing and heating 1g of trehalose, 1g of hydroxyethyl urea, 0.2g of allantoin, 0.2g of dipotassium glycyrrhizinate, 0.05g of disodium ethylenediamine tetraacetic acid, 0.05g of sodium hyaluronate and 83g of deionized water to 75-80 ℃, stirring to completely dissolve the mixture, and keeping the temperature for 30 minutes for later use.
(3) Cooling the liquid prepared in the step (2) to 50 ℃, adding the liquid prepared in the step (1), stirring to be uniform, cooling to 38 ℃, filtering and discharging to obtain the cosmetic composition for improving the acne.
Example 3.
The cosmetic composition for improving the closed acne is prepared from the following raw materials in parts by weight: 10g of lavender oil, 12g of juniper oil in the ground, 11g of melaleuca alternifolia leaf oil, 8g of oregano leaf oil, 6g of vetiver root oil, 4g of frankincense oil, 5g of patchouli oil, 5g of peppermint oil, 4g of thyme oil, 20g of pomegranate seed oil, 10g of chamomile oil and 5g of dipropylene glycol.
The preparation process of the cosmetic composition for improving the closed acne specifically comprises the following steps:
(1) 2g of butanediol, 2g of betaine salicylate, 2g of ethoxydiglycol, 3g of 1, 2-pentanediol, 3g of 1, 3-propanediol, 0.2g of caprylylglycine, 0.2g of caprylylsalicylic acid, 1g of glyceryl caprylate and 0.05g of hydroxyphenylpropionamide benzoic acid were mixed and heated to 75 ℃ and stirred to be completely dissolved. Cooling to 50 deg.C, adding 0.05g of acne-removing essential oil, and stirring.
(2) Mixing and heating 1g of trehalose, 1g of hydroxyethyl urea, 0.2g of allantoin, 0.2g of dipotassium glycyrrhizinate, 0.05g of disodium ethylenediamine tetraacetic acid, 0.05g of sodium hyaluronate and 84g of deionized water to 75-80 ℃, stirring to completely dissolve the mixture, and keeping the temperature for 30 minutes for later use.
(3) And (3) cooling the liquid prepared in the step (2) to 50 ℃, adding the liquid prepared in the step (1), stirring uniformly, cooling to 38-40 ℃, filtering and discharging to obtain the cosmetic composition for improving the acne.
Example 4.
The cosmetic composition for improving the closed acne is prepared from the following raw materials in parts by weight: 10g of lavender oil, 12g of juniper wood oil, 11g of melaleuca alternifolia leaf oil, 8g of oregano leaf oil, 6g of vetiver root oil, 4g of frankincense oil, 5g of patchouli oil, 5g of peppermint oil, 4g of thyme oil, 20g of pomegranate seed oil, 10g of chamomile oil and 5g of dipropylene glycol.
The preparation process of the cosmetic composition for improving the closed acne specifically comprises the following steps:
(1) 2g of butanediol, 2g of ethoxydiglycol, 3g of 1, 2-pentanediol, 3g of 1, 3-propanediol, 0.1g of caprylylglycine, 0.2g of caprylylsalicylic acid, 1g of glyceryl caprylate and 0.05g of hydroxyphenylpropionamide benzoic acid were mixed and heated to 75 ℃ and stirred to be completely dissolved. Cooling to 50 deg.C, adding 0.05g of acne-removing essential oil, and stirring.
(2) Mixing and heating 1g of trehalose, 1g of hydroxyethyl urea, 0.2g of allantoin, 0.2g of dipotassium glycyrrhizinate, 0.05g of disodium ethylenediamine tetraacetic acid, 0.05g of sodium hyaluronate and 86.1g of deionized water to 75-80 ℃, stirring to completely dissolve the mixture, and keeping the temperature for 30 minutes for later use.
(3) And (3) cooling the liquid prepared in the step (2) to 50 ℃, adding the liquid prepared in the step (1), stirring uniformly, cooling to 38-40 ℃, filtering and discharging to obtain the cosmetic composition for improving the acne.
Verification example 1: test for bacteriostatic efficacy
To demonstrate the effect of improving closed-mouth comedones provided by the present invention, the composition for improving closed-mouth comedones prepared in examples 1 to 4 of the present invention was subjected to a propionibacterium acnes bacteriostatic test:
1. experimental materials:
propionibacterium acnes (ATCC 6919), enhanced clostridial culture medium 1053#, and physiological saline.
2. The test method is briefly described as follows:
10mL of each of the compositions for improving closed-mouth acne prepared in examples 1 to 4 was added to 1mL of each of the suspensions of Propionibacterium acnes (concentration: 2.9X 10)6cfu/mL), mixed well.
