CN102018646B - Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof - Google Patents
Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof Download PDFInfo
- Publication number
- CN102018646B CN102018646B CN 201010561928 CN201010561928A CN102018646B CN 102018646 B CN102018646 B CN 102018646B CN 201010561928 CN201010561928 CN 201010561928 CN 201010561928 A CN201010561928 A CN 201010561928A CN 102018646 B CN102018646 B CN 102018646B
- Authority
- CN
- China
- Prior art keywords
- ethanol
- parts
- acne
- chinese medicine
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a skin-care composition with acne-removing effect. The composition is prepared from the following raw materials in percentage by mass: 2 to 10 percent of Chinese medicinal extract, 2 to 8 percent of stimulus inhibiting factor; 0.1 to 0.7 percent of aloe powder, 1 to 5 percent of plant hyaluronic acid and the balance of substrate. All the raw materials are selected natural emollient components, have low stimulation to skin and have effect of treating and removing acnes in multiple ways. Compared with the same products in market, the skin-care composition is safer and more effective and has no dependence (the composition does not contain antibiotics or chemicals); the raw materials are easily obtained; different formulations can serve as carriers; the preparation method is convenient and quick; and the composition is easily accepted by most of consumers and has very good application prospect and market prospect.
Description
Technical field
The present invention relates to a kind of skin care compositions, a kind of effectively anti-acne specifically, and have the skin care compositions of acne removing seal effect concurrently, and by external preparation of said composition preparation and preparation method thereof.
Background technology
Comedo is a kind of pilosebaceous chronic inflammatory disease, is common in the youth of both sexes of adolescence, mainly occurs in face, shirtfront and omoplate position, forms pimple, and the traditional Chinese medical science claims " acne ", and the doctor trained in Western medicine name of disease is " acne ".The adolescence androgen increases, and smegma increases, and makes hair follicle, the different hyperkeratosis of sebaceous gland simultaneously, and the flat dead cell that horny layer comes off falls the hair follicle infundibulum, is combined with sebum, produces mixture.If these mixture can not freely be discharged skin surface, in hair follicle, form the fat bolt and deposit.When these dyskeratosis cell aggregationes, when expanding, lower hopper just forms ripe acne.The bacterial decomposition that sebum is existed in the hair follicle produces fatty acid, and latter's hair follicle stimulating causes inflammation, and causes the follicular wall damage to be broken, and the hair follicle content enters corium, thereby, cause the hair follicle inflammatory reaction of varying degree on every side.The genesis mechanism of comedo, relevant with following three big factors:
(1) to the agnogenio property aggravation of androgen steroid (as testosterone, dehydroepiandros-sterone, hydroxyprogesterone) reaction, causes sebum to produce and increase.
(2) propionibacterium acnes hypertrophy.This bacterium is formed for the hair follicle normal flora, and it is its effect machine matter with sebum, and makes it partly to be converted into free fatty.But propionibacterium acnes is the activating complement path also, produces two kinds of chemotactic factors at least, impels inflammation to take place.
(3) the capsular epithelium cell quantity increases, and tackness is arranged, and it is excessive to form the hair follicle tetention keratosis.Latter's occurrence cause is undistinct yet.Propionibacterium acnes produces free fatty, may be the principal element that comedo forms.
The problem of the product for resolving poxes on the market: 1, easily cause skin allergy, big to skin irritation; 2, add chemical antibacterial and destroy the skin normal flora; 3, add hormones such as some banned substances such as chloromycetin; 4, add heavy metal substance.
Summary of the invention
The purpose of this invention is to provide a kind of is the cosmetic composition that primary raw material has acne-removing with the Chinese medicine activity extract.
Another object of the present invention is to propose a kind of skin care formulation that utilizes the above-mentioned composition preparation.
A further object of the present invention is to propose the preparation method of above-mentioned skin care formulation.
Invention thinking of the present invention is for achieving the above object:
The present invention is important component with the Chinese medicine compound Chinese medicine extract, and add stimulation inhibitory factor, Aloe powder, phyto-hyaluronic acid, allantoin, water solublity Jojoba oil and pantothenylol as active component, produce synergism between each component, also have acne removing seal effect when realizing acne-removing concurrently, have no side effect to skin is non-stimulated.
