CN103169632A - Application of dogbane leaf extract in preparation of skin-care product - Google Patents
Application of dogbane leaf extract in preparation of skin-care product Download PDFInfo
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- CN103169632A CN103169632A CN2011104357137A CN201110435713A CN103169632A CN 103169632 A CN103169632 A CN 103169632A CN 2011104357137 A CN2011104357137 A CN 2011104357137A CN 201110435713 A CN201110435713 A CN 201110435713A CN 103169632 A CN103169632 A CN 103169632A
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Abstract
The invention relates to application of a Chinese traditional medicine preparation, and discloses application of a dogbane leaf extract in preparation of a skin-care product. The dogbane leaf extract has strong anti-aging function, strong antioxidant function, strong ultraviolet protection, strong moisturizing function, strong bacteriostatic inflammation function, and strong functions of removing beverage and acnes when being used as a cosmetic additive, and has significant effect of protecting the skin. In addition, the skin-care product prepared by the dogbane leaf extract is free of toxic and side effects, and is safe and reliable.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of application of Chinese medicine preparation, more specifically, relate to the application of dogbane leaf extractive in the preparation skin care item.
Background technology
Along with the continuous progress of society and the raising of living standard, the skin care item with protection skin effect have become one of various daily neces saries of people.In recent years, various skin care item with effects such as whitening, moisturizing, defying age, speckle dispelling emerge in an endless stream.Even the wherein a kind of technology for preparing above-mentioned effect skin care item is used as the plant extract of additive.The plant variety of the Nature is various, the wide material sources of plant extract; The more important thing is, the natural component in plant extract is safer and low toxicity than synthetic, and these are the development and research of plant extract in skin care item bright prospects are provided.
Herba Apocyni veneti has another name called wild flax, Zha Ha, is the Apocynaceae herbaceos perennial, is rich in the compositions such as flavone, Quercetin, aminoacid in its root and leaf, has the abundant medical value such as blood pressure lowering, defying age, atherosclerosis.But at present Herba Apocyni veneti, especially the abundant Folium Apocyni Veneti of medical value not yet is applied in skin care item.
Summary of the invention
The technical problem to be solved in the present invention is, for the shortcoming that Folium Apocyni Veneti in prior art not yet is applied in skin care item, provides the application of dogbane leaf extractive in the preparation skin care item.
The technical problem to be solved in the present invention is achieved through the following technical solutions: the application of dogbane leaf extractive in the preparation skin care item is provided.
In the application of above-mentioned dogbane leaf extractive in the preparation skin care item, described Herba Apocyni veneti is hemp or ambary.
In the application of above-mentioned dogbane leaf extractive in the preparation skin care item, described skin care item comprise Skin whitening care cosmetics, Moisturizer, sunlight screening skin-protecting product, anti-aging skin care product, control oil skin care products, antiallergic skin care item or removing acne and freckle skin care item.
In the application of above-mentioned dogbane leaf extractive in the preparation skin care item, described skin care item are water preparation, cream, Emulsion or facial film.
Implement technical scheme of the present invention; can obtain following beneficial effect: when dogbane leaf extractive is used as cosmetics additive; it can have the effects such as stronger defying age, antioxidation, ultraviolet protection, moisturizing, inhibiting bacteria and diminishing inflammation, speckle removing, acne removing, and the effect of its protection skin is remarkable.On the other hand, the test show dogbane leaf extractive have no side effect, safe and reliable.In sum, dogbane leaf extractive can be applied to the preparation of skin care item.
The specific embodiment
Below will be further explained in detail and illustrate the present invention by specific embodiment.It should be understood that method as described herein and step etc. only are used for task of explanation, rather than limit the invention.
The metric system Preparation Method of dogbane leaf extractive is provided in prior art, also can have easily bought the dogbane leaf extractive that adopts the method to prepare on market.The preparation of dogbane leaf extractive and composition Study etc. are not emphasis of the present invention, so in the present invention, the employing general flavone content is that the dogbane leaf extractive of 5-10% is as the raw material of preparation skin care item.
