CN110151585A - One kind having whitening desalination acne print performance oligopeptides stoste and preparation method thereof - Google Patents
One kind having whitening desalination acne print performance oligopeptides stoste and preparation method thereof Download PDFInfo
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- CN110151585A CN110151585A CN201910599536.2A CN201910599536A CN110151585A CN 110151585 A CN110151585 A CN 110151585A CN 201910599536 A CN201910599536 A CN 201910599536A CN 110151585 A CN110151585 A CN 110151585A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
One kind having whitening desalination acne print performance oligopeptides stoste and preparation method thereof, it is related to cosmetic field, the oligopeptides stoste includes: 12.554-16.604 parts of A group raw material, the component of the A group raw material and the parts by weight of each component are as follows: 40.3-72.96 parts of small active peptides, 3.98-15.77 parts of anti-acne component, -73 0.008-0.06 parts of quaternary ammonium salt, 0.04-15.94 parts of ethoxydiglycol, 0.83-20.8 parts of Gotu Kola P.E, 5.235-23.9 parts of niacinamide.Oligopeptides stoste in the present invention contains active peptide and skin-active repairs moisturizing ingredient, active constituent can be passed through epidermis rapid osmotic to basal layer, deep layer is played to nourish skin, acne-removing and skin-clearing and finally eliminate acne print, enhance the effect of elasticity of skin and compact degree, damage of the external environment to skin is isolated, improve impaired skin, highlight skin colour, it is formed in skin surface and nourishes moisture film, continuing use enables skin soft and smooth careful, permanent plump, skin shows light, net, saturating, tender texture, obtains facial skin newborn.
Description
Technical field:
The present invention relates to cosmetic fields, and in particular to one kind has whitening desalination acne print performance oligopeptides stoste and its preparation
Method.
Background technique:
Since present more and more application on human skin are unhealthy, crowd's quantity of adult acne or skin change sensitivity is more and more,
Especially by external environment influence, the skin of present people becomes more fragile than in the past.Therefore sensitive skin repairs class recently
Cosmetic Market development is swift and violent, has 6 in 10, skin is in the process for becoming sensitive skin type.Many 2, feel by March
Skin starts dry people, 4, starts May to think that skin more water shortage causes sebum secretion more vigorous, add
Dust caused by environment, pollution, the factors such as haze lead to that numerous people start to look for dermatological treatment small pox and to repair skin quick
Sense." traditional Chinese medicines adornment industry development pattern and the report of investment planning prospect in 2016-2022 " display of consulting publication is ground according to intelligence,
2015, anti-acne class medicine adornment demand was just up to 6,100,000,000.From 2009 to 2017, anti-acne class medicine adornment demand size all exists every year
Gradually increase, is easy to cause along with the life of current many people is stayed up late without rule, often, eating habit is improper etc. and give birth to
Acne, there are about ten thousand person-times of 400-600 growths every year.
There are multiple batches of anti-acne class cosmetics to be detected containing the sugared cortex such as betamethasone, clobetasol propionate in recent years
Hormonal components, and this constituents is equally defined as the taboo in cosmetics in " cosmetics safety technical specification " (version in 2015)
Use substance.Expert in terms of cosmetic composition expert indicates, very possible commonly using the anti-acne class cosmetics containing antibiotic
Make skin surface flora imbalance and lead to the appearance of drug-fast bacteria, or cause other infection, the cosmetics containing antibiotic are also easy
Lead to consumer's allergy and causes serious allergic phenomena.In addition, the existing cosmetics without antibiotics are in desalination acne print
It is poor with the effect in terms of whitening, it takes effect little, or even be unable to reach whitening and desalinate the effect of acne print.
Summary of the invention:
In place of overcoming above-mentioned the shortcomings of the prior art, and provide a kind of light with whitening
Change acne print performance oligopeptides stoste and preparation method thereof.
The technical solution adopted by the present invention are as follows: there is one kind whitening to desalinate acne print performance oligopeptides stoste, the oligopeptides stoste packet
It includes: 12.554-16.604 parts of A group raw material.
Preferably, the parts by weight of the component of the A group raw material and each component are as follows: small active peptides 40.3-72.96
Part, 3.98-15.77 parts of anti-acne component, -73 0.008-0.06 parts of quaternary ammonium salt, 0.04-15.94 parts of ethoxydiglycol, accumulated snow
Careless extract 0.83-20.8 parts, 5.235-23.9 parts of niacinamide.
