CN108938498A - A kind of antiallergic remediation composition and its preparation method and application with inhibition histamine release - Google Patents
A kind of antiallergic remediation composition and its preparation method and application with inhibition histamine release Download PDFInfo
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Abstract
The invention belongs to cosmetic fields, specially a kind of antiallergic remediation composition with inhibition histamine release, containing following components by weight percentage: Fructus Monordicae extract 5-15%, phosphoglycerol inositol choline salt 0.5-5%, licorice 0.2-2%, Gotu Kola P.E 0.1-2%, polypeptide 0.1-5%, agastache extract 0.5-3%, Radix Gentianae extract 1-5%, polyalcohol 30-50%, water 30-40%.The problem of the composition can effectively inhibit histamine release, weaken allergic reaction and eliminate organized amine bring pruitus, meanwhile, the invention also discloses the preparation method and application of the composition.
Description
Technical field
It is specially a kind of with the antiallergic remediation composition and its system that inhibit histamine release the present invention relates to cosmetic field
Preparation Method and application.
Background technique
Histamine is generated under the action of decarboxylase by histidine.Containing big in many tissues, especially Skin Cell
The histamine of amount.When tissue is damaged or is inflamed with allergic reaction, all releasable histamine.Histamine has strong vasodilator
Effect, and the tube wall permeability of capillary and venule can be made to increase, blood plasma leaks into tissue, leads to local organization oedema.
Skin allergy is a kind of allergy, after entering body by allergen, body is promoted to generate corresponding antibody, caused
Antigen-antibody reaction, the biological interleukin such as release histamine, leukotriene cause skin erythema, papule, itch, red and swollen dry bits, water occur
The symptoms such as bubble.With the excessive use of air, environment, the pollution of food and cosmetics, human body supports external material incentive
Worse and worse, phenomena such as skin irritatin allergy occur, is more and more frequent for anti-ability.In recent years, consumer more pays close attention to skin sensitivity
With the related dermal problem caused by skin sensitivity, cause lot of domestic and foreign cosmetics company and research work very big concern and
Investment.
As a kind of more commonly used skin conditioning agent in this field, CN 201610239261.8 disclose it is a kind of have repair
The composition of multiple skin function, including following component by weight percentage: functional components 4.5-16%, additive 5-10%
With deionized water 74-90%；The sum of weight percent of mentioned component is 100%；Wherein, the functional components include pressing institute
State composition weight percentages following component: glycosylglycerol 1-3%, phosphoinositide choline salt 0.5-0.8%, ceramide
0.5-2%, glucan 1-5%, Baical Skullcap root P.E 0.5-1.5%, shrubby sophora extract 0.5-1.5%, licorice 0.5-
1.5%.The wet effect of the composition benefit is good, energy nti-freckle eliminates red and swollen, reduction wrinkle, nontoxic non-stimulated.It is in beneficial effect part
Point out: phosphoinositide choline salt (GPI), GPI are a kind of innovation active constituents obtained in the sunflower lecithin, are cytolipins
The natural component GPI of matter metabolism can inhibit cytosolic phospholipase A2 (cpLA2), and cpLA2 is the key enzyme of inflammatory reaction, i.e.,
GPI can act on the source of cascade of response of inflammation, comply fully with the physiology self-adjusting system of body, will not interfere swashing for body
Element balance.In addition, GPI can inhibit by the secretion of the UVB Prostaglandin PGE2 caused in epidermal keratinocytes, and can be effectively relieved
The erythema caused by UVB.
Recorded according to Chinese Pharmacopoeia (2015): Siraitia grosvenorii is cucurbitaceous plant Siraitia grosvenorii Siraitia grosvenorii
(Swingle) dry fruit of C.Jeffrey ex A.M.Lu et Z.Y.Zhang.Autumn fruit deepens green by peak green
Shi Caishou, after a couple of days of drying in the air, low temperature drying.One of its main pharmacological components are triterpene glucoside V (C60H102O29), it is gone back certainly
Vitamin C rich in and effective PEARLITOL 25C (being mainly used to cough-relieving)；It opens sound, laxation with clearing heat and moistening lung, relieving sore-throat
Defaecation.For lung-heat type cough, pharyngalgia aphonia, the effect of dry constipation of intestines.For it is used alone, do not have it is extensive anti-inflammatory and
The effect of inhibiting histamine releasing.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicine compositions with antiallergic sense；The composition can be effective
The problem of inhibiting histamine release, weakening allergic reaction and eliminate organized amine bring pruitus, meanwhile, invention additionally discloses
The preparation method and application of the composition.