The present invention selects Radix Salviae Miltiorrhizae, Flos Lonicerae, Flos Caryophylli, Cortex Magnoliae Officinalis and Radix Et Rhizoma Rhei five tastes drug regimen for use, thereby these drug regimens can effectively be played acne-removing.The brief introduction of five tastes medicine medical material effect is as follows:
Radix Salviae Miltiorrhizae: the nature and flavor hardship is slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Cure mainly: menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Flos Lonicerae: sweet in the mouth; Cold.Return lung; The stomach warp.Effect cures mainly: heat-clearing and toxic substances removing.The epidemic febrile disease heating; Toxic-heat and blood stasis; The carbuncle furuncle; Sore throat and multiple infectious disease.
Flos Caryophylli: the nature and flavor suffering, temperature is returned bright, the shaoyin channel of lunar, the sufficient sun of hands.Effect: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.
Cortex Magnoliae Officinalis: nature and flavor: hardship; Hot; Warm in nature.Return spleen channel; The stomach warp; Large intestine channel.Function: circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, the gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest is breathed with cough.
Radix Et Rhizoma Rhei: nature and flavor: hardship, cold.Return the stomach warp; Large intestine channel; Liver Channel; Spleen channel.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation.Cure mainly: the excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; The edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald.
The present inventor carries out compatibility with above-mentioned five tastes medicine and finds that its external acne-removing inflammation-diminishing effect is remarkable, can effectively prevent and treats dissimilar acnes.Wherein Radix Salviae Miltiorrhizae can play the effect of blood circulation promoting and blood stasis dispelling, removing heat from blood, and the Chinese medicine main component TANSHINONES that contains is goed deep into the hair follicle depths, eliminates skin oil and fat and dirt, kills the relevant flora with other acnes of corynebacterium acnes.The Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating; Flos Caryophylli helps the effect of Flos Lonicerae strong osmotic bactericidal antiphlogistic, the control local infection.Cortex Magnoliae Officinalis, regulating the flow of vital energy has the effect of dredging pore.Can dredge the pilosebaceous duct of obstruction, guarantee the eupnea of skin.Radix Et Rhizoma Rhei, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, blood circulation promoting and blood stasis dispelling.
Among the present invention, also use Aloe powder, Aloe is to the protective effect of cell tissue and the tax regeneration alive of damaged cell, and pathogenic bacteria has resistivity in the polysaccharide confrontation body in the Aloe, and gives the human body premunition, reaches the purpose of fundamentally improving body constitution.Tinctura aloes is the very strong material of antibiotic property, has the effect of direct sterilization, compares even betterly with antibiotic, and it can not produce the cell drug resistance, and can also kill the drug-resistant bacteria because using antibiotic to produce effectively.
The pantothenylol nursing role shows as the wetting agent of deep infiltration, stimulates epithelial growth, promotes wound healing, plays antiinflammation.
Stimulation inhibitory factor has the excellent cell function of releiving; common chemical irritant, UV-induced cell injury in the skin care item had significant protective effect; can obviously slow down the phenomenon of common general red, the pruritus of responsive skin, the ultraviolet sunburn is also had certain repair.
The water solublity Jojoba oil: the characteristic that it can cut grease, splendid to fuel-displaced, acne, comedo skin effects.
Allantoin: can form double salt in conjunction with multiple material, have lucifuge, sterilization and anticorrosion, pain relieving, antioxidation, can make skin keep moisture content, moist and soft.
Phyto-hyaluronic acid: its main active is α-mannan, is rich in great amount of hydroxy group, carboxyl isopolarity group in the molecule, can be in conjunction with a large amount of moisture.Intermolecular being interweaved reticulates, and has extremely strong lock water performance of keeping humidity, performance efficient moisture-retention skin-protecting function.α-the mannan of macromolecule has fabulous film property, gives the Rinsing of skin water sliding sensation.
Concrete technical scheme of the present invention is as follows:
A kind of skin care compositions with acne-removing, described compositions is made by the raw material of following mass percent:
Chinese medicine extract 2～10wt%
Stimulation inhibitory factor 2～8wt%
Aloe powder 0.1～0.7wt%
Phyto-hyaluronic acid 1～5wt%
Surplus is substrate.
Another kind has the skin care compositions of acne-removing, and described compositions is made by the raw material of following mass percent:
Chinese medicine extract 2～10wt%
Stimulation inhibitory factor 2～8wt%
Aloe powder 0.1～0.7wt%
Phyto-hyaluronic acid 1～5wt%
Allantoin 0.1～0.5wt%
Water solublity Jojoba oil 0.2～1wt%
Pantothenylol 0.1～1wt%
Surplus is substrate.
