CN103961480B - Treat external medicine composition, preparation of comprehensive acne and preparation method thereof - Google Patents
Treat external medicine composition, preparation of comprehensive acne and preparation method thereof Download PDFInfo
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- CN103961480B CN103961480B CN201310031297.3A CN201310031297A CN103961480B CN 103961480 B CN103961480 B CN 103961480B CN 201310031297 A CN201310031297 A CN 201310031297A CN 103961480 B CN103961480 B CN 103961480B
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Abstract
The invention discloses a kind of external medicine composition for treating acne, the bulk drug that the composition is matched by following weight parts is constituted：The bark of official magnolia 10~30, Ligusticum wallichii 10~20, daffodil 10~20, Cajeputtree Leaf 10~30, peppermint 10~30, alfalfa 10~20.The external application Chinese medicine extract of present invention treatment acne and the external-use skin care preparation prepared by the extract can effectively cure comprehensive acne.Such crowd for suffering from acne is the red and swollen heat pain symptom as caused by bacterium and some inflammatory factors, the present invention can improve the microenvironment of skin surface bacteria breed, control sebaceous glands abnormal metabolism, it is inherently eliminated the illnesss such as acne, acne print, cicatricial tissue caused by after being eliminated in addition to poor blood circulation, acne, it may have good curative effect.
Description
Technical field
The present invention relates to a kind of external medicine composition, specifically a kind of external application Chinese medicine group for treating comprehensive acne
Compound, preparation and preparation method thereof.
Background technology
Acne is a kind of chronic sebaceous glands inflammation, leads the acnegenic cause of disease a lot, such as the growth of propionibacterium acnes, sebum
Secreted the factors such as prosperous or skin microcirculation is not smooth, it is also possible to which many factors comprehensive function is formed, when the cause of disease of acne is more
All sometimes, it is difficult to prove effective to take single therapy to the factor of kind.The existing treatment acne products of in the market are a lot, but big multifunctional single
One, only effect of local bacteriostatic is antibacterial to suppress acne really, but if does not control and eliminate bacterial growth ring
Border --- grease, regulation skin microenvironment is difficult to fundamentally cure acne, and recurrence probability is high.Meanwhile, acne eliminate after by
It is damaged in skin histology and cicatricial tissue often occurs, had an impact to the attractive in appearance of face, how is cured acne simultaneously and smooth skin
Scar is the focus of those skilled in the art's research.
The content of the invention
The primary and foremost purpose of the present invention is to propose a kind of external medicine composition for the treatment of.
The second object of the present invention is the extracting method for proposing above-mentioned Chinese medicine composition.
Another object of the present invention is to propose the skin care formulation that said extracted thing is prepared as additive.
The present invention uses following concrete technical scheme：
A kind of external medicine composition for treating acne, the bulk drug that the composition is matched by following weight parts is constituted：
The bark of official magnolia 10~30, Ligusticum wallichii 10~20, daffodil 10~20, Cajeputtree Leaf 10~30, peppermint 10~30, alfalfa 10
~20.
Each bulk drug optimum weight part of above-mentioned composition, which is matched, is：
The bark of official magnolia 20, Ligusticum wallichii 15, daffodil 15, Cajeputtree Leaf 10, peppermint 10, alfalfa 10.
A kind of method for preparing above-mentioned external medicine composition, methods described step is as follows：
（1）Bulk drug is weighed according to described weight；
（2）Bulk drug is put in into percent by volume to extract twice for condensing reflux in 70~90% ethanol, extracts former for the first time
The mass ratio for expecting medicine and ethanol is 1：10~1：30, extraction time obtains extract solution for 30~120min；Second of extraction bulk drug
Mass ratio with ethanol is 1：5~1：20, extraction time obtains extract solution for 60~120min；Merge extract solution twice；
（3）Extract solution is cooled down, filtering, is taken filtrate, is concentrated the filtrate to 0.1~0.5g/ml, produces.
