CN105342943B - A kind of condensation and preparation method thereof containing Chinese herbal medicine extract - Google Patents
A kind of condensation and preparation method thereof containing Chinese herbal medicine extract Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention discloses a kind of condensation and preparation method thereof containing Chinese herbal medicine extract；It is intended to provide a kind of skin sense water profit, a touching is changed, and safety is mild, the good condensation of moistening effect；Technical points: the condensation, each component mass percent: reed fragrant plant oil 0.4~0.6%, carbomer 0.22~0.34%, triethanolamine 0.22~0.34%, beta glucan 0.64~0.96%, Sodium Hyaluronate 0.024~0.5%, 1.2~1.8% Jojoba wax PEG-120 esters 0.32~0.48% of ethoxy urea, EDETATE SODIUM 0.08~0.12%, glycerin polyether -261.2~1.8%, methyl hydroxybenzoate 0.16~0.24%, essence 0.0048~0.0072%, Cremophor RH40 0.024~0.036%, Alps glacial water 8~12%, soak regulator 0.008~0.012%, Selaginella tamariscina extracting solution 0.0 1~3%, camomile extract 0.01~3%, surplus is water.
Description
Technical field
The invention discloses a kind of condensations, specifically, be a kind of condensation containing Chinese herbal medicine extract, the invention further relates to
The preparation method of the condensation；Belong to technical field of skin care.
Background technique
As the improvement of people's living standards, women also increasingly payes attention to the maintenance of itself.Liking to be beautiful is each woman
Nature, everyone thinks perpetual youth, possesses skin at an early age forever, and the pollution with modern industry to living environment,
Earth environment pollution is got worse, also increasingly severe to the injury of human skin, along with the development of modern science and technology, computer,
Mobile phone is almost everyone indispensable tool, human skin all day all in various radiation and pollution among, skin of face allergy,
Itch, the situation of drying are more and more, and skin aging accelerates, and people have to seek various skin-protection products to carry out delaying skin to decline
Always.Currently, having various moisture retention waters, moisturizer, moisturiser in the market, effect is different, and the people of different skin quality needs
The product of corresponding effect is selected according to the skin quality of oneself, and with the arriving of autumn and winter, the skin of majority is all by season shadow
It rings and becomes very dry, and ingredient is different in miscellaneous water conservation water, cream, most of cosmetics are all by pure chemistry ingredient
It is made, skin water profit is felt after fresh out of, after more than one hours, due to the volatilization or stimulation of chemical component, skin is usual
It will become drying, and the human skin that seems is aged simple and unadorned, is used for a long time, and also will cause skin water shortage, it can not to skin generation
Inverse damage.
Current condensation various types existing on the market are primarily intended to when basic moisturizing is not focused on safety and used
Skin sense, and moistening effect is undesirable.
Summary of the invention
In view of the above-mentioned problems, one touching is changed, and safety is mild the object of the present invention is to provide a kind of skin sense water profit, moisturizing effect
The good condensation containing Chinese herbal medicine extract of fruit, the invention further relates to the preparation methods of the condensation.
In order to solve the above technical problems, first technical solution provided by the invention is such that
A kind of condensation containing Chinese herbal medicine extract is calculated by gross mass 100%, and each component and mass percentage content are such as
Under:
Preferably, above-mentioned a kind of condensation containing Chinese herbal medicine extract is calculated by gross mass 100%, each component and quality
Degree is as follows:
More there are choosing, a kind of above-mentioned condensation containing Chinese herbal medicine extract, the wet regulator is Xylitol-based glucose
Glycosides or one of anhydro xylitol or xylitol or any combination.
The above-mentioned condensation preparation method containing Chinese herbal medicine extract provided by the invention
1) each component is weighed；
2) essence will be weighed to be dissolved in Cremophor RH40, and will obtain prefabrication 1；
3) agitated kettle will be added in deionized water, under agitation carbomer, it is oily, saturating adds ethoxy urea, reed fragrant plant
Bright matter acid sodium, Jojoba wax PEG-120 esters, EDETATE SODIUM, glycerin polyether -26, methyl hydroxybenzoate, at the uniform velocity stirring are warming up to 80-
85 DEG C, insulated and stirred 10-15min, prefabrication 2；
4) prefabrication 2 is cooled to 65-70 DEG C, beta glucan and triethanolamine, insulated and stirred 10-15min is added；Continue
It is cooled to 40-45 DEG C, prefabrication 1, Alps glacial water, wetting regulator, Selaginella tamariscina extracting solution and camomile extract is added,
Insulated and stirred 10-15min discharges after detection is qualified
Compared with prior art, each component scientific compatibility provided by the invention, reasonable formula, sense of touch is fine, and skin sense is soft
With, one brush can change water, with rear water moisten moisturizing, it is safe and non-stimulating non-stimulated.