The optimal components ratio of each raw material of above-mentioned composition is as follows:
Chinese medicine extract 4～8wt%
Stimulation inhibitory factor 4～8wt%
Aloe powder 0.3～0.7wt%
Phyto-hyaluronic acid 1～3wt%
Allantoin 0.1～0.4wt%
Water solublity Jojoba oil 0.5～1wt%
Pantothenylol 0.2～0.8wt%
Surplus is substrate.
Described stimulation inhibitory factor is the Opuntia Streptacantha stem extract.
Described Chinese medicine extract is made by following weight parts proportion raw material medicine:
30～50 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Flos Loniceraes, 10～30 parts of Flos Caryophyllis, 5～15 parts of Cortex Magnoliae Officinalis, 5～15 parts of Radix Et Rhizoma Rhei.
Described Chinese medicine extract is made according to following method, and concrete steps are:
(1) takes by weighing each crude drug according to said components and consumption;
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 70%～85% the ethanol, soak time is more than 2 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 70%～85% ethanol mixes stirring, and are heated to 55～70 ℃ of extractions 1～2 hour; The mass volume ratio of described crude drug and ethanol (g/ml) is 0.5～1: 10～20;
(4) filter, filtration residue adding percentage by volume is 70%～85% ethanol, is heated to 55～70 ℃ and carries out second extraction, and extraction time is 1～2 hour; The mass volume ratio of described filtration residue and ethanol (g/ml) is 0.5～1: 3～10;
(5) filter, the filtrate that step (3) and step (4) are obtained mixes and concentrates 16～18 times, and ethanol is steamed back collection concentrated solution;
(6) be that 1: 1～4 ratio adds propylene glycol to concentrated solution according to volume ratio, stirred 0.5～2 hour down at 30～50 ℃, cooled and filtered, sterilization namely obtains Chinese medicine extract.
The mass volume ratio (g/ml) of crude drug and ethanol described in the described step (3) is that the mass volume ratio (g/ml) of filtration residue described in 1: 15 and/or the step (4) and ethanol is 1: 5.
Filter in described step (4) and/or the step (5) is that 100～200 orders filter.
A kind of preparation has the method for the skin care compositions of acne-removing, and described method step is as follows:
(1) prepares each raw material according to said ratio;
(2) Chinese medicine extract, stimulation inhibitory factor, Aloe powder, phyto-hyaluronic acid, allantoin, water solublity Jojoba oil, pantothenylol and substrate are added to the water are heated to 50～80 ℃ and mix, wherein said substrate does not comprise thickening agent and antiseptic.
(3) behind the mix homogeneously, be cooled to 30～50 ℃ and add thickening agent and the packing of antiseptic mix homogeneously.
The dosage form that method for preparing goes out is facial treatment repair.
Described substrate can be used the special substrate of using of skin care field each dosage form commonly used, as long as guarantee other active component such as above-mentioned, all can realize purpose of the present invention, does not do concrete restriction at this.
Described water can use deionized water, distilled water or pure water etc.
The anti-acne preparation that the present invention makes, soft, the nonirritant abnormal flavour.Its usage and consumption are as follows:
Method: after clean of every day, on skin and the acne position be coated with anti-acne preparation of the present invention, each is once sooner or later.
Consumption: for nursing usefulness on ordinary days, smear preparation of the present invention in right amount and get final product according to individual demand.For easily sending out position and pox seal position, can repeatedly smear, be as the criterion with whole coverings.
Beneficial effect of the present invention:
Raw material selection of the present invention is the natural composition of releiving, and is little to skin irritation, realizes treatment acne, acne-removing by number of ways.Relative like product in the market, safer, effective, nothing relies on (antibiotic-free and chemicals composition); Raw material of the present invention obtains simply, can be with different dosage forms as carrier, and preparation method is convenient, is easy to be accepted by consumers in general, has good application prospects and market prospect.
Foregoing invention content part of the present invention has been done detailed description to technical scheme of the present invention, and those skilled in the art can repeat the present invention and obtain described technique effect according to foregoing.Below by the specific embodiment the technology of the present invention content is further explained, so that the clearer understanding of those skilled in the art is not limitation of the present invention, any being equal to, replace or known change all belongs to protection domain of the present invention.
