CN109431873A - It is a kind of to repair the composition for soothing the skin inflammation - Google Patents
It is a kind of to repair the composition for soothing the skin inflammation Download PDFInfo
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- CN109431873A CN109431873A CN201811596452.5A CN201811596452A CN109431873A CN 109431873 A CN109431873 A CN 109431873A CN 201811596452 A CN201811596452 A CN 201811596452A CN 109431873 A CN109431873 A CN 109431873A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to the composition that a kind of reparation soothes the skin inflammation, the components including following weight percentage: 1.00-3.00% lecithin；0.10-0.30% boswellia serrata resin extract；0.10-0.30% carboxymethylchitosan；0.10-0.30% phosphoglycerol inositol salt；0.50-1.00% phytosterol and its derivative.The present invention is by lecithin, boswellia serrata resin extract, carboxymethylchitosan, phosphoglycerol inositol salt, the combination of phytosterol isostearate are used cooperatively, for restoration, skin frost, restoration, skin cream and repair in toner, anti-inflammatory effect of releiving is repaired with preferable, it is red obvious with detumescence effect for moving back for sensitive, the anti-inflammatory repair ability of releiving of skin can be improved, it can also make that skin is kept to moisten moisturizing, there is good repairing effect of releiving to a variety of scytitis such as eczema.
Description
Technical field
The present invention relates to the compositions that personal skin care field more particularly to a kind of reparation soothe the skin inflammation.
Background technique
Dermatitis and eczema are used to refer to a kind of scytitis frequently as synonym, represent skin for chemicals, albumen, thin
The allergic reaction of various substances such as bacterium and fungi.One word of eczema does not have special meaning, and dermatitis then has the meaning of restriction.If
It uses dermatitis to replace eczema as diagnosis term, then refers to corium, epidermis association response, it can be acute, subacute and slow
Property.The pathogenic factor of dermatitis and eczema is extremely complex, is simply divided into internal factor, external factor and other factors.
The allergic constitution of patient is the key factor of this disease, related with heredity, can change with the growth at age, environment and change
Become, neural factors such as: excessively it is worried, nervous, excited, have a sleepless night, fatigue all may induce or aggravate the state of an illness.Furthermore divide in
It secretes, metabolism and gastrointestinal dysfunction, infection focus etc. also have relationship with morbidity.External cause is such as: daylight, it is damp and hot, dry, scratch, rub
Wiping, cosmetics, soap, fur, fuel, staple fibre etc. can induce eczema.Certain foods are such as: fishes and shrimps, egg can also induce
Eczema.
Currently, treating the drug that such disease uses typically contains hormone constituents, such components have toxic side effect with
And it can develop drug resistance.
Summary of the invention
Aiming at the problems existing in the prior art, the purpose of the present invention is to provide the groups that a kind of reparation soothes the skin inflammation
Close object.
It is a kind of to repair the composition for soothing the skin inflammation, the component including following weight percentage: 1.00-3.00% ovum
Phosphatide；0.10-0.30% boswellia serrata resin extract；0.10-0.30% carboxymethylchitosan；0.10-0.30%
Phosphoglycerol inositol salt；0.50-1.00% phytosterol and its derivative.
Further, the phytosterol and its derivative are comprising in phytosterol, hydrogenated phytosterols, phytosterin ester
It is one or more.
Further, the composition includes restoration, skin frost, restoration, skin cream and repairs toner.
Further: 3.00% lecithin, 0.25% boswellia serrata resin extract, the deacetylated shell of 0.20% carboxymethyl are more
Sugar, 0.25% phosphoglycerol inositol salt, 1.00% phytosterol isostearate.
Further, the composition is restoration, skin frost, also includes 0.1-3% thickener, 5-30% emollient, 1-
20% moisturizer, 0.02-0.2% aromatic, 0.02-0.1% chelating agent, 0.1-1% preservative, 0.05-1%pH regulator,
Deionized water surplus.