In the case where not doing specified otherwise, % of the invention, part are weight percentage and parts by weight.
To achieve the above object, the invention provides the following technical scheme:
A kind of antiallergic remediation composition with inhibition histamine release, contains following components by weight percentage: arhat
Berry extract 5-15%, phosphoglycerol inositol choline salt 0.5-5%, licorice 0.2-2%, Gotu Kola P.E 0.1-
2%, polypeptide 0.1-5%, agastache extract 0.5-3%, Radix Gentianae extract 1-5%, polyalcohol 30-50%, water 30-40%.
Have in the antiallergic remediation composition for inhibiting histamine release in above-mentioned, containing following group by weight percentage
Point: Fructus Monordicae extract 10%, phosphoglycerol inositol choline salt 1%, licorice 2%, Gotu Kola P.E 1%, polypeptide
0.5%, agastache extract 2%, Radix Gentianae extract 3%, polyalcohol 45%, water 35.5%.
Have in the antiallergic remediation composition for inhibiting histamine release in above-mentioned, containing following group by weight percentage
Point: Fructus Monordicae extract 8%, phosphoglycerol inositol choline salt 0.5%, licorice 1%, Gotu Kola P.E 2%, polypeptide
1%, agastache extract 1%, Radix Gentianae extract 2%, polyalcohol 50%, water 34.5%.
Have in the antiallergic remediation composition for inhibiting histamine release in above-mentioned, containing following group by weight percentage
Point: Fructus Monordicae extract 15%, phosphoglycerol inositol choline salt 2%, licorice 0.5%, Gotu Kola P.E 0.5%,
Polypeptide 0.2%, agastache extract 1.5%, Radix Gentianae extract 3%, polyalcohol 40%, water 37.3%.
Have in the antiallergic remediation composition for inhibiting histamine release in above-mentioned, containing following group by weight percentage
Point: Fructus Monordicae extract 9%, phosphoglycerol inositol choline salt 5%, licorice 2%, Gotu Kola P.E 2%, polypeptide
5%, agastache extract 1.5%, Radix Gentianae extract 3%, polyalcohol 40%, water 32.5%
In the above-mentioned antiallergic remediation composition for having and inhibiting histamine release, the polyalcohol is butanediol, the third two
The mixing of alcohol one or two；The polypeptide is palmitic acid acyl tetrapeptide -7, the one or two kinds of mixing of acetyl group tetrapeptide -15；The water
For deionized water.
Meanwhile the invention also discloses the preparation method of the above-mentioned antiallergic remediation composition for having and inhibiting histamine release,
The following steps are included:
Fructus Monordicae extract, licorice, Gotu Kola P.E are first pre-dissolved dispersion with polyalcohol, then with phosphoglycerol
Inositol choline salt, polypeptide, agastache extract, Radix Gentianae extract, which is added to the water, to be uniformly dissolved.
In addition, the invention also discloses the above-mentioned application with the antiallergic remediation composition for inhibiting histamine release, it is described
Composition is for being configured to cosmetics.
Preferably, the composition accounts for the 0.5-8% of the cosmetics total weight.
