CN101732205A - Skin-care composition and preparation for relieving skin allergies and resisting inflammatory and irritation and preparation method thereof - Google Patents
Skin-care composition and preparation for relieving skin allergies and resisting inflammatory and irritation and preparation method thereof Download PDFInfo
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- CN101732205A CN101732205A CN200910244365A CN200910244365A CN101732205A CN 101732205 A CN101732205 A CN 101732205A CN 200910244365 A CN200910244365 A CN 200910244365A CN 200910244365 A CN200910244365 A CN 200910244365A CN 101732205 A CN101732205 A CN 101732205A
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Abstract
The invention discloses a skin-care composition for relieving skin allergies and resisting inflammatory and irritation, which comprises one or more of grape seed extract, cactus extract and dipotassium glycyrrhizinate. Raw materials of the skin-care composition are relieving natural components, are natural and mild and small in skin irritation, resist inflammatory, relieve allergies and repair skin through various ways, and improve skin immunity. The skin-care composition has the advantages of simple acquisition of the raw materials, convenient and quick preparation method, lower cost than other allergy resisting methods, easy acception by consumers and good application and market prospects.
Description
Technical field
The present invention relates to a kind of skin care item, specifically a kind of allergic skin of releiving, antiinflammatory, counteirritantia composite skin care product and preparation method thereof.
Background technology
Skin allergy is a very common physiological reaction.Most of people can have the experience of skin allergy.Along with the continuous development of modern society, the continuous increase that cosmetics, chemicals use, original sensitizers such as increasing environmental pollution and pollen, some food all make the probability of skin allergy constantly increase.Because a variety of causes makes the crowd of sensitive skin also constantly increase.Sensitivity skin skin incidence study to various countries shows that sensitive skin has higher incidence.
It is reported, Europe, the women of the U.S. and the about 40%-50% of Japan is the sensitivity skin.Britain finds that in the research to 2058 study subjects (comprising masculinity and femininity) there are the problem of skin sensitivity in about 51.4% women and 38.2% male.France carries out telephone poll to crowd more than 15 years old, and 52% surveyee is a sensitive skin, and wherein great majority are the women, and masculinity and femininity sensitivity person's ratio is respectively 44% and 59%.And in China, one of L'Oreal studies show that, about 36.1% women is a sensitive skin.
The approach of control skin allergy has a lot, generalizedly can be divided into following several big class.
Away from anaphylactogen: allergy be have allergic constitution the people after contact allergy is former, reaction of the dysimmunity of initiation and immunoregulatory disorder.Prevent that skin allergy from the most important thing is to avoid to contact with causing material hypersensitive as far as possible.Anaphylactogen is the essential condition that anaphylaxis takes place, and has left anaphylactogen, just can avoid generation hypersensitive, but therefore different human body is not all effect can be arranged to all irritated patients to the original very big-difference of allergy.
Use anti-histamine substance: antihistamine is the biological effect of antagonism histamine to human body.Promptly use anti-histamine substance.Anti-histamine substance can suppress mastocyte and discharge allergins such as histamine, suppresses the splitting action of oxyphil cell and mastocyte, thereby stops the gathering of this class cell at inflammation part, and the amelioration of inflammation reaction reaches therapeutic purposes.Yet the anti-histamine substance major part is a medicinal ingredient, is not allow in cosmetics, and medicine is anti-.
Remove free radical: current research shows, the formation of allergic constitution, and outbreak hypersensitive are all relevant with the too much accumulation of the intravital free radical of machine.And the environmental pollution that is on the rise, chemicals abuse and radiation problem all can directly cause free radical accumulation in vivo.By removing free radical, regulate immunity of organism, can reach and progressively improve allergic constitution, still, required time is longer, and short-term response is not obvious.
Antipruritic, irritation: skin pruritus is the common complication of sensitivity skin, causes that the reason of skin pruritus is a lot, and main cause is an xerosis cutis.The treatment skin pruritus is on the one hand by medicine, but the more important thing is that the patient will notice that restraint is scratched, and scratches can cause grabbing and more itching to the taking good care of of skin, and the vicious cycle of itching and more grabbing further increases the weight of symptom.Chemical substance is damaging cells film at first usually, makes the cell tolerance reduction, impels the various inflammatory factors of emiocytosis, and then causes inflammation.Therefore by improving cell tolerance, the protection cell membrane is one of effective way of control skin allergy.
Strengthen skin barrier function: the unusual water storage moisture-keeping functions that has not only reduced skin of skin lipid barrier, the growth that also directly affects keratinocyte is regulated with differentiation, unhealthful cuticular formation, and repair or the barrier function that strengthens skin is the effective means that reduces the skin sensitivity degree latter core of skin physical barrier structure just.