Embodiment 1: the application of Herba Apocyni veneti (ambary or hemp) leaf extract in whitening cream skin care item
a kind of whitening day cream that contains dogbane leaf extractive, the component that comprises following percentage by weight: BS (BS) 3%, emulsifying agent (721) 1.5%, emulsifying agent (72) 1%, olive oil 2%, cocoa butter 3%, shea butter 2%, silicone oil (DC-200) 2%, VE oil 0.5%, mixed alcohol 2%, monoglyceride 1%, vitamin PP 0.1%, bisabolol 0.2%, disodiumedetate (EDTA) 0.05%, glycerol 5%, polyglutamic acid (PGA) 3%, transparent HANSHENGJIAO 0.2%, IrgasanDP-300 0.2%, nature moisturizing factor (NMF-50) 2%, tetrandrine 0.5%, thickening agent (305) 0.4%, dogbane leaf extractive 2% and deionized water 68.35%.Its preparation method comprises the following steps:
Above-mentioned BS, 721,72, olive oil, cocoa butter, shea butter, DC-200, VE oil, bisabolol, glycerol, tetrandrine and 305 are heated to 75 ℃, are oil phase; Said vitamin PP, EDTA, PGA, transparent HANSHENGJIAO and NMF-50 are dissolved in deionized water, are water; Follow to stir to add oil phase to aqueous phase, add IrgasanDP-300 and dogbane leaf extractive after stirring, again stir by sterilization treatment, namely get the described whitening day cream that contains dogbane leaf extractive after cooling.Wherein, BS, 721,72, DC-200 and 305 are trade names.
Embodiment 2: the application of Herba Apocyni veneti (ambary or hemp) leaf extract in sun-proof Emulsion skin care item
A kind of tender white sun-proof isolation breast that contains dogbane leaf extractive comprises the component of following percentage by weight: sodium rice flour 5%, Pulvis Talci 4%, the different monooctyl ester of Petiolus Trachycarpi oil (EHP) 4%, Trivent OCG (GTCC) 4%, Cera Flava 0.3%, triclosan (DP300) 0.05%, IrgasanDP-300 0.2%, magnesium sulfate 0.5%, sodium chloride 0.5%, silicone oil (DC345) 5%, vitamin PP 0.1%, bisabolol 0.2%, glycerol 7%, VE oil 0.5%, dogbane leaf extractive 2% and deionized water 66.65%.Its preparation method comprises the following steps:
Above-mentioned sodium rice flour, Pulvis Talci, EHP, GTCC, Cera Flava, DC345, bisabolol, glycerol and VE oil are heated to 75 ℃, are oil phase; Above-mentioned magnesium sulfate, sodium chloride and vitamin PP are dissolved in deionized water, are water; Follow to stir to add oil phase to aqueous phase, add IrgasanDP-300, DP300 and dogbane leaf extractive after stirring, again stir by sterilization treatment, namely get the described tender white sun-proof isolation that contains dogbane leaf extractive after cooling newborn.Wherein, DC345, DP300 are trade names.
Embodiment 3: the application of Herba Apocyni veneti (ambary or hemp) leaf extract in crease-resistant Firm skin care item
A kind of crease-resistant Firm essence that contains dogbane leaf extractive comprises the component of following percentage by weight: EDTA0.05%, IrgasanDP-300 0.1%, carbopol 940 (C940) 0.4%, transparent HANSHENGJIAO 0.15%, glycerol 5%, PGA5%, triethanolamine (TEA) 0.25%, tetrandrine 1%, antiseptic (LGP) 0.4%, glucosan 2%, dogbane leaf extractive 1% and deionized water 84.65%.Its preparation method comprises the following steps:
Above-mentioned EDTA, C940, transparent HANSHENGJIAO, glycerol, PGA, TEA, tetrandrine and glucosan are dissolved in deionized water, add IrgasanDP-300, LGP and dogbane leaf extractive after stirring, again stir by sterilization treatment, namely get the described crease-resistant Firm essence that contains dogbane leaf extractive after cooling.
Embodiment 4: the application of Herba Apocyni veneti (ambary or hemp) leaf extract in skin-active compacts facial film
A kind of skin-active that contains dogbane leaf extractive facial film that compacts comprises the component of following percentage by weight: EDTA0.1%, transparent HANSHENGJIAO 0.2%, propylene glycol 5%, glycerol 5%, NMF-50 2%, glucosan 2%, metallothionein 0.1%, tetrandrine 0.3%, dogbane leaf extractive stock solution 1%, dream Paris essence 0.01% and deionized water 84.29%.Its preparation method comprises the following steps:
Above-mentioned EDTA, transparent HANSHENGJIAO, propylene glycol, glycerol, NMF-50, glucosan, metallothionein, tetrandrine and dream Paris essence are dissolved in deionized water, add dogbane leaf extractive stock solution after stirring, again stir by sterilization treatment, facial film is dipped in the above-mentioned solution for preparing after cooling, namely gets the described skin-active that the contains dogbane leaf extractive facial film that compacts.
