AR032392A1 - Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. - Google Patents
Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.Info
- Publication number
- AR032392A1 AR032392A1 ARP020100070A ARP020100070A AR032392A1 AR 032392 A1 AR032392 A1 AR 032392A1 AR P020100070 A ARP020100070 A AR P020100070A AR P020100070 A ARP020100070 A AR P020100070A AR 032392 A1 AR032392 A1 AR 032392A1
- Authority
- AR
- Argentina
- Prior art keywords
- prepared
- pharmaceutical preparation
- mixtures
- pharmaceutical preparations
- enzymes
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- 230000029087 digestion Effects 0.000 abstract 2
- 230000000813 microbial effect Effects 0.000 abstract 2
- 239000004382 Amylase Substances 0.000 abstract 1
- 102000013142 Amylases Human genes 0.000 abstract 1
- 108010065511 Amylases Proteins 0.000 abstract 1
- 241000981399 Aspergillus melleus Species 0.000 abstract 1
- 240000006439 Aspergillus oryzae Species 0.000 abstract 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000035467 Pancreatic insufficiency Diseases 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 241000303962 Rhizopus delemar Species 0.000 abstract 1
- 235000019418 amylase Nutrition 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
Abstract
Se describen nuevas mezclas de enzimas microbianas, que contienen una lipasa concentrada de Rhizopus delemar y adicionalmente una proteasa de Aspergillus melleus así como una amilasa de Aspergillus oryzae. Además se describen preparados farmacéuticos que contienen estas mezclas de enzimas microbianas. Los nuevos preparados farmacéuticos son especialmente bien apropiados para el tratamiento y/o la profilaxis de la mala digestion, en particular la mala digestion que se debe a una insuficiencia pancreática en animales mamíferos y seres humanos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10102495 | 2001-01-19 | ||
DE10144711A DE10144711A1 (de) | 2001-01-19 | 2001-09-11 | Neue Gemische mikrobieller Enzyme |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032392A1 true AR032392A1 (es) | 2003-11-05 |
Family
ID=26008287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020100070A AR032392A1 (es) | 2001-01-19 | 2002-01-10 | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20040057944A1 (es) |
EP (1) | EP1381386A2 (es) |
JP (1) | JP2004524838A (es) |
CN (1) | CN1236817C (es) |
AR (1) | AR032392A1 (es) |
BR (1) | BR0206521A (es) |
CA (1) | CA2434808A1 (es) |
CZ (1) | CZ20031900A3 (es) |
HU (1) | HUP0500560A3 (es) |
IL (1) | IL157004A0 (es) |
MX (1) | MXPA03005960A (es) |
NO (1) | NO20033261L (es) |
NZ (1) | NZ527148A (es) |
PL (1) | PL362646A1 (es) |
RU (1) | RU2003124078A (es) |
SK (1) | SK9292003A3 (es) |
WO (1) | WO2002060474A2 (es) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
US20010046493A1 (en) * | 2000-02-24 | 2001-11-29 | Alex Margolin | Lipase-containing composition and methods of use thereof |
US20070053895A1 (en) * | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
US8030002B2 (en) * | 2000-11-16 | 2011-10-04 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
US8100844B2 (en) * | 2002-04-25 | 2012-01-24 | Ultraflex Systems, Inc. | Ambulating ankle and knee joints with bidirectional dampening and assistance using elastomeric restraint |
EP1682168B1 (en) * | 2003-10-29 | 2013-05-01 | Eli Lilly And Co. | Non-pancreatic proteases for controlling plasma cholecystokinin (cck) concentration and for treating pain |
EP1729797B1 (en) | 2004-03-22 | 2008-09-10 | Solvay Pharmaceuticals GmbH | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
ATE473010T1 (de) | 2004-05-24 | 2010-07-15 | Novozymes As | Enzyme für pharmazeutische anwendung |
US20060198838A1 (en) * | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
JP4908420B2 (ja) * | 2004-10-14 | 2012-04-04 | アルタス ファーマシューティカルズ インコーポレイテッド | 膵機能不全を治療するための、リパーゼ、プロテアーゼおよびアミラーゼを含有する組成物 |
CA2612806A1 (en) * | 2005-06-24 | 2006-12-28 | Solvay Pharmaceuticals Gmbh | Proteases for pharmaceutical use |
AU2006261442A1 (en) * | 2005-06-24 | 2006-12-28 | Novozymes A/S | Lipases for pharmaceutical use |
NZ563737A (en) | 2005-06-24 | 2010-08-27 | Novozymes As | Amylases derived from Bacillus stearothermophilus optionally in combination with proteases and/or lipases for pharmaceutical use |