Description of drawings
Fig. 1 be extract stock solution to P.acnes (P1), S.aureus (P2), S.epidermidis (P3), E.coli (P4), the fungistatic effect of the relevant pathogen of five kinds of acnes such as P.aeruginosa (P5);
Fig. 2 is that extract stock solution and 5% diluent are to the fungistatic effect of P.acnes and S.aureus.
The specific embodiment
The used medical material of present embodiment all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.Each raw material sources is as shown in table 1:
Table 1
Aloe powder, allantoin, water solublity Jojoba oil, pantothenylol all do not have very strict specification limits, and it all is the common substantially cosmetic material of market sale.Substrate is except functional component of the present invention, and basis in the cosmetics is for the needs that adapt to dosage form select for use other substrate also passable.Thickening agent is selected acryloyl group dimethyl taurine ammonium/VP copolymer for use.The embodiment of the invention adopts the LGP liquid preservative, and this antiseptic full name is LIQUID GERMALLPLUS, available from the international special product company limited of ISP.The antiseptic consumption is not done concrete restriction, as long as meet the national standard addition.
The preparation of embodiment 1 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 40g, Flos Lonicerae 20g, Flos Caryophylli 20g, Cortex Magnoliae Officinalis 10g, Radix Et Rhizoma Rhei 10g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 70% the ethanol, soak time is 2.5 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 70% ethanol mixes stirring, and are heated to 55 ℃ of extractions 1 hour; The mass volume ratio g/ml of described crude drug and ethanol is 1: 15; Be that the 70g crude drug adds 1050ml ethanol.
(4) 100 orders filter, and filtration residue adding percentage by volume is 70% ethanol, is heated to 55 ℃ and carries out second extraction, and extraction time is 1 hour; The mass volume ratio g/ml of described filtration residue and ethanol is 1: 5;
(5) 100 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 16 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator and steams back collection concentrated solution fully;
(6) be that 1: 2 ratio adds propylene glycol to concentrated solution according to volume ratio, stirred 1 hour down at 30 ℃, cooled and filtered, sterilization namely obtains Chinese medicine extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 40～46%, electrical conductivity 200～500 μ s/cm2, pH value 4～6, flavones content 0.2～0.5mg/ml.
The preparation of embodiment 2 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 30g, Flos Lonicerae 30g, Flos Caryophylli 10g, Cortex Magnoliae Officinalis 5g, Radix Et Rhizoma Rhei 15g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 85% the ethanol, soak time is 2 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 85% ethanol mixes stirring, and are heated to 60 ℃ of extractions 1.5 hours; The mass volume ratio g/ml of described crude drug and ethanol is 0.5: 10; Be that the 70g crude drug adds 1400ml ethanol.
(4) 200 orders filter, and filtration residue adding percentage by volume is 80% ethanol, is heated to 60 ℃ and carries out second extraction, and extraction time is 1.5 hours; The mass volume ratio g/ml of described filtration residue and ethanol is 0.5: 10;
(7) 200 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 18 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator and steams back collection concentrated solution fully;
(5) be that 1: 3 ratio adds propylene glycol to concentrated solution according to volume ratio, stirred 2 hours down at 40 ℃, cooled and filtered, sterilization namely obtains Chinese medicine extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 45～50%, electrical conductivity 200～500 μ s/cm2, pH value 4～6, flavones content 0.2～0.4mg/ml.
The preparation of embodiment 3 Chinese medicine extract of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 50g, Flos Lonicerae 10g, Flos Caryophylli 30g, Cortex Magnoliae Officinalis 15g, Radix Et Rhizoma Rhei 5g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 80% the ethanol, soak time is 4 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 80% ethanol mixes stirring, and are heated to 70 ℃ of extractions 2 hours; The mass volume ratio g/ml of described crude drug and ethanol is 1: 20; Be that the 90g crude drug adds 1800ml ethanol.
(4) 200 orders filter, and filtration residue adding percentage by volume is 80% ethanol, is heated to 70 ℃ and carries out second extraction, and extraction time is 2 hours; The mass volume ratio g/ml of described filtration residue and ethanol is 0.5: 3;
(5) 200 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 16 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator and steams back collection concentrated solution fully;
(6) be that 1: 4 ratio adds propylene glycol to concentrated solution according to volume ratio, stirred 2 hours down at 50 ℃, cooled and filtered, sterilization namely obtains Chinese medicine extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 40～44%, electrical conductivity 200～500 μ s/cm2, pH value 4～6, flavones content 0.3～0.5mg/ml.
