CN106924121A - A kind of long-acting bacteriostatic skin cream - Google Patents
A kind of long-acting bacteriostatic skin cream Download PDFInfo
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- CN106924121A CN106924121A CN201710290253.0A CN201710290253A CN106924121A CN 106924121 A CN106924121 A CN 106924121A CN 201710290253 A CN201710290253 A CN 201710290253A CN 106924121 A CN106924121 A CN 106924121A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of long-acting bacteriostatic skin cream, skin cream includes plant composition that mass percent is 0.8~2.5%, plant composition is serissa extract, apocynum extract, the mixture of Herba humuli scandentis extract, and serissa extract, apocynum extract, Herba humuli scandentis extract are (2~5) by weight：(3~8)：(5~12).Long-acting bacteriostatic skin cream of the present invention overcomes the problem do not grown fungistatic effect action time, comprehensively antibacterial with being carried out from different time angles, and with good anti-aging effects.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of long-acting bacteriostatic skin cream.
Background technology
Skin cream, is one kind of emulsion, can deeply moisten dry skin, the moisture content that supplement skin is lost in daily.It is natural to protect
The wet factor, its natural moisture preserving layer is strengthened by inside, special efficacy containing oil formula, moistened to you are more.Skin cream can be deep rapidly
Enter Glycerin, make its Crystal Recovery, lubricate, full of gloss.Skin cream relevantly meets the demand of Oily, is oiliness skin
The optimal skin care item of skin.Skin cream is a kind of liquid frost class cosmetics, has good moisturizing to act on, and also has damping effect.
As living standard is improved, everybody amount of exercise is but being reduced, immunity reduction, easily because of contact pollen, medicine
Allergy, or influenceed by air, weather, cause pruitus, often most people is thought the symptom of allergy, typically all uses band
There is the skin cream of antipruritic function, but the reason for causing itch is serious various, present environmental pollution, and many itch are all
It is causing because of bacterium, it is necessary to a kind of antibacterial skin cream, although and the existing skin cream fungistatic effect with fungistatic effect
Very well, but often action time is not long.
The content of the invention
In view of the shortcomings of the prior art, present invention aim at a kind of skin cream is provided, the skin cream has long-acting suppression
Bacterium effect.
The present invention is realized by following scheme：
The skin cream includes the plant composition that mass percent is 0.8~2.5%, and plant composition is carried for serissa serissoide
The mixture of thing, apocynum extract, Herba humuli scandentis extract is taken, serissa extract, apocynum extract, Herba humuli scandentis extract are by weight
It is (2~5) that amount part is compared：(3~8)：(5~12).
The preparation method of the serissa extract is：Serissa serissoide is cleaned into drying, 40~60 mesh sieves was crushed, by feed liquid
Than 1：(5~10) 30~50% ethanol are added, 1~2h, 30~60min of ultrasonic extraction, filtering, the rotated evaporimeter of filtrate is soaked
It is concentrated under reduced pressure.
The preparation method of the apocynum extract is：Bluish dogbane is cleaned into drying, 40~60 mesh sieves was crushed, by feed liquid
Than 1：(10~20) 60~80% ethanol, 10~30min of ultrasonic extraction, filtering, the rotated evaporation under reduced pressure concentration of filtrate are added
.
The preparation method of the Herba humuli scandentis extract is：Humulus grass is cleaned into drying, 40~60 mesh sieves was crushed, by solid-liquid ratio 1：
(50~60) 65~85% ethanol, 30~50min of ultrasonic extraction, filtering, the rotated evaporation under reduced pressure concentration of filtrate are added.