It is preferred that, the step（2）The percent by volume of middle ethanol is 70%；The matter of bulk drug and ethanol is extracted for the first time
Amount is than being 1：15, extraction time is 30min.It is 1 that second, which is extracted bulk drug and the mass ratio of ethanol,：10, extraction time is
60min。
It is preferred that, the step（3）In, extract solution is cooled to 20~50 DEG C, the filtering of 100~200 mesh.
A kind of external application Chinese medicine extract for treating acne, the extract extracts what is obtained by the above method.
Purposes of the above-mentioned extract in the external-use skin care preparation for preparing treatment acne.
A kind of skin care formulation for treating acne, the skin care formulation is by said extracted thing and skin care industry customary adjuvant system
Into.
A kind of external skin-care composition for treating acne, the skin care compositions is made up of following materials in percentage by mass：
A kind of preparation method of the skin care compositions, methods described step is as follows：
（1）Each raw material in A phases is weighed up, other A phase components in addition to AVC
It is mixed and heated to after 80 DEG C~85 DEG C, adds AVC, stirring is uniform to being completely dissolved,
It is incubated after 20~60min and cools；
（2）Less than 45 DEG C are cooled to, each raw material of B phases is added, is produced after mixing.
What the above method was prepared is gel skin care formulation.
The present invention recommends method：After daily face cleaning, inventive gel preparation is uniformly applied to facial affected part, it is early daily
Evening twice, the 4 Monday courses for the treatment of.
Beneficial effect of the present invention：
The present invention chooses the natural plants bark of official magnolia, Ligusticum wallichii, daffodil, Cajeputtree Leaf, peppermint, alfalfa and forms Chinese medicine compound prescription,
And the external-use skin care preparation that extraction obtains external application Chinese medicine extract and prepared by the extract can effectively cure comprehensive
Acne.Such crowd for suffering from acne is the red and swollen heat pain symptom as caused by bacterium and some inflammatory factors, and the present invention can improve
The microenvironment of skin surface bacteria breed, controls sebaceous glands abnormal metabolism, suppresses a plurality of approach collective effect of thrombin activity, from
And reach and be inherently eliminated the illnesss such as acne, acne print, scar group caused by after being eliminated in addition to poor blood circulation, acne
Knit, it may have good curative effect.
Embodiment
The Chinese medicine composition that the present invention is used is commercially available medicinal material.Each raw material sources used in embodiment are shown in Table 1.
Table 1
The preparation of the Chinese medical extract of the present invention of embodiment 1
Bulk drug and consumption：
Bark of official magnolia 20g, Ligusticum wallichii 15g, daffodil 15g, Cajeputtree Leaf 10g, peppermint 10g, alfalfa 10g.
Preparation method：
（1）Weigh bulk drug；
（2）Bulk drug is put in 70% ethanol and heats the extraction of micro-boiling reflux condensation mode twice；Bulk drug and second are extracted for the first time
The mass ratio of alcohol is 1：15；Extraction time is 30min；It is 1 that second, which is extracted bulk drug and the mass ratio of ethanol,：10, during decoction
Between be 60min, merge extract solution twice；
（3）30 DEG C are cooled to, the filtering of 200 mesh takes filtrate, is concentrated into 0.2g/mL and obtains activity extract.
PH value, solid content, electrical conductivity are determined, measurement result is：PH value 4.8, solid content 45, electrical conductivity 800us/cm.
The preparation of the Chinese medical extract of the present invention of embodiment 2
Bulk drug and consumption：
Bark of official magnolia 10g, Ligusticum wallichii 20g, daffodil 10g, Cajeputtree Leaf 18g, peppermint 30g, alfalfa 20g.