The preparation of embodiment 4 sprays of the present invention
(1) with the Chinese medicine extract of embodiment 1 preparation vacuum 1.33Kpa (being 10mmHg), under 40～50 ℃ of environment, be condensed into relative density and be 1.2～1.3 extractum;
(2) 70% ethanol is slowly added in the above-mentioned extractum, leave standstill after 18 hours and get supernatant, filter rear filtrate and put the room temperature cooling, after the precipitate with ethanol cooling for the second time, add an amount of distilled water, move to the icebox cooling, after the filtration, it is standby to be prepared into clear paste liquid;
(3) an amount of laurocapram solution (transdermal enhancer) is added in the clear paste liquid, be stirred to and be uniformly dispersed, divide in the spray bottle of packing into.
The preparation of embodiment 5 essences of the present invention
(1) prepares each raw material according to following proportioning;
Embodiment 1 preparation Chinese medicine extract 5wt%
Stimulation inhibitory factor 4wt%
Aloe powder 0.3wt%
Phyto-hyaluronic acid 3wt%
EDTA-2Na?0.02wt％
Oat polypeptide (AT-1) 5wt%
Glycerol 3wt%
Ammonium acryloyldime-thyltaurate// VP copolymer (thickening agent) 1.2wt%
Antiseptic 0.1wt%
The deionized water surplus.
(2) composition except antiseptic and thickening agent is joined be heated to 50 ℃ in the deionized water and mix 100 rev/mins of stir speed (S.S.)s;
(3) behind the mix homogeneously, be cooled to 30 ℃ and add thickening agent and the packing of antiseptic mix homogeneously.
The preparation of embodiment 6 essences of the present invention
(1) prepares each raw material according to following proportioning;
Embodiment 2 preparation Chinese medicine extract 2wt%
Stimulation inhibitory factor 8wt%
Aloe powder 0.7wt%
Phyto-hyaluronic acid 1wt%
Allantoin 0.5wt%
Water solublity Jojoba oil 1wt%
Pantothenylol 1wt%
EDTA-2Na?0.05wt％
Oat polypeptide (AT-1) 3wt%
Glycerol 5wt%
Ammonium acryloyldime-thyltaurate// VP copolymer (thickening agent) 1.5wt%
Antiseptic 0.2wt%
The deionized water surplus.
(2) composition except antiseptic and thickening agent is joined be heated to 60 ℃ in the pure water and mix 300 rev/mins of stir speed (S.S.)s;
(3) behind the mix homogeneously, be cooled to 30 ℃ and add thickening agent and the packing of antiseptic mix homogeneously.
The preparation of embodiment 7 facial films of the present invention
(1) prepares each raw material according to following proportioning;
The Chinese medicine extract 10wt% of embodiment 3 preparations
Stimulation inhibitory factor 2wt%
Aloe powder 0.1wt%
Phyto-hyaluronic acid 5wt%
Allantoin 0.1wt%
Water solublity Jojoba oil 0.2wt%
Pantothenylol 0.1wt%
Substrate is:
HANSHENGJIAO 0.4%wt%
Butanediol 4wt%
EDTA-2Na0.02wt％
Beta glucan (AT-2) 3wt%
Glycerol 4wt%
Antiseptic 0.4wt%
The deionized water surplus.
(2) HANSHENGJIAO and butanediol mix dispersion back adding distil water dissolving mix homogeneously, add other components (except antiseptic) again, and stirring and dissolving after being heated to 80 ℃, are cooled to 40 ℃, add antiseptic and mix, and soak non-woven fabrics also with the encapsulation of facial film bag.
Using method: after clean, flush coat 20min, once a day.
Clinical trial certificate uses among the 30 routine crowds of this product, and 29 examples use the back acne to be clearly better, and have the oily effect of control simultaneously, and effective percentage reaches more than 97%.This facial film has the oily acne-removing of control simultaneously, and the result shows also have certain seal effect of going.
Above-mentioned dosage form be prepared as general knowledge known in this field, the present invention only illustrates at this, the adjuvant of all dosage forms is selected and consumption is not limited thereto, those skilled in the art can do suitably adjustment to it.The present invention is suitable for multiple exterior-applied formulation, differs at this and one enumerates.
