BRPI0509148A - composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos prcessos de fabricação - Google Patents
composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos prcessos de fabricaçãoInfo
- Publication number
- BRPI0509148A BRPI0509148A BRPI0509148-9A BRPI0509148A BRPI0509148A BR PI0509148 A BRPI0509148 A BR PI0509148A BR PI0509148 A BRPI0509148 A BR PI0509148A BR PI0509148 A BRPI0509148 A BR PI0509148A
- Authority
- BR
- Brazil
- Prior art keywords
- lipase
- surfactant
- pharmaceutical compositions
- pancreatin
- oral pharmaceutical
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/745—Polymers of hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
Abstract
COMPOSIçõES FARMACêUTICAS ORAIS DE PRODUTOS CONTENDO LIPASE, EM PARTICULAR DE PANCREATINA CONTENDO TENSOATIVOS, SEUS USOS E RESPECTIVOS PROCESSOS DE FABRICAçãO. A presente invenção refere-se a novas composições farmacêuticas de produtos contendo lipase para administração por via oral, em particular, pancreatina e produtos contendo pancreatina, ou de produtos enzimáticos que contêm pelo menos uma lipase de origem não-animal, especialmente de origem microbiana. Estas composições farmacêuticas melhoram a atividade lipolítica e, em particular, resultam na estabilização da lipase na faixa de pH ácido. Estas novas composições farmacêuticas orais são caracterizadas por conterem um sistema que compreende, pelo menos, um tensoativo e um co-tensoativo e, optionalmente, uma fase lipofilica, e por serem autoemulsionáveis em contato com uma fase hidrofílica e uma fase lipofílica. Estas novas composições farmacêuticas são bem apropriadas para o tratamento e/ou profilaxia de má digestão, em particular, má digestão baseada em insuficiência pancreática exócrina crónica, em mamíferos e seres humanos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55499304P | 2004-03-22 | 2004-03-22 | |
EP04101164.4A EP1579869A1 (de) | 2004-03-22 | Pharmazeutische Zusammensetzung enthaltend Lipase, insbesondere Pankreatin, und Tenside | |
PCT/EP2005/051295 WO2005092370A1 (en) | 2004-03-22 | 2005-03-21 | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0509148A true BRPI0509148A (pt) | 2007-09-11 |
BRPI0509148B1 BRPI0509148B1 (pt) | 2016-07-12 |
BRPI0509148B8 BRPI0509148B8 (pt) | 2021-05-25 |
Family
ID=34964300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509148A BRPI0509148B8 (pt) | 2004-03-22 | 2005-03-21 | composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina contendo tensoativos, seus usos e respectivos processos de fabricação |
Country Status (15)
Country | Link |
---|---|
US (3) | US8802087B2 (pt) |
EP (1) | EP1729797B1 (pt) |
JP (1) | JP5032300B2 (pt) |
CN (1) | CN1933850B (pt) |
AT (1) | ATE407693T1 (pt) |
AU (1) | AU2005227090B2 (pt) |
BR (1) | BRPI0509148B8 (pt) |
CA (1) | CA2560613C (pt) |
DE (1) | DE602005009677D1 (pt) |
ES (1) | ES2314646T3 (pt) |
HK (1) | HK1101342A1 (pt) |
PL (1) | PL1729797T3 (pt) |
PT (1) | PT1729797E (pt) |
RU (1) | RU2381813C2 (pt) |
WO (1) | WO2005092370A1 (pt) |
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-
2005
- 2005-03-21 CA CA2560613A patent/CA2560613C/en active Active
- 2005-03-21 PL PL05733481T patent/PL1729797T3/pl unknown
- 2005-03-21 ES ES05733481T patent/ES2314646T3/es active Active
- 2005-03-21 PT PT05733481T patent/PT1729797E/pt unknown
- 2005-03-21 EP EP05733481A patent/EP1729797B1/en active Active
- 2005-03-21 CN CN2005800093147A patent/CN1933850B/zh active Active
- 2005-03-21 DE DE602005009677T patent/DE602005009677D1/de active Active
- 2005-03-21 BR BRPI0509148A patent/BRPI0509148B8/pt active IP Right Grant
- 2005-03-21 RU RU2006137325/15A patent/RU2381813C2/ru active
- 2005-03-21 JP JP2007504411A patent/JP5032300B2/ja active Active
- 2005-03-21 AT AT05733481T patent/ATE407693T1/de active
- 2005-03-21 AU AU2005227090A patent/AU2005227090B2/en active Active
- 2005-03-21 WO PCT/EP2005/051295 patent/WO2005092370A1/en active IP Right Grant
- 2005-03-22 US US11/085,073 patent/US8802087B2/en active Active
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2007
- 2007-06-07 HK HK07106104.3A patent/HK1101342A1/xx unknown
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2014
- 2014-06-18 US US14/308,543 patent/US20140302000A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
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JP2007530503A (ja) | 2007-11-01 |
ATE407693T1 (de) | 2008-09-15 |
PL1729797T3 (pl) | 2009-02-27 |
CN1933850B (zh) | 2011-01-12 |
BRPI0509148B8 (pt) | 2021-05-25 |
EP1729797A1 (en) | 2006-12-13 |
AU2005227090A1 (en) | 2005-10-06 |
CN1933850A (zh) | 2007-03-21 |
JP5032300B2 (ja) | 2012-09-26 |
RU2006137325A (ru) | 2008-04-27 |
EP1729797B1 (en) | 2008-09-10 |
CA2560613C (en) | 2015-11-24 |
US20140302000A1 (en) | 2014-10-09 |
US20190275122A1 (en) | 2019-09-12 |
WO2005092370A1 (en) | 2005-10-06 |
HK1101342A1 (en) | 2007-10-18 |
CA2560613A1 (en) | 2005-10-06 |
US8802087B2 (en) | 2014-08-12 |
AU2005227090B2 (en) | 2010-12-09 |
DE602005009677D1 (de) | 2008-10-23 |
BRPI0509148B1 (pt) | 2016-07-12 |
RU2381813C2 (ru) | 2010-02-20 |
PT1729797E (pt) | 2008-12-17 |
ES2314646T3 (es) | 2009-03-16 |
US20050250817A1 (en) | 2005-11-10 |
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