DE60036961D1 - Gamma-hydroxy-2-(fluoralkylaminocarbonyl)-1-piperazinpentanamide als hiv-proteasehemmer - Google Patents
Gamma-hydroxy-2-(fluoralkylaminocarbonyl)-1-piperazinpentanamide als hiv-proteasehemmerInfo
- Publication number
- DE60036961D1 DE60036961D1 DE60036961T DE60036961T DE60036961D1 DE 60036961 D1 DE60036961 D1 DE 60036961D1 DE 60036961 T DE60036961 T DE 60036961T DE 60036961 T DE60036961 T DE 60036961T DE 60036961 D1 DE60036961 D1 DE 60036961D1
- Authority
- DE
- Germany
- Prior art keywords
- hiv
- compounds
- gamma
- hydroxy
- hiv protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16747899P | 1999-11-24 | 1999-11-24 | |
US167478P | 1999-11-24 | ||
US17705300P | 2000-01-20 | 2000-01-20 | |
US177053P | 2000-01-20 | ||
PCT/US2000/032089 WO2001038332A1 (en) | 1999-11-24 | 2000-11-21 | Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides as hiv protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60036961D1 true DE60036961D1 (de) | 2007-12-13 |
DE60036961T2 DE60036961T2 (de) | 2008-08-28 |
Family
ID=26863215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60036961T Expired - Lifetime DE60036961T2 (de) | 1999-11-24 | 2000-11-21 | Gamma-hydroxy-2-(fluoralkylaminocarbonyl)-1-piperazinpentanamide als hiv-proteasehemmer |
Country Status (11)
Country | Link |
---|---|
US (1) | US6642237B1 (de) |
EP (1) | EP1242426B1 (de) |
JP (1) | JP2003514910A (de) |
AT (1) | ATE377011T1 (de) |
AU (1) | AU777824B2 (de) |
CA (1) | CA2391643C (de) |
CO (1) | CO5261497A1 (de) |
DE (1) | DE60036961T2 (de) |
ES (1) | ES2295068T3 (de) |
PE (1) | PE20011025A1 (de) |
WO (1) | WO2001038332A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9815567D0 (en) * | 1998-07-18 | 1998-09-16 | Glaxo Group Ltd | Antiviral compound |
WO2001055326A2 (en) * | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
US7049146B2 (en) | 2000-11-14 | 2006-05-23 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
US7122376B2 (en) * | 2001-11-01 | 2006-10-17 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
AU2002305720A1 (en) * | 2001-05-30 | 2002-12-09 | Huening, Tracy, T. | Piperazine pentanamide hiv protease inhibitors |
US6649761B2 (en) | 2001-05-30 | 2003-11-18 | Merck & Co., Inc. | Process for preparing piperazinepentaneamide HIV protease inhibitors |
US6835860B2 (en) | 2002-02-01 | 2004-12-28 | Merck & Co., Inc. | Iodohydroxylation of olefins |
US20040067216A1 (en) * | 2002-02-22 | 2004-04-08 | Karki Shyam B. | Hiv protease inhibitors supported on cation exchange resins for oral administration |
GB0218876D0 (en) * | 2002-08-13 | 2002-09-25 | Merck Sharp & Dohme | Therapeutic agents |
WO2004027361A1 (en) * | 2002-09-17 | 2004-04-01 | University Of Virginia Patent Foundation | Remote temperature sensing of small volume and related apparatus thereof |
US7199240B2 (en) | 2002-12-11 | 2007-04-03 | Merck & Co., Inc. | Reductive alkylation of saturated cyclic amines |
ES2571779T3 (es) * | 2002-12-13 | 2016-05-26 | Ym Biosciences Australia Pty | Inhibidores de cinasa a base de nicotinamida |
TW574132B (en) * | 2003-04-14 | 2004-02-01 | Univ Nat Cheng Kung | Integrated microfluidic electro-spray chip system and the analysis method thereof |
US7161015B1 (en) * | 2005-09-08 | 2007-01-09 | The United States Of America As Represented By The Secretary Of The Navy | Method of making 2-furylalkylketones |