Below the effectiveness of the skin care item that prepare respectively in embodiment 1-4 is verified, and the safety of above-mentioned skin care item is estimated.
1, skin-whitening test
Adopt the whitening function of the whitening day cream of the living animal verification experimental verification embodiment of the present invention 1.Adopt 10 of yellowish-brown Cavia porcelluss, the hair of its spinal column both sides, back is cut off, forming area is the unhairing district of 1cm * 2cm size.With swab stick, the whitening day cream of embodiment 1 is coated with a circle successively, separately establishes the skin of unhairing clear area in contrast every day 2 times, adopt the cosmetic base emulsion that does not contain dogbane leaf extractive to be coated with outward.After 28 days, get the guinea pig skin living tissue and check, fixing, embedding and section are to the melanin granule cell in basal cell and DOPA positive cell counting.Relatively find with the skin of unhairing clear area, adopt melanin granule cell in the skin base cell that the whitening day cream of embodiment 1 is coated with and the quantity of DOPA positive cell obviously to reduce outward.
2, the in vitro study of anti-ultraviolet damage
Adopt the ultraviolet protection effect of the tender white sun-proof isolation breast of the living animal verification experimental verification embodiment of the present invention 2.With 10 rat back unhairing, form respectively area and be three unhairing district A and the B of 4cm * 4cm, two unhairing districts are the outer tender white sun-proof isolation breast that is coated with embodiment 2 and without the cosmetic base emulsion of dogbane leaf extractive respectively.Then under uviol lamp apart from lamp 20cm vertical irradiation rat back 30min, again in the back unhairing, form another unhairing district C after irradiation stops 4h.Get the skin of A, B and C three parts, do tissue slice and He dyeing, the fibroblast number in optical microphotograph Microscopic observation dermal tissue unit are.Although find that the fibroblast of unhairing district A is slightly less than the fibroblast of unhairing district C, its quantity is obviously more than the fibroblast quantity of unhairing district B.As seen the tender white sun-proof isolation breast of embodiment 2 has certain ultraviolet protection effect.
3, research on anti-senescence
Adopt the anti-aging effects of the crease-resistant Firm essence of the living animal verification experimental verification embodiment of the present invention 3.Specific as follows: that 20 12 month female Kunming mouses are divided into 2 groups (n=10) at random: naturally-aged Normal group (N group) and dogbane leaf extractive group (S group); Separately with 10 3 monthly age mice composition young matched groups (Y group).The S group is coated with outward with the crease-resistant Firm essence of embodiment 3, and N group and Y group are coated with outward with the cosmetic base emulsion that does not contain dogbane leaf extractive.After smearing continuously 60 days, get the skin that mice is smeared the position, hydroxyproline (HYP), superoxide dismutase (SOD) and lipid peroxide (LPO) the metabolite malonaldehyde (MDA) in the homogenate of mensuration skin histology and the content of lipofuscin (LF).The SOD vigor rising of S group, the content of HYP obviously increase as a result, and the content of MDA and LF obviously reduces.The crease-resistant Firm essence with dogbane leaf extractive of the above results explanation embodiment 3 has certain anti-aging effects.
4, skin irritation test
Select 8 of the new zealand rabbits of body weight 2-2.5kg, the hair of its spinal column both sides, back is cut off, forming area is respectively the unhairing district of 2.5 * 2.5cm, begins test after confirming not damaged skin.The facial film of the skin care item of embodiment 1-3 and embodiment 4 is smeared respectively and is attached to the left side in unhairing district, the right side is blank; Remove skin care item residual on skin with warm water after 4 hours, go out with warm water the residue that adheres to equally after removing facial film, and the skin difference of observing respectively unhairing district, the left and right sides in after removing 1,24 and 48 hour, find, unhairing district, left side is without abnormal phenomenas such as rubescent, dermexanthesis, edema.This result of the test proves absolutely and adopts skin care item and the facial film of dogbane leaf extractive preparation that skin is had no side effect, and is safe and reliable.
In sum, dogbane leaf extractive can have the effects such as stronger defying age, antioxidation, ultra-violet absorption, moisturizing, inhibiting bacteria and diminishing inflammation, speckle removing, acne removing when using as cosmetics additive, and the effect of its protection skin is remarkable.And, the test show dogbane leaf extractive have no side effect, safe and reliable.In sum, dogbane leaf extractive can be applied to the preparation of skin care item.
The above is only the preferred embodiments of the present invention, not in order to limiting the present invention, all any modifications of doing in the spirit and principles in the present invention, is equal to and replaces or improvement etc., all should be included in protection scope of the present invention.