Compared with prior art, the beneficial effects of the present invention are:
Of the invention has the antiallergic remediation composition for inhibiting histamine release, passes through Fructus Monordicae extract, phosphoglycerol
Inositol choline salt acts on cell-cell communication level-directly with specific neuroceptor, enhances the tolerance threshold value of skin.As
Sensitive knob can reduce the flow of calcium in cell membrane, and the sensibility of skin is made to be restored to normal level, and antagonizing histamine is antipruritic
Inhibit oedema；Agastache extract, Radix Gentianae extract are able to suppress the lymphopoiesis of division primary stimuli, promote cellular immunity
Power inhibits the generation of oxygen radical, can completely inhibit the activity of hyaluronidase, inhibits the release of histamine, to direct skin
Skin contact dermatitis has good inhibiting effect, excellent antiallergic effect, calm condition susceptible；Licorice, centella
Extract promotes skin collagen regeneration, enhances cell basal layer cell vigor, inhibits free radical activity, rebuilds skin screen
Barrier；The inflammatory reaction that polypeptide is capable of overreaction and skin allergy to body is worked, and the tolerance of skin is improved, and is reduced scorching
Disease reaction；Polyalcohol can absorb moisture from corium and external environment, and polyalcohol can sufficiently insert cutin gap, stay in skin
Skin cuticula enhances skin barrier function, and then achievees the purpose that antiallergic reparation.
Composition of the invention is rich in multiple efficacies ingredient, reconciles mutually between each ingredient, acts synergistically, enables composition
Inhibit histamine release, adjust neuroceptor, increase skin-tolerant, rebuild skin barrier, so that improvement of effectively releiving is because of skin
Allergy generates rubescent, and fever, itch is tight, the symptom of oedema.
Detailed description of the invention
Fig. 1 is the effect data figure of hyaluronidase body outer suppressioning test of the invention；
Fig. 2 is the test effect datagram that skin antipruritic effect of the invention is tested.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1 is a kind of with the antiallergic remediation composition (I) for inhibiting histamine release
A kind of antiallergic remediation composition (I) with inhibition histamine release, by following components by weight percentage system
At: Fructus Monordicae extract 10%, phosphoglycerol inositol choline salt 1%, licorice 2%, Gotu Kola P.E 1%, polypeptide
0.5%, agastache extract 2%, Radix Gentianae extract 3%, polyalcohol 45%, water 35.5%.
Preparation method: being first pre-dissolved dispersion with polyalcohol for Fructus Monordicae extract, licorice, Gotu Kola P.E, then
With phosphoglycerol inositol choline salt, polypeptide, agastache extract, Radix Gentianae extract, which is added to the water, to be uniformly dissolved.
Embodiment 2 is a kind of with the antiallergic remediation composition (II) for inhibiting histamine release
A kind of composition (II) with long-lasting moisturization, is made: arhat of following components by weight percentage
Berry extract 8%, phosphoglycerol inositol choline salt 0.5%, licorice 1%, Gotu Kola P.E 2%, polypeptide 1%, the leaves of pulse plants
Fragrant extract 1%, Radix Gentianae extract 2%, polyalcohol 50%, water 34.5%.
Preparation method: being first pre-dissolved dispersion with polyalcohol for Fructus Monordicae extract, licorice, Gotu Kola P.E, then
With phosphoglycerol inositol choline salt, polypeptide, agastache extract, Radix Gentianae extract, which is added to the water, to be uniformly dissolved.
Embodiment 3 is a kind of with the antiallergic remediation composition (III) for inhibiting histamine release
A kind of antiallergic remediation composition (III) with inhibition histamine release, by following components by weight percentage system
At: Fructus Monordicae extract 15%, phosphoglycerol inositol choline salt 2%, licorice 0.5%, Gotu Kola P.E 0.5%,
Polypeptide 0.2%, agastache extract 1.5%, Radix Gentianae extract 3%, polyalcohol 40%, water 37.3%.
Preparation method: being first pre-dissolved dispersion with polyalcohol for Fructus Monordicae extract, licorice, Gotu Kola P.E, then
With phosphoglycerol inositol choline salt, polypeptide, agastache extract, Radix Gentianae extract, which is added to the water, to be uniformly dissolved.
Embodiment 4 is a kind of with the antiallergic remediation composition (IV) for inhibiting histamine release
A kind of antiallergic remediation composition (IV) with inhibition histamine release, by following components by weight percentage system
At: Fructus Monordicae extract 9%, phosphoglycerol inositol choline salt 5%, licorice 2%, Gotu Kola P.E 2%, polypeptide
5%, agastache extract 1.5%, Radix Gentianae extract 3%, polyalcohol 40%, water 32.5%.