JP2006316049A (ja) * | 2006-04-11 | 2006-11-24 | Tanabe Seiyaku Co Ltd | 2,2−ジアルコキシエチルアミン化合物およびその製造方法 |
US8497383B2 (en) | 2009-05-27 | 2013-07-30 | Merck Sharp & Dohme Corp. | HIV protease inhibitors |
CA2777937C (en) | 2009-10-26 | 2017-08-29 | Merck Sharp & Dohme Corp. | Solid pharmaceutical compositions containing an integrase inhibitor |
WO2011120153A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
CN103270029B (zh) | 2010-10-22 | 2016-01-20 | 拜耳知识产权有限责任公司 | 作为农药的杂环化合物 |
US9079834B2 (en) | 2010-10-28 | 2015-07-14 | Merck Canada Inc. | HIV protease inhibitors |
GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
GB201101139D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
EP2757886A1 (de) | 2011-09-23 | 2014-07-30 | Bayer Intellectual Property GmbH | Verwendung 4-substituierter 1-phenyl-pyrazol-3-carbonsäurederivate als wirkstoffe gegen abiotischen pflanzenstress |
WO2013059928A1 (en) | 2011-10-26 | 2013-05-02 | Merck Canada Inc. | Hiv protease inhibitors |
JP2015527403A (ja) | 2012-09-11 | 2015-09-17 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Hivプロテアーゼ阻害剤 |
WO2015013835A1 (en) | 2013-07-31 | 2015-02-05 | Merck Sharp & Dohme Corp. | Piperazine derivatives as hiv protease inhibitors |
WO2015048770A2 (en) | 2013-09-30 | 2015-04-02 | Beth Israel Deaconess Medical Center, Inc. | Antibody therapies for human immunodeficiency virus (hiv) |
US9834526B2 (en) | 2013-12-19 | 2017-12-05 | Merck Sharp & Dohme Corp. | HIV protease inhibitors |
US9737545B2 (en) | 2013-12-19 | 2017-08-22 | Merck Sharp & Dohme Corp. | HIV protease inhibitors |
EP3113780B1 (de) | 2014-03-06 | 2019-08-14 | Merck Sharp & Dohme Corp. | Hiv-proteasehemmer |
EP3116862B1 (de) | 2014-03-10 | 2019-04-17 | Merck Sharp & Dohme Corp. | Piperazinderivate als hiv-proteasehemmer |
EP2944955A1 (de) * | 2014-05-13 | 2015-11-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Bezugspunkt für LC-MS-Systeme |
ES2726927T3 (es) * | 2014-07-08 | 2019-10-10 | Dow Agrosciences Llc | Proceso para la preparación de ácidos 3-hidroxipicolínicos |
CN104311479B (zh) * | 2014-09-15 | 2016-06-15 | 西华大学 | 3,5-二碘-4-羟基吡啶的合成 |
US9938265B2 (en) * | 2015-11-30 | 2018-04-10 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
WO2019175464A1 (en) | 2018-03-14 | 2019-09-19 | Orion Corporation | Compounds useful as inhibitors of sodium-calcium exchanger (ncx) |
AR114422A1 (es) | 2018-03-30 | 2020-09-02 | Syngenta Participations Ag | Compuestos herbicidas |
US20210403435A1 (en) | 2018-11-12 | 2021-12-30 | Syngenta Crop Protection Ag | Herbicidal compounds |
CN112824417A (zh) * | 2019-11-21 | 2021-05-21 | 上海天慈国际药业有限公司 | 一种劳拉替尼的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8927913D0 (en) | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
US5413999A (en) * | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
CA2195027C (en) | 1991-11-08 | 2000-01-11 | Joseph P. Vacca | Hiv protease inhibitors useful for the treatment of aids |
US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
IL110255A (en) | 1993-07-16 | 1998-12-06 | Merck & Co Inc | Creation and resolution of 2 tert-butylcarboxamidopiprazine |
US5455351A (en) | 1993-12-13 | 1995-10-03 | Abbott Laboratories | Retroviral protease inhibiting piperazine compounds |