Each component effect is as follows in prescription:
Reed fragrant plant oil: water-soluble viscous liquid, acidity of the pH value close to human skin, multi-functional skin moisturizer can
Improve skin sense and lubricity.
Carbomer: good water-soluble thickener has extremely short rheological characteristic, high transparency, high endurance of cutting, pole
Good high-temperature stability, the salubrious water profit of skin sense, the primary raw material of offer water.
Triethanolamine: splendid mild neutralizer.
Beta glucan: skin sense is splendid, is the active constituent of multi-functional moisturizing, reparation.
Sodium Hyaluronate: internationally recognized natural moisturizing factor assigns product water and moistens soft skin sense, and compact skin is long
Kubo is wet, prevents from being dehydrated, histocyte regeneration.
Ethoxy urea: splendid moisturizer can provide efficient moisture-retention effect simultaneously again without sticky feel to skin care item.
Jojoba wax PEG-120 esters: moisturizer keeps continuous skin wet.
A kind of EDTA disodium: excellent chelating agent.
Glycerin polyether -26: the double-deck moisture film, effectively latching moisture can be formed, is skin emolliency, lubricant, has after use
There are superior sense of touch, no greasy feeling.
Methyl hydroxybenzoate: broad-spectrum antibacterial agent is easy to various compound compatibilities.
PEG-40 rilanit special: efficient solubilizing agents, compatibilization ability is strong, and dosage is low, and low-temperature transparent degree is good.
Alps glacial water: coming from alpine glacial water, has moisture-keeping function.
Xylitol-based glucoside (and) anhydro xylitol (and) xylitol: the moisturizing ingredient of natural botanical source improves table
The moisture content of skin reinforces skin barrier effect, reduces water loss.
Selaginella tamariscina (bringing back to life grass) extracting solution: natural component, mild non-stimulated, efficient water suction and water lock function supplement skin
Normal moisture is tender to reach the permanent water of skin.
Camomile extract: natural component, mild non-stimulated, Beauty promise effect of calming.
Nonanedioyl Diglycocol potassium inhibits injury of the free radical to skin, inhibits the abnormal life of horn cell in hair follicle
It is long, moisture-retaining capacity is improved, the activity of TYR enzyme is inhibited, effectively blocks the formation of melanin；
Radix paeoniae alba extraction, whitening of easing pain；
Aloe leaf extract can form one layer of smooth hygroscopic mem-brane in skin surface, mention in the case where not increasing viscosity
The beautiful feeling and flexibility for rising formula, because being rich in polysaccharide and the effect of releiving.
Specific embodiment
With reference to embodiment, claim of the invention is described in further detail, but do not constituted pair
Any restrictions of the invention, the modification of anyone limited times made in the claims in the present invention protection scope, still in this hair
Within bright claims.
Embodiment 1
A kind of condensation containing Chinese herbal medicine extract provided by the invention is calculated by gross mass 100g, is made of the following components:
Reed fragrant plant oil 0.6g, carbomer 0.22g, triethanolamine 0.34g, beta glucan 0.64g, Sodium Hyaluronate 0.5g, ethoxy urea
1.2g Jojoba wax PEG-120 esters 0.48g, EDETATE SODIUM 0.08g, glycerin polyether -261.8g, methyl hydroxybenzoate 0.16g, essence
0.0072g, Cremophor RH40 0.024g, Alps glacial water 12g, xylitol 0.008g, Selaginella tamariscina extracting solution 3g, ocean
Flos Chrysanthemi extract 0.01g, surplus are water.
Embodiment 2
Condensation of the another kind containing Chinese herbal medicine extract provided by the invention, is calculated by gross mass 100g, by following component systems
At: reed fragrant plant oil 0.4g, carbomer 0.34g, triethanolamine 0.22g, beta glucan 0.96g, Sodium Hyaluronate 0.024g, ethoxy
Urea 1.8g Jojoba wax PEG-120 esters 0.32g, EDETATE SODIUM 0.12g, glycerin polyether -26 1.2g, methyl hydroxybenzoate 0.24g,
Essence 0.0048g, Cremophor RH40 0.036g, Alps glacial water 8g, anhydro xylitol 0.012g, Selaginella tamariscina are extracted
Liquid 0.01g, camomile extract 3g, surplus are water.