Preparation method: being first pre-dissolved dispersion with polyalcohol for Fructus Monordicae extract, licorice, Gotu Kola P.E, then
With phosphoglycerol inositol choline salt, polypeptide, agastache extract, Radix Gentianae extract, which is added to the water, to be uniformly dissolved.
A kind of antiallergic remediation composition (I) of comparative example 1
A kind of antiallergic remediation composition (I), is made of following components by weight percentage: phosphoglycerol inositol choline
Salt 1%, licorice 2%, Gotu Kola P.E 1%, polyalcohol 50%, water 46%.
Preparation method: being first pre-dissolved dispersion with polyalcohol for licorice, Gotu Kola P.E, then with phosphoglycerol inositol
Choline salt, which is added to the water, to be uniformly dissolved.
A kind of antiallergic remediation composition (II) of comparative example 2
A kind of antiallergic remediation composition (II), is made of following components by weight percentage: licorice 2%,
Gotu Kola P.E 1%, polypeptide 0.5%, polyalcohol 50%, water 46.5%.
Preparation method: licorice, Gotu Kola P.E first will be pre-dissolved dispersion with polyalcohol, then water is added with polypeptide
In be uniformly dissolved.
A kind of antiallergic remediation composition (III) of comparative example 3
A kind of antiallergic remediation composition (III), is made of following components by weight percentage: phosphoglycerol inositol gallbladder
Alkali salt 1%, polypeptide 0.5%, agastache extract 2%, Radix Gentianae extract 3%, polyalcohol 50%, water 43.5%,
Preparation method: by phosphoglycerol inositol choline salt, polypeptide, agastache extract, Radix Gentianae extract is added to the water molten
Solution is uniform.
A kind of antiallergic remediation composition (IV) of comparative example 4
A kind of antiallergic remediation composition (IV), is made of following components by weight percentage: phosphoglycerol inositol gallbladder
Alkali salt 0.5%, licorice 1%, Gotu Kola P.E 2%, polypeptide 1%, agastache extract 1%, Radix Gentianae extract
2%, polyalcohol 50%, water 42.5%,
Preparation method: first will be pre-dissolved dispersion with polyalcohol for licorice, Gotu Kola P.E, then with by phosphoglycerol
Inositol choline salt, polypeptide, agastache extract, Radix Gentianae extract, which is added to the water, to be uniformly dissolved.
Effect assessment
1 histamine of test example inhibits evaluation
1, the HPLC detection method of histamine content
Histamine is both without fluorescence chromophoric group or without ultraviolet chromophoric group, but dansyl Cl can be the same as the primary amine of histamine
Or the active hydrogen reaction in secondary amine, it takes off HCl and generates the derivative with fluorescence and ultraviolet light.
2, experimental material and method:
Material: DMEM, FBS, MTT, dansyl Cl, NaHCO3, ammonium hydroxide, acetonitrile, ammonium acetate
3, experimental method:
P815 cell culture:
(1) DMEM training base is drawn with liquid-transfering gun and dispel P815 cell cell dispersion, counted using Hemacytometer thin
Born of the same parents, then using DMEM come diluting cells, being diluted to concentration is 5 × 104cells/ml。
(2) cell solution after releasing is inoculated into respectively in 6well petri dish, each hole be 1ml, i.e., 0.5 ×
107cells/well。
(3) 37 DEG C, 5%CO2Incubator in cultivate 24 hours.
(4) sample to be tested and blank sample prepare: sample to be tested is trained base with DMEM and is diluted, and the concentration after dilution is respectively as follows: 2%
(concentration is tested by the MTT of front, and result is nontoxic).
After (5) 24 hours, 6well petri dish is placed in irradiation 20 seconds below 15W ultraviolet lamp, induction P815 is thin
Born of the same parents generate allergic reaction, discharge histamine.
(6) since P815 cell is the growth of half wall-attaching type, add 1ml's under the premise of being changed without Pei Ji, in blank sample
DMEM trains base, and the culture medium for containing 2% sample to add 1ml in test sample makes the concentration of sample in total culture medium reach 1%.