HUT74681A (en) * | 1993-12-15 | 1997-01-28 | Merck & Co Inc | N-(2-hydroxy-1-indenyl)-2-phenylmethyl-4-hydroxy-5-(2-carboxamido-piperazinyl)-pentaneamide derivatives of hiv protease inhibitor activity and phrmaceutical compositions contining them |
IL111991A (en) | 1994-01-28 | 2000-07-26 | Abbott Lab | Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent |
TW438799B (en) * | 1997-05-29 | 2001-06-07 | Merck & Co Inc | HIV protease inhibitor |
WO1999033795A1 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
-
2000
- 2000-11-21 AT AT00980679T patent/ATE377011T1/de not_active IP Right Cessation
- 2000-11-21 ES ES00980679T patent/ES2295068T3/es not_active Expired - Lifetime
- 2000-11-21 US US09/718,223 patent/US6642237B1/en not_active Expired - Fee Related
- 2000-11-21 WO PCT/US2000/032089 patent/WO2001038332A1/en active IP Right Grant
- 2000-11-21 EP EP00980679A patent/EP1242426B1/de not_active Expired - Lifetime
- 2000-11-21 AU AU17909/01A patent/AU777824B2/en not_active Ceased
- 2000-11-21 JP JP2001540095A patent/JP2003514910A/ja not_active Withdrawn
- 2000-11-21 CA CA002391643A patent/CA2391643C/en not_active Expired - Fee Related
- 2000-11-21 DE DE60036961T patent/DE60036961T2/de not_active Expired - Lifetime
- 2000-11-23 CO CO00089726A patent/CO5261497A1/es not_active Application Discontinuation
- 2000-11-24 PE PE2000001259A patent/PE20011025A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CO5261497A1 (es) | 2003-03-31 |
ATE377011T1 (de) | 2007-11-15 |
EP1242426A1 (de) | 2002-09-25 |
CA2391643C (en) | 2010-01-12 |
AU777824B2 (en) | 2004-11-04 |
DE60036961T2 (de) | 2008-08-28 |
EP1242426B1 (de) | 2007-10-31 |
AU1790901A (en) | 2001-06-04 |
WO2001038332A1 (en) | 2001-05-31 |
CA2391643A1 (en) | 2001-05-31 |
ES2295068T3 (es) | 2008-04-16 |
PE20011025A1 (es) | 2001-10-12 |
US6642237B1 (en) | 2003-11-04 |
JP2003514910A (ja) | 2003-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE377011T1 (de) | Gamma-hydroxy-2-(fluoralkylaminocarbonyl)-1- piperazinpentanamide als hiv-proteasehemmer | |
DE69228106D1 (de) | HIV-Protease-Inhibitoren | |
EA200300449A1 (ru) | Аза- и полиаза-нафталинилкарбоксамиды, полезные в качестве ингибиторов вич-интегразы | |
DE60128936D1 (en) | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer | |
DE60124577D1 (en) | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer | |
EA200400585A1 (ru) | N-замещённые гидроксипиримидинон-карбоксамидные ингибиторы вич интегразы | |
DE69531944D1 (de) | Neue hiv-protease-inhibitoren | |
MY109834A (en) | Benzoxazinones as inhibitors of hiv reverse transcriptase | |
BR9406503A (pt) | Combinação de compostos composição farmacêutica e processos para tratar aids para evitar e para tratar infecção por HIV e para inibir protease de HIV | |
DE69430385T2 (de) | Hiv-proteaseinhibitoren | |
ATE404563T1 (de) | 8-hydroxy-1- oxotetrahydropyrrolopyrazinverbindungen, die sich als inhibitoren von hiv-integrase eignen | |
MX9705916A (es) | Terapia de combinacion para infeccion por vih usando el inhibidor de proteasa de vih indinavir y el inhibidor de transcriptasa inversa 3tc, opcionalmente junto con azt, ddi, o ddc. | |
WO1996000068A3 (en) | Combination therapy for hiv infection | |
DK0774969T3 (da) | HIV-proteaseinhibitor kombination | |
WO2002096359A3 (en) | Piperazine pentanamide hiv protease inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP, LUXEMBOURG, LU |