Preferably, the anti-acne component includes white willow bark extract and Arabic gum natural gum.
Preferably, the anti-acne component is by 1.99-7.885 parts of white willow bark extract and 1.99-7.885 part
Arabic gum natural gum composition.
Preferably, which further includes 0.3-0.68 parts of B group raw material, and B group raw material is arginine.
Preferably, which further includes 0.032-0.05 parts of C group raw material, the component of the C group raw material and each
The parts by weight of component are as follows: 0.016-0.025 parts of menthol, 0.016-0.025 parts of leaf of Mentha piperita extract.
Preferably, which further includes 0.295-0.85 parts of D group raw material, the component of the D group raw material and each
The parts by weight of component are as follows: 0.005-0.02 parts of essence, 0.01-0.2 parts of Cremophor RH40,1,2- hexylene glycol 0.24-
0.54 part, 0.04-0.09 parts of decoyl hydroximic acid.
Preferably, which further includes 77.931-90.193 parts of E group raw material, the component of the E group raw material and
The parts by weight of each component are as follows: 72.621-80.463 parts of water, 5.0-9.0 parts of 1,3-PD, acrylic acid (ester) class/C10-30
0.3-0.68 parts of alkylol acrylamide acid esters cross-linked polymer, 0.01-0.05 parts of EDETATE SODIUM.
A kind of preparation method with whitening desalination acne print performance oligopeptides stoste, method includes the following steps:
Step 1: thorough cleaning and sterilizing production equipment, and calibrate production equipment；
Step 2: accurately weighing E group raw material, first the water in E group raw material is added in ingredients pot, then will be in E group raw material
Surplus stock is added in ingredients pot, opens and stirs after E group raw material complete wetting, mixing speed 10-15rpm, and homogeneous 5 minutes
And 82 DEG C -90 DEG C are warming up to, 50 DEG C -70 DEG C are cooled to after keeping the temperature 30-35min；
Step 3: B group raw material is individually dispersed with cooling deionized water, and by the B group raw material and water after dispersion
Mixed liquor be added step 1 in ingredients pot in, homogeneous 5min；
Step 4: being down to 42 DEG C -45 DEG C for the temperature of the ingredients pot in step 3, and it is former that A group is then added into ingredients pot
Material, C group raw material and D group raw material simultaneously stir and evenly mix, mixing speed 10-15rpm, stir 15-20min, until Material is uniform；
Step 5: the temperature of the ingredients pot in step 4 is down to 25 DEG C -38 DEG C, sample detection is shut down, cleans and sterilize
Filter screen uses the filter screen filtration after cleaning and sterilizing and discharging after detection is qualified.
The small active peptides refer to oligopeptides -1, Argireline, carnosine, oligopeptides -32 etc., and the small molecule of addition is more
Peptide matters repair moisturizing ingredient containing distinctive skin-active, can play nourishing skin by epidermal penetration to basal layer, enhance skin
Damage of the external environment to skin is isolated in the effect of elastic and compact degree, improves impaired skin, skin colour is highlighted, in skin
Surface, which is formed, nourishes moisture film, continues use and enables skin soft and smooth careful, permanent plump, skin shows light, net, saturating, tender matter
Sense.The component of small molecular active peptide of the present invention and the parts by weight of each component are as follows: 29.715 parts of water, 70 parts of 1,3-PD,
0.07 part of Argireline, 0.08 part of carnosine, -320.085 parts of oligopeptides, -10.05 parts of oligopeptides.
White willow (SALIX ALBA) bark extract and acacia (ACACIA SENEGAL) glue has speed
Anti-acne, the high and low irritation of compatibility, the characteristic that film is formed in skin surface are imitated, Arabic gum generates a kind of tenderization in epidermis
Effect assigns skin smooth and soft sense of touch.
The quaternary ammonium salt -73 has the acne of antibacterial activity, acne inhibitor, is a kind of excellent anti-acne raw material.Season
Ammonium salt -73 is equipped with centella (CENTELLA ASIATICA) extract, for oil-control, careful pore, improves mixed type or oiliness
Skin, while there is moistening effect, enable skin reach water and oil balance.Inhibit excess oil secretion, conditioning skin to balance health
The problems such as state, pore is coarse caused by improving because of small pox, acne enables skin clearly fine and smooth, balance skin pH value, supplements skin
It is lost moisture, improves skin anti-acne ability.