Preparation method：
（1）Weigh bulk drug；
（2）Bulk drug is put in 90% ethanol and heats the extraction of micro-boiling reflux condensation mode twice；Bulk drug and second are extracted for the first time
The mass ratio of alcohol is 1：30；Extraction time is 60min；It is 1 that second, which is extracted bulk drug and the mass ratio of ethanol,：20, during decoction
Between be 120min, merge extract solution twice；
（3）50 DEG C are cooled to, the filtering of 200 mesh takes filtrate, is concentrated into 0.1g/mL and obtains activity extract.
PH value, solid content, electrical conductivity are determined, measurement result is：PH value 4.7, solid content 55, electrical conductivity 800us/cm.
The preparation of the Chinese medical extract of the present invention of embodiment 3
Bulk drug and consumption：
Bark of official magnolia 30g, Ligusticum wallichii 10g, daffodil 20g, Cajeputtree Leaf 30g, peppermint 15g, alfalfa 15g.
Preparation method：
（1）Weigh bulk drug；
（2）Bulk drug is put in 80% ethanol and heats the extraction of micro-boiling reflux condensation mode twice；Bulk drug and second are extracted for the first time
The mass ratio of alcohol is 1：10；Extraction time is 120min；It is 1 that second, which is extracted bulk drug and the mass ratio of ethanol,：5, during decoction
Between be 100min, merge extract solution twice；
（3）20 DEG C are cooled to, the filtering of 100 mesh takes filtrate, is concentrated into 0.5g/mL and obtains activity extract.
PH value, solid content, electrical conductivity are determined, measurement result is：PH value 4.7, solid content 55, electrical conductivity 800us/cm.
The preparation of the inventive gel preparation of embodiment 4
Raw material and proportioning（Mass percent）, it is shown in Table 2：
Table 2
Preparation method：
（1）Each raw material in A phases is weighed up（In addition to AVC）AVC stirrings are added after 80 DEG C of heating makes dissolution of raw material substantially uniformity,
It is incubated after 30min and cools；
（2）Less than 45 DEG C are cooled to, B phase raw materials are added, discharged after mixing.
The preparation of the inventive gel preparation of embodiment 5
Raw material and proportioning（Mass percent）, it is shown in Table 3：
Table 3
Preparation method：
（1）Each raw material in A phases is weighed up（In addition to AVC）AVC stirrings are added after 85 DEG C of heating makes dissolution of raw material substantially uniformity,
It is incubated after 30min and cools；
（2）Less than 45 DEG C are cooled to, B phase raw materials are added, discharged after mixing.
The preparation of the inventive gel preparation of embodiment 6
Raw material and proportioning（Mass percent）, it is shown in Table 4：
Table 4
Preparation method：
（1）Each raw material in A phases is weighed up（In addition to AVC）AVC stirrings are added after 80 DEG C of heating makes dissolution of raw material substantially uniformity,
It is incubated after 30min and cools；
（2）Less than 45 DEG C are cooled to, B phase raw materials are added, discharged after mixing.
Efficacy experiments checking of the present invention
1. suppress sebum secretion experiment：
Experimental principle：Human experimentation, by particular experiment crowd（It is more than 30 people）Test population is constituted, test subject uses
The embodiment of the present invention 2 prepares extract, and concentration is the change of skin oil and fat content before and after 0.1g/ml, calculates relative suppression fat rate
[relative suppression fat rate=(blank group fat content-sample sets fat content)/blank group fat content；This value is bigger, illustrates experiment
Sample is more obvious with respect to blank sample suppression fat effect] so that it is determined that cosmetics（Or functional component）Suppression fat effect.
Laboratory apparatus：Skin oil and fat testerSM815。
The experimental result of table 5
Experiment conclusion：Extract of the present invention can persistently suppress sebum secretion in first 3 hours, and have obvious suppression fat effect
Really, while its long-acting suppression fat effect is substantially better than commercially available prod.Inventor prepares extract with embodiment 1 and 3 and repeats above-mentioned reality
Test result be the same as Example 2.