The experiment of Chinese medicine extract effect
Suppress the growth (to the inhibition of the relevant pathogen of acne) of the relevant cause of disease flora of acne in the hair follicle sebum
Adopt the filter paper method, observing samples is to the inhibition zone size of pathogen on flat board.Sample liquid and 20 times of diluents are adopted in experiment respectively, contrast the liquid (propylene glycol) into sample dissolution.And be positioned over dull and stereotyped central.Each handles 3 repetitions.Sample liquid is the Chinese medicine extract of embodiment 1 preparation.
This experimental result: Fig. 1 be extract stock solution to P.acnes (P1), S.aureus (P2), S.epidermidis (P3), E.coli (P4), the fungistatic effect figure of the relevant pathogen of five kinds of acnes of P.aeruginosa (P5); The result of Fig. 1 shows that this extract stock solution all has the obvious suppression effect to five kinds of relevant pathogen that are separated to from patient's acne.Fig. 2 is extract stock solution (left figure) and the fungistatic effect figure of 5% diluent (right figure) to P.acnes and S.aureus.The result of Fig. 2 shows that this extract of variable concentrations all has the ability of the relevant pathogen of obvious suppression acne.
Clinical experiment of the present invention and result
Adopt example 6 to carry out clinic trial and observe 100 examples, pimple and acne appear in the clinical face, breast, back of mainly showing as, majority darkly, hoary hair's acne sample, color is red, pimple or cyst appear in the top, conscious slight pruritus or pain are difficult repeatedly.
Usage: after clean of every day, on acne and easily send out a position to smear the embodiment of the invention 6 preparations (anti-acne essence) an amount of, each is once sooner or later.3 days, 7 days, 1 month, 3 months each statistics once.
Evaluation criterion: (1) cures: clinical symptom disappearance, erythra acne disappear; (2) effective: clinical symptom relief, erythra acne partly disappear or disappear, and reduce or reduce; (3) invalid: the commentaries on classics of not getting better of clinical symptoms, erythra acne.
Result on trial: (1) instant effect, effective percentage can reach more than 95% in 3 days, 7 days, and certain cure rate, 3 months cure rate are arranged is more than 80%.(2) the acne treatment effect to homeliness type is all remarkable.(3) there is not an example reflection phenomenons such as allergy, skin discomfort to occur.
Claims (8)
1. the skin care compositions with acne-removing is characterized in that, described compositions is made by the raw material of following mass percent:
Chinese medicine extract 2～10wt%
Stimulation inhibitory factor 2～8wt%
Aloe powder 0.1～0.7wt%
Phyto-hyaluronic acid 1～5wt%
Surplus is substrate;
Wherein, this Chinese medicine extract is made by following weight parts proportion raw material medicine:
30～50 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Flos Loniceraes, 10～30 parts of Flos Caryophyllis, 5～15 parts of Cortex Magnoliae Officinalis, 5～15 parts of Radix Et Rhizoma Rhei;
This stimulation inhibitory factor is the Opuntia Streptacantha stem extract.
2. the skin care compositions with acne-removing is characterized in that, described compositions is made by the raw material of following mass percent:
Chinese medicine extract 2～10wt%
Stimulation inhibitory factor 2～8wt%
Aloe powder 0.1～0.7wt%
Phyto-hyaluronic acid 1～5wt%
Allantoin 0.1～0.5wt%
Water solublity Jojoba oil 0.2～1wt%
Pantothenylol 0.1～1wt%
Surplus is substrate;
Wherein, this Chinese medicine extract is made by following weight parts proportion raw material medicine:
30～50 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Flos Loniceraes, 10～30 parts of Flos Caryophyllis, 5～15 parts of Cortex Magnoliae Officinalis, 5～15 parts of Radix Et Rhizoma Rhei;
This stimulation inhibitory factor is the Opuntia Streptacantha stem extract.
3. skin care compositions according to claim 2 is characterized in that, described compositions is made by the raw material of following mass percent:
Chinese medicine extract 4～8wt%
Stimulation inhibitory factor 4～8wt%
Aloe powder 0.3～0.7wt%
Phyto-hyaluronic acid 1～3wt%
Allantoin 0.1～0.4wt%
Water solublity Jojoba oil 0.5～1wt%
Pantothenylol 0.2～0.8wt%
Surplus is substrate.
