CN115227624A - Infant skin care oil containing nut oil - Google Patents
Infant skin care oil containing nut oil Download PDFInfo
- Publication number
- CN115227624A CN115227624A CN202211051884.4A CN202211051884A CN115227624A CN 115227624 A CN115227624 A CN 115227624A CN 202211051884 A CN202211051884 A CN 202211051884A CN 115227624 A CN115227624 A CN 115227624A
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- CN
- China
- Prior art keywords
- oil
- skin care
- momordica grosvenori
- parts
- crushed
- Prior art date
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- Granted
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- 239000003921 oil Substances 0.000 title claims abstract description 74
- 235000019198 oils Nutrition 0.000 title claims abstract description 74
- 235000019488 nut oil Nutrition 0.000 title claims abstract description 41
- 239000010466 nut oil Substances 0.000 title claims abstract description 41
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims abstract description 46
- 244000185386 Thladiantha grosvenorii Species 0.000 claims abstract description 46
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000000341 volatile oil Substances 0.000 claims abstract description 30
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 16
- 229940046009 vitamin E Drugs 0.000 claims abstract description 16
- 239000011709 vitamin E Substances 0.000 claims abstract description 16
- 244000144725 Amygdalus communis Species 0.000 claims abstract description 12
- 235000011437 Amygdalus communis Nutrition 0.000 claims abstract description 11
- 239000008168 almond oil Substances 0.000 claims abstract description 11
- 235000019498 Walnut oil Nutrition 0.000 claims abstract description 10
- 239000008170 walnut oil Substances 0.000 claims abstract description 10
- 239000002131 composite material Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 238000011282 treatment Methods 0.000 claims description 24
- 241001313857 Bletilla striata Species 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 19
- 238000003756 stirring Methods 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 14
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- 238000005303 weighing Methods 0.000 claims description 12
- 239000011259 mixed solution Substances 0.000 claims description 8
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- 239000002537 cosmetic Substances 0.000 claims description 6
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- 239000000203 mixture Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 4
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- 239000008363 phosphate buffer Substances 0.000 claims description 4
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- 238000009210 therapy by ultrasound Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000010025 steaming Methods 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 abstract description 16
- 208000024891 symptom Diseases 0.000 abstract description 10
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- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 25
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 18
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- 206010030113 Oedema Diseases 0.000 description 10
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- 210000005069 ears Anatomy 0.000 description 6
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- 231100000444 skin lesion Toxicity 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- VYZAHLCBVHPDDF-UHFFFAOYSA-N Dinitrochlorobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 VYZAHLCBVHPDDF-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 230000005284 excitation Effects 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 241001313855 Bletilla Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 235000014571 nuts Nutrition 0.000 description 3
- 238000002390 rotary evaporation Methods 0.000 description 3
- 206010051814 Eschar Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000002199 base oil Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000002951 depilatory effect Effects 0.000 description 2
- 231100000333 eschar Toxicity 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 238000011552 rat model Methods 0.000 description 2
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- 231100000314 skin damage score Toxicity 0.000 description 2
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- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 241000208223 Anacardiaceae Species 0.000 description 1
- 235000009025 Carya illinoensis Nutrition 0.000 description 1
- 244000068645 Carya illinoensis Species 0.000 description 1
- 241000723382 Corylus Species 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000019487 Hazelnut oil Nutrition 0.000 description 1
- 241000758791 Juglandaceae Species 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000020226 cashew nut Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229940021231 clearskin Drugs 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000010468 hazelnut oil Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
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- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229940052016 turmeric extract Drugs 0.000 description 1
- 235000020240 turmeric extract Nutrition 0.000 description 1
- 239000008513 turmeric extract Substances 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a baby skin care oil containing nut oil, which comprises 100 parts of composite nut oil, 1-3 parts of momordica grosvenori volatile oil and 3-8 parts of vitamin E; wherein the composite nut oil is prepared from the following components in a mass ratio of 1: 0.1-0.2 of sweet almond oil and walnut oil are evenly mixed to prepare the oil. The baby skin care oil prepared by the invention has higher stability, can relieve eczema symptoms and has an anti-inflammatory effect.
Description
Technical Field
The invention relates to the field of skin care product preparation. More particularly, the present invention relates to a skin care oil for infants comprising nut oil.