(7) after sample is added, 37 DEG C are put into, 5%CO2Incubator in cultivate 24 hours.
After (8) 24 hours, the culture medium for pipetting 200ul carries out the derivative reaction of histamine.
4, the HPLC analysis of histamine
(1) analyte derivative
It takes 100ul culture based in 2ml tube, sequentially adds and be saturated NaHCO3Solution 200ul, 10mg/ml dansyl Cl
Solution 400ul, lid plug whirlpool after mixing, are protected from light 60 minutes at room temperature.20% ammonium hydroxide-is added in reaction after sixty minutes
Acetonitrile solution 100ul, the reaction of termination in static 30 minutes.Whirlpool is uniformly mixed after 100ul acetonitrile is added, and is crossed 0.45um filter membrane and is carried out
HPLC analysis.
(2) chromatographic condition
Chromatographic column: Agilent C18 reverse-phase chromatographic column, 250mm × 4.6mm, 5um
Mobile phase: acetonitrile: 0.1mol/L ammonium acetate=80:20 (v:v)
Flow velocity: 1ml/min
Column temperature: 35 DEG C
Sample volume: 20ul
Ultraviolet detection wavelength: 254nm.
3, evaluation result
Shown in evaluation results are shown in Table 1.
Table 1 has the antiallergic remediation composition for inhibiting histamine release to histamine release suppression result
The result shows that of the invention there is the antiallergic remediation composition for inhibiting histamine release to have conspicuousness to histamine release
Inhibitory effect, inhibiting rate reach 81.44%.
2 hyaluronidase body outer suppressioning test of test example
There to be the antiallergic remediation composition for inhibiting histamine release according to Elson-Morgan made from embodiment, comparative example
Method is tried.[Ingo Muckenschnabel,Gunther Bernhardt,Thilo Spurss,
etal.Quantitation of hyaluronidases by the Morgan-Elson reaction:comparison
of the enzyme activities in the plasma of tumor patient and healthy
volunteers[J].Cancer Letters,1998,131:13-20.]
Evaluation criterion: 4 grades of standard scores, inhibition Shuai≤70% is strong anti-allergic effects；Inhibition Shuai≤50% is medium anti-mistake
Quick effect；30%≤inhibiting rate < 50% is weak anti-allergic effects；Inhibiting rate < 30% is no anti-allergic effects.
As seen from Figure 1, embodiment 1,2,3,4 have inhibit histamine release antiallergic remediation compositions in Elson-
Strong antiallergic effect is shown in Morgan method.
The test of 3 skin antipruritic effect of test example
The mouse ear swelling model of histamine induction: histamine induced skin inflammation carries out the mouse ear back side with itch
Depilation, using having his rice of the antiallergic remediation composition for inhibiting histamine release and 5% propionic acid times made from embodiment, comparative example
Pine respectively smears mouse affected part, continuous to smear two days, smears histamine to affected part, observation mouse scratches number.
As seen from Figure 2, there is embodiment 1 the antiallergic remediation composition for inhibiting histamine release to have the antipruritic effect of significant Shu Min
Fruit, it is substantially consistent with 5% betamethasone dipropionate effect.
1 antiallergic water of Application Example
By prepared by embodiment 1 there is the antiallergic remediation composition for inhibiting histamine release to be applied to antiallergic water.By weight hundred
Point than meter, antiallergic gel of releiving includes following components: 3% glycerol, 0.05% allantoin, 0.1% panthenol, 0.03% transparent
Matter acid sodium, 0,0.2% trehalose, 0.02% hyaluronic acid, 4% butanediol, 0.5% parahydroxyacet-ophenone, 0.4%1.2- oneself two
Prepared by alcohol, 5% embodiment 1 has the antiallergic remediation composition for inhibiting histamine release, and surplus is water.