Embodiment 3
Condensation of the another kind containing Chinese herbal medicine extract provided by the invention, is calculated by gross mass 100g, by following component systems
At: reed fragrant plant oil 0.45g, carbomer 0.30g, triethanolamine 0.26g, beta glucan 0.85g, Sodium Hyaluronate 0.1g, ethoxy
Urea 1.6g Jojoba wax PEG-120 esters 0.38g, EDETATE SODIUM 0.10g, glycerin polyether -26 1.45g, methyl hydroxybenzoate 0.22g,
Essence 0.0055g, Cremophor RH40 0.030g, Alps glacial water 9g, anhydro xylitol 0.011g, Selaginella tamariscina are extracted
Liquid 0.5g, camomile extract 2g, surplus are water.
Embodiment 4
A kind of condensation containing Chinese herbal medicine extract provided by the invention is calculated by gross mass 100g, is made of the following components:
Reed fragrant plant oil 0.55g, carbomer 0.26g, triethanolamine 0.30g, beta glucan 0.75g, Sodium Hyaluronate 0.3g, ethoxy urea
1.4g Jojoba wax PEG-120 esters 0.40g, EDETATE SODIUM 0.09g, glycerin polyether -261.55g, methyl hydroxybenzoate 0.18g are fragrant
Smart 0.0065g, Cremophor RH40 0.028g, Alps glacial water 11g, Xylitol-based glucoside 0.009g, Selaginella tamariscina
Extracting solution 2g, camomile extract 0.5g, surplus are water.
Embodiment 5
A kind of condensation containing Chinese herbal medicine extract provided by the invention is calculated by gross mass 100g, is made of the following components:
Reed fragrant plant oil 0.5g, carbomer 0.28g, triethanolamine 0.28g, beta glucan 0.8g, Sodium Hyaluronate 0.03g, ethoxy urea
1.5g, Jojoba wax PEG-120 esters 0.4g, EDETATE SODIUM 0.1g, glycerin polyether -261.5g, methyl hydroxybenzoate 0.2g, essence
0.006g, Cremophor RH40 0.03g, Alps glacial water 0.01g, Xylitol-based glucoside 0.008 are dehydrated xylose
Alcohol 0.001, xylitol 0.01g, Selaginella tamariscina (bringing back to life grass) extracting solution 0.01g, camomile extract 0.01g, surplus is water.
Any one group of condensation preparation method containing Chinese herbal medicine extract in embodiment 1 to 5 provided by the invention successively include
Following step:
1) each component is weighed by any one group of mass number in embodiment 1 to 5；
2) essence will be weighed to be dissolved in Cremophor RH40, and will obtain prefabrication 1；
3) agitated kettle will be added in deionized water, under agitation carbomer, it is oily, saturating adds ethoxy urea, reed fragrant plant
Bright matter acid sodium, Jojoba wax PEG-120 esters, EDETATE SODIUM, glycerin polyether -26, methyl hydroxybenzoate, at the uniform velocity stirring are warming up to 80-
85 DEG C, insulated and stirred 10-15min, prefabrication 2；
4) prefabrication 2 is cooled to 65-70 DEG C, beta glucan and triethanolamine, insulated and stirred 10-15min is added；Continue
It is cooled to 40-45 DEG C, prefabrication 1, Alps glacial water profit, wet regulator, Selaginella tamariscina extracting solution and camomile extract is added,
Insulated and stirred 10-15min discharges after detection is qualified.
Embodiment 6
A kind of condensation containing Chinese herbal medicine extract provided by the invention is calculated by gross mass 100g, is made of the following components:
Reed fragrant plant oil 0.55g, carbomer 0.26g, triethanolamine 0.30g, beta glucan 0.75g, Sodium Hyaluronate 0.3g, ethoxy urea
1.4g Jojoba wax PEG-120 esters 0.40g, EDETATE SODIUM 0.09g, glycerin polyether -261.55g, methyl hydroxybenzoate 0.18g are fragrant
Smart 0.0065g, Cremophor RH40 0.028g, Alps glacial water 11g, Xylitol-based glucoside 0.009g, Selaginella tamariscina
Extracting solution 2g, camomile extract 0.5g, nonanedioyl Diglycocol potassium 1.5g, peony extract 0.5g, aloe leaf extract
0.8g, surplus are water.