Background
The nuts are plant raw materials with high oil content, common nuts comprise almonds, walnuts, cashews, hazelnuts, pecans and the like, and the oil extracted from the nuts can be applied to the fields of food, cosmetics and skin care products and the like, such as sweet almond oil, walnut oil, hazelnut oil and the like. In the prior art, sweet almond oil is often used as base oil of skin care oil, has the magical effects of easy absorption, nourishing and moisturizing and is convenient to use. At present, most of the existing baby skin care oils only have the efficacy of moisturizing or nourishing skin, have single function, and urgently need to develop more skin care oil products with safety and other efficacies.
Disclosure of Invention
An object of the present invention is to solve at least the above problems and to provide a baby skin care oil containing nut oil, which has a good treatment effect on eczema and a certain anti-inflammatory effect by adding momordica grosvenori volatile oil and bletilla striata treatment substances, and improves the efficacy of the baby skin care oil.
To achieve these objects and other advantages in accordance with the present invention, there is provided a nut oil-containing skin care oil for infants comprising the following components in parts by weight:
100 parts of compound nut oil, 1-3 parts of momordica grosvenori volatile oil and 3-8 parts of vitamin E;
wherein the composite nut oil is prepared from the following components in a mass ratio of 1: 0.1-0.2 of sweet almond oil and walnut oil are evenly mixed to prepare the oil.
Preferably, the momordica grosvenori volatile oil is prepared by the following steps: and putting the crushed momordica grosvenori into deionized water, uniformly stirring, then putting at 100 ℃ for refluxing for 5-6 hours to obtain an oil-water mixed solution, and extracting and rotationally steaming the oil-water mixed solution to obtain the momordica grosvenori volatile oil.
Preferably, before the crushed momordica grosvenori is placed in deionized water, the crushed momordica grosvenori is placed in 0.2M phosphoric acid buffer solution, then the crushed momordica grosvenori is placed at 45-50 ℃ and heated for 15-20 min, then the crushed momordica grosvenori is placed in an ultrasonic environment and subjected to ultrasonic treatment for 15-20 min to obtain treatment liquid, and then the deionized water is added into the treatment liquid for reflux; the mass ratio of the crushed momordica grosvenori to the phosphate buffer is 1:2.5.
preferably, the bletilla striata health food further comprises 5 to 10 parts by weight of bletilla striata treatment substance.
Preferably, the bletilla striata treatment product is prepared as follows: weighing the crushed cortex dictamni, placing the crushed cortex dictamni into white oil special for cosmetics, slowly stirring the mixture for 12 to 24 hours at the temperature of between 40 and 45 ℃, filtering the mixture, collecting filtrate, and cooling the filtrate to room temperature to obtain a bletilla striata treatment substance; wherein the mass ratio of the bletilla striata to the white oil is 1:5 to 10.
Preferably, the preparation of the skin care oil specifically comprises the following steps: weighing the compound nut oil, the momordica grosvenori volatile oil, the vitamin E and the bletilla striata treatment substance according to the proportion, and uniformly stirring at the temperature of 20-25 ℃ to obtain the traditional Chinese medicine composition.
The invention at least comprises the following beneficial effects:
firstly, the momordica grosvenori volatile oil is added, so that the eczema symptom can be effectively relieved; the treatment effect of eczema can be further improved in an auxiliary way by adding the bletilla striata treatment substance.
Secondly, the invention provides the baby skin care oil, the raw materials of which are derived from natural substances, no other chemical additives are contained, the use is safe, the eczema symptom can be effectively relieved, and the baby skin care oil has high stability and a certain anti-inflammation effect.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
The invention discloses infant skin care oil containing nut oil, which takes the disclosed components (compound nut oil, fructus momordicae volatile oil, vitamin E and bletilla striata treatment product) as basic effective components, and can be added with other functional components such as moisturizing and nourishing components (such as hyaluronic acid, avocado oil unsaponifiable matters and the like), water film repairing factors (such as caprylic/capric triglyceride), anti-irritation components (such as turmeric extract, alpha-bisabolol and the like), preservatives, antioxidants and the like when being prepared into commodities.
< example 1>
An infant skin care oil containing nut oil comprises the following formula components:
100 parts of compound nut oil, 3 parts of momordica grosvenori volatile oil and 8 parts of vitamin E; wherein the composite nut oil is prepared from the following components in a mass ratio of 1:0.2 of sweet almond oil and walnut oil are evenly mixed to prepare the oil; the sweet almond oil and the walnut oil are skin-care base oil well known to those skilled in the art, the sweet almond oil, the walnut oil and the vitamin E are all purchased from the market, and the momordica grosvenori volatile oil is prepared by a conventional steam distillation method;
preparing skin care oil: weighing the compound nut oil, the momordica grosvenori volatile oil and the vitamin E according to the proportion, and uniformly stirring at 25 ℃ to obtain the skin care oil.