The skin cream is made up of the component of following mass percent：
The preparation method of the skin cream is comprised the following steps：
(1) by isopropyl myristate, dimethyl silicone polymer, Dormant oils, cetostearyl alcohol, saualane, poly dimethyl silicon
Oxygen alkane, stearine, ring five dimethyl silicone polymer, jojoba seed oil, methyl hydroxybenzoate, Nipasol mixing constitutes oil phase
Oil phase pot is added, 75-85 DEG C is heated with stirring to, waits all components to be incubated after dissolving, A phases are obtained；
(2) by glycerine, propane diols, allantoin, Sodium Hyaluronate, EDETATE SODIUM, deionized water mixing constitutes water and is added to
Water phase pot, is heated with stirring to 70-85 DEG C, and insulation 15-30min makes it fully dissolve, and B phases are obtained；
(3) first B phases are pumped into emulsification pot and add A phases, homogeneous 5-15min, stir speed (S.S.) is 2000-4000r/
Min, then insulated and stirred 15-45min, stir speed (S.S.) is 30-50r/min；40-45 DEG C is cooled to, described plant group is added
Compound and Bis(hydroxymethyl)imidazolidinyl urea, stir.
Make following introduction to the part material in long-acting bacteriostatic skin cream of the present invention：
Apocynum extract：Bluish dogbane, another name bluish dogbane, bluish dogbane, red building etc., upright fruticuli is high 1.5-3 meters, and one
As it is high about 2 meters, reach as high as 4 meters, be grown on riverbank, gully, hillside chiltern ground, in Chinese Huaihe River, the Qinling Mountains, to the north of Kun Lun Mountain
Each province (autonomous region) has bluish dogbane to be distributed, and relieves inflammation or internal heat, step-down, cardiac stimulant, diuresis.Control the effect such as heart disease.Apocynum extract
Middle flavone compound and cupreol material have extremely strong effect always to Escherichia coli and staphylococcus aureus, to spreading out
Nettle extract contacted with Escherichia coli and staphylococcus aureus vibration 6h when, Escherichia coli and staphylococcus aureus whole quilts
Kill, bacteriostasis rate reaches 100%；Polyphenol has good antioxidation in apocynum extract.
Herba humuli scandentis extract：Humulus grass also known as strangle careless, black grass, climing numb Pueraria lobota, climing Pueraria lobota humulus, Ge Leman, come poisonous weeds, Pueraria lobota humulus grass, puckery trailing plants
Climing, balsampear stem, psilate catchweed bedstraw herb, draw rattan, cairo morningglory root or leaf, great Ye the dragon five dry rattans of pawl snake, snake cut rattan, cut people rattan, uproot plants after their edible portions have been harvested (perverse seedling),
Draw rattan (perverse rattan), draw climing, cairo morningglory root or leaf, climing foreign puckery bar, puckery Barre seedling, puckery seedling, perennial vines herbaceous plant.Strain is long
1~5 meter, dioecism, usual all living creatures has thin barb on stem and petiole, blade is in palmate, and stem happiness winds other plant growths.
Herba humuli scandentis extract is inhibited to staphylococcus aureus, and with the increase of Herba humuli scandentis extract concentration, it is to golden yellow Portugal
The inhibitory action of grape coccus also gradually strengthens, and when concentration is 100mg/mL, inhibition zone can reach 15mm, in 4h, extract
Average diameter of inhibition zone reach maximum：18.3mm；Humulus grass flavones can significantly improve the work of SOD in human body in Herba humuli scandentis extract
Property, so as to reach anti-aging effects.
Serissa extract：Serissa serissoide, Rubiaceae evergreen dwarf shrub is high up to 90 centimetres, there is foul smell.Leaf keratin, handle is short.