Hyaluronidase is a kind ofly can decompose one of lysosomal enzyme of mucopolysaccharide, and relevant with the permeability and the inflammation of blood vessel, plays an important role in many vital movements.External scientist had once reported the activity that the various medicines that influence mastocyte release histamine can be regulated hyaluronidase.Hyaluronidase activity inhibition and mastocyte discharge between the histamine good dependency are arranged.Having scientist to propose hyaluronidase and participate in tissue inflammation's process, is the participant of type i allergic reaction.In recent years, Japanese Korea S etc. countries with the inhibition test of hyaluronidase activity as one of basic skills, a large amount of screening antiallergic action chemical compounds from natural product.
Summary of the invention
Main purpose of the present invention provides a kind of allergic skin that is used to releive, antiinflammatory, counteirritantia cosmetic composition; this combination is primary raw material with the natural extract; utilize various component reasonable combination, cooperate sharedly, reach the allergic skin of releiving, antiinflammatory, counteirritantia effect, and can effectively protect skin, improve skin immune function controlling by number of ways.
Another object of the present invention is to utilize the skin care item preparation of above-mentioned composite skin care product preparation.
A further object of the present invention provides the preparation method of above-mentioned skin care item preparation.
To achieve these goals, the present invention selects for use Semen Vitis viniferae extract, Radix et Caulis Opuntiae Dillenii extract, glycyrrhizic acid dipotassium and allantoin as active component, in skin care item, add wherein one or more can realize releiving allergic skin, antiinflammatory, counteirritantia effects, add each component simultaneously and can produce synergism, effect is better.
In the composite skin care product of the present invention, Semen Vitis viniferae extract is an efficient antioxidants, in the body and in vitro tests shows, the antioxidant effect of Semen Vitis viniferae extract, be vitamin C and vitamin E 30-50 doubly.Superpower antioxidation efficient has the powerful effect of removing free radical, improving body immunity.Semen Vitis viniferae extract is natural sunlight overcover, can encroach on skin by shielding of ultraviolet, can also repair injured collagen protein and elastic fiber.Semen Vitis viniferae extract has astriction, tightens up skin, prevents occurring ahead of time of wrinkle of skin, and life-time service can make skin smooth, and high resilience has the effect of looks improving and the skin nourishing.
The glycyrrhizic acid dipotassium effective content of anti inflammation is that monoammonium glycyrrhizinate, Radix Glycyrrhizae are inferior.The administration of monoammonium glycyrrhizinate salt pair guinea pig intraperitoneal injection can obviously suppress the generation of guinea pig bronchial asthma, shows as to draw the time of breathing heavily and obviously prolong.Glycyrrhizin can significantly suppress the guinea pig skin reaction that Ovum Gallus domesticus album causes, and alleviates the anaphylactic shock symptom.The liquorice beverage decocting liquid can suppress the models of passive skin irritability of rats reaction, reduces mice serum IgE antibody horizontal.Compositions such as isoliquiritigenin can suppress the activity of hyaluronidase, and to by the inductive mastocyte histamine release of immunostimulation inhibitory action being arranged.
The Radix et Caulis Opuntiae Dillenii extract has the excellent cell function of releiving; common chemical irritant, UV-induced cell injury in the cosmetics had significant protective effect; can obviously slow down the phenomenon of common general red, the pruritus of responsive skin, the ultraviolet sunburn is also had certain repair.
Allantoin is a synthetic.Have calm antiinflammatory, the healthy ability that generates of activated cell and the effect of healing of wound.
Experiment shows that the compound of Semen Vitis viniferae extract, Radix Glycyrrhizae extract and Opuntia Streptacantha extract reaches more than 95% the suppression ratio of hyaluronidase.
Concrete technical scheme of the present invention is:
A kind of allergic skin of releiving, antiinflammatory, counteirritantia composite skin care product wherein, contain in Semen Vitis viniferae extract, Radix et Caulis Opuntiae Dillenii extract and the glycyrrhizic acid dipotassium one or more in the described compositions.
Above-mentioned composite skin care product, wherein, the use amount of described Semen Vitis viniferae extract, Radix et Caulis Opuntiae Dillenii extract and glycyrrhizic acid dipotassium is:
Semen Vitis viniferae extract 0.1～1%
The Radix et Caulis Opuntiae Dillenii extract 1～10%
Glycyrrhizic acid dipotassium 0.1～2%
Surplus is the common carrier or the substrate of skin care item dosage form.
Also comprise allantoin in the described compositions, the addition of described allantoin in compositions is 0.05～3%.
The contain 95% above procyanidin composition of described Semen Vitis viniferae extract for from Semen Vitis viniferae, extracting.