2. propionibacterium acnes bacteriostatic experiment
Experimental method：Oxford cup Bactericidal test
The extract concentrations of embodiment 1 are 0.2g/ml, carry out the inhibition zone measurement to propionibacterium acnes, and assay is shown in
Table 6.
The extract of 6 embodiment of table 1 suppresses the antibacterial circle diameter of propionibacterium acnes（n=3）
Table 6 shows that the extract of the embodiment of the present invention 1 has good fungistatic effect, and inventor is extracted using embodiment 2,3
Thing repeats above-mentioned experimental result be the same as Example 1.
3. fibrin ferment body outer suppressioning test
Because containing fibrin ferment in tissue, the height of the concentration of fibrin ferment directly influences the rate of setting of blood,
If blood coagulation speed is very fast, the phenomenons such as thrombus, scar, tubercle will be formed.Fibrin ferment is suppressed using fibrinogen plate assay
The experimental evaluation invention is to improving the effect of microcirculation.
Experimental principle：Using fibrinogen as substrate, fibrinogen is fabricated to agarose and fibrinogen
Flat board, with the diffusion reaction of thrombin standard product respectively on the flat board, makes corresponding standard curve and regression curve, and right
Sample suppresses thrombin activity and quantitative determined.By between the enzyme activity and standard items enzyme activity of comparative sample-standard items mixture
Difference, to calculate the blood coagulation enzyme inhibition rate of sample.Experimental result is shown in Table 7, from following table as can be seen that the sample has to fibrin ferment
Good inhibiting effect.Inventor repeats above-mentioned experimental result be the same as Example 2 using embodiment 1 and the extract of embodiment 3.
Table 7
| Sample | Inhibiting rate |
| The extract of 0.1g/ml embodiments 2 | 36.5% |
| 0.1g/ml " perfect board " Aloe Vera Gel | 15% |
3. clinical test
Test population：48 22~47 years old, male 22, women 14.Patient with nodular type Acne Scar.
Amount of samples：After daily face cleaning, facial affected part is uniformly applied to gel prepared by embodiment 4, sooner or later twice daily,
The 4 Monday courses for the treatment of.
Curative effect judging standard：It is flat with surface skin, no scar, without sufferings, elasticity is good, skin color is normal is
Cure；It is effective：Treatment face 70% is close to criterion of cure, and part appearance and normal skin are slightly different, substantially neat with surrounding skin
Flat, color is slightly red or slightly white；Effectively：Partly there is hyperplastic scar slightly higher than surface close to effective standard in treatment face 80%, tide
Red hyperemia, the slightly hard person of matter；It is invalid：There is obvious hyperplastic scar protuberance point sheet in treatment face 80%, and in irregular shape, height is not
It is flat, or skin is in patch pattern change, flush is congested, matter is hard, obfuscation, there is cusalgia and scratchiness person.
As a result：3 months obvious effective rates are 22.2%（8）, effective percentage is 63.89%（23）.Total effective rate is up to 86.09%.
The gel preparation that inventor is equally prepared with embodiment 5,6 repeats above-mentioned human experimentation, as a result be the same as Example 4.
Claims (10)
1. a kind of external medicine composition for treating acne, it is characterised in that the external medicine composition is by following weight parts
The bulk drug of proportioning is made：
The bark of official magnolia 10~30, Ligusticum wallichii 10~20, daffodil 10~20, Cajeputtree Leaf 10~30, peppermint 10~30, alfalfa 10~
20。
2. external medicine composition as claimed in claim 1, it is characterised in that the external medicine composition is by following weight
The bulk drug of part proportioning is made：
The bark of official magnolia 20, Ligusticum wallichii 15, daffodil 15, Cajeputtree Leaf 10, peppermint 10, alfalfa 10.
