GB1084431A - Improvements in and relating to lipases - Google Patents

Improvements in and relating to lipases

Info

Publication number
GB1084431A
GB1084431A GB1882564A GB1882564A GB1084431A GB 1084431 A GB1084431 A GB 1084431A GB 1882564 A GB1882564 A GB 1882564A GB 1882564 A GB1882564 A GB 1882564A GB 1084431 A GB1084431 A GB 1084431A
Authority
GB
United Kingdom
Prior art keywords
lipase
culture
filtrate
separated
rhizopus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1882564A
Inventor
Roland Yves Mauvernay
Pierre Laboureur
Michel Labrousse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ANALYSES ET DE RECH S BIOLOG M
APPLIC BIOCHEMIQUES SOC ET
Original Assignee
ANALYSES ET DE RECH S BIOLOG M
APPLIC BIOCHEMIQUES SOC ET
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ANALYSES ET DE RECH S BIOLOG M, APPLIC BIOCHEMIQUES SOC ET filed Critical ANALYSES ET DE RECH S BIOLOG M
Priority to GB1882564A priority Critical patent/GB1084431A/en
Priority to FR13218A priority patent/FR1605287A/en
Priority to CH550065A priority patent/CH433162A/en
Priority to BE662862D priority patent/BE662862A/xx
Priority to IT900865A priority patent/IT1061781B/en
Priority to IL2348465A priority patent/IL23484A/en
Priority to NL6505658A priority patent/NL6505658A/xx
Priority to ES0312586A priority patent/ES312586A1/en
Priority to DK229365A priority patent/DK112721B/en
Priority to FR24528A priority patent/FR4566M/fr
Publication of GB1084431A publication Critical patent/GB1084431A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

In a process for the preparation of a stable lipase of high activity, a culture is made with aeration and stirring with a species of microorganism chosen from Mucor Hiemalis, Rhizopus Delemar and Rhizopus Arrhizus on a nutrient medium containing organic substances, nitrogen sources and mineral elements, and if desired vitamins, the culture is continued until the moment when the enzymatic activity of the medium remains constant, the culture medium is separated by filtration from the filtrate and the lipase contained in the filtrate is collected. The separated enzyme may be purified by fractional precipitation, dialysis or the use of a cation exchange resin or molecular sieve.ALSO:A therapeutic composition useful in treating pacreatic insufficiencies &c. comprises a microbial lipase (see Division C3) plus an excipient, in the form of tablets (which may be effervescent) or capsules for oral administration; or the lipase dissolved in physiological saline or a buffer may be injected.
GB1882564A 1964-05-06 1964-05-06 Improvements in and relating to lipases Expired GB1084431A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB1882564A GB1084431A (en) 1964-05-06 1964-05-06 Improvements in and relating to lipases
FR13218A FR1605287A (en) 1964-05-06 1965-04-14 Lipase neth 6 505 658 provided
CH550065A CH433162A (en) 1964-05-06 1965-04-21 Process for the preparation of a stable high activity lipase
BE662862D BE662862A (en) 1964-05-06 1965-04-22
IT900865A IT1061781B (en) 1964-05-06 1965-04-23 PROCEDURE FOR OBTAINING A LIPASE WITH HIGH ACTIVITY AND PRODUCTS THAT RESULT
IL2348465A IL23484A (en) 1964-05-06 1965-05-04 Lipase and its preparation
NL6505658A NL6505658A (en) 1964-05-06 1965-05-04
ES0312586A ES312586A1 (en) 1964-05-06 1965-05-05 Procedure for the obtaining of a new stable lipase of great activity. (Machine-translation by Google Translate, not legally binding)
DK229365A DK112721B (en) 1964-05-06 1965-05-06 Process for the production of a stable lipase with high activity.
FR24528A FR4566M (en) 1964-05-06 1965-07-13

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1882564A GB1084431A (en) 1964-05-06 1964-05-06 Improvements in and relating to lipases

Publications (1)

Publication Number Publication Date
GB1084431A true GB1084431A (en) 1967-09-20

Family

ID=10119057

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1882564A Expired GB1084431A (en) 1964-05-06 1964-05-06 Improvements in and relating to lipases

Country Status (9)

Country Link
BE (1) BE662862A (en)
CH (1) CH433162A (en)
DK (1) DK112721B (en)
ES (1) ES312586A1 (en)
FR (2) FR1605287A (en)
GB (1) GB1084431A (en)
IL (1) IL23484A (en)
IT (1) IT1061781B (en)
NL (1) NL6505658A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117553A2 (en) * 1983-02-25 1984-09-05 Daikin Kogyo Co., Ltd. Heat-resistant lipase
US5489530A (en) * 1991-07-01 1996-02-06 Basf Aktiengesellschaft Lipase from Pseudomonas and strain
WO1996038170A1 (en) * 1995-05-31 1996-12-05 Medzyme N.V. Composition to improve digestibility and utilisation of nutrients
WO2002060474A2 (en) * 2001-01-19 2002-08-08 Solvay Pharmaceuticals Gmbh Mixtures of mushroom enzymes and the use thereof for treating maldigestion
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2418238A2 (en) * 1978-02-23 1979-09-21 Degussa Lipase stabilisation in enzyme preparations - using animal globular proteins e.g. ovalbumin

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117553A2 (en) * 1983-02-25 1984-09-05 Daikin Kogyo Co., Ltd. Heat-resistant lipase
EP0117553A3 (en) * 1983-02-25 1986-09-10 Daikin Kogyo Co., Ltd. Heat-resistant lipase
US5489530A (en) * 1991-07-01 1996-02-06 Basf Aktiengesellschaft Lipase from Pseudomonas and strain
US5645832A (en) * 1991-07-01 1997-07-08 Basf Aktiengesellschaft Use of lipases for producing drugs
WO1996038170A1 (en) * 1995-05-31 1996-12-05 Medzyme N.V. Composition to improve digestibility and utilisation of nutrients
US6051220A (en) * 1995-05-31 2000-04-18 Medzyme N.V. And Simon Lodewijk Scharpe Composition to improve digestibility and utilization of nutrients
WO2002060474A2 (en) * 2001-01-19 2002-08-08 Solvay Pharmaceuticals Gmbh Mixtures of mushroom enzymes and the use thereof for treating maldigestion
WO2002060474A3 (en) * 2001-01-19 2003-10-30 Solvay Pharm Gmbh Mixtures of mushroom enzymes and the use thereof for treating maldigestion
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
US9555083B2 (en) 2011-09-23 2017-01-31 Bio-Cat, Inc. Methods and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase

Also Published As

Publication number Publication date
BE662862A (en) 1965-08-17
NL6505658A (en) 1965-11-08
ES312586A1 (en) 1965-07-01
DK112721B (en) 1969-01-13
IT1061781B (en) 1983-04-30
IL23484A (en) 1970-01-29
FR1605287A (en) 1974-04-05
CH433162A (en) 1967-04-15
FR4566M (en) 1966-11-07

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