Described Radix et Caulis Opuntiae Dillenii extract extracts according to following steps from the Radix et Caulis Opuntiae Dillenii lyophilized powder:
(1) with cellulose treatment Radix et Caulis Opuntiae Dillenii lyophilized powder,, obtains cell pyrolysis liquid with the degradation of cell wall;
(2) with above-mentioned steps 1) the cell pyrolysis liquid enzyme denaturing, the solution left standstill behind the enzyme denaturing is got supernatant;
The pH value to 4.2 of supernatant (3) adjusting above-mentioned steps 2) to wherein adding activated carbon, stirs again, filters, and collects filtrate, obtains cactus extraction;
(4) with above-mentioned steps 3) cactus extraction carry out ion-exchange chromatography, with desalination and decolouring, collect effluent
(5) with above-mentioned steps 4) effluent concentrate, obtain the Radix et Caulis Opuntiae Dillenii extract.
Described Radix et Caulis Opuntiae Dillenii extract's soluble solid content is more than 35%, and active component content is greater than 16%.
A kind of allergic skin of releiving, antiinflammatory, counteirritantia skin care item, described skin care item are to be made by above-mentioned composite skin care product interpolation skin care item substrate commonly used or carrier.Be generally exterior-applied formulation, as antiallergic essence, facial film or cream etc.Only need utilize compositions of the present invention, add conventional substrate or carrier, utilize the preparation method of conventional skin care item to get final product as active component.
The preparation method of a kind of above-mentioned allergic skin of releiving, antiinflammatory, counteirritantia skin care item is provided, it is characterized in that described preparation method comprises the steps:
(1) with glucosan, allantoin, Semen Vitis viniferae extract and Radix et Caulis Opuntiae Dillenii extract and substrate: trehalose, phyto-hyaluronic acid, pantothenylol, 1,3 butylene glycol and glycerol join in the deionized water simultaneously;
(2) be heated to 80 ℃ after stirring and dissolving, add hyaluronate sodium when cooling to 40 ℃, add AVC and stir;
(3) regulate pH value between 5.0～6.5, add antiseptic.
Above-mentioned preparation method preparation cost invention antiallergic skin care item essence.
Advantage of the present invention and beneficial effect: raw material selection of the present invention is the natural component of releiving, and the natural gentleness of raw material is little to skin irritation, by number of ways antiinflammatory, Shu Min, restoration and protection skin, improves skin immunization power.Raw material of the present invention obtains simply, preparation method is convenient, and cost is cheap than other antiallergic methods, is easy to be accepted by consumers in general, has good application and market prospect.
Foregoing invention content part of the present invention has been done detailed description to technical scheme of the present invention, and those skilled in the art can repeat the present invention and obtain technique effect of the present invention according to foregoing.Below by the specific embodiment the technology of the present invention content being further explained, understanding content of the present invention so that those skilled in the art are clearer, is not limitation of the present invention, and any being equal to replaces or known change all belongs to protection domain of the present invention.
The specific embodiment
The raw material sources of following embodiment:
Semen Vitis viniferae extract: Sciphar company
The Radix et Caulis Opuntiae Dillenii extract: the exploitation of plant resources research and development key lab of Beijing Technology and Business University, what use in this specific embodiment is Opuntia Streptacantha extract, other kinds the Radix et Caulis Opuntiae Dillenii extract also can.
Glycyrrhizic acid dipotassium: Beijing Berry Lai Si company
Allantoin: ISP company
The antiallergic essence of embodiment 1 present composition preparation
1, the component and the percentage composition thereof of the above-mentioned antiallergic essence product of composition are:
Glucosan 2.00
Trehalose 1.00
Phyto-hyaluronic acid 5.00
Pantothenylol 0.22
1,3 butylene glycol 6.00
Glycerol 2.00
Allantoin 2.5
Radix Glycyrrhizae extract 0.1
Semen Vitis viniferae extract 0.25
Opuntia Streptacantha extracts 10
Thing
1% hyaluronate sodium 6.00
AVC 1.20
Antiseptic is an amount of
The deionized water surplus
2, the preparation method of above-mentioned antiallergic essence is:
Glucosan, trehalose, phyto-hyaluronic acid, pantothenylol, 1,3 butylene glycol, glycerol, allantoin, Semen Vitis viniferae extract, Radix et Caulis Opuntiae Dillenii extract joined slowly be heated to 80 ℃ in the deionized water, fully dissolving is stirred in the back.Add 1% hyaluronate sodium when slowly cooling to 40 ℃, add AVC and stir.Regulate pH value between 5.0～6.5, add antiseptic.
Antiallergic essence of the present invention is that natural component is made, and the natural gentleness of raw material is little to skin irritation, by number of ways antiinflammatory, Shu Min, restoration and protection skin, improves skin immunization power.