The preparation method of above-mentioned antiallergic water, comprising the following steps:
(1) it pre-processes: hyaluronic acid being uniformly dispersed in glycerol, obtains component A；By parahydroxyacet-ophenone in butanediol
In, it is heated to dissolving transparent, obtains B component；
(2) by component A, allantoin, panthenol, hyaluronic acid are sequentially added in water, are warming up to 80 DEG C, stirring is equal to dissolving
It is even, cooling；
(3) when temperature is reduced to 60 DEG C, B component is added, is stirred until homogeneous；
(5) when temperature is reduced to 40 DEG C, the antiallergic with inhibition histamine release of 1.2- hexylene glycol and the preparation of embodiment 1 is repaired
Compound composition stirs homogeneous to substantially uniformity with the speed homogeneous 4min of 3000r/min；
(6) filtering and discharging is to get antiallergic water.
2 antiallergic of Application Example is releived gel
There is the antiallergic remediation composition for inhibiting histamine release to be applied to antiallergic releive gel by prepared by embodiment 1.It presses
Weight percent meter, antiallergic gel of releiving includes following components: 3% glycerol, 0.05% allantoin, 0.1% panthenol,
0.03% Sodium Hyaluronate, 0.4% Acritamer 940,0.4% acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymeric
Object, 3% dimethyl silicone polymer, 0.3% isononyl isononanoate, 0.2% Parleam, 0.05% tocopherol acetate,
4% butanediol, 0.1% methyl hydroxybenzoate, 0.05% Nipasol, 0.3% aminomethyl propanol, 0.2% Phenoxyethanol, 4% are implemented
Prepared by example 1 has the antiallergic remediation composition for inhibiting histamine release, and surplus is water.
Above-mentioned antiallergic is releived the preparation method of gel, comprising the following steps:
(1) it pre-processes: hyaluronic acid being uniformly dispersed in glycerol, obtains component A；By methyl hydroxybenzoate and Nipasol point
It is dispersed in butanediol, is heated to dissolving transparent, obtain B component；
(2) by component A, allantoin, panthenol, Acritamer 940, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters crosslinking
Polymer sequentially adds in water, is warming up to 80 DEG C, and stirring is to being uniformly dissolved；
(3) dimethyl silicone polymer, isononyl isononanoate, Parleam, tocopherol acetate are uniformly mixed, are added
In the solution for entering step (2) processing, with the speed homogeneous 7.5min of 3000r/min, homogeneous is stirred to substantially uniformity, cooling；
(4) when temperature is reduced to 60 DEG C, B component is added, is stirred until homogeneous；
(5) when temperature is reduced to 40 DEG C, aminomethyl propanol, Phenoxyethanol and the preparation of embodiment 1 is added has antiallergic sense
The Chinese medicine composition of effect stirs homogeneous to substantially uniformity with the speed homogeneous 4min of 3000r/min；
(6) vacuum defoamation, filtering and discharging are releived gel to get antiallergic.
3 antiallergic of Application Example is releived lotion
There is the antiallergic remediation composition for inhibiting histamine release to be applied to antiallergic releive lotion by prepared by embodiment 1.It presses
Weight percent meter, antiallergic lotion of releiving includes following components: 1.2% polyglycereol -3- methyl distearate,
0.5% stearine, 0.5% stearic acid, 0.3% mango seed rouge, 3% Trivent OCG, 3% white pond flower seed oil, 3%
Parleam, 0.1% vitamin E, 0.5% dimethyl silicone polymer, 0.02%EDTA-2Na, 3% glycerol, 5%1,3-
Butanediol, 0.05% Sodium Hyaluronate, 0.15% carbomer, 0.2% glucan, 0.3% Phenoxyethanol, 0.2% methyl hydroxybenzoate,
0.1% Nipasol, 0.09% aminomethyl propanol, 0.1% essence, 20% embodiment 1 be obtained to be had and inhibits histamine release
Antiallergic remediation composition, surplus are water.