Claims (4)
1. the application of dogbane leaf extractive in the preparation skin care item.
2. the application of dogbane leaf extractive according to claim 1 in the preparation skin care item is characterized in that described Herba Apocyni veneti is hemp or ambary.
3. the application of dogbane leaf extractive according to claim 1 and 2 in the preparation skin care item, it is characterized in that, described skin care item comprise Skin whitening care cosmetics, Moisturizer, sunlight screening skin-protecting product, anti-aging skin care product, control oil skin care products, antiallergic skin care item or removing acne and freckle skin care item.
4. the application of dogbane leaf extractive according to claim 1 and 2 in the preparation skin care item is characterized in that described skin care item are water preparation, cream, Emulsion or facial film.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011104357137A CN103169632A (en) | 2011-12-22 | 2011-12-22 | Application of dogbane leaf extract in preparation of skin-care product |
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| CN2011104357137A CN103169632A (en) | 2011-12-22 | 2011-12-22 | Application of dogbane leaf extract in preparation of skin-care product |
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| CN103169632A true CN103169632A (en) | 2013-06-26 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924121A (en) * | 2017-04-27 | 2017-07-07 | 广州巴宝莉化妆品有限公司 | A kind of long-acting bacteriostatic skin cream |
| CN109223666A (en) * | 2018-12-04 | 2019-01-18 | 范承功 | A kind of plant extracts with transdermal enhancing effect and its application in skin care item |
| CN112516014A (en) * | 2021-01-08 | 2021-03-19 | 中华全国供销合作总社南京野生植物综合利用研究所 | Apocynum venetum extract, preparation method thereof, anti-ultraviolet, anti-oxidation and whitening cosmetic and preparation method thereof |
| EP3720462A4 (en) * | 2017-10-19 | 2021-12-22 | Yale University | Inhibition of androgen receptor by extracts of medicinal herbs and compositions thereof |
| CN114469816A (en) * | 2022-03-03 | 2022-05-13 | 深圳润邦之家生物科技有限公司 | Antioxidant plant essence skin care emulsion and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966139A (en) * | 2010-10-26 | 2011-02-09 | 戈宝绿业(深圳)有限公司 | Apocynum venetum extract, preparation method thereof and application thereof to cosmetics |
-
2011
- 2011-12-22 CN CN2011104357137A patent/CN103169632A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966139A (en) * | 2010-10-26 | 2011-02-09 | 戈宝绿业(深圳)有限公司 | Apocynum venetum extract, preparation method thereof and application thereof to cosmetics |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924121A (en) * | 2017-04-27 | 2017-07-07 | 广州巴宝莉化妆品有限公司 | A kind of long-acting bacteriostatic skin cream |
| EP3720462A4 (en) * | 2017-10-19 | 2021-12-22 | Yale University | Inhibition of androgen receptor by extracts of medicinal herbs and compositions thereof |
| US11839639B2 (en) | 2017-10-19 | 2023-12-12 | Yale University | Inhibition of androgen receptor by extracts of medicinal herbs and compositions thereof |
| TWI826395B (en) * | 2017-10-19 | 2023-12-21 | 耶魯大學 | Inhibition of androgen receptor by extracts of medicinal herbs and compositions thereof |
| CN109223666A (en) * | 2018-12-04 | 2019-01-18 | 范承功 | A kind of plant extracts with transdermal enhancing effect and its application in skin care item |
| CN109223666B (en) * | 2018-12-04 | 2021-05-25 | 施莱新研(杭州)生物科技有限公司 | Plant extract composition and application thereof in skin care products |
| CN112516014A (en) * | 2021-01-08 | 2021-03-19 | 中华全国供销合作总社南京野生植物综合利用研究所 | Apocynum venetum extract, preparation method thereof, anti-ultraviolet, anti-oxidation and whitening cosmetic and preparation method thereof |
| CN112516014B (en) * | 2021-01-08 | 2023-04-14 | 中华全国供销合作总社南京野生植物综合利用研究所 | Apocynum venetum extract, preparation method thereof, anti-ultraviolet, anti-oxidation and whitening cosmetic and preparation method thereof |
| CN114469816A (en) * | 2022-03-03 | 2022-05-13 | 深圳润邦之家生物科技有限公司 | Antioxidant plant essence skin care emulsion and preparation method thereof |
| CN114469816B (en) * | 2022-03-03 | 2024-01-30 | 深圳润邦之家生物科技有限公司 | Antioxidant plant essence skin care emulsion and preparation method thereof |
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Application publication date: 20130626 |