Jojoba oil, saualane, Butyrospermum parkii fruit rouge, Prunus Amygdalus Dulcis Oil, sunflower seed oil, wheat can be selected in the emollient
Embryo oil, maize germ oil, white pond flower seed oil, avocado oil, camellia seed oil, tocopherol acetate, dimethyl silicone polymer, ring five
Dimethyl silicone polymer, cyclohexasiloxane, diethyl hexylcarbonate, caprylic/capric triglyceride, Nexbase 2004, Ji Wusi
Alcohol tetrastearate, ethylhexyl palmitate, Parleam, octyl polymethyl siloxane, isononyl isononanoate, palmitinic acid
Isopropyl ester, cetanol ethylhexoate.
The moisturizer can be selected glycerol, glycerin polyether -26, propylene glycol, 1,3- propylene glycol, methyl gluceth -20,
Butanediol, Xylitol-based glucoside, anhydro xylitol, xylitol, 1,2- pentanediol, 1,2- hexylene glycol, glycine betaine, erythrite,
Sodium Hyaluronate, panthenol, sorbierite, trehalose, pulullan polysaccharide any one of them or two or more collocation use.
Floral perfume, illusion flavor essence, fruit essence, costustoot essence any one of them or two can be selected in the aromatic
Kind or more collocation use.
The chelating agent can be selected EDETATE SODIUM, tetra- sodium of EDTA, sodium phytate any one of them or two or more collocation and use.
Methyl hydroxybenzoate, Nipasol, Bis(hydroxymethyl)imidazolidinyl urea, Phenoxyethanol, iodine third can be selected in the preservative
Alkynol butyl mephenesin Carbamate, sodium benzoate, potassium sorbate any one of them or two or more collocation use.
The pH adjusting agent can be selected triethanolamine, potassium hydroxide, sodium hydroxide, aminomethyl propanol, arginine and wherein appoint
One or more collocation uses.
Further, the thickener includes water phase thickener and oil phase thickeners.The thickener includes that oil mutually thickens
Agent and water phase thickener, the oil phase thickeners can be selected cetostearyl alcohol, docosyl alcohol, beeswax, ceresine, candelila wax, haze tallow,
Cocoa butter, stearic acid any one of them or two or more collocation use；The water phase thickener can be selected xanthan gum, carbomer,
Hydroxy-ethyl acrylate/acryloyldimethyl taurine copolymer, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymeric
Object, ammonium acryloyl taurate/VP copolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymers, polyacrylic acid
Sodium any one of them or two or more collocation use.
Further, the molecular weight of the carboxymethylchitosan is less than 3.0 × 104Dalton, pH 6.0-
8.0。
Lecithin is the ingredient that can be received completely by skin, can be used as a kind of natural safe emulsifier.Lecithin is
The indispensable substance of each cell of human body will reduce the power of regeneration of Skin Cell, cause skin thick if lacked
It is rough, have wrinkle.As can suitably absorbing lecithin, skin regeneration vigor can be ensured, add the good hydrophily of lecithin
And lipophilicity, make skin rich in gloss.
Its main pharmaceutical component of boswellia serrata resin extract is AKBA (11- ketone-beta boswellic acid).It is ground in antiphlogistic effects
Study carefully middle discovery, in biochemical and cell external model, the potential target of AKBA is 5- and 12- lipoxidase, cyclooxygenase -1,
Human leukocyte elastase and IB kinases.It has releive, anti-irritant, relieve pain, Red blood streak dispelling and repair.
Carboxymethylchitosan, also known as β-Isosorbide-5-Nitrae straight glucose derivative, molecular weight: less than 3.0 × 104Dongle
, pH:6.0-8.0 (1%solution), deacetylation: > 65%, 0- degree of substitution by carboxymethyl: 90%.Have to human body relatively strong
Anti-inflammatory effect, have the effects that be able to suppress both proinflammatory factors for being secreted by keratinocyte of IL-6 and TNF-α.With
In treatment and control, slight eczema, dermatitis, the significant effect of allergic skin, the dexamethasone that resistance state effect reaches
60%.Hormone therapy can be partially replaced, the hormone dependant disease of patient is reduced.Carboxymethylchitosan and H1 histamine receptor are high
Affinity competitive binding prevents activation of the histamine to the H1 receptor for causing gargalesthesia, to achieve the effect that antipruritic.With promotion
Wound granulation organizes the formation of, and activates epithelial tissue, alleviates fibroblast and scar proliferation, scar is reduced or avoided, makes skin lesion
Restore smooth, accelerates wound healing.