< example 2>
An infant skin care oil containing nut oil, which comprises the following formula components:
100 parts of compound nut oil, 1 part of momordica grosvenori volatile oil and 3 parts of vitamin E; wherein the composite nut oil is prepared from the following components in a mass ratio of 1:0.1 of sweet almond oil and walnut oil are evenly mixed to prepare the oil;
the preparation method of the momordica grosvenori volatile oil comprises the following steps: placing the crushed momordica grosvenori into deionized water, stirring uniformly, placing at 100 ℃ for refluxing for 5 hours to obtain an oil-water mixed solution, extracting the oil-water mixed solution by using n-hexane, taking a n-hexane extraction layer, and removing the n-hexane by rotary evaporation to obtain the momordica grosvenori volatile oil; wherein the mass ratio of the crushed momordica grosvenori to the deionized water is 1:6;
preparing skin care oil: weighing the compound nut oil, the momordica grosvenori volatile oil and the vitamin E according to the proportion, and uniformly stirring at 25 ℃ to obtain the skin care oil.
< example 3>
An infant skin care oil containing nut oil, which comprises the following formula components:
100 parts of compound nut oil, 3 parts of momordica grosvenori volatile oil, 8 parts of vitamin E and 10 parts of bletilla striata treatment substances; wherein the composite nut oil is prepared from the following components in percentage by mass of 1:0.2 of sweet almond oil and walnut oil are evenly mixed to prepare the oil;
the preparation method of the momordica grosvenori volatile oil comprises the following steps: placing the crushed momordica grosvenori into deionized water, stirring uniformly, placing at 100 ℃ for refluxing for 6 hours to obtain an oil-water mixed solution, extracting the oil-water mixed solution by using n-hexane, taking a n-hexane extraction layer, and removing the n-hexane by rotary evaporation to obtain the momordica grosvenori volatile oil; wherein the mass ratio of the crushed momordica grosvenori to the deionized water is 1:6;
the rhizoma bletilla processed product is prepared as follows: weighing pulverized cortex Dictamni Radicis, placing in white oil special for cosmetics, slowly stirring at 45 deg.C for 24 hr, filtering, collecting filtrate, and cooling to room temperature to obtain rhizoma Bletillae treated substance; wherein the mass ratio of the bletilla striata to the white oil is 1:10.
preparing skin care oil: weighing the compound nut oil, the momordica grosvenori volatile oil, the vitamin E and the bletilla striata treatment substances according to the proportion, and uniformly stirring at 25 ℃ to obtain the skin care oil.
< example 4>
An infant skin care oil containing nut oil comprises the following formula components:
100 parts of compound nut oil, 3 parts of momordica grosvenori volatile oil, 8 parts of vitamin E and 5 parts of bletilla striata treatment substance; wherein the composite nut oil is prepared from the following components in a mass ratio of 1:0.2 of sweet almond oil and walnut oil are evenly mixed to prepare the oil;
the preparation method of the momordica grosvenori volatile oil comprises the following steps: putting crushed momordica grosvenori into 0.2M phosphoric acid buffer solution, heating at 50 ℃ for 15min, then carrying out ultrasonic treatment at 40Hz for 15min to obtain treatment liquid, adding deionized water into the treatment liquid, carrying out reflux at 100 ℃ for 6h to obtain oil-water mixed liquid, then extracting the oil-water mixed liquid by using n-hexane, taking an n-hexane extraction layer, and carrying out rotary evaporation to remove the n-hexane to obtain momordica grosvenori volatile oil; wherein the mass ratio of the crushed momordica grosvenori to the phosphate buffer is 1-2.5, and the mass ratio of the crushed momordica grosvenori to the deionized water is 1:6;
the rhizoma bletilla processed product is prepared as follows: weighing pulverized cortex Dictamni Radicis, placing in white oil special for cosmetics, slowly stirring at 40 deg.C for 12 hr, filtering, collecting filtrate, and cooling to room temperature to obtain rhizoma bletilla processed product; wherein the mass ratio of the bletilla striata to the white oil is 1:5.
preparing skin care oil: weighing the compound nut oil, the momordica grosvenori volatile oil, the vitamin E and the bletilla striata treatment substance according to the proportion, and uniformly stirring at 25 ℃ to obtain the skin care oil.