4. skin care compositions according to claim 3 is characterized in that, described Chinese medicine extract is made according to following method, and concrete steps are:
(1) takes by weighing each crude drug according to the described component of claim 1 and consumption;
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 70%～85% the ethanol, soak time is more than 2 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 70%～85% ethanol mixes stirring, and are heated to 55～70 ℃ of extractions 1～2 hour; The mass volume ratio g/ml of described crude drug and ethanol is 0.5～1:10～20;
(4) filter, filtration residue adding percentage by volume is 70%～85% ethanol, is heated to 55～70 ℃ and carries out second extraction, and extraction time is 1～2 hour; The mass volume ratio g/ml of described filtration residue and ethanol is 0.5～1:3～10;
(5) filter, the filtrate that step (3) and step (4) are obtained mixes and concentrates 16～18 times, and ethanol is steamed back collection concentrated solution;
(6) be that the ratio of 1:1～4 adds propylene glycol to concentrated solution according to volume ratio, stirred 0.5～2 hour down at 30～50 ℃, cooled and filtered, sterilization namely obtains Chinese medicine extract.
5. skin care compositions according to claim 4 is characterized in that, filtering in described step (4) and/or the step (5) is that 100～200 orders filter.
6. skin care compositions according to claim 5 is characterized in that, the mass volume ratio g/ml of crude drug and ethanol described in the described step (3) is that the mass volume ratio g/ml of filtration residue described in 1:15 and/or the step (4) and ethanol is 1:5.
7. a method for preparing the skin care compositions with acne-removing is characterized in that, described method step is as follows:
(1) prepares each raw material according to the described compositions of claim 6;
(2) Chinese medicine extract, stimulation inhibitory factor, Aloe powder, phyto-hyaluronic acid, allantoin, water solublity Jojoba oil, pantothenylol and substrate are added to the water are heated to 50～80 ℃ and mix, wherein said substrate does not comprise thickening agent and antiseptic.
(3) behind the mix homogeneously, be cooled to 30～50 ℃ and add thickening agent and the packing of antiseptic mix homogeneously.
8. the facial treatment repair with acne-removing is characterized in that, it is made with the described method of claim 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010561928 CN102018646B (en) | 2010-11-26 | 2010-11-26 | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010561928 CN102018646B (en) | 2010-11-26 | 2010-11-26 | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102018646A CN102018646A (en) | 2011-04-20 |
| CN102018646B true CN102018646B (en) | 2013-08-21 |
Family
ID=43860701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010561928 Active CN102018646B (en) | 2010-11-26 | 2010-11-26 | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102018646B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102949461B (en) * | 2012-10-25 | 2014-06-11 | 北京华夏众芳生物科技有限公司 | External traditional Chinese medicine composition and preparation for treating nodular type acnes and preparation method thereof |
| CN103961480B (en) * | 2013-01-28 | 2017-07-14 | 北京东方淼森生物科技有限公司 | Treat external medicine composition, preparation of comprehensive acne and preparation method thereof |
| CN104622763A (en) * | 2015-03-06 | 2015-05-20 | 谢妮妮 | Acne-preventing herbal essence composition, acne-preventing herbal essence extract, acne-preventing herbal facial cleanser and production method of acne-preventing herbal facial cleanser |
| CN105816411A (en) * | 2016-04-30 | 2016-08-03 | 马明娥 | Mask capable of removing acne, whitening skin and achieving nourishing and preparation method of mask |
| CN109806194A (en) * | 2017-11-22 | 2019-05-28 | 广州慕可生物科技有限公司 | A kind of blemish clearing gel and preparation method thereof |
| CN109394666A (en) * | 2018-12-06 | 2019-03-01 | 广州市诺兰精细化工有限公司 | A kind of face mask of traditional Chinese medicine and preparation method for scytitis |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091280A (en) * | 1993-11-25 | 1994-08-31 | 温长路 | Antipruritic bath lotion with traditional Chinese medicine |
| CN101670000A (en) * | 2009-10-09 | 2010-03-17 | 北京工商大学 | Compound acne-removing Chinese herbal extract and preparation method therefor |
| CN101732205A (en) * | 2009-12-29 | 2010-06-16 | 北京工商大学 | Skin-care composition and preparation for relieving skin allergies and resisting inflammatory and irritation and preparation method thereof |