WO2007014896A1 (en) | 2005-07-29 | 2007-02-08 | Solvay Pharmaceuticals Gmbh | Processes for the manufacture of sterilized pancreatin powder |
RU2408364C2 (ru) * | 2005-08-15 | 2011-01-10 | Зольвай Фармасьютиклз Гмбх | Ядра микропеллет панкреатина, пригодные для нанесения энтеросолюбильного покрытия |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
US20070116695A1 (en) * | 2005-09-21 | 2007-05-24 | Fallon Joan M | Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders |
US20100196344A1 (en) * | 2005-10-14 | 2010-08-05 | Cystic Fibrosis Foundation Therapeutics, Inc. | Compositions and methods for treating pancreatic insufficiency |
WO2007053619A2 (en) * | 2005-11-01 | 2007-05-10 | Bio-Cat, Inc. | A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
US20080081035A1 (en) * | 2006-10-03 | 2008-04-03 | National Enzyme Company | Therapeutic protease compositions |
WO2008066715A2 (en) | 2006-11-22 | 2008-06-05 | Standard Biologics, Inc. | Method of treatment using aspergillus oryzae protease |
CA3081308C (en) | 2006-12-21 | 2024-02-20 | Novozymes A/S | Lipase variants for pharmaceutical use |
US20080199448A1 (en) * | 2007-02-16 | 2008-08-21 | Ross Mairi R | Enzyme composition for improving food digestion |
PT2079445E (pt) | 2007-02-20 | 2016-02-29 | Allergan Pharmaceuticals Internat Ltd | Composições de enzimas digestivas estáveis |
US20090068174A1 (en) * | 2007-09-12 | 2009-03-12 | Kansas University Medical Center Research Institute, Inc. | Therapeutic alkaline protease compositions and use in facilitating the transport of agents across the gastrointestinal mucosal lining |
US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
RU2010127329A (ru) | 2007-12-04 | 2012-01-10 | Новозимс А/С (Dk) | Варианты протеаз для фармацевтического применения |
JP2011508755A (ja) * | 2008-01-03 | 2011-03-17 | アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 精製微生物リパーゼの顆粒を有する医薬組成物ならびに消化器疾患を予防又は治療する方法 |
WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
US20090324730A1 (en) * | 2008-06-26 | 2009-12-31 | Fallon Joan M | Methods and compositions for the treatment of symptoms of complex regional pain syndrome |
US9320780B2 (en) * | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
PL2318035T3 (pl) * | 2008-07-01 | 2019-10-31 | Curemark Llc | Sposoby i kompozycje do leczenia objawów zaburzeń neurologicznych i zaburzeń zdrowia psychicznego |
US10776453B2 (en) * | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
US20110171294A1 (en) * | 2008-09-30 | 2011-07-14 | Dsm Ip Assets B.V. | Enzyme composition and application thereof in the treatment of pancreatic insufficiency |
US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
AU2015252099B2 (en) * | 2009-01-06 | 2017-08-10 | Galenagen, Llc | Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces |
BRPI1007379B8 (pt) | 2009-01-06 | 2022-07-19 | Curemark Llc | composições farmacêuticas para o tratamento ou prevenção de infecções orais por e. coli |
CA2747611C (en) | 2009-01-06 | 2019-09-17 | Curemark Llc | Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces |
US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
WO2011050135A1 (en) | 2009-10-21 | 2011-04-28 | Curemark Llc | Methods and compositions for the prevention and treatment of influenza |
MX2012010755A (es) * | 2010-03-19 | 2013-03-08 | Aptalis Pharma Canada Inc | Composiciones farmaceuticas de enzimas gastro-resistentes. |
ES2657673T3 (es) | 2010-10-01 | 2018-03-06 | Aptalis Pharma Limited | Formulaciones recubiertas entéricas de pancrelipasa, de baja intensidad |
WO2012088303A2 (en) | 2010-12-22 | 2012-06-28 | Novozymes North America, Inc. | Processes for producing fermentation products |
GB2503852B (en) | 2011-04-21 | 2018-12-12 | Curemark Llc | Compounds for the treatment of neuropsychiatric disorders |
RU2602183C2 (ru) | 2011-08-08 | 2016-11-10 | Апталис Фарма Лтд. | Способ проведения теста на растворение твердых композиций, содержащих пищеварительные ферменты |
EP2785847B1 (en) * | 2011-12-02 | 2017-07-26 | Novozymes A/S | Liquefaction process with selected alpha-amylases and proteases |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
CA2884592C (en) | 2012-09-19 | 2021-08-31 | Grespo Ab | Compositions for improvement of brain function |
