CN114569506A

CN114569506A - Natural active beautifying and acne removing gel composition and preparation method thereof

Info

Publication number: CN114569506A
Application number: CN202210222601.1A
Authority: CN
Inventors: 梁锋; 熊中立; 张晓帆
Original assignee: Shanghai Zhengxin Biotechnology Co ltd
Current assignee: Shanghai Zhengxin Biotechnology Co ltd
Priority date: 2022-03-07
Filing date: 2022-03-07
Publication date: 2022-06-03

Abstract

The invention discloses a natural active face-refreshing acne-removing gel composition and a preparation method thereof. The acne removing gel is a composition prepared from the following raw materials in percentage by weight: u20200.1-1%, 1, 3-butanediol 2-6%, glycerol 1-5%, p-hydroxyacetophenone 0.1-1%, antibacterial peptide 5-11%, tripeptide-81-3%, radix paeoniae extract 0.5-2%, 1, 2-hexanediol 0.5-3%, acne removing agent 2-6%, triethanolamine 0.1-1%, and the balance of deionized water. Wherein the active substances comprise a plurality of components such as antibacterial peptide, tripeptide-8, radix paeoniae alba extract, acne removing agent and the like, and are prepared according to a certain technical scheme. The acne-removing gel composition prepared by the invention has an excellent acne-removing effect on skin, is easy to absorb, safe and mild, and is suitable for sensitive muscles; the acne removing product has good acne removing effect, simple preparation process and low preparation cost.

Description

Natural active face-beautifying acne-removing gel composition and preparation method thereof

Technical Field

The invention provides a natural active skin-refreshing gel composition, and particularly relates to a natural active skin-refreshing acne-removing gel composition capable of being applied to acne removal, and a preparation method and application thereof.

Background

Among the common skin problems, pox is a word often mentioned by people, also known as acne, and is commonly found on the face and back. Propionibacterium acnes is one of causes for inducing acne, is invaded into sebaceous glands, can produce a small-molecule polypeptide, attracts phagocytes to bacterial parasitic sites, releases hydrolytic enzymes and various inflammatory mediators, induces local inflammatory reaction, and finally destroys the sebaceous glands to form the acne.

Different treatment regimens are recommended for different acne types. For mild acne, the skin renewal is mainly promoted; for moderate acne, the main effects are antibiosis and antiphlogosis; for high-grade acne, the acne is repaired, and the acne is prevented and the acne scar is mainly formed. In a common acne removing formula, the common raw materials are as follows: salicylic acid, sulfur, tretinoin and benzoyl peroxide are used too frequently, which can cause intolerance of skin and face rot. Skin care products containing antibiotics or medicines are easy to cause contact dermatitis and allergic dermatitis. Among the latest edition of legislation, there are a number of materials that have been expressly banned from being added to cosmetics.

Therefore, how to provide a safe and effective acne removing product is a technical problem which needs to be solved urgently by technical personnel in the field.

Disclosure of Invention

In order to solve the technical problem of solving the problem of acne generation by the existing antibiotics, the invention aims to provide a safe and effective natural active acne-removing gel composition and a preparation method thereof.

The object of the present invention is achieved by the following technical means.

A natural active beautifying and acne removing gel composition is prepared from the following raw material components in percentage by weight:

ingredients other than active: u20200.1-1%, 1, 3-butanediol 2-6%, glycerol 1-5%, p-hydroxyacetophenone 0.1-1%, 1, 2-hexanediol 0.5-3%, triethanolamine 0.1-1%, and the balance of deionized water.

Wherein, the active matter (functional component) comprises: 5-11% of antibacterial peptide, 81-3% of tripeptide, 0.5-2% of radix paeoniae alba extract and 2-6% of acne removing agent.

Further, the acne removing gel composition comprises the following components except for the active substances in the following ratio:

u20200.2%, 1, 3-butanediol 4%, glycerol 3%, p-hydroxyacetophenone 0.5%, 1, 2-hexanediol 1%, triethanolamine 0.2%, and deionized water 75.9%;

further, the active matter comprises the following raw materials in proportion:

8% of antibacterial peptide, 82% of tripeptide, 1.2% of radix paeoniae alba extract and 4% of acne removing agent.