| CN101732204A (en) * | 2009-12-29 | 2010-06-16 | 北京工商大学 | Cosmetic composition for removing acnes, preparation and preparation method thereof |
| CN102068498A (en) * | 2010-11-26 | 2011-05-25 | 新时代健康产业（集团）有限公司 | Chinese medicinal composition with acne treatment and anti-inflammation effects, preparation and preparation method thereof |
-
2010
- 2010-11-26 CN CN 201010561928 patent/CN102018646B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091280A (en) * | 1993-11-25 | 1994-08-31 | 温长路 | Antipruritic bath lotion with traditional Chinese medicine |
| CN101670000A (en) * | 2009-10-09 | 2010-03-17 | 北京工商大学 | Compound acne-removing Chinese herbal extract and preparation method therefor |
| CN101732205A (en) * | 2009-12-29 | 2010-06-16 | 北京工商大学 | Skin-care composition and preparation for relieving skin allergies and resisting inflammatory and irritation and preparation method thereof |
| CN101732204A (en) * | 2009-12-29 | 2010-06-16 | 北京工商大学 | Cosmetic composition for removing acnes, preparation and preparation method thereof |
| CN102068498A (en) * | 2010-11-26 | 2011-05-25 | 新时代健康产业（集团）有限公司 | Chinese medicinal composition with acne treatment and anti-inflammation effects, preparation and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102018646A (en) | 2011-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102068498B (en) | Chinese medicinal composition for external use with acne treatment and anti-inflammation effects, preparation and preparation method thereof | |
| CN100496579C (en) | Antipruritic compositions and compositions for wound healing | |
| KR101478945B1 (en) | Shampoo composition containing native plant extracts and natural oriental material extracts | |
| CN102018646B (en) | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof | |
| CN102342993B (en) | Anti-sensitization and restoration external preparation for skin | |
| CN103735458A (en) | Novel anti-allergy repairing composition for skin | |
| CN103070961B (en) | Chinese medicinal anti-bacteria health care foot-massage solution and preparation method thereof | |
| CN104606106A (en) | Natural plant nano-emulsion bath lotion | |
| JP4495406B2 (en) | Sendangusa plant extract-containing composition | |
| CN105434275A (en) | Shampoo salt rich in mineral trace elements and preparation method | |
| CN105106099A (en) | Acne-removing bamboo charcoal mask containing plant compound preservative | |
| CN101181208B (en) | Gargle containing natural antibiotics and preparation method thereof | |
| KR101274811B1 (en) | Potent anti-acne composition containing perilla frutescens and/or lygodium japonicum extract | |
| CN102488814B (en) | Chinese medicinal composition for treating bovine mastitis | |
| CN107496792B (en) | Gel for treating onychomycosis by diminishing inflammation and resisting bacteria and preparation method thereof | |
| CN101732204A (en) | Cosmetic composition for removing acnes, preparation and preparation method thereof | |
| KR20170130690A (en) | Natural detergent composition and preparation method thereof | |
| CN106344460A (en) | Special moisturizing and acne-removing face cream for acne-prone skin and preparation method thereof | |
| CN113616774B (en) | Antibacterial composition containing plant stem cells, maintenance antibacterial liquid and preparation method thereof | |
| CN105287352A (en) | Orange-flavored toothpaste for children capable of preventing tooth decay | |
| CN101721543A (en) | Pure traditional Chinese medicine lotion for treating gynecological diseases | |
| CN105687050A (en) | Bath salt and preparation method | |
| JP5325727B2 (en) | Sendangusa plant extract-containing composition | |
| KR20110077754A (en) | Cosmetic composition having improving ability for atopy dermatitis and method for using the same | |
| CN104922449A (en) | Traditional Chinese medicine disinfection solution and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder |
Address after: 264006 No.15 Guiyang street, Yantai Economic and Technological Development Zone, Shandong Province Patentee after: NEW ERA HEALTH INDUSTRY (Group) Co.,Ltd. Patentee after: YANTAI NEW ERA HEALTH INDUSTRY Co.,Ltd. Patentee after: YANTAI NEW ERA HEALTH INDUSTRY DAILY CHEMICAL Co.,Ltd. Address before: 102200 9th floor, Beikong science and technology building, 10 baifuquan Road, Changping Science and Technology Park, Beijing Patentee before: NEW ERA HEALTH INDUSTRY (Group) Co.,Ltd. Patentee before: YANTAI NEW ERA HEALTH INDUSTRY Co.,Ltd. Patentee before: YANTAI NEW ERA HEALTH INDUSTRY DAILY CHEMICAL Co.,Ltd. |
|
| CP02 | Change in the address of a patent holder |