WO2014141121A1 (en) | 2013-03-15 | 2014-09-18 | Aptalis Pharma Ltd. | Composition containing digestive enzymes and nutrients suitable for enteral administration |
US11939552B2 (en) | 2013-06-24 | 2024-03-26 | Novozymes A/S | Process of recovering oil |
ES2754203T3 (es) | 2013-06-24 | 2020-04-16 | Novozymes As | Proceso de extracción de aceite a partir de vinaza diluida |
RU2686460C2 (ru) * | 2013-07-22 | 2019-04-26 | Апталис Фарма Лтд. | Высокоэффективные фармацевтические композиции панкреатина |
JP2016537387A (ja) | 2013-08-09 | 2016-12-01 | アラガン ファーマシューティカルズ インターナショナル リミテッド | 経腸投与に適した消化酵素組成物 |
RU2015155470A (ru) * | 2013-11-05 | 2017-08-21 | Апталис Фарма Лтд. | Высокоэффективные фармацевтические композиции панкреатина |
CA2947998A1 (en) | 2014-06-19 | 2015-12-23 | Aptalis Pharma Ltd. | Methods for removing viral contaminants from pancreatic extracts |
GB201501081D0 (en) | 2015-01-22 | 2015-03-11 | Cilian Ag | Use of enzymes with a wide pH activity range as medicaments for promoting digestion |
WO2016126970A1 (en) | 2015-02-04 | 2016-08-11 | Abbvie Inc. | Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency |
US20200291375A1 (en) * | 2017-09-24 | 2020-09-17 | Bio-Cat, Inc. | Fungal protease mixtures and uses thereof |
FR3079146B1 (fr) | 2018-03-23 | 2020-04-17 | Karim Ioualalen | Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive. |
FR3111559A1 (fr) * | 2020-06-18 | 2021-12-24 | Azurrx Biopharma, Inc. | Formulations non porcines et leurs procédés |
US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1084431A (en) * | 1964-05-06 | 1967-09-20 | Analyses Et De Rech S Biolog M | Improvements in and relating to lipases |
DE2638088C3 (de) * | 1976-08-24 | 1979-06-21 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Verwendung von SuBmolkenpulver |
JP3152958B2 (ja) * | 1991-06-14 | 2001-04-03 | 天野エンザイム株式会社 | 微生物起源リパーゼの安定化組成物及び安定化法 |
DE4332985A1 (de) * | 1993-09-28 | 1995-03-30 | Konrad Peter Maria Dr Sommer | Arzneimittel zur Behandlung der Dysfunktion des exokrinen Pankreas |
US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
US6013680A (en) * | 1997-10-21 | 2000-01-11 | Amano Pharmaceutical Co., Ltd. | Digestive enzyme-containing medicament |
-
2002
- 2002-01-10 AR ARP020100070A patent/AR032392A1/es not_active Application Discontinuation
- 2002-01-16 PL PL02362646A patent/PL362646A1/xx not_active Application Discontinuation
- 2002-01-16 RU RU2003124078/15A patent/RU2003124078A/ru not_active Application Discontinuation
- 2002-01-16 HU HU0500560A patent/HUP0500560A3/hu unknown
- 2002-01-16 EP EP02716661A patent/EP1381386A2/de not_active Withdrawn
- 2002-01-16 JP JP2002560665A patent/JP2004524838A/ja not_active Withdrawn
- 2002-01-16 NZ NZ527148A patent/NZ527148A/en unknown
- 2002-01-16 SK SK929-2003A patent/SK9292003A3/sk unknown
- 2002-01-16 MX MXPA03005960A patent/MXPA03005960A/es unknown
- 2002-01-16 CN CNB028038894A patent/CN1236817C/zh not_active Expired - Fee Related
- 2002-01-16 WO PCT/EP2002/000374 patent/WO2002060474A2/de not_active Application Discontinuation
- 2002-01-16 CZ CZ20031900A patent/CZ20031900A3/cs unknown
- 2002-01-16 CA CA002434808A patent/CA2434808A1/en not_active Abandoned
- 2002-01-16 BR BR0206521-5A patent/BR0206521A/pt not_active IP Right Cessation
- 2002-01-16 IL IL15700402A patent/IL157004A0/xx unknown
-
2003
- 2003-07-17 US US10/620,759 patent/US20040057944A1/en not_active Abandoned
- 2003-07-18 NO NO20033261A patent/NO20033261L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1236817C (zh) | 2006-01-18 |
CA2434808A1 (en) | 2002-08-08 |
WO2002060474A2 (de) | 2002-08-08 |
RU2003124078A (ru) | 2005-01-27 |
CN1487837A (zh) | 2004-04-07 |
IL157004A0 (en) | 2004-02-08 |
JP2004524838A (ja) | 2004-08-19 |
WO2002060474A3 (de) | 2003-10-30 |
CZ20031900A3 (cs) | 2003-10-15 |
EP1381386A2 (de) | 2004-01-21 |
NO20033261D0 (no) | 2003-07-18 |
US20040057944A1 (en) | 2004-03-25 |
NO20033261L (no) | 2003-07-18 |
HUP0500560A3 (en) | 2006-06-28 |
MXPA03005960A (es) | 2003-09-05 |
BR0206521A (pt) | 2004-02-17 |
HUP0500560A2 (hu) | 2005-09-28 |
PL362646A1 (en) | 2004-11-02 |
NZ527148A (en) | 2005-01-28 |
SK9292003A3 (en) | 2003-12-02 |
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