FR1605287A - Lipase neth 6 505 658 provided - Google Patents
Lipase neth 6 505 658 providedInfo
- Publication number
- FR1605287A FR1605287A FR13218A FR13218A FR1605287A FR 1605287 A FR1605287 A FR 1605287A FR 13218 A FR13218 A FR 13218A FR 13218 A FR13218 A FR 13218A FR 1605287 A FR1605287 A FR 1605287A
- Authority
- FR
- France
- Prior art keywords
- lipase
- fat
- insufficiency
- pancreas
- metabolism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Stable lipase prepd. by culturing a strain of Mucoraceae under aerobic conditions until the enzyme-activity of the medium has become constant; the mycelium is then separated from the liquid and the lipase removed from the filtrate. Lipase in general is an important enzyme in fat-metabolism by hydrolysis of triglycerides. The new lipase may be used in the therapy of gastrointestinal ailments caused by pancreas-insufficiency, insufficiency of secretion caused by age, atheromatoses and psoriasis, which is often accompanied by disturbances in the fat-metabolism. Specially purified prepns. may be used in the treatment of all forms of pancreas insufficiency, possibly accompanied by steatorrhea, dyspepsia, difficulties of fat-metabolism, fat intolerance, dyslepemias and difficulties in fat-absorption after operations of the metabolic system. The very pure form may be injected whereby the lipase is present in the form of a lyophilic-dried powder which is dissolved in situ in physiological salt soln. or suitable buffer. Therapeutic indications: Xanthomatoses, arteriosclerosis, severe pancreas-insufficiency, essential hyperlipidemia and inherent dyslipidemia. The known lipase is based on dried and powdered pancreas which has limited activity, is only active at pH 7.5-9.5, has great instability together with unpleasant odour and taste. The new lipase is very active, stable and free from unpleasant odour.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1882564A GB1084431A (en) | 1964-05-06 | 1964-05-06 | Improvements in and relating to lipases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR1605287A true FR1605287A (en) | 1974-04-05 |
Family
ID=10119057
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR13218A Expired FR1605287A (en) | 1964-05-06 | 1965-04-14 | Lipase neth 6 505 658 provided |
| FR24528A Expired FR4566M (en) | 1964-05-06 | 1965-07-13 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR24528A Expired FR4566M (en) | 1964-05-06 | 1965-07-13 |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE662862A (en) |
| CH (1) | CH433162A (en) |
| DK (1) | DK112721B (en) |
| ES (1) | ES312586A1 (en) |
| FR (2) | FR1605287A (en) |
| GB (1) | GB1084431A (en) |
| IL (1) | IL23484A (en) |
| IT (1) | IT1061781B (en) |
| NL (1) | NL6505658A (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2418238A2 (en) * | 1978-02-23 | 1979-09-21 | Degussa | Lipase stabilisation in enzyme preparations - using animal globular proteins e.g. ovalbumin |
| JPS59156282A (en) * | 1983-02-25 | 1984-09-05 | Daikin Ind Ltd | Preparation of novel heat-resistant lipase |
| US5489530A (en) * | 1991-07-01 | 1996-02-06 | Basf Aktiengesellschaft | Lipase from Pseudomonas and strain |
| AU6221496A (en) * | 1995-05-31 | 1996-12-18 | Simon Lodewijk Scharpe | Composition to improve digestibility and utilisation of nutr ients |
| AR032392A1 (en) * | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | ENZYMES MIX, PHARMACEUTICAL PREPARATION AND USE OF PREPARED SAID. |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
-
1964
- 1964-05-06 GB GB1882564A patent/GB1084431A/en not_active Expired
-
1965
- 1965-04-14 FR FR13218A patent/FR1605287A/en not_active Expired
- 1965-04-21 CH CH550065A patent/CH433162A/en unknown
- 1965-04-22 BE BE662862D patent/BE662862A/xx unknown
- 1965-04-23 IT IT900865A patent/IT1061781B/en active
- 1965-05-04 IL IL2348465A patent/IL23484A/en unknown
- 1965-05-04 NL NL6505658A patent/NL6505658A/xx unknown
- 1965-05-05 ES ES0312586A patent/ES312586A1/en not_active Expired
- 1965-05-06 DK DK229365A patent/DK112721B/en unknown
- 1965-07-13 FR FR24528A patent/FR4566M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH433162A (en) | 1967-04-15 |
| NL6505658A (en) | 1965-11-08 |
| FR4566M (en) | 1966-11-07 |
| ES312586A1 (en) | 1965-07-01 |
| DK112721B (en) | 1969-01-13 |
| GB1084431A (en) | 1967-09-20 |
| BE662862A (en) | 1965-08-17 |
| IT1061781B (en) | 1983-04-30 |
| IL23484A (en) | 1970-01-29 |
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