The ethoxydiglycol has good permeability, promotes functional component infiltration.Active constituent can be passed through
Epidermis rapid osmotic plays deep layer and nourishes skin, can keep skin surface moisture content, accelerate healing, make acne, small pox to basal layer
Decline and disappearance rapidly, reach safe anti-acne, can effectively repair acne print.
The niacinamide is also known as vitamin B3, has and inhibits melanin pigmentation effect, other than traditional whitening effect,
Also it be used to reduce the melanin for having generated, having precipitated, obstruct its transfer to cells of superficial layer, accelerate cell metabolism, add
Fast melanin horn cell falls off.Niacinamide is able to maintain that skin water content, promotes skin corium microcirculation.Niacinamide can also pole
Reduce or eliminate skin ageing phenomenon greatly, for example wrinkle, peeling, pore are coarse etc., reduce injury of the free radical to skin, play
Pre- anti-aging repairs skin and reduces the obscure effect of face.
The invention has the benefit that the oligopeptides stoste in the present invention contains active peptide and skin-active repairs moisturizing ingredient, energy
By active constituent by epidermis rapid osmotic to basal layer, plays deep layer and nourish skin, acne-removing and skin-clearing and finally eliminate acne print, increase
Damage of the external environment to skin is isolated in the effect of strong elasticity of skin and compact degree, improves impaired skin, highlights skin colour,
Formed in skin surface and nourish moisture film, continued use and enable skin soft and smooth careful, permanent plump, skin show light, it is net, saturating,
Tender texture obtains facial skin newborn.The oligopeptides stoste green, is free of antibiotic at safety, passes through white willow bark extract
It matches to reach anti-acne effect, small active peptides combination centella with quaternary ammonium salt -73 with the cementing merging of acacia
Extract reaches and repairs acne, acne print and moisturizing repair, effectively eliminates cut acne to realize, reproduce fine and smooth skin without
Mark prevents long acne repeatedly.
Specific embodiment:
Invention is further explained in conjunction with specific embodiments:
Technical solution of the present invention is clearly and completely described below in conjunction in the embodiment of the present invention, it is clear that institute
The embodiment of description is only a part of the embodiments of the present invention, instead of all the embodiments.Based on the embodiments of the present invention,
All other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair
The range of bright protection.
Embodiment one uses the weight in following table one with whitening desalination acne print performance oligopeptides stoste into embodiment five
Number is configured, specific as follows:
Table one: the formula of oligopeptides stoste of the embodiment one into embodiment five
By observation embodiment one to its smell of the appearance and smelling of embodiment five, it is known that embodiment one is to implementation
The product appearance of example five is uniform, and the equal fragrant odour of product odour is graceful, passes through 200 volunteer's testing example one to implementation
The usage comfort of example five and using feeling, whitening and softening skin and desalination acne print repairing performance is preferably embodiment three and embodiment
Five.
Therefore, the above embodiments one and the proportion of the A group raw material in embodiment five is selected to prepare embodiment six to reality
Applying in example 11, there is whitening to desalinate acne print performance oligopeptides stoste, and specific formula is carried out using the component content in following table two
Configuration, specific as follows:
Table two: the formula of oligopeptides stoste of the embodiment six into embodiment 11
The A group that embodiment six matches in the embodiment three into embodiment eight added with 12.554-16.504 parts by weight
Raw material, the A group that embodiment nine matches in the embodiment five into embodiment 11 added with 12.554-16.604 parts by weight are former
Material.