In addition, the preparation method of the natural active face-refreshing acne-removing gel composition specifically comprises the following steps:

1) taking a clean beaker, dispersing U2020, 1, 3-butanediol and glycerol uniformly in advance, adding water into the beaker, and starting stirring; after the mixture is uniformly stirred, adding p-hydroxyacetophenone, continuously heating to 75-95 ℃, stirring while heating, and after the mixture is completely stirred, keeping the temperature for 5-20 minutes;

2) cooling to 40-50 deg.C, adding antibacterial peptide, tripeptide-8, radix Paeoniae extract, 1, 2-hexanediol, and acne removing agent, and stirring;

3) dissolving triethanolamine in water, adding into a beaker, and stirring;

4) cooling to 35-40 ℃, sampling, inspecting, and discharging to obtain the acne-removing gel composition.

The preparation method of the natural active beautifying and acne removing gel comprises the step 1), wherein the temperature rise is 85 ℃, and the heat preservation time is 10 minutes.

The preparation method of the natural active beautifying and acne removing gel comprises the step 2) of cooling at 45 ℃.

The preparation method of the natural active beautifying and acne removing gel comprises the step 4), wherein the cooling temperature is 38 ℃.

In conclusion, the invention has the following advantages and effects:

1) in the formula of the natural active face-refreshing acne-removing gel, the antibacterial peptide can replace antibiotics to improve papules, pustules and cysts; the tripeptide-8 has the effects of resisting inflammation and relieving, and can inhibit inflammation and pain caused by acne in acne-removing products; the radix paeoniae extract can whiten and brighten skin color, and can lighten acne marks and scars; the acne removing agent is a bactericide and is used for killing bacteria on the surface of the skin by cooperating with antibacterial peptide.

2) The formula of the invention is simple, no components sensitive to skin exist, and the invention is also applicable to sensitive muscles; compared with the traditional salicylic acid and erythromycin, the antibacterial peptide used in the formula can effectively inhibit the generation of propionibacterium acnes and staphylococcus aureus, prevent inflammatory acne from forming and effectively improve whelk;

3) compared with a single acne removing product on the market, the antibacterial peptide and the peony extract used in the formula of the invention solve the problem of acne from the root, and can repair skin barriers and remove acne at the same time.

Drawings

Fig. 1 is a graph comparing the effect before and after using the acne-removing gel composition of the present invention;

fig. 2 is a graph of clinical efficacy using the anti-acne gel composition of the present invention.

Detailed Description

The present invention will be described in further detail below with reference to specific preferred examples and effect test examples, but the present invention is not limited to the following examples.

The invention discloses a natural active face-refreshing acne-removing gel composition and a preparation method thereof. The acne-removing gel composition is prepared from the following raw materials in percentage by weight:

u20200.1-1%, 1, 3-butanediol 2-6%, glycerol 1-5%, p-hydroxyacetophenone 0.1-1%, antibacterial peptide 5-11%, tripeptide-81-3%, radix paeoniae extract 0.5-2%, 1, 2-hexanediol 0.5-3%, acne removing agent 2-6%, triethanolamine 0.1-1%, and the balance of deionized water.

Wherein the active substances comprise a plurality of components such as antibacterial peptide, tripeptide-8, radix paeoniae alba extract, acne removing agent and the like, and are prepared according to a certain technical scheme.

The acne-removing gel composition prepared by the invention has an excellent acne-removing effect on skin, is easy to absorb, is safe and mild, and is suitable for sensitive muscles; the acne removing product has good acne removing effect, simple preparation process and low preparation cost.

The following are introduced as raw material components and efficacy descriptions respectively:

(ii) antibacterial peptides

The antibacterial peptide antigen refers to a basic polypeptide substance with antibacterial activity generated by induction in an insect body, has a molecular weight of about 2000-7000 and consists of 20-60 amino acid residues. Most of the active polypeptides have the characteristics of strong alkalinity, heat stability, broad-spectrum antibiosis and the like.

The antibacterial peptide is prepared by compounding 98.7% of water, 0.5% of 1,2 hexanediol, 0.5% of 1,2 pentanediol and 0.3% of hexapeptide-5.

② tripeptide-8

The tripeptide-8 is mainly composed of palmitoyl tripeptide-8, which is also called "tripeptide" or "collagen peptide COLL-O2". The synthesis method is solid phase peptide or liquid phase peptide synthesis. The tripeptide-8 can be added into cosmetics to reduce skin reaction to irritants, prevent and improve neurogenic inflammation, and maintain healthy skin barrier.

③ peony root extract

Paeonia lactiflora is from Sichuan Bashu region, and is a rare and genuine Chinese medicinal material. The company selects high-quality radix paeoniae, boils and dries in the sun, thereby compounding the radix paeoniae extract. The radix Paeoniae extract has effects of keeping moisture, repairing skin barrier and relieving skin redness.