Phosphoglycerol inositol salt, abbreviation GPI, pH:6.0-7.8, density g/mL:0.9-1.1 are mentioned from sunflower lecithin
A kind of ingredient got, the mechanism of action are to inhibit cellular type phospholipase A2 (cPLA2), and cPLA2 is the key enzyme of inflammatory reaction,
Mainly cause arachidonic release.The source for directly acting on cascade of response of inflammation, it is identical as cortisone pharmacy effect, it can
Pine there is side effect, phosphoglycerol inositol salt do not have.
Phytosterol isostearate has stronger anti-inflammatory effect to human body, can keep skin surface moisture, promotes
The metabolism of skin inhibits scytitis.
Compared with prior art, the present invention is by lecithin, boswellia serrata resin extract, carboxymethylchitosan,
Phosphoglycerol inositol salt, the combination of phytosterol isostearate are used cooperatively, and for restoration, skin frost, restoration, skin cream and are repaired
In toner, has and preferably repair anti-inflammatory effect of releiving, it is red obvious with detumescence effect for moving back for sensitive, it can improve
The anti-inflammatory repair ability of releiving of skin, moreover it is possible to make that skin is kept to moisten moisturizing, have well to a variety of scytitis such as eczema
Repairing effect of releiving.
Detailed description of the invention
Fig. 1 be the skin cream that eczema patients soothe the skin inflammation using the reparation of embodiment 1 before photo；
Fig. 2 is that eczema patients soothe the skin the photo after the skin cream fortnight of inflammation using the reparation of embodiment 1.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, the present invention is made into one below in conjunction with attached drawing
Step ground detailed description.
Embodiment 1
A kind of to repair the skin cream for soothing the skin inflammation, each component weight percent shared by system is as shown in table 1:
1 embodiment 1 of table repairs the component and its weight percent for soothing the skin the skin cream of inflammation
Preparation method: oil being mixed and is placed in oily phase pot, and stirring is warming up to 85 DEG C；Water phase is mixed and is placed in water phase pot
In, stirring is warming up to 85 DEG C；It takes the mode vacuumized to be mutually successively pumped into water phase and oil in emulsion pot, opens stirring, stirring
Speed is 35r/min, homogeneous 5 minutes, then keeps the temperature 30 minutes, mixing speed 30r/min；45 DEG C are cooled to, is added other
Raw material；Continue to stir, be cooled to 38 DEG C, discharges to get the skin cream is arrived.
Fig. 1 be the skin cream that eczema patients soothe the skin inflammation using the reparation of embodiment 1 before photo；Fig. 2 is wet
Rash patient soothes the skin the photo after the skin cream fortnight of inflammation using the reparation of embodiment 1.From Fig. 1 and Fig. 2 it can be concluded that,
The skin cream that the reparation of the present embodiment soothes the skin inflammation has preferable therapeutic effect to eczema.
Embodiment 2
Remove the phytosterol isostearate in embodiment 1, Butyrospermum parkii fruit rouge content is adjusted to 2%, and other components contain
It measures and its prepares and is same as Example 1.
Embodiment 3
By 3.00% lecithin in embodiment 1 use instead other emulsifiers for example alkyl glycosides replace, other components, content and its
It prepares same as Example 1.
Embodiment 4
Remove the carboxymethylchitosan in embodiment 1, adjusts the content of deionized water to 100%, other components,
It content and its prepares same as Example 1.
Embodiment 5
Remove the boswellia serrata resin extract in embodiment 1, adjusts the content of deionized water to 100%, other components,
It content and its prepares same as Example 1.
Embodiment 6
Remove the phosphoglycerol inositol salt in embodiment 1, adjusts the content of deionized water to 100%, other components, content
And its it prepares same as Example 1.
Embodiment 7
By lecithin, boswellia serrata resin extract, carboxymethylchitosan, phosphoglycerol inositol in embodiment 1
The mass ratio of salt and phytosterol isostearate is adjusted to 1:1:1:1:1, lecithin, boswellia serrata resin extract, carboxymethyl
The gross mass of chitosan, phosphoglycerol inositol salt and phytosterol isostearate is constant, other components, content and its
It prepares same as Example 1.