Embodiment one to embodiment 11 is all made of following preparation method and prepares in the present invention, and specific preparation method is such as
Under:
A kind of preparation method with whitening desalination acne print performance oligopeptides stoste, method includes the following steps:
Step 1: thorough cleaning and sterilizing production equipment, and calibrate production equipment；Rinse water use deionized water, go from
Sub- water when in use, is first heated to 90 DEG C, is cooled to that room temperature is stand-by, and calibrates the items of equipment of production；
Step 2: accurately weighing E group raw material, first the water in E group raw material is added in ingredients pot, then will be in E group raw material
Surplus stock is added in ingredients pot, opens and stirs after E group raw material complete wetting, mixing speed 10-15rpm, and homogeneous 5 minutes
And 82 DEG C -90 DEG C are warming up to, 50 DEG C -70 DEG C are cooled to after keeping the temperature 30-35min, homogeneous speed is 8-10Hz；
Step 3: B group raw material is individually dispersed with cooling deionized water, and by the B group raw material and water after dispersion
Mixed liquor be added step 1 in ingredients pot in, homogeneous 5min, homogeneous speed be 8-10Hz；
Step 4: being down to 42 DEG C -45 DEG C for the temperature of the ingredients pot in step 3, and it is former that A group is then added into ingredients pot
Material, C group raw material and D group raw material simultaneously stir and evenly mix, mixing speed 10-15rpm, stir 15-20min, until Material is uniform；If having
Dispersion, can optionally open low speed homogeneous, and homogeneous speed is 8-10Hz；
Step 5: the temperature of the ingredients pot in step 4 is down to 25 DEG C -38 DEG C, sample detection is shut down, cleans and sterilize
Filter screen uses the filter screen filtration after cleaning and sterilizing and discharging after detection is qualified.In filtering, selected according to the consistency of Material
Select the strainer using suitable mesh number.The strainer of preferably 300 mesh when the oligopeptides stoste filtering applied in the present invention.
The oligopeptides stoste that testing example six is produced into embodiment 11, specific test data and test method are as follows:
(1) moistening effect is tested:
17-40 years old 140 people are selected, men and women is fifty-fifty, health, rule of life, and no skin disease is randomly divided into 7 groups, often
In addition 20 people of group use the present invention for six groups wherein one group uses commercially available Whitening, spot anti-acne skin-protection product as a control group respectively
Oligopeptides stoste of the middle embodiment six into embodiment 11.Specific experimental method is as follows: study subject is used with a facial cleanser
After carrying out cleaning facial skin, face's droplet is dried using the dry towel after disinfection, cleans both hands, with finger by 2g test
Product is uniformly applied on facial skin, then allow volunteer test environment temperature be 20 DEG C, relative humidity be 63% ring
It rests in border 5 hours, measures the moisture content of each volunteer face.In each volunteer left side the same area on the face, use
The Corneometer CM825 probe of Multi-functional skin tester carries out moisture content of skin test, and measurement obtains CM value, and test is surveyed
The CM value of examination is higher, and to represent keratoderma water content higher.Multi-functional skin tester is tested before spread product respectively and is smeared
3,5 hours facial skin moisture content after sample product record result.Specifically it see the table below:
| Test item | Before use (CM value) | It uses 3h (CM value) | It uses 5h (CM value) |
| Embodiment six | 50.21 | 78.57 | 74.39 |
| Embodiment seven | 50.46 | 79.12 | 76.57 |
| Embodiment eight | 50.29 | 78.42 | 75.09 |
| Embodiment nine | 50.27 | 78.19 | 74.27 |
| Embodiment ten | 50.41 | 77.86 | 74.39 |
| Embodiment 11 | 50.45 | 77.94 | 75.11 |
| Control group | 50.36 | 64.13 | 58.63 |
As can be seen from the above table, oligopeptides stoste of the embodiment six into embodiment 11 imitates skin with moisturizing outstanding
Fruit, moisture preserving time is long, moisture it is lost relatively slow, wherein the oligopeptides stoste in embodiment seven, which has, is better than embodiment six, embodiment
Eight, the moistening effect of embodiment nine, embodiment ten and embodiment 11.
(2) product appearance and pH value test
Observe embodiment six to embodiment 11 oligopeptides stoste appearance, and smelling its smell, record product appearance and
Product odour.When carrying out pH value test, 1 part of sample (being accurate to 0.1g) is weighed first, adds not carbonated deionization
10 parts of water, 40 DEG C are heated to, and is stirred continuously to being uniformly dissolved, is cooled to room temperature, as solution to be measured.Use PH value detector
It detects and records pH value.
As can be seen from the above table, appearance, smell and the pH value of oligopeptides stoste of the embodiment six into embodiment 11 accord with
The requirement of combination cosmetic.And the fragrant of the oligopeptides stoste in the present invention is graceful, is liked by masses.
(3) product viscosity is tested
Viscosity of the embodiment of the present invention six into embodiment 11 can be used rotational viscometer and measure, and use No. 3
Rotor is measured at 12rpm.The viscosity of the embodiment six of survey to embodiment 11 is 3400-3600.Meet cosmetics
It is required that range of viscosities.