Secondly, respectively preparing 10 mixtures of 4 samples prepared in the first step-1、10-2、10-3And (3) respectively injecting 1mL of test solution with different gradients into a sterilized plate added with the culture medium, rotating the plate immediately to fully and uniformly mix the test solution and the culture medium, after agar is solidified, inversely placing the test solution in an anaerobic incubator at the temperature of 1 ℃ and 36 ℃ for culturing for 5 days, and then counting colonies.
Note: two replicates of each test solution were made and three replicates of each sample were made.
3. And (3) processing experimental data:
the bacteriostatic effect of the bacteriostatic product can be reduced by the logarithm of the colony number (R)X) As an evaluation index. The calculation method is as follows:
RX＝lgN0-lgNX
in the formula:
N0: the initial concentration of the bacterial liquid in the sample;
NX: the number of colonies detected in the test solution.
4. The experimental results are as follows:
note: rXStrong bacteriostasis of not less than 5Effect, indicated as +++; r is more than or equal to 4XLess than 5 has good antibacterial effect, and is expressed by + + in the specification; r is more than or equal to 3XThe antibacterial effect is less than 4, and is expressed as +; rXLess than 3, no bacteriostatic effect.
The embodiment examples 1 to 4 all prove that the compositions of the embodiment examples 1 to 4 have good bacteriostatic effect.
Verification example 2: evaluation of human body efficacy
In order to demonstrate the effect of improving closed comedones provided by the present invention, the compositions for improving closed comedones prepared in examples 1 to 4 were subjected to human efficacy evaluation:
120 closed acne volunteers were collected, 65 of the men and 55 of the women. Divided into 4 groups of 30 people each. The application method comprises the following steps: experimental groups 1 to 4 were applied daily with the closed acne improving composition prepared in examples 1 to 4 of the present invention, respectively. The smearing method comprises the following steps: after cleaning the skin, the skin is smeared on the closed acne part respectively in the morning and at the evening. The effect was observed after one week.
And (3) judging the effect:
the method has the following advantages: more than 50% of closed comedones subside;
and (4) invalidation: the closed acne is not obviously improved or aggravated or has other adverse effects.
The observed effects are shown in the following table:
and (4) conclusion: the experiment group 1 has the best effect, the experiment group 2 has the excellent effect, the experiment group 3 has the good effect, the experiment group 4 has the common effect, but the effect still exists, so the experiment groups 1 to 4 all prove that the composition of the experiment groups 1 to 4 has the good effective rate of treating the closed comedo.
The foregoing detailed description has set forth in detail the methods of the present invention. The above description is only for the purpose of helping those skilled in the art better understand the method and idea of the present invention, and not for the purpose of limiting the relevant content.
Claims (10)
1. A cosmetic composition for ameliorating closed comedones, comprising: butanediol, betaine salicylate, ethoxy diglycol, 1, 2-pentanediol, 1, 3-propanediol, trehalose, hydroxyethyl urea, caprylyl glycine, caprylyl salicylic acid, acne-removing essential oil, glyceryl caprylate, allantoin, dipotassium glycyrrhizinate, disodium ethylenediamine tetraacetate, sodium hyaluronate, hydroxyphenyl propionamide benzoic acid and deionized water.
2. The cosmetic composition for improving closed comedones according to claim 1, which comprises the following components in parts by weight: 1-8 parts of butanediol, 2-5 parts of betaine salicylate, 1-5 parts of ethoxy diglycol, 0.5-5 parts of 1, 2-pentanediol, 0.5-5 parts of 1, 3-propanediol, 0.5-1 part of trehalose, 0.2-5 parts of hydroxyethyl urea, 0.1-1 part of caprylyl glycine, 0.1-1 part of caprylyl salicylic acid, 0.05-0.5 part of acne-removing essential oil, 0.1-1.5 parts of glyceryl caprylate, 0.1-0.5 part of allantoin, 0.05-0.25 part of dipotassium glycyrrhizinate, 0.05-0.2 part of disodium ethylenediamine tetraacetic acid, 0.01-0.05 part of sodium hyaluronate, 0.05-0.5 part of hydroxyphenylpropionamide benzoic acid and 60.5-93.69 parts of deionized water.
3. The cosmetic composition for improving closed comedones according to claim 2, wherein the composition comprises the following components in parts by weight: 2 parts of butanediol, 4 parts of betaine salicylate, 2 parts of ethoxy diglycol, 3 parts of 1, 2-pentanediol, 3 parts of 1, 3-propanediol, 1 part of trehalose, 1 part of hydroxyethyl urea, 0.5 part of caprylyl glycine, 0.2 part of caprylyl salicylic acid, 0.05 part of acne-removing essential oil, 1 part of glyceryl caprylate, 0.2 part of allantoin, 0.2 part of dipotassium glycyrrhizinate, 0.05 part of disodium ethylenediamine tetraacetic acid, 0.05 part of sodium hyaluronate, 0.05 part of hydroxyphenylpropionamide benzoic acid and 81.7 parts of deionized water.