< comparative example 1>
An infant skin care oil containing nut oil is the same as that in example 2, except that momordica grosvenori volatile oil is not added in comparative example 1.
Preparing skin care oil: weighing the compound nut oil and the vitamin E according to the proportion, and uniformly stirring at 25 ℃ to obtain the skin care oil.
< comparative example 2>
An infant skin care oil containing nut oil is similar to that in example 2, except that the momordica grosvenori volatile oil in example 2 is replaced by a momordica grosvenori ethanol extract, and extraction is performed in a conventional extraction mode, wherein the ethanol concentration is 70%, and the ratio of material to liquid is 1:15, refluxing extraction time is 4h, and extraction temperature is 70 ℃.
< acute skin irritation test >
The acute skin irritation test is carried out according to technical Specification for safety of cosmetics (2021), and the test is as follows:
SD rats of 5 male and female animals each were selected, and both sides of the dorsal spine were cut off 24 hours before the test without damaging the skin, about 2cm × 2cm each. 0.5ml of the test substance is directly smeared on one side of the skin, and then covered by two layers of gauze and fixed by a non-irritant adhesive plaster. The skin on the other side was a blank control. The application time is 4h, and then warm water is used for removing residual test substances. At 2h after the removal of the test substance, the skin of the dorsal application part of the SD rat was observed for erythema and edema, and the skin was scored according to the degree of erythema and edema in tables 1 and 2, and the average value of the scores of the 10 test groups (i.e., the reaction average score) was taken as the final score. The skin irritation of the test article was graded by table 3. Wherein the mean score of the response = (total score of erythema formation + total score of edema formation)/total number of animals.
TABLE 1 erythema degree Scoring Standard
| Erythema and eschar formation | Score value |
| No erythema | 0 |
| Mild erythema (barely visible) | 1 |
| Obvious erythema | 2 |
| Moderate or severe erythema | 3 |
| Severe erythema (purplish red) to slight eschar formation | 4 |
TABLE 2 edema degree score criteria
| Edema formation | Score value |
| Without edema | 0 |
| Slight edema (barely visible) | 1 |
| Mild edema (clear outline of skin bulge) | 2 |
| Moderate edema (skin doming about 1 mm) | 3 |
| Severe edema (skin doming over 1mm, extended range) | 4 |
TABLE 3 evaluation criteria for skin irritation intensity
| Mean score of reaction | Evaluation of |
| 0-0.49 | Has no irritation |
| 0.5-2.99 | Mild irritation |
| 3.0-5.99 | Moderate irritation |
| 6.0-8.0 | Strong irritation |
Sample preparation: the skin care oils of examples 1 to 4 and comparative examples 1 to 2 were used as test substances, and acute skin irritation tests were performed to record skin irritation intensity, and the specific results are shown in table 4.
TABLE 4 acute skin irritation test results of examples and comparative examples
| Experimental group | Skin irritation |
| Example 1 | 0 |
| Example 2 | 0 |
| Example 3 | 0 |
| Example 4 | 0 |
| Comparative example 1 | 0 |
| Comparative example 2 | 0 |
As can be seen from Table 4, the skin care oils prepared in examples 1-4 and comparative examples 1-2 are non-irritating to the skin of the tested rats, which indicates that the skin care oil prepared by the invention is non-irritating to the skin and relatively safe.
< stability test >
The skin care oils prepared in examples 1 to 4 and comparative example 1 were placed in an oven at 45 ℃ for 30 days and then taken out, and compared with a sample placed at room temperature, color and odor were observed, and the results are shown in table 5:
table 5 skin oil stability test results in each of examples and comparative examples
| Experimental group | Apparent color | Smell(s) |
| Example 1 | Without obvious change | Without obvious change |
| Example 2 | Without obvious change | Without obvious change |
| Example 3 | Without obvious change | Without obvious change |
| Example 4 | Without obvious change | Without obvious change |
| Comparative example 1 | Without obvious change | Without obvious change |
| Comparative example 2 | Without obvious change | Without obvious change |
As can be seen from table 5, the skin care oils prepared in examples 1 to 4 and comparative examples 1 to 2 have better stability.