(4) skin comfort degree is tested
The skin comfort degree after use is tested by 210 volunteers, 210 volunteers are divided into 7 groups, every group 30
People, wherein one group as a control group, using commercially available similar-type products, remaining six groups are test group, respectively using embodiment six to
Implement the oligopeptides stoste in 11, specific experiment method are as follows: respectively take 3g product even application that sheet overlay film is made on non-woven fabrics,
It allows 7 groups of volunteers to apply respectively during 5 days target sheet overlay film 2 times, 10 minutes every time, then rinses face with clear water.And
The ballot of dermal sensation of each volunteer to overlay film is recorded, wherein passing through whitening, moisturizing, anti-acne, the non-stimulated and sense do not itched
Feel measurement dermal sensation.As a result, control group has 50% volunteer to vote sheet overlay film: " having during and after application
Moisturizing, the non-stimulated and feeling do not itched, but whitening and anti-acne effect are general ", in addition 50% volunteer using rear comfort level not
It is good, there are slight itch, tingling sensation, and 100% volunteer prepares the oligopeptides stoste according to the present invention in each test group
Sheet overlay film ballot " extraordinary whitening, moisturizing, anti-acne, the non-stimulated and feeling do not itched during and after application ".This
Oligopeptides stoste in invention has skin comfort degree and whitening anti-acne effect better than commercial like product.
(5) anti-acne effect is tested:
Whelk is a kind of chronic inflammation of pilosebaceous follicle, is common in the youth of both sexes of adolescence, specific youth
The origin cause of formation of acne are as follows: puberty male sex hormone increases, and smegma increases, while making the different hyperkeratinization of hair follicle, sebaceous glands, cutin
The flat dead cell that layer falls off falls hair follicle pars infundibularis, in conjunction with sebum, mixture is generated, if these mixtures cannot be free
Skin surface is discharged and concentrates on formation rouge bolt in hair follicle, the bacterial decomposition present in hair follicle forms fatty acid, and then stimulates
Hair follicle causes inflammation, causes follicular wall lesion ruptures, and hair follicle content enters corium, so as to cause inflammatory reaction, forms the youth
Acne.The bacterium that can cause whelk is mainly caused by propionibacterium acnes hyperplasia.This test passes through test oligopeptides stoste pair
The inhibiting effect of propionibacterium acnes tests its anti-acne effect, and the specific test method is as follows: using culture dish culture Cuo first
Sore Propionibacterium, for 24 hours, each 1g of product of the Example one into embodiment 11 is dissolved in respectively in 11 parts of 1mL sterile waters for culture,
The disk filter paper that diameter is 2cm is added in every part of sterile water dissolved with product, impregnates 10 minutes, disk filter paper is taken out and is placed
It in the culture dish of propionibacterium acnes, closes the lid, is placed under preference temperature, cultivate 2-3 days, observe and press down around disk filter paper
The presence or absence of bacterium circle and size, it is available by observing: around disk filter paper prepared by the present embodiment one to embodiment 11
It observes apparent inhibition zone, shows oligopeptides stoste that the embodiment of the present invention one is prepared into embodiment 11 to acne propionic acid
Bacillus has stronger biocidal property, it can be seen that prepared by apparent inhibition zone, therefore, the embodiment of the present invention one to embodiment 11
Oligopeptides stoste can prevent propionibacterium acnes hyperplasia, to realize elimination whelk.Wherein the inhibition zone of embodiment seven is most
Obviously.
In conclusion the oligopeptides stoste in the present invention contains active peptide and skin-active repairs moisturizing ingredient, it can be by active constituent
By epidermis rapid osmotic to basal layer, plays deep layer and nourish skin, acne-removing and skin-clearing and finally eliminate acne print, enhance elasticity of skin
With the effect of compact degree, damage of the external environment to skin is isolated, improves impaired skin, skin colour is highlighted, in skin surface
It is formed and nourishes moisture film, continued use and enable skin soft and smooth careful, permanent plump, skin shows light, net, saturating, tender texture, makes
Facial skin obtains newborn.The oligopeptides stoste green, is free of antibiotic at safety, passes through white willow bark extract and Arabic gum
Natural gum combines and matches with quaternary ammonium salt -73 to reach anti-acne effect, and small active peptides combination Gotu Kola P.E reaches
Acne, acne print and moisturizing repair are repaired, effectively eliminates cut acne to realize, reproduces fine and smooth skin without mark, pre- counnter attack
Multiple long acne.