Embodiment 7
A kind of condensation containing Chinese herbal medicine extract provided by the invention is calculated by gross mass 100g, is made of the following components:
Reed fragrant plant oil 0.5g, carbomer 0.28g, triethanolamine 0.28g, beta glucan 0.8g, Sodium Hyaluronate 0.03g, ethoxy urea
1.5g, Jojoba wax PEG-120 esters 0.4g, EDETATE SODIUM 0.1g, glycerin polyether -261.5g, methyl hydroxybenzoate 0.2g, essence
0.006g, Cremophor RH40 0.03g, Alps glacial water 0.01g, Xylitol-based glucoside 0.008 are dehydrated xylose
Alcohol 0.001, xylitol 0.01g, Selaginella tamariscina (bringing back to life grass) extracting solution 0.01g, camomile extract 0.01g, nonanedioyl Diglycocol
Potassium 1.5g, peony extract 0.5g, aloe leaf extract 0.8g, surplus is water.
Any one group of condensation preparation method containing Chinese herbal medicine extract in embodiment 6 to 7 provided by the invention successively include
Following step:
1) each component is weighed by any one group of mass number in embodiment 1 to 5；
2) essence will be weighed to be dissolved in Cremophor RH40, and will obtain prefabrication 1；
3) agitated kettle will be added in deionized water, under agitation carbomer, it is oily, saturating adds ethoxy urea, reed fragrant plant
Bright matter acid sodium, Jojoba wax PEG-120 esters, EDETATE SODIUM, glycerin polyether -26, methyl hydroxybenzoate, at the uniform velocity stirring are warming up to 80-
85 DEG C, insulated and stirred 10-15min, prefabrication 2；
4) prefabrication 2 is cooled to 65-70 DEG C, beta glucan and triethanolamine, insulated and stirred 10-15min is added；Continue
It is cooled to 40-45 DEG C, prefabrication 1, Alps glacial water profit, wet regulator, Selaginella tamariscina extracting solution and chamomile is added and extracts
Object, nonanedioyl Diglycocol potassium, peony extract, aloe leaf extract, insulated and stirred 10-15min discharges after detection is qualified.
Wherein:
The extracting method of Selaginella tamariscina extracting solution is as follows: taking 10g Selaginella tamariscina medicine materical crude slice, is placed in flask, 95wt% ethanol solution is added
100g, after impregnating 0.5h, the refluxing extraction 1h under 80 DEG C of water bath conditions, extraction fluid, the dregs of a decoction continuously add 95wt% ethyl alcohol
Solution 100g, the refluxing extraction 1h at 80 DEG C obtain secondary raffinate, merge two batches extracting solution.Using Buchner funnel to Selaginella tamariscina
Extracting solution is filtered, and obtains clarified solution (Selaginella tamariscina extracting solution).
The extracting method of camomile extract is as follows: taking 10g chamomile medicine materical crude slice, is placed in flask, 70wt% ethyl alcohol is added
Solution 100g, after impregnating 0.5h, refluxing extraction 1h, extraction fluid, the dregs of a decoction continuously add 70wt% under 70 DEG C of water bath conditions
Ethanol solution 100g, the refluxing extraction 1h at 70 DEG C obtain secondary raffinate, merge two batches extracting solution.Use Buchner funnel pair
Chamomile extracting solution is filtered, and obtains clarified solution (chamomile extracting solution).It by clarified solution, is placed in a vacuum drying oven, Yu Wen
80 DEG C are spent, 48h is continued drying out under conditions of vacuum degree -0.05MPa, obtains desciccate, is crushed to get chamomile extraction
Object powder.
Peony extract: taking 10g Chinese herbaceous peony medicine materical crude slice, be placed in flask, and 70wt% ethanol solution 100g is added, and impregnates 0.5h
Afterwards, the refluxing extraction 1h under 80 DEG C of water bath conditions, extraction fluid, the dregs of a decoction continuously add 70wt% ethanol solution 100g, in 80
Refluxing extraction 1h at DEG C obtains secondary raffinate, merges two batches extracting solution.Chinese herbaceous peony extracting solution was carried out using Buchner funnel
Filter, obtains clarified solution.It by clarified solution, is placed in a vacuum drying oven, continues under conditions of 80 DEG C of temperature, vacuum degree -0.05MPa
Dry 48h, obtains desciccate, is crushed to get peony extract powder.