Embodiment 8
Mass percent by lecithin in embodiment 1 is still 3%, and boswellia serrata resin extract, carboxymethyl are taken off second
The mass ratio of acyl chitin, phosphoglycerol inositol salt and phytosterol isostearate is adjusted to 1:1:1:1, and boswellia serrata resin mentions
Take the gross mass of object, carboxymethylchitosan, phosphoglycerol inositol salt and phytosterol isostearate constant, other groups
Point, content and its prepare same as Example 1.
Efficacy assessments
1, to the effect experiment of eczema
Subject and its method
Subject: random, open, Self-controlled study is taken.Choose the eczema patients 240 that age distribution is 1 to 40 years old
Name is randomly divided into 8 groups, every group of 30 people, wherein every group includes male 15, female 15.Method:
Application method: patient is daily sooner or later twice after clearing skin, and embodiment 1-8 skin cream is applied to affected part, and one
Trial effect is paid a return visit after month.
The Contrast on effect of the skin cream of 2 embodiment 1-8 of table
| Healing number | The obvious number of effect | Unobvious to the invalid number of effect | |
| Embodiment 1 | 25 | 5 | 0 |
| Embodiment 2 | 15 | 13 | 2 |
| Embodiment 3 | 20 | 10 | 0 |
| Embodiment 4 | 14 | 15 | 1 |
| Embodiment 5 | 16 | 11 | 3 |
| Embodiment 6 | 17 | 11 | 2 |
| Embodiment 7 | 19 | 10 | 1 |
| Embodiment 8 | 22 | 7 | 1 |
Conclusion: these results suggest that the skin cream of embodiment 1 has preferable repairing effect to eczema.
2, mouse ear anti-inflammation test
Referring to the method for (pharmacological experimental methodology) fourth edition, according to following condition experiment
Experimental animal: mouse (male) weight: 25g~30g
Experiment reagent: Dexamethasone Cream (20g:15mg) (positive group reagent), dimethylbenzene (model reagent)
The reparation of selection example 1-8 soothes the skin the skin cream of inflammation and test, and experimental result is as shown in table 3.
Influence of the skin cream of 3 embodiment 1-8 of table to mice auricle swelling
Note: P is compared with model group
Conclusion (of pressure testing): these results suggest that the skin cream of embodiment 1 can reduce Mice Auricle inflammation, have preferable anti-inflammatory
Effect.
3, sensitive is anti-inflammatory repairs data statistics on probation of scoring of releiving: 320 young man (wherein males of trier
16-20 years old 80,21-25 years old 80 people, women 16-20 years old 80,21-25 years old 80) be randomly divided into 8 groups, trier's skin is quick
Feel, on the face acne lingering, red swelling of the skin.
Trial method: trier smears the skin cream of embodiment 1-8 respectively, once in the morning and once at night, by being usually accustomed to dosage.One
Trial effect is paid a return visit after a month in the form of questionnaire, effect scoring is carried out to sample, 10 points are full marks, and are averaged,
As shown in table 4.
The skin cream trial effect of 4 embodiment 1-8 of table scores
Conclusion (of pressure testing): preferably releiving these results suggest that the skin cream of embodiment 1 has, move back red and detumescence effect, special
Not Shi Yongyu sensitive, the anti-inflammatory repair ability of releiving of skin can be improved.
Embodiment 9
A kind of to repair the milky lotion for soothing the skin inflammation, each component weight percent shared by system is as shown in table 4:
The reparation of 5 embodiment 9 of table soothes the skin the component and its weight percent of the milky lotion of inflammation
Preparation method: oil being mixed and is placed in oily phase pot, and stirring is warming up to 85 DEG C；Water phase is mixed and is placed in water phase pot
In, stirring is warming up to 85 DEG C；It takes the mode vacuumized to be mutually successively pumped into water phase and oil in emulsion pot, opens stirring, stirring
Speed is 35r/min, homogeneous 5 minutes, then keeps the temperature 30 minutes, mixing speed 30r/min；45 DEG C are cooled to, is added other
Raw material；Continue to stir, be cooled to 38 DEG C, discharges to get the milky lotion is arrived.