For those skilled in the art, it is various corresponding that other can be made according to above technical scheme and design
Change and deformation, and all these change and modification all should belong within the scope of protection of the claims of the present invention.
Claims (9)
1. there is one kind whitening to desalinate acne print performance oligopeptides stoste, it is characterised in that: the oligopeptides stoste includes: A group raw material
12.554-16.604 parts.
2. according to claim 1 there is whitening to desalinate acne print performance oligopeptides stoste, it is characterised in that: the A group is former
The component of material and the parts by weight of each component are as follows: 40.3-72.96 parts of small active peptides, 3.98-15.77 parts of anti-acne component, season
- 73 0.008-0.06 parts of ammonium salt, 0.04-15.94 parts of ethoxydiglycol, 0.83-20.8 parts of Gotu Kola P.E, niacinamide
5.235-23.9 part.
3. according to claim 2 there is whitening to desalinate acne print performance oligopeptides stoste, it is characterised in that: the anti-acne group
Part includes white willow bark extract and Arabic gum natural gum.
4. according to claim 2 there is whitening to desalinate acne print performance oligopeptides stoste, it is characterised in that: the anti-acne group
It part is made of the Arabic gum natural gum of 1.99-7.885 parts of white willow bark extract and 1.99-7.885 part.
5. according to claim 1 there is whitening to desalinate acne print performance oligopeptides stoste, it is characterised in that: the oligopeptides raw material is also
Including 0.3-0.68 parts of B group raw material, B group raw material is arginine.
6. according to claim 1 there is whitening to desalinate acne print performance oligopeptides stoste, it is characterised in that: the oligopeptides raw material is also
Including 0.032-0.05 parts of C group raw material, the component of the C group raw material and the parts by weight of each component are as follows: menthol
0.016-0.025 parts, 0.016-0.025 parts of leaf of Mentha piperita extract.
7. according to claim 1 there is whitening to desalinate acne print performance oligopeptides stoste, it is characterised in that: the oligopeptides raw material is also
Including 0.295-0.85 parts of D group raw material, the component of the D group raw material and the parts by weight of each component are as follows: essence 0.005-
0.02 part, 0.01-0.2 parts of Cremophor RH40,1,2- 0.24-0.54 parts of hexylene glycol, decoyl hydroximic acid 0.04-0.09
Part.
8. according to claim 1,5,6,7 any described there is whitening to desalinate acne print performance oligopeptides stoste, it is characterised in that: should
Oligopeptides raw material further includes 77.931-90.193 parts of E group raw material, the component of the E group raw material and the parts by weight of each component
Are as follows: 72.621-80.463 parts of water, 5.0-9.0 parts of 1,3-PD, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters crosslinking
0.3-0.68 parts of polymer, 0.01-0.05 parts of EDETATE SODIUM.
9. a kind of preparation method with whitening desalination acne print performance oligopeptides stoste, it is characterised in that: this method includes following step
It is rapid:
Step 1: thorough cleaning and sterilizing production equipment, and calibrate production equipment；
Step 2: accurately weighing E group raw material, first the water in E group raw material is added in ingredients pot, then by the residue in E group raw material
Raw material is added in ingredients pot, opens and stirs after E group raw material complete wetting, mixing speed 10-15rpm, and homogeneous 5 minutes simultaneously rises
Temperature is cooled to 50 DEG C -70 DEG C after keeping the temperature 30-35min to 82 DEG C -90 DEG C；
Step 3: B group raw material is individually dispersed with cooling deionized water, and by after dispersion B group raw material and water mix
It closes liquid to be added in the ingredients pot in step 1, homogeneous 5min；
Step 4: being down to 42 DEG C -45 DEG C for the temperature of the ingredients pot in step 3, and A group raw material, C are then added into ingredients pot
Group raw material and D group raw material simultaneously stir and evenly mix, mixing speed 10-15rpm, stir 15-20min, until Material is uniform；
Step 5: being down to 25 DEG C -38 DEG C for the temperature of the ingredients pot in step 4, shut down sample detection, cleans simultaneously sterilised filtration
Net uses the filter screen filtration after cleaning and sterilizing and discharging after detection is qualified.
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