The preparation process of the peony root extract comprises the following steps:

1) peeling fresh radix Paeoniae, steaming, oven drying, and pulverizing to obtain radix Paeoniae raw material;

2) soaking the radix paeoniae alba raw material in an ethanol solution, wherein the volume concentration of the ethanol solution is 50-90%; simultaneously carrying out ultrasonic extraction for 10-30 min; after the completion, centrifuging, and taking supernatant as an extracting solution;

3) passing the radix Paeoniae extract through macroporous adsorbent resin, and washing the macroporous adsorbent resin with eluent to obtain eluent; removing the eluent in the eluent by adopting a reduced pressure distillation mode to obtain a concentrated solution, and carrying out vacuum freeze drying on the concentrated solution to obtain a peony root extract;

removing ethanol in the extracting solution by adopting a reduced pressure distillation mode to obtain a peony root extract; the ratio of the volume of the ethanol solution to the mass of the peony root raw material is 5 mL/g-15 mL/g.

'Xiaobanling' for removing acne

The quaternary ammonium salt-75 is a compound generated by chemical synthesis and four hydrogen atoms in ammonium ions of the quaternary ammonium salt are all replaced by alkyl, is a cationic surfactant, has good bactericidal performance, and is also a good antibacterial raw material, and the bactericidal effective part of the cationic surfactant is a cationic group formed by combining an organic radical and a nitrogen atom.

The acne removing agent is prepared by compounding 0.1 percent of quaternary ammonium salt-75 percent and 99.9 percent of butanediol.

Example 1

A natural active beautifying and acne removing gel composition is prepared from the following raw material components in percentage by weight as shown in Table 1:

table 1 composition of materials (wt%)

Starting materials	Amount of formulation
		Water (W)	75.9％
U2020	0.2％
		1, 3-butanediol	4％
Glycerol	3％
		P-hydroxyacetophenone	0.5％
Antibacterial peptide	8％
		Tripeptide-8	2％
Radix Paeoniae extract	1.2％
		1, 2-hexanediol	1％
Acne removing medicine	4％
		Triethanolamine	0.2％

Wherein, the antibacterial peptide described in the table 1 is compounded by 98.7% of water, 0.5% of 1,2 hexanediol, 0.5% of 1,2 pentanediol and 0.3% of hexapeptide-5; the acne removing agent is prepared by compounding 0.1 percent of quaternary ammonium salt-75 percent and 99.9 percent of butanediol.

The preparation method of the natural active face-refreshing acne-removing gel composition in the embodiment 1 of the invention specifically comprises the following steps:

1) taking a clean beaker, dispersing U2020, 1, 3-butanediol and glycerol uniformly in advance, adding water into the beaker, and starting stirring; after the mixture is stirred uniformly, adding p-hydroxyacetophenone, continuously heating to 85 ℃, heating while stirring, and after the mixture is completely stirred, keeping the temperature for 10 minutes;

2) cooling to 45 ℃, adding antibacterial peptide (the main formula is: 0.5% of 1, 2-hexanediol, 0.5% of 1, 2-pentanediol, hexapeptide-50.3%), tripeptide-8, radix paeoniae alba extract, 1, 2-hexanediol and acne removing agent (the main formula is: 750.1 percent of quaternary ammonium salt and 99.9 percent of butanediol) and stirring evenly;

3) dissolving triethanolamine in water, adding into a beaker, and stirring;

4) cooling to 38 deg.C, sampling, and discharging to obtain the final product.

Example 2

A natural active beautifying and acne-removing gel composition is prepared from the following raw materials in percentage by weight as shown in the following table 2:

table 2 composition of materials (wt%)

Raw materials	Amount of formulation
		Water (W)	78.4％
U2020	0.5％
		1, 3-butanediol	4％
Glycerol	3％
		P-hydroxyacetophenone	0.5％
Antibacterial peptide	5％
		Tripeptide-8	2％
Paeonia lactiflora root extract	1.2％
		1, 2-hexanediol	1％
Acne removing medicine	4％
		Triethanolamine	0.4％

The preparation method of the natural active beautifying and acne removing gel specifically comprises the following steps:

1) taking a clean beaker, dispersing U2020, 1, 3-butanediol and glycerol uniformly in advance, adding water into the beaker, and starting stirring. After the mixture is stirred uniformly, adding p-hydroxyacetophenone, continuously heating to 85 ℃, heating while stirring, and after the mixture is completely stirred, keeping the temperature for 10 minutes;

2) cooling to 50 ℃, adding antibacterial peptide (the main formula is: 0.5% of 1, 2-hexanediol, 0.5% of 1, 2-pentanediol, 50.3% of hexapeptide), tripeptide-8, a peony root extract, 1, 2-hexanediol and acne removing agent (the main formula is: 750.1 percent of quaternary ammonium salt and 99.9 percent of butanediol) and stirring evenly;

3) dissolving triethanolamine in water, adding into a beaker, and stirring;

4) cooling to 38 ℃, sampling, inspecting, discharging, and preparing the acne-removing gel composition.