Hua Dansheng or several grows thickly in sprig top or axillary, corolla pale red or white, style protrusion long, the month at florescence 5-7.Root, stem,
Ye Junke is used as medicine.Light, micro-pungent, it is cool.Liver soothing and depression relief, clearing heat and promoting diuresis, detumescence and drawing out poison is relieving cough and reducing sputum.Serissa extract is to golden yellow
Color staphylococcus, Escherichia coli, hay bacillus and P aeruginosa bacteria have very strong inhibitory action, antibacterial instant effect, minimum suppression
Bacteria concentration is 1.25%；There is good inhibiting effect to hydroxy radical in serissa extract, be in serissa extract concentration
During 3000.000mg/mL, hydroxy radical is completely removed substantially, when being diluted to 1/4,1/16, the 1/64 of 3000.000mg/mL,
Hydroxy radical is equally completely removed (clearance rate is all 99% or so), is diluted to the 1/256 of 3000.000mg/mL
When (11.719mg/mL), a small amount of photon is can detect with superweak luminescence instrument, in the gradually reduction with diluted concentration, its removing
The ability of hydroxy radical is gradually reduced, when 1/16384 (0.183mg/mL) of original content is diluted to, serissa serissoide water extract pair
The clearance rate of hydroxy radical remains at 12.727%.
Compared with prior art, the method have the advantages that
(1) in long-acting bacteriostatic skin cream of the present invention, apocynum extract, Herba humuli scandentis extract and serissa extract according to
Special ratios are arranged in pairs or groups so that skin cream of the present invention not only has very strong bacteriostasis, and long-acting, serissa extract
Fungistatic effect instant effect, Herba humuli scandentis extract antibacterial ability in 4h is most strong, and apocynum extract antibacterial effect in 6h reaches
Preferably, long-acting bacteriostatic skin cream of the present invention is enable to be carried out from different time angles comprehensively antibacterial.
(2) in long-acting bacteriostatic skin cream of the present invention serissa extract can remove with the generation for delaying hydroxy radical, spread out
Nettle extract then removes other free radicals by the effect of free state polyphenol, and Herba humuli scandentis extract is even more can significantly improve deep skin
SOD, allow the cleaning free radical that human body is autonomous, this three removing free radical from inside to outside skin is reached anti-aging effects.
(3) long-acting bacteriostatic skin cream of the present invention, it is safe, gentle non-stimulated.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.The long-acting bacteriostatic skin cream of the present invention of embodiment 1~5
Formula is shown in Table one
Table one
The preparation method of serissa extract is described in embodiment 1~5：Serissa serissoide is cleaned into drying, 60 mesh were crushed
Sieve, by solid-liquid ratio 1：10 add 50% ethanol, soak 2h, ultrasonic extraction 60min, and filtering, the rotated evaporation under reduced pressure of filtrate is dense
Contracting.
The preparation method of apocynum extract is described in embodiment 1~5：Bluish dogbane is cleaned into drying, 60 mesh were crushed
Sieve, by solid-liquid ratio 1：20 add 80% ethanol, ultrasonic extraction 30min, filtering, the rotated evaporation under reduced pressure concentration of filtrate.
The preparation method of Herba humuli scandentis extract is described in embodiment 1~5：Humulus grass is cleaned into drying, 60 mesh sieves were crushed, pressed
Solid-liquid ratio 1：60 add 85% ethanol, ultrasonic extraction 50min, filtering, the rotated evaporation under reduced pressure concentration of filtrate.
The preparation method of the skin cream is comprised the following steps：
(1) by isopropyl myristate, dimethyl silicone polymer, Dormant oils, cetostearyl alcohol, saualane, poly dimethyl silicon
Oxygen alkane, stearine, ring five dimethyl silicone polymer, jojoba seed oil, methyl hydroxybenzoate, Nipasol mixing constitutes oil phase
Oil phase pot is added, 85 DEG C are heated with stirring to, waits all components to be incubated after dissolving, A phases are obtained；
(2) by glycerine, propane diols, allantoin, Sodium Hyaluronate, EDETATE SODIUM, deionized water mixing constitutes water and is added to
Water phase pot, is heated with stirring to 85 DEG C, and insulation 30min makes it fully dissolve, and B phases are obtained；
(3) first B phases are pumped into emulsification pot and add A phases, homogeneous 15min, stir speed (S.S.) is 3000r/min, then
Insulated and stirred 45min, stir speed (S.S.) is 50r/min；45 DEG C are cooled to, plant composition and double (methylol) imidazolidinyls is added
Urea, stirs.