4. The cosmetic composition for improving closed acne according to claim 3, wherein the weight ratio of each component in the acne-removing essential oil is as follows: 10-20% of lavender oil, 10-20% of juniper oil, 10-20% of melaleuca alternifolia leaf oil, 5-10% of oregano leaf oil, 5-10% of vetiver root oil, 4-10% of frankincense oil, 5-10% of patchouli oil, 5-10% of peppermint oil, 4-10% of thyme oil, 5-20% of pomegranate seed oil, 5-10% of chrysanthemum morifolium oil and 5-20% of dipropylene glycol.
5. The cosmetic composition for improving the closed acne according to claim 4, wherein the weight ratio of each component in the acne-removing essential oil is as follows: 10% of lavender oil, 12% of juniper oil, 11% of melaleuca alternifolia leaf oil, 8% of origanum vulgaris leaf oil, 6% of vetiver root oil, 4% of frankincense oil, 5% of patchouli oil, 5% of mint oil, 4% of thyme oil, 20% of pomegranate seed oil, 10% of chamomile oil and 5% of dipropylene glycol.
6. A process for preparing a cosmetic composition for improving closed comedones according to any one of claims 1 to 5, comprising the steps of:
(1) mixing and heating butanediol, betaine salicylate, ethoxy diglycol, 1, 2-pentanediol, 1, 3-propanediol, caprylyl glycine, caprylyl salicylic acid, glyceryl caprylate and hydroxyphenyl propionamide benzoic acid according to the proportion, stirring to completely dissolve the mixture, cooling to 40-60 ℃, adding acne-removing essential oil, and stirring to be uniform;
(2) mixing and heating trehalose, hydroxyethyl urea, allantoin, dipotassium glycyrrhizinate, disodium ethylene diamine tetraacetate, sodium hyaluronate and deionized water according to the proportion, stirring to completely dissolve the mixture, and preserving the temperature for 20-40 minutes for later use;
(3) and (3) cooling the liquid prepared in the step (2), adding the liquid prepared in the step (1), stirring uniformly, cooling to 38-40 ℃, filtering and discharging to obtain the cosmetic composition for improving the acne.
7. A process for preparing a cosmetic composition for improving closed comedones according to claim 6, wherein: the mixing and heating temperature in the step (1) is 75-80 ℃, and the cooling temperature in the step (1) is 50 ℃.
8. A process for preparing a cosmetic composition for improving closed comedones according to claim 6, wherein: and (3) in the step (2), the temperature of mixing and heating is 75-80 ℃.
9. A process for preparing a cosmetic composition for improving closed comedones according to claim 6, wherein: and (3) keeping the temperature for 30 minutes in the step (2).
10. A process for preparing a cosmetic composition for improving closed comedones according to claim 6, wherein: and (3) cooling the liquid prepared in the step (2) to 50 ℃.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115813785A (en) * | 2022-12-28 | 2023-03-21 | 水羊化妆品制造有限公司 | Salicylic acid and composition of derivatives thereof, preparation method and application |
| CN116019731A (en) * | 2022-11-15 | 2023-04-28 | 广州好肌肤科技有限公司 | Herba centellae compound with safety acne removing effect for prepubertal period |
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| WO2014108846A2 (en) * | 2013-01-10 | 2014-07-17 | L'oreal | Soothing cosmetic composition based on salicylic acid |
| CN107049890A (en) * | 2017-06-27 | 2017-08-18 | 广东芭薇生物科技股份有限公司 | A kind of skin care item with anti-acne effect of releiving |
| CN108938513A (en) * | 2017-10-25 | 2018-12-07 | 游云利 | A kind of clear skin anti-acne face beautifying cream of quantum and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014108846A2 (en) * | 2013-01-10 | 2014-07-17 | L'oreal | Soothing cosmetic composition based on salicylic acid |
| CN107049890A (en) * | 2017-06-27 | 2017-08-18 | 广东芭薇生物科技股份有限公司 | A kind of skin care item with anti-acne effect of releiving |
| CN108938513A (en) * | 2017-10-25 | 2018-12-07 | 游云利 | A kind of clear skin anti-acne face beautifying cream of quantum and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116019731A (en) * | 2022-11-15 | 2023-04-28 | 广州好肌肤科技有限公司 | Herba centellae compound with safety acne removing effect for prepubertal period |
| CN115813785A (en) * | 2022-12-28 | 2023-03-21 | 水羊化妆品制造有限公司 | Salicylic acid and composition of derivatives thereof, preparation method and application |
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