Example 3

A natural active beautifying and acne-removing gel composition is prepared from the following raw materials in percentage by weight as shown in the following table 3:

table 3 composition of materials (wt%)

The preparation method of the natural active face-refreshing acne-removing gel composition in the embodiment 3 of the invention specifically comprises the following steps:

3) dissolving triethanolamine in water, adding into a beaker, and stirring;

4) cooling to 40 ℃, sampling, inspecting, and discharging to obtain the acne-removing gel composition.

Example 4

A natural active beautifying and acne-removing gel composition is prepared from the following raw materials in percentage by weight as shown in the following table 4:

table 4 composition of materials (wt%)

The preparation method of the natural active beautifying and acne-removing gel composition in embodiment 4 of the invention specifically comprises the following steps:

3) dissolving triethanolamine in water, adding into a beaker, and stirring;

4) cooling to 35 deg.C, sampling, and discharging to obtain the final product.

Example 5

A natural active beautifying and acne-removing gel composition is prepared from the following raw materials in percentage by weight as shown in the following table 5:

table 5 composition of materials (wt%)

The preparation method of the natural active face-refreshing acne-removing gel composition in the embodiment 5 of the invention specifically comprises the following steps:

1) taking a clean beaker, dispersing U2020, 1, 3-butanediol and glycerol uniformly in advance, adding water into the beaker, and starting stirring; after the mixture is stirred uniformly, adding p-hydroxyacetophenone, continuously heating to 85 ℃, heating while stirring, and after the mixture is completely stirred, keeping the temperature for 20 minutes;

3) dissolving triethanolamine in water, adding into a beaker, and stirring;

Comparative examples 1 to 5

The formulations of comparative examples 1-5 were identical except for the inconsistency of the active ingredients, as shown in table 6 below:

TABLE 6 gel formulation compositions of comparative examples 1-5 (% by weight)

Raw materials	Comparative example 1	Comparative example 2	Comparative example 3	Comparative example 4	Comparative example 5
						Water (W)	83.1％	90.1％	81.1％	91％	85.6％
U2020	0.2％	0.2％	0.2％	0.2％	0.2％
						1, 3-butanediol	4％	4％	4％	4％	4％
Glycerol	3％	3％	3％	3％	3％
						P-hydroxyacetophenone	0.5％	0.5％	0.5％	0.5％	0.5％
Antibacterial peptide	8％	0	0	0	0
						Salicylic acid	0	1％	0	0	0
Sulfur	0	0	10％	0	0
						Adapalene	0	0	0	0.1％	0
Benzoyl peroxide	0	0	0	0	5.5％
						1, 2-hexanediol	1％	1％	1％	1％	1％
Triethanolamine	0.2％	0.2％	0.2％	0.2％	0.2％

The method for preparing the gel compositions of comparative examples 1 to 5 specifically includes the steps of:

2) cooling to 45 deg.C, adding antibacterial peptide (salicylic acid or sulfur or adapalene or benzoyl peroxide) and 1, 2-hexanediol, and stirring;

3) dissolving triethanolamine in water, adding into a beaker, and stirring;

4) cooling to 38 deg.C, sampling, and discharging to obtain the final product.

Effect test example 1 (clinical efficacy test)

Subjects: collecting 56 qualified volunteers, and dividing into 8 groups of 7 persons (age: 15-40 years, facial condition requirement: acne is obvious on both left and right faces);

the experimental method comprises the following steps: after cleaning the face every night, the face was smeared with acne removing gel.

Experiment time: one week;

evaluation criteria, as shown in table 7:

TABLE 7 evaluation criteria

Evaluation grade (score)	The skin condition can be seen with naked eyes
		Is completely effective (3)	Acne basically disappears, and skin is fine and smooth
Very effective (2)	Small pox was visible with pox marks and pits
		Generally effective (1)	The acne part disappears
Ineffectiveness (0)	Substantially no change in skin

TABLE 8 comparative example use effect score Table (average score for each group)

As can be seen from table 8: compared with other acne-removing raw materials, formula and preparation process, the acne-removing effect of example 1 is the best.