The antiallergic facial film of embodiment 2 present compositions preparation
1, the component and the percentage composition thereof of the above-mentioned antiallergic essence product of composition are:
Glucosan 2.00
Trehalose 1.00
Phyto-hyaluronic acid 2.00
Pantothenylol 0.22
1,3 butylene glycol 6.00
Glycerol 2.00
Allantoin 0.15
Radix Glycyrrhizae extract 2.00
Hyaluronate sodium 1% 6.00
Opuntia Streptacantha extract 5.00
U20 0.70
Semen Vitis viniferae extract 1.00
HANSHENGJIAO 0.10
KOH 1.40
The deionized water surplus
Antiseptic 0.4
2, the preparation method of above-mentioned antiallergic essence is:
(1) U20 is added part deionized water swelling;
(2) after HANSHENGJIAO adds glycerol, 1,3 butylene glycol dissolving, add water again and stir;
(3) glucosan, trehalose, phyto-hyaluronic acid, pantothenylol, allantoin, Opuntia Streptacantha extract, Radix Glycyrrhizae extract, HANSHENGJIAO solute are joined among the U20, slowly the heated and stirred dissolving evenly;
(4) add the KOH neutralization, stir.
(5) add antiseptic.
Embodiment 3 clinic trial are observed:
Adopt example 1 to go clinical observation 90 examples, the clinical skin sensitivity that mainly shows as of skin before observing, pruritus discomfort, the long-term outbreak that has.
1. method:
Behind every day clean of the cleansing milk, on skin and easily send out a position to be coated with the antiallergic preparation an amount of, each is once sooner or later.3 days, 7 days, 1 month each statistics once.
2. standard:
(1) cures: clinical symptom disappearance, the reaction of no skin sensitivity;
(2) effective: clinical symptom relief, skin sensitivity reactive moieties disappear or disappear, and reduce or reduce;
(3) invalid: the commentaries on classics of not getting better of clinical symptoms, skin sensitivity.
3. result:
(1) instant effect, effective percentage can reach 91.26% in 3 days, 7 days, and certain cure rate, 1 month cure rate are arranged is 76.01%.
(2) all remarkable to the general responsive therapeutic effect of skin.
(3) there is not an example reaction phenomenons such as allergy, skin discomfort to occur.
Claims (9)
1. the allergic skin of releiving, antiinflammatory, irritation composite skin care product is characterized in that, contain in Semen Vitis viniferae extract, Radix et Caulis Opuntiae Dillenii extract and the glycyrrhizic acid dipotassium one or more in the described compositions.
2. composite skin care product according to claim 1 is characterized in that, contains in Semen Vitis viniferae extract, Radix et Caulis Opuntiae Dillenii extract and the glycyrrhizic acid dipotassium one or more in the described compositions; The consumption of described Semen Vitis viniferae extract, Radix et Caulis Opuntiae Dillenii extract and glycyrrhizic acid dipotassium is respectively:
Semen Vitis viniferae extract 0.1～1wt%
Radix et Caulis Opuntiae Dillenii extract 1～10wt%
Glycyrrhizic acid dipotassium 0.1～2wt%
Surplus is the common carrier or the substrate of skin care item dosage form.
3. according to claim 1 or 2 described composite skin care products, it is characterized in that, also comprise allantoin in the described compositions.
4. according to the described composite skin care product of claim 3, it is characterized in that the allantoin addition in the described compositions is 0.5～5%.
5. according to claim 1,2 or 4 described composite skin care products, it is characterized in that the contain 1% above procyanidin composition of described Semen Vitis viniferae extract for from Semen Vitis viniferae, extracting.
6. according to the described composite skin care product of claim 3, it is characterized in that the material that contain 1% above procyanidin composition of described Semen Vitis viniferae extract for from Semen Vitis viniferae, extracting.
7. according to claim 1,2,4 or 6 described composite skin care products, it is characterized in that described Radix et Caulis Opuntiae Dillenii extract's soluble solid content is more than 35%, active component content is greater than 16%.
8. the allergic skin of releiving, antiinflammatory, irritation skin care item is characterized in that, described skin care item are to add skin care item substrate commonly used or carrier is made by claim 1 or 2 described composite skin care products.
9. the preparation method of the allergic skin of releiving, antiinflammatory, counteirritantia skin care item is characterized in that described preparation method comprises the steps:
(1) join one or more and substrate among glucosan, allantoin, Semen Vitis viniferae extract and the Radix et Caulis Opuntiae Dillenii extract in the deionized water simultaneously; Described substrate is: trehalose, phyto-hyaluronic acid, pantothenylol, 1,3 butylene glycol and glycerol;
(2) be heated to 80 ℃ after stirring and dissolving, add hyaluronate sodium when cooling to 40 ℃, add AVC and stir;
(3) regulate pH value between 5.0～6.5, add antiseptic.
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