< replication of Chronic eczema rat model >
1. Experimental reagent
2, 4-Dinitrochlorobenzene (DNCB) (analytically pure), acetone solution (analytically pure), depilatory cream (from vettin), baby emollient oil (from Qiangsheng)
2. Experimental animals and groups
90 healthy SD male rats weighing 200 + -20 g; after one week of adaptive feeding of SD rats with basal feed and purified water, the SD rats were randomly divided into a blank group, a chronic eczema group, an example 1 group, an example 2 group, an example 3 group, an example 4 group, a comparative example 1 group, a comparative example 2 group and a model group, and 10 rats were housed in cages.
3. Replication of animal models
Depilating the skin of the back of the rat with depilatory cream, depilating the area 4cm × 4cm, applying 5% DNCB acetone solution 100 μ l to the skin of the depilated area, exciting once every 5d, and exciting 4 times continuously. The blank group did not have any excitation, and the other experimental groups were excited. Erythema, pimples, scratches, scales and scabs gradually appear on the skin at the depilated part after the first excitation, the skin damage condition is recorded after each excitation and scored according to a table 6, the average score of 10 groups of experiments is taken, the average score of the average scores of four excitations is taken as the final skin damage score, and the specific result is shown in a table 7.
4. Result of molding
2, 4-dinitrochlorobenzene is applied to repeatedly stimulate the back skin of a rat, so that the back skin of the rat has skin lesion expressions such as erythema, pimple, scale, lichenification and the like which accord with the clinical expression of chronic eczema, and a chronic eczema rat model is further established. The results show that: the skin on the back of the rats in the blank group has no symptoms, is light red, and has clear skin texture and soft texture; more specifically, as shown in table 7, the rats in the example 1 group to the example 4 group and the comparative example 1 group to the comparative example 2 all had significant skin lesions on the backs, had visible skin symptoms such as erythema, scales, scabbing, rough thickening, pigmentation and the like, and met the diagnosis standard of chronic eczema, and the rats were successfully modeled.
TABLE 6 skin Damage Performance Scoring standards
| Manifestation of skin damage | Score value |
| Without skin lesions (asymptomatic) | 0 |
| Slight skin damage (symptoms can be seen after careful observation) | 0～1 |
| Moderate skin lesions (symptoms are immediately visible) | 1～2 |
| Severe skin damage (very obvious symptoms) | 2～3 |
TABLE 7 skin Damage scoring results for each experimental group
| Experimental group | Skin damage scoring |
| Blank space | 0 |
| Chronic eczema group | 2.813 |
| Example 1 | 2.790 |
| Example 2 | 2.788 |
| Example 3 | 2.775 |
| Example 4 | 2.800 |
| Comparative example 1 | 2.810 |
| Comparative example 2 | 2.820 |
| Model (model) | 2.805 |
5. Therapeutic effects
In each experimental group, the blank group and the chronic eczema group were not treated with drugs, the skin care oils prepared in examples 1 to 4 were applied to groups of examples 1 to 4, the skin care oils prepared in comparative examples 1 to 2 were applied to groups of comparative examples 1 to 2, respectively, the skin care oils for infant invigoration were applied to groups of models, the skin care oils were applied in an amount of 0.1mL per square centimeter area of skin, the skin care oils were applied twice a day, each time at intervals of 12 hours, continuously applied for 7 days, fasted and water-free after the last application, and the skin lesions of the affected parts of rats in each group were scored after 12 hours, and the experimental results are shown in table 8.
TABLE 8 evaluation results of skin lesions on the backs of rats in each experimental group
As can be seen from table 8, the skin care oil prepared by the present application can effectively relieve the chronic eczema symptom of rats by applying the skin care oil, wherein, the addition of the bletilla striata treatment substance can further treat the chronic eczema of rats compared with the data of examples 3 to 4 and examples 1 to 2.
< Effect of swelling of mouse auricle due to Paraxylene >
30 mice (18-22 g) were divided into a blank group, an example 2 group and a comparative example 1 group, each group containing 10 mice, each of which was divided into male and female halves at random according to sex and body weight. The control is prepared by uniformly coating the right ears of mice in a blank group with 0.5ml of physiological saline, the right ears of mice in an example 2 group with 0.5ml of the skin care oil in an example 2, the right ears of mice in a comparative example 1 group with 0.5ml of the skin care oil in a comparative example 1, uniformly coating the two sides of each right ear of each group of mice with 0.05ml of dimethylbenzene to cause inflammation after coating for 10 minutes, and not coating the left ears of the mice. After 30 minutes of xylene application, the mice were sacrificed, the left and right ears of the mice were cleaned with distilled water and dried, the same portions of the left and right ears were cut off in equal areas with a punch having a diameter of 8mm, and weighed with an electronic balance. The difference between the weights of the left and right ear pieces was used as the swelling index to calculate the swelling index for each experimental group, and the specific results are shown in Table 9.