Typical cases are as follows:

1) in a boy of 25 years, acne is more visible on the face and the skin color is dark. After the product is used, the acne marks are reduced, and the skin color is greatly lightened, as shown in figure 1;

2) a girl is 18 years old, and has a remarkable acne at the chin and yellow skin color. The disappearance of the pimples and the whitening of the skin color can be obviously seen after 3 days of using the product, as shown in figure 2.

Effect test example 2 (comparison of antibacterial Properties)

The tested strains: propionibacterium acnes (ATCC 11827); staphylococcus aureus (ATCC 6538);

the test method comprises the following steps:

preparing a suspension of Propionibacterium acnes and Staphylococcus aureus.

Preparation of a bactericide-containing culture medium: diluting the bacteriostatic solution by using distilled water, and diluting according to a series of times. 2.5ml of each dilution of test solution was added to a test tube containing 2.5ml of double strength nutrient broth.

0.1ml of the bacterial suspension was inoculated into a test tube of nutrient broth containing the bacteriostatic agent as a sample for the test group and numbered.

Nutrient broth tubes without bacteriostatic were inoculated in the same manner as positive controls.

2 nutrient broth tubes were used as negative controls.

All samples were incubated in an incubator at 37 ℃ for 24 h.

The working concentration of the bacterial suspension for the test is 5 multiplied by 10⁵cfu/ml-5×10⁶cfu/ml。

When the positive control group is turbid and the negative control group is transparent, the bacteriostatic concentration corresponding to the highest dilution concentration of the aseptic growth of the test group is the MIC value of the tested bacteria of the sample.

TABLE 9 test results Table

As can be seen from table 9: the minimum inhibitory concentration of the sample on staphylococcus aureus (ATCC 6538) is 1: 32; the minimum inhibitory concentration of the sample against Propionibacterium acnes (ATCC 11827) was 1: 32.

Evaluation of acne treatment (synergistic test)

The acne-removing gel composition is prepared from the following raw materials in percentage by weight:

TABLE 10 gel composition formulation compositions of comparative examples 1-5 (% by weight)

Raw materials	Comparative example 1	Comparative example 2	Comparative example 3	Comparative example 4	Comparative example 5
						Water (W)	81.1％	81.9％	79.1％	87.9％	85.1％
U2020	0.2％	0.2％	0.2％	0.2％	0.2％
						1, 3-butanediol	4％	4％	4％	4％	4％
Glycerol	3％	3％	3％	3％	3％
						P-hydroxyacetophenone	0.5％	0.5％	0.5％	0.5％	0.5％
Antibacterial peptide	8％	8％	8％	0	0
						Tripeptide-8	2％	0	0	2％	2％
Radix Paeoniae extract	0	1.2％	0	1.2％	0
						Acne removing medicine	0	0	4％	0	4％
1, 2-hexanediol	1％	1％	1％	1％	1％
						Triethanolamine	0.2％	0.2％	0.2％	0.2％	0.2％

TABLE 11 gel composition formulation compositions of comparative examples 6-10 (% by weight)

Raw materials	Comparative example 6	Comparative example 7	Comparative example 8	Comparative example 9	Comparative example 10
						Water (W)	85.9％	79.9％	77.1％	77.9％	％
U2020	0.2％	0.2％	0.2％	0.2％	0.2％
						1, 3-butanediol	4％	4％	4％	4％	4％
Glycerol	3％	3％	3％	3％	3％
						P-hydroxyacetophenone	0.5％	0.5％	0.5％	0.5％	0.5％
Antibacterial peptide	0	8％	8％	8％	0
						Tripeptide-8	0	2％	2％	0	2％
Radix Paeoniae extract	1.2％	1.2％	0	1.2％	1.2％
						Acne removing medicine	4％	0	4％	4％	4％
1, 2-hexanediol	1％	1％	1％	1％	1％
						Triethanolamine	0.2％	0.2％	0.2％	0.2％	0.2％

The preparation method thereof is referred to the above comparative examples 1 to 5.

Subject: 110 qualified volunteers were collected, half of each boy and a girl.

The experimental method comprises the following steps: after cleansing the face every night, the gel composition was applied to the face, a questionnaire was filled out, and the feeling of use was recorded.

Experiment time: one month.