Extract solution from aloe: taking fresh aloe, chopping, in the cloth bag after setting cleaning-sterilizing, squeezes out aloe juice, and with 80
The filtering of mesh nylon gauze, obtains Aloe original juice, i.e. extract solution from aloe.
In order to prove advantages of the present invention, applicant carries out 3T3 cytotoxicity test to condensation provided by the invention, obtains
Half lethal concentration is 36494 μ g/ml, and (the general permeability of cosmetics) cell activity does not influence under 1% concentration；Together
When, it is 5261.9mg/kg that LD50, which is calculated, by the prediction model of Oral toxicity and cytotoxicity, and being classified according to GHS, this is produced
Product in the column of acute oral toxicity classification, i.e., do not predict acute oral toxicity；And certain famous product passes through orally on the market
It is 638.12mg/kg that LD50, which is calculated, in the prediction model of toxicity and cytotoxicity, is classified this product acute oral poison according to GHS
Property be classified as the fourth stage, that is, swallow harmful (oral).
Claims (3)
1. a kind of condensation containing Chinese herbal medicine extract, which is characterized in that calculated by gross mass 100%, including following each components, respectively
Constituent mass percentage is as follows:
The wetting regulator is Xylitol-based glucoside or one of anhydro xylitol or xylitol or any group
It closes.
2. a kind of condensation containing Chinese herbal medicine extract, which is characterized in that calculated by gross mass 100%, each component and quality percentage
Than as follows:
The wetting regulator is Xylitol-based glucoside or one of anhydro xylitol or xylitol or any group
It closes.
3. the method for preparing a kind of condensation containing Chinese herbal medicine extract described in claim 1, which is characterized in that under successively including
State step:
1) mass number according to claim 1 weighs each component；
2) essence will be weighed to be dissolved in Cremophor RH40, and will obtain prefabrication 1；
3) agitated kettle will be added in deionized water, under agitation carbomer, and add ethoxy urea, reed fragrant plant oil, hyalomitome
Sour sodium, Jojoba wax PEG-120 esters, EDETATE SODIUM, glycerin polyether -26, methyl hydroxybenzoate, at the uniform velocity stirring are warming up to 80-85 DEG C,
Insulated and stirred 10-15min, prefabrication 2；
4) prefabrication 2 is cooled to 65-70 DEG C, beta glucan and triethanolamine, insulated and stirred 10-15min is added；Continue to cool down
To 40-45 DEG C, prefabrication 1, Alps glacial water, wetting regulator, Selaginella tamariscina extracting solution and camomile extract, heat preservation is added
10-15min is stirred, is discharged after detection is qualified.
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| CN105748354B (en) * | 2016-03-09 | 2017-07-18 | 广东芭薇生物科技股份有限公司 | A kind of facial mask liquid and preparation method thereof |
| CN106236691A (en) * | 2016-09-07 | 2016-12-21 | 高宝化妆品（中国）有限公司 | A kind of antioxidation moisturizing elite dew and preparation method thereof |
| CN106619304A (en) * | 2016-12-31 | 2017-05-10 | 广州品爵生物科技有限公司 | Composition for repairing skin surface lipid film and preparation method and application thereof |
| CN114081850A (en) * | 2021-12-27 | 2022-02-25 | 广州源燊创生物科技有限公司 | Efficient cosmetic humectant |
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| CN101296684B (en) * | 2005-08-25 | 2012-10-10 | 高露洁-棕榄公司 | Moisturizing compositions |
| CN102908304B (en) * | 2012-11-19 | 2013-12-11 | 浙江省林业科学研究院 | Anti-ageing wrinkle reduction toning lotion enriched with active peptide, and preparation method thereof |
| CN103251534B (en) * | 2013-05-15 | 2014-12-17 | 苏州谷力生物科技有限公司 | Chinese medicine skin-caring and hydrating gel |
| CN103655313B (en) * | 2013-12-03 | 2015-09-16 | 诺斯贝尔(中山)无纺日化有限公司 | A kind of whitening skin and preserving moisture skin care suncream |
| CN104940047B (en) * | 2015-06-25 | 2017-12-01 | 广州保税区雅兰国际化妆品有限公司 | A kind of cosmetic composition of replenishing water and preserving moisture and preparation method thereof |
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