TABLE 9 results of swelling degree and swelling inhibition ratio in each experimental group
| Experimental group | Number of mice | Swelling degree (mg) |
| Blank space | 10 | 9.2 |
| Example 2 | 10 | 3.8 |
| Comparative example 1 | 10 | 6.3 |
As can be seen from table 9, the swelling degree of the mice is effectively relieved by applying the skin care oil, which indicates that the skin care oil has a certain anti-inflammatory effect.
In conclusion, the skin care oil prepared from the momordica grosvenori volatile oil has certain effects of relieving chronic eczema and diminishing inflammation, and can further relieve the symptoms of chronic eczema after being assisted by the bletilla striata treatment substance.
While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable to various fields of endeavor for which the invention may be embodied with additional modifications as would be readily apparent to those skilled in the art, and the invention is therefore not limited to the details given herein and to the embodiments shown and described without departing from the generic concept as defined by the claims and their equivalents.
Claims (6)
1. The infant skin care oil containing nut oil is characterized by comprising the following components in parts by weight:
100 parts of compound nut oil, 1-3 parts of momordica grosvenori volatile oil and 3-8 parts of vitamin E;
wherein the composite nut oil is prepared from the following components in a mass ratio of 1: 0.1-0.2 of sweet almond oil and walnut oil are evenly mixed to prepare the oil.
2. The nut oil-containing infant skin oil of claim 1, wherein the lo han guo volatile oil is prepared by: putting the crushed momordica grosvenori into deionized water, uniformly stirring, then placing at 100 ℃ for refluxing for 5-6 hours to obtain an oil-water mixed solution, and extracting and rotationally steaming the oil-water mixed solution to obtain the momordica grosvenori volatile oil.
3. The nut oil-containing infant skin care oil according to claim 2, wherein before placing the crushed momordica grosvenori in deionized water, the crushed momordica grosvenori is placed in 0.2M phosphate buffer, then is placed at 45-50 ℃ for heating for 15-20 min, is placed in an ultrasonic environment for ultrasonic treatment for 15-20 min to obtain a treatment solution, and then is added with deionized water for reflux; the mass ratio of the crushed momordica grosvenori to the phosphate buffer is 1:2.5.
4. the nut oil-containing infant skin care oil according to claim 1, further comprising 5 to 10 parts by weight of a bletilla striata treatment.
5. The nut oil containing infant skin oil of claim 4, wherein the bletilla striata treatments are prepared as follows: weighing the crushed cortex dictamni, placing the crushed cortex dictamni into white oil special for cosmetics, slowly stirring the mixture for 12 to 24 hours at the temperature of between 40 and 45 ℃, filtering the mixture, collecting filtrate, and cooling the filtrate to room temperature to obtain a bletilla striata treatment substance; wherein the mass ratio of the bletilla striata to the white oil is 1:5 to 10.
6. The nut oil-containing infant skin care oil of claim 5, wherein the skin care oil is prepared by: weighing the compound nut oil, the momordica grosvenori volatile oil, the vitamin E and the bletilla striata treatment substances according to the proportion, and uniformly stirring at the temperature of 20-25 ℃ to obtain the traditional Chinese medicine composition.