Comparative example 1
It is not add serissa extract with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 2
It is not add apocynum extract with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 3
It is not add Herba humuli scandentis extract with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 4
It is to add 0.7 part of plant composition with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 5
It is to add 2.6 parts of plant composition with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Comparative example 6
It is not add plant composition with the difference of embodiment 1, other preparation conditions and method are same as Example 1.
Long-term bacteriostatic efficacy is verified
This case chooses staphylococcus aureus and Escherichia coli and carries out antibacterial reality with reference to GB 15979-2002 appendix Cs 3
Test.Table two lists embodiment 1 of the simulation human body skin environmental treatment after 4 hours, comparative example 1~6 and claims have on the market
The skin cream of good long-acting bacteriostatic effect antibacterial experiment result as a control group.
Table two
Can show that each plant component of long-acting bacteriostatic skin cream of the present invention has cooperative effect, and this hair by above-mentioned use result
Bright formulation ratio span is better than other spans, and using effect is good.In a word, the foregoing is only of the invention preferable
Embodiment, all impartial changes made according to scope of the present invention patent and modification, should all belong to the covering scope of patent of the present invention.
Claims (7)
1. a kind of long-acting bacteriostatic skin cream, it is characterised in that the skin cream includes plant that mass percent is 0.8~2.5%
Compositions；
Wherein, plant composition is serissa extract, apocynum extract, the mixture of Herba humuli scandentis extract.
2. a kind of long-acting bacteriostatic skin cream according to claim 1, it is characterised in that the serissa extract, spread out
Nettle extract, Herba humuli scandentis extract are (2~5) by weight：(3~8)：(5~12).
3. a kind of long-acting bacteriostatic skin cream according to claim 1 and 2, it is characterised in that the serissa extract
Preparation method is：Serissa serissoide is cleaned into drying, 40~60 mesh sieves was crushed, by solid-liquid ratio 1：(5~10) 30~50% second are added
Alcohol, soaks 1~2h, 30~60min of ultrasonic extraction, filtering, the rotated evaporation under reduced pressure concentration of filtrate.
4. a kind of long-acting bacteriostatic skin cream according to claim 1 and 2, it is characterised in that the apocynum extract
Preparation method is：Bluish dogbane is cleaned into drying, 40~60 mesh sieves was crushed, by solid-liquid ratio 1：(10~20) 60~80% second are added
Alcohol, 10~30min of ultrasonic extraction, filtering, the rotated evaporation under reduced pressure concentration of filtrate.
5. a kind of long-acting bacteriostatic skin cream according to claim 1 and 2, it is characterised in that the system of the Herba humuli scandentis extract
Preparation Method is：Humulus grass is cleaned into drying, 40~60 mesh sieves was crushed, by solid-liquid ratio 1：(50~60) 65~85% ethanol are added,
30~50min of ultrasonic extraction, filtering, the rotated evaporation under reduced pressure concentration of filtrate.