3. a kind of method of the external medicine composition prepared described in claim 1 or 2, it is characterised in that methods described step
It is as follows：
(1) bulk drug is weighed according to the weight described in claim 1 or 2；
(2) bulk drug is put in into percent by volume to extract twice for condensing reflux in 70~90% ethanol, raw material is extracted for the first time
The mass ratio of medicine and ethanol is 1：10~1：30, extraction time obtains extract solution for 30~120min；Second extract bulk drug with
The mass ratio of ethanol is 1：5~1：20, extraction time obtains extract solution for 60~120min；Merge extract solution twice；
(3) extract solution is cooled down, filtering, is taken filtrate, is concentrated the filtrate to 0.1~0.5g/ml, produces.
4. preparation method as claimed in claim 3, it is characterised in that the percent by volume of ethanol is in the step (2)
70%；The mass ratio for extracting bulk drug and ethanol for the first time is 1：15, extraction time is 30min；Second extract bulk drug with
The mass ratio of ethanol is 1：10, extraction time is 60min.
5. preparation method as claimed in claim 3, it is characterised in that in the step (3), extract solution is cooled to 20~50
DEG C, the filtering of 100~200 mesh.
6. a kind of external application Chinese medicine extract for treating acne, it is characterised in that the external application Chinese medicine extract is by claim
3rd, 4 or 5 methods describeds extract what is obtained.
7. purposes of the external application Chinese medicine extract in the external-use skin care preparation for preparing treatment acne described in claim 6.
8. a kind of skin care formulation for treating acne, it is characterised in that the skin care formulation is carried as external application Chinese medicine described in claim 6
Thing and skin care industry customary adjuvant is taken to be made.
9. a kind of external skin-care composition for treating acne, it is characterised in that the external skin-care composition is by following quality hundred
Divide than raw material composition：
B phases
1~5wt% of external application Chinese medicine extract described in claim 6
0.1~0.6wt% of preservative.
10. a kind of preparation method of external skin-care composition described in claim 9, it is characterised in that the preparation method step
It is as follows：
(1) each raw material in A phases is weighed up, other A phase components mixing in addition to AVC
It is heated to after 80 DEG C~85 DEG C, adds AVC, stirring is uniform to being completely dissolved, insulation
Cool after 20~60min；
(2) less than 45 DEG C are cooled to, each raw material of B phases is added, is produced after mixing.
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| CN201310031297.3A CN103961480B (en) | 2013-01-28 | 2013-01-28 | Treat external medicine composition, preparation of comprehensive acne and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357188A (en) * | 2008-09-05 | 2009-02-04 | 何进爱 | Beautification traditional Chinese medicine composition |
| CN101623352A (en) * | 2009-08-12 | 2010-01-13 | 鲍旭刚 | Medicine for treating acne and preparation method thereof |
| CN102018937A (en) * | 2010-12-14 | 2011-04-20 | 金亮亮 | Medicament for treating acne and preparation method thereof |
| CN102018646A (en) * | 2010-11-26 | 2011-04-20 | 新时代健康产业（集团）有限公司 | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof |
| CN102274338A (en) * | 2011-08-15 | 2011-12-14 | 成都绿迪科技有限公司 | Chinese patent medicine for treating acne |
-
2013
- 2013-01-28 CN CN201310031297.3A patent/CN103961480B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357188A (en) * | 2008-09-05 | 2009-02-04 | 何进爱 | Beautification traditional Chinese medicine composition |
| CN101623352A (en) * | 2009-08-12 | 2010-01-13 | 鲍旭刚 | Medicine for treating acne and preparation method thereof |
| CN102018646A (en) * | 2010-11-26 | 2011-04-20 | 新时代健康产业（集团）有限公司 | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof |
| CN102018937A (en) * | 2010-12-14 | 2011-04-20 | 金亮亮 | Medicament for treating acne and preparation method thereof |
| CN102274338A (en) * | 2011-08-15 | 2011-12-14 | 成都绿迪科技有限公司 | Chinese patent medicine for treating acne |
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