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Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559494A (en) * | 2004-02-22 | 2005-01-05 | 通化方大药业股份有限公司 | Medicine for treating throat disease |
| CN1732019A (en) * | 2002-10-28 | 2006-02-08 | 高砂香料工业株式会社 | Deodorant composition |
| CN102499373A (en) * | 2011-11-21 | 2012-06-20 | 广西壮族自治区农业科学院农产品加工研究所 | Siraitia grosvenorii seed oil microcapsule powder and preparation method thereof |
| CN102688171A (en) * | 2012-06-18 | 2012-09-26 | 陈小锋 | Infant skin care oil and preparation method thereof |
| CN104606081A (en) * | 2013-11-05 | 2015-05-13 | 邹诚杰 | Pure natural massage skin moistening oil for babies |
| CN105018259A (en) * | 2015-08-10 | 2015-11-04 | 李大兴 | Handmade soap with momordica grosvenori and derivatives and preparation method of handmade soap |
| CN108498654A (en) * | 2018-06-01 | 2018-09-07 | 西安泉脉生物科技有限公司 | The composition and preparation method for the treatment of breathing problem, bite by mosquitos, rubella redness |
| WO2018186705A1 (en) * | 2017-04-05 | 2018-10-11 | 한국 한의학 연구원 | Composition, containing siraitia grosvenorii residue extract as active ingredient, for prevention, alleviation, or treatment of inflammation |
| CN108938498A (en) * | 2018-09-25 | 2018-12-07 | 广州好润生物科技有限公司 | A kind of antiallergic remediation composition and its preparation method and application with inhibition histamine release |
| CN109054991A (en) * | 2018-08-31 | 2018-12-21 | 湖南华诚生物资源股份有限公司 | A method of extracting arhat fruit seed oil from arhat fruit seed |
| CN109364001A (en) * | 2018-11-08 | 2019-02-22 | 中山爱护日用品有限公司 | It is a kind of to have effects that anti-irritant and the baby skin protection repaired oil and preparation method and application |
| CN109453056A (en) * | 2018-11-12 | 2019-03-12 | 宁波蒙曼生物科技有限公司 | A kind of moisture saver mask liquid and preparation method thereof |
| CN113398157A (en) * | 2021-07-14 | 2021-09-17 | 湖南华诚生物资源股份有限公司 | Method for continuously extracting and separating multiple natural active ingredients from momordica grosvenori flower |
-
2022
- 2022-08-30 CN CN202211051884.4A patent/CN115227624B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732019A (en) * | 2002-10-28 | 2006-02-08 | 高砂香料工业株式会社 | Deodorant composition |
| CN1559494A (en) * | 2004-02-22 | 2005-01-05 | 通化方大药业股份有限公司 | Medicine for treating throat disease |
| CN102499373A (en) * | 2011-11-21 | 2012-06-20 | 广西壮族自治区农业科学院农产品加工研究所 | Siraitia grosvenorii seed oil microcapsule powder and preparation method thereof |
| CN102688171A (en) * | 2012-06-18 | 2012-09-26 | 陈小锋 | Infant skin care oil and preparation method thereof |
| CN104606081A (en) * | 2013-11-05 | 2015-05-13 | 邹诚杰 | Pure natural massage skin moistening oil for babies |
| CN105018259A (en) * | 2015-08-10 | 2015-11-04 | 李大兴 | Handmade soap with momordica grosvenori and derivatives and preparation method of handmade soap |
| WO2018186705A1 (en) * | 2017-04-05 | 2018-10-11 | 한국 한의학 연구원 | Composition, containing siraitia grosvenorii residue extract as active ingredient, for prevention, alleviation, or treatment of inflammation |
| CN108498654A (en) * | 2018-06-01 | 2018-09-07 | 西安泉脉生物科技有限公司 | The composition and preparation method for the treatment of breathing problem, bite by mosquitos, rubella redness |
| CN109054991A (en) * | 2018-08-31 | 2018-12-21 | 湖南华诚生物资源股份有限公司 | A method of extracting arhat fruit seed oil from arhat fruit seed |
| CN108938498A (en) * | 2018-09-25 | 2018-12-07 | 广州好润生物科技有限公司 | A kind of antiallergic remediation composition and its preparation method and application with inhibition histamine release |
| CN109364001A (en) * | 2018-11-08 | 2019-02-22 | 中山爱护日用品有限公司 | It is a kind of to have effects that anti-irritant and the baby skin protection repaired oil and preparation method and application |
| CN109453056A (en) * | 2018-11-12 | 2019-03-12 | 宁波蒙曼生物科技有限公司 | A kind of moisture saver mask liquid and preparation method thereof |
| CN113398157A (en) * | 2021-07-14 | 2021-09-17 | 湖南华诚生物资源股份有限公司 | Method for continuously extracting and separating multiple natural active ingredients from momordica grosvenori flower |
Non-Patent Citations (1)
| Title |
|---|
| 陈海燕等: "气相色谱-质谱法分析无籽罗汉果果实中挥发油成分", 广西大学学报(自然科学版), vol. 36, no. 3, pages 489 - 492 * |
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