Embodiment 10
A kind of to repair the toner for soothing the skin inflammation, each component weight percent shared by system is as shown in table 6:
The reparation of 6 embodiment 10 of table soothes the skin the component and its weight percent of the toner of inflammation
Preparation method: water phase being mixed and is placed in pot, and stirring is warming up to 85 DEG C, and oil is mixed and is added in pot, stirring speed
Degree is 30r/min, keeps the temperature 30 minutes；45 DEG C are cooled to, other raw materials are added；Continue to stir, be cooled to 38 DEG C, discharging to get
To the toner.
Finally it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not limited to this hair
It is bright, although referring to signature embodiment, the present invention will be described in detail, it will be apparent to those skilled in the art that it still can be with
It modifies the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.It is all
Within the spirit and principles in the present invention, any modification, equivalent substitution, improvement and etc. done should be included in guarantor of the invention
Within the scope of shield.
Claims (7)
1. a kind of repair the composition for soothing the skin inflammation, which is characterized in that the component including following weight percentage:
1.00-3.00% lecithin；0.10-0.30% boswellia serrata resin extract；The deacetylated shell of 0.10-0.30% carboxymethyl is more
Sugar；0.10-0.30% phosphoglycerol inositol salt；0.50-1.00% phytosterol and its derivative.
2. repairing soothe the skin the composition of inflammation according to claim 1, which is characterized in that the phytosterol and its spread out
Biology includes one of phytosterol, hydrogenated phytosterols, phytosterin ester or a variety of.
3. repairing the composition for soothing the skin inflammation according to claim 1, which is characterized in that the composition includes repairing
Skin cream, restoration, skin cream and reparation toner.
4. repairing the composition for soothing the skin inflammation according to claim 1, which is characterized in that contain including following weight percent
The group of amount: 3.00% lecithin, 0.25% boswellia serrata resin extract, 0.20% carboxymethylchitosan, 0.25%
Phosphoglycerol inositol salt, 1.00% phytosterol isostearate.
5. repairing the composition for soothing the skin inflammation according to claim 4, which is characterized in that the composition is to repair profit
Skin frost also includes 0.1-3% thickener, 5-30% emollient, 1-20% moisturizer, 0.02-0.2% aromatic, 0.02-
0.1% chelating agent, 0.1-1% preservative, 0.05-1%pH regulator, deionized water surplus.
6. repairing the composition for soothing the skin inflammation according to claim 5, which is characterized in that the thickener includes water phase
Thickener and oil phase thickeners.
7. repairing the composition for soothing the skin inflammation according to claim 1, which is characterized in that the deacetylated shell of carboxymethyl
The molecular weight of polysaccharide is less than 3.0 × 104Dalton, pH 6.0-8.0.
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| CN201811596452.5A CN109431873B (en) | 2018-12-25 | 2018-12-25 | Composition for repairing and relieving skin inflammation |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111265434A (en) * | 2020-03-19 | 2020-06-12 | 猫头鹰(福州)日用品有限公司 | Plant-derived emulsifier water-in-oil cream and preparation method thereof |
| IT201900018659A1 (en) * | 2019-10-14 | 2021-04-14 | Valetudo S R L Con Socio Unico | COMBINATION OF NATURAL ACTIVE INGREDIENTS THAT PROMOTE APOPTOSIS IN DAMAGED OR SUFFERING SKIN TISSUES |
| CN114601748A (en) * | 2021-12-21 | 2022-06-10 | 星智豫美(上海)生物科技有限公司 | Soothing and repairing composition and application thereof |
| CN115245477A (en) * | 2021-04-28 | 2022-10-28 | 广州市索柔生物科技有限公司 | After-sun repair compound, preparation method and application thereof |
| CN115282168A (en) * | 2022-08-30 | 2022-11-04 | 马应龙大健康有限公司 | Soothing moisturizer for relieving infantile eczema symptom and preparation method and application thereof |
| CN115887317A (en) * | 2022-11-04 | 2023-04-04 | 上海臻臣化妆品有限公司 | Moisturizing composition and moisturizing liquid for skin |
| CN117414313A (en) * | 2023-10-12 | 2024-01-19 | 广东丸美生物技术股份有限公司 | Moisturizing composition and application thereof |
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