The results of the experiment are shown in table 12 below:

TABLE 12 skin verification Effect of various examples

As can be seen from table 12:

1) example 1VS comparative example 1: the composition also has a good effect of inhibiting acnes, but the embodiment 1 also has the effects of whitening and enabling pores to be finer and smoother;

2) example 1VS comparative examples 1-10: the invention uses the combination of four raw materials, and the comprehensive effect after the use is better than the combination of two or three components.

In conclusion, the natural active face-refreshing acne-removing gel disclosed by the invention can obviously see the situation of acne removal in a short period, and the antibacterial peptide contained in the gel has good antibacterial performance. The peony root extract in the formula can also moisturize and repair skin barriers.

For consumers, the acne is expected to disappear, and the pores and the skin are also expected to be finer and tender.

The acne-removing gel can simultaneously meet the three requirements, and is a product with a very promising prospect.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.

Claims

1. The natural active face-beautifying acne-removing gel composition is characterized by being prepared from the following raw materials in percentage by weight:

u20200.1-1%, 1, 3-butanediol 2-6%, glycerol 1-5%, p-hydroxyacetophenone 0.1-1%, antimicrobial peptide 5-11%, tripeptide-81-3%, radix paeoniae extract 0.5-2%, 1, 2-hexanediol 0.5-3%, acne removing agent 2-6%, triethanolamine 0.1-1%, and the balance of deionized water;

the antibacterial peptide consists of water, 1,2 hexanediol, 1,2 pentanediol and hexapeptide-5;

the acne removing agent consists of quaternary ammonium salt-75 and butanediol.

2. The natural active face-beautifying and anti-acne gel composition of claim 1, wherein the anti-acne gel composition is prepared from the following raw materials in percentage by weight:

u20200.12%, 1, 3-butanediol 4%, glycerol 3%, p-hydroxyacetophenone 0.5%, antibacterial peptide 8%, tripeptide-82%, radix paeoniae alba extract 2%, 1, 2-hexanediol 1%, acne removing agent 3%, triethanolamine 0.2%, and the balance of deionized water.

3. The natural active peel-off acne-removing gel composition according to claim 1, wherein the acne-removing gel composition is prepared from the following raw materials in percentage by weight:

u20200.2%, 1, 3-butanediol 4%, glycerol 3%, p-hydroxyacetophenone 0.5%, 1, 2-hexanediol 1%, triethanolamine 0.2%, antimicrobial peptide 8%, tripeptide-82%, radix paeoniae alba extract 1.2%, acne removing agent 4%, and the balance of deionized water.

4. The natural active peel and acne removing gel composition of claim 2 or 3, wherein: the antibacterial peptide is prepared by compounding 98.7% of water, 0.5% of 1,2 hexanediol, 0.5% of 1,2 pentanediol and 0.3% of hexapeptide-5; the acne removing agent is prepared by compounding 0.1 percent of quaternary ammonium salt-75 percent and 99.9 percent of butanediol.

5. The natural active peel acne removal gel composition of claim 1, wherein: the preparation process of the peony root extract comprises the following steps:

2) soaking the radix Paeoniae raw material in ethanol solution, simultaneously performing ultrasonic extraction, centrifuging after completion, and taking supernatant as extractive solution; removing ethanol in the extracting solution by adopting a reduced pressure distillation mode to obtain a peony root extract;

3) passing the radix Paeoniae extract through macroporous adsorbent resin, and washing the macroporous adsorbent resin with eluent to obtain eluent; removing the eluent in the eluent by adopting a reduced pressure distillation mode to obtain a concentrated solution, and carrying out vacuum freeze drying on the concentrated solution to obtain the paeonia lactiflora pall extract.

6. The natural active peel acne removal gel composition of claim 5, wherein: in the extraction process of the peony root extract, the ultrasonic extraction time is 10 min-30 min; the volume concentration of the ethanol solution is 50-90%; the ratio of the volume of the ethanol solution to the mass of the peony root raw material is 5 mL/g-15 mL/g.

7. The preparation method of the natural active peel acne-removing gel composition of any one of claims 1 to 6, which is characterized by comprising the following steps:

3) dissolving triethanolamine in water, adding into a beaker, and stirring;

8. The method for preparing natural active face-refreshing acne-removing gel composition according to claim 7, is characterized in that: in the step 1), the temperature rise is 85 ℃, and the heat preservation time is 10 minutes.

9. The method for preparing natural active face-refreshing acne-removing gel composition according to claim 7, is characterized in that: in the step 2), the cooling temperature is 45 ℃; in the step 4), the cooling temperature is 38 ℃.