Above-mentioned antiallergic is releived the preparation method of lotion, comprising the following steps:
(1) will 1,3-BDO and Sodium Hyaluronate mix after be evenly stirred until transparent, obtain component A, carbomer matched
At the carbomer aqueous dispersions of mass concentration 1%；
(2) polyglycereol -3- methyl distearate, stearine, stearic acid, mango seed rouge, octanoic acid is sweet
After oily three esters, white pond flower seed oil, Parleam, vitamin E and dimethyl silicone polymer mixing, 80 DEG C are heated with stirring to,
As oily phase；
(3) deionized water, EDTA-2Na, glycerol, component A are mixed, 80 DEG C is heated with stirring to, as water phase；
(4) oil is added in water phase, with the revolving speed homogeneous 3min of 1000r/min, and stirs cooling；
(5) when temperature is down to 65 DEG C, 1% carbomer aqueous dispersions are added, homogeneous 2min is stirred until homogeneous；
(6) when temperature is down to 45 DEG C, be added glucan, Phenoxyethanol, methyl hydroxybenzoate, Nipasol, aminomethyl propanol,
Prepared by essence and embodiment 1 has the antiallergic remediation composition for inhibiting histamine release.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
Claims (9)
1. a kind of with the antiallergic remediation composition for inhibiting histamine release, which is characterized in that containing it is following by weight percentage
Component: Fructus Monordicae extract 5-15%, phosphoglycerol inositol choline salt 0.5-5%, licorice 0.2-2%, centella mention
Take object 0.1-2%, polypeptide 0.1-5%, agastache extract 0.5-3%, Radix Gentianae extract 1-5%, polyalcohol 30-50%, water
30-40%.
2. according to claim 1 have the antiallergic remediation composition for inhibiting histamine release, which is characterized in that containing pressing below
The component of weight percent meter: Fructus Monordicae extract 10%, phosphoglycerol inositol choline salt 1%, licorice 2%, accumulated snow
Careless extract 1%, polypeptide 0.5%, agastache extract 2%, Radix Gentianae extract 3%, polyalcohol 45%, water 35.5%.
3. according to claim 1 have the antiallergic remediation composition for inhibiting histamine release, which is characterized in that containing pressing below
The component of weight percent meter: Fructus Monordicae extract 8%, phosphoglycerol inositol choline salt 0.5%, licorice 1%, accumulated snow
Careless extract 2%, polypeptide 1%, agastache extract 1%, Radix Gentianae extract 2%, polyalcohol 50%, water 34.5%.
4. according to claim 1 have the antiallergic remediation composition for inhibiting histamine release, which is characterized in that containing pressing below
The component of weight percent meter: Fructus Monordicae extract 15%, phosphoglycerol inositol choline salt 2%, licorice 0.5%, product
Avenge careless extract 0.5%, polypeptide 0.2%, agastache extract 1.5%, Radix Gentianae extract 3%, polyalcohol 40%, water
37.3%.
5. according to claim 1 have the antiallergic remediation composition for inhibiting histamine release, which is characterized in that containing pressing below
The component of weight percent meter: Fructus Monordicae extract 9%, phosphoglycerol inositol choline salt 5%, licorice 2%, centella
Extract 2%, polypeptide 5%, agastache extract 1.5%, Radix Gentianae extract 3%, polyalcohol 40%, water 32.5%.
6. according to any one of claims 1-5 have the antiallergic remediation composition for inhibiting histamine release, feature exists
In the polyalcohol is butanediol, the mixing of propylene glycol one or two；The polypeptide is palmitic acid acyl tetrapeptide -7, acetyl group four
The one or two kinds of mixing of peptide -15；The water is deionized water.
7. the preparation side with the antiallergic remediation composition for inhibiting histamine release according to claim 1 to 6
Method, which comprises the following steps:
Fructus Monordicae extract, licorice, Gotu Kola P.E are first pre-dissolved dispersion with polyalcohol, then with phosphoglycerol inositol
Choline salt, polypeptide, agastache extract, Radix Gentianae extract, which is added to the water, to be uniformly dissolved.
8. the application with the antiallergic remediation composition for inhibiting histamine release according to claim 1 to 6,
It is characterized in that, the composition is for being configured to cosmetics.
9. the application with the antiallergic remediation composition for inhibiting histamine release according to claim 8, which is characterized in that institute
State the 0.5-8% that composition accounts for the cosmetics total weight.
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