6. a kind of long-acting bacteriostatic skin cream according to claim 1, it is characterised in that the skin cream is by following quality hundred
Divide the component composition of ratio：
7. a kind of long-acting bacteriostatic skin cream according to any one of claim 1~6, it is characterised in that the skin cream
Preparation method is comprised the following steps：
(1) by isopropyl myristate, dimethyl silicone polymer, Dormant oils, cetostearyl alcohol, saualane, dimethyl silicone polymer,
Stearine, ring five dimethyl silicone polymer, jojoba seed oil, methyl hydroxybenzoate, Nipasol mixing constitutes oil phase and adds
Oil phase pot, is heated with stirring to 75-85 DEG C, waits all components to be incubated after dissolving, and A phases are obtained；
(2) by glycerine, propane diols, allantoin, Sodium Hyaluronate, EDETATE SODIUM, deionized water mixing constitutes water and is added to water phase
Pot, is heated with stirring to 70-85 DEG C, and insulation 15-30min makes it fully dissolve, and B phases are obtained；
(3) first B phases are pumped into emulsification pot and add A phases, homogeneous 5-15min, stir speed (S.S.) is 2000-4000r/min, and
Insulated and stirred 15-45min afterwards, stir speed (S.S.) is 30-50r/min；40-45 DEG C is cooled to, as claimed in claim 1 plant is added
Compositions and Bis(hydroxymethyl)imidazolidinyl urea, stir.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710290253.0A CN106924121A (en) | 2017-04-27 | 2017-04-27 | A kind of long-acting bacteriostatic skin cream |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710290253.0A CN106924121A (en) | 2017-04-27 | 2017-04-27 | A kind of long-acting bacteriostatic skin cream |
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| CN106924121A true CN106924121A (en) | 2017-07-07 |
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| CN201710290253.0A Pending CN106924121A (en) | 2017-04-27 | 2017-04-27 | A kind of long-acting bacteriostatic skin cream |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755277A (en) * | 2019-12-05 | 2020-02-07 | 新疆维吾尔自治区中药民族药研究所 | Toothpaste containing various plant extracts and preparation method thereof |
| CN113398057A (en) * | 2020-12-22 | 2021-09-17 | 重庆中佳信健康管理有限公司 | Bacteriostatic agent and preparation method thereof |
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|---|---|---|---|---|
| CN103169632A (en) * | 2011-12-22 | 2013-06-26 | 黄玉良 | Application of dogbane leaf extract in preparation of skin-care product |
| CN103239388A (en) * | 2013-05-15 | 2013-08-14 | 郭春荣 | Skin care product for beauty and health care and preparation method thereof |
| CN103271861A (en) * | 2013-06-29 | 2013-09-04 | 荆霞 | Sun-proof and moisturizing treatment face cream |
| CN104997678A (en) * | 2015-07-09 | 2015-10-28 | 刘学勤 | Wrinkle-resisting wrinkle-removing beautifying liquid |
| CN106309629A (en) * | 2016-08-24 | 2017-01-11 | 宁波枫叶杰科生物技术有限公司 | Herbal essence extract and and preparing method thereof |
| CN106309321A (en) * | 2016-09-13 | 2017-01-11 | 广西顺帆投资有限公司 | Anti-wrinkle whitening mask and preparation method thereof |
-
2017
- 2017-04-27 CN CN201710290253.0A patent/CN106924121A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103169632A (en) * | 2011-12-22 | 2013-06-26 | 黄玉良 | Application of dogbane leaf extract in preparation of skin-care product |
| CN103239388A (en) * | 2013-05-15 | 2013-08-14 | 郭春荣 | Skin care product for beauty and health care and preparation method thereof |
| CN103271861A (en) * | 2013-06-29 | 2013-09-04 | 荆霞 | Sun-proof and moisturizing treatment face cream |
| CN104997678A (en) * | 2015-07-09 | 2015-10-28 | 刘学勤 | Wrinkle-resisting wrinkle-removing beautifying liquid |
| CN106309629A (en) * | 2016-08-24 | 2017-01-11 | 宁波枫叶杰科生物技术有限公司 | Herbal essence extract and and preparing method thereof |
| CN106309321A (en) * | 2016-09-13 | 2017-01-11 | 广西顺帆投资有限公司 | Anti-wrinkle whitening mask and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755277A (en) * | 2019-12-05 | 2020-02-07 | 新疆维吾尔自治区中药民族药研究所 | Toothpaste containing various plant extracts and preparation method thereof |
| CN110755277B (en) * | 2019-12-05 | 2022-08-09 | 新疆维吾尔自治区中药民族药研究所 | Toothpaste containing various plant extracts and preparation method thereof |
| CN113398057A (en) * | 2020-12-22 | 2021-09-17 | 重庆中佳信健康管理有限公司 | Bacteriostatic agent and preparation method thereof |
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Application publication date: 20170707 |