NO20080437L - Lipaser til farmasoytisk anvendelse - Google Patents

Lipaser til farmasoytisk anvendelse

Info

Publication number
NO20080437L
NO20080437L NO20080437A NO20080437A NO20080437L NO 20080437 L NO20080437 L NO 20080437L NO 20080437 A NO20080437 A NO 20080437A NO 20080437 A NO20080437 A NO 20080437A NO 20080437 L NO20080437 L NO 20080437L
Authority
NO
Norway
Prior art keywords
lipases
pharmaceutical use
diabetes type
stable
protease
Prior art date
Application number
NO20080437A
Other languages
English (en)
Inventor
Peter-Colin Gregory
Allan Svendsen
Kim Borch
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Publication of NO20080437L publication Critical patent/NO20080437L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Den farmasøytiske anvendelsen av lipaser som er beslektet med en variant av lipasen fra Thermomyces lanuginosus (Humicola lanuginosa) som omfatter aminosyrene 1-269 ifølge SEKV.ID. NR. 1, eventuelt i kombinasjon med en protease og/eller en amylase. Eksempler på medisinske indikasjoner er: Behandling av fordøyelseslidelser, pankreaseksokrin utilstrekkelighet (PEI), pankreatitt, cystisk fibrose, diabetes type I og/eller diabetes type 11. Lipasene ifølge oppfinnelsen har en forbedret effektivitet in vivo, er stabile mot proteasedegradering og/eller er stabile i nærvær av gallesalter.
NO20080437A 2005-06-24 2008-01-23 Lipaser til farmasoytisk anvendelse NO20080437L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500929 2005-06-24
PCT/DK2006/000352 WO2006136159A2 (en) 2005-06-24 2006-06-16 Lipases for pharmaceutical use

Publications (1)

Publication Number Publication Date
NO20080437L true NO20080437L (no) 2008-03-25

Family

ID=34956781

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080437A NO20080437L (no) 2005-06-24 2008-01-23 Lipaser til farmasoytisk anvendelse

Country Status (17)

Country Link
US (1) US20090047266A1 (no)
EP (1) EP1896577A2 (no)
JP (1) JP2008546394A (no)
KR (1) KR20080017025A (no)
CN (1) CN101208429A (no)
AR (1) AR053634A1 (no)
AU (1) AU2006261442A1 (no)
BR (1) BRPI0612274A2 (no)
CA (1) CA2612648A1 (no)
IL (1) IL187511A0 (no)
MX (1) MX2007015472A (no)
NO (1) NO20080437L (no)
NZ (1) NZ563693A (no)
RU (1) RU2007149045A (no)
TW (1) TW200738256A (no)
WO (1) WO2006136159A2 (no)
ZA (1) ZA200710643B (no)

Families Citing this family (37)

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CA2560613C (en) 2004-03-22 2015-11-24 Solvay Pharmaceuticals Gmbh Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
EP1896057A2 (en) * 2005-06-24 2008-03-12 Novozymes A/S Amylases for pharmaceutical use
WO2007014896A1 (en) 2005-07-29 2007-02-08 Solvay Pharmaceuticals Gmbh Processes for the manufacture of sterilized pancreatin powder
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
US9668501B2 (en) * 2006-07-13 2017-06-06 Dsm Ip Assets B.V. Use of bacterial amylases in feed for bovine animals
EP2455462B1 (en) 2006-12-21 2016-03-16 Novozymes A/S Lipase variants for pharmaceutical use
US8455235B2 (en) 2007-12-04 2013-06-04 Novozymes A/S Protease variants for pharmaceutical use
CA2711187A1 (en) * 2008-01-03 2009-07-09 George Shlieout Pharmaceutical compositions comprising granules of purified microbial lipase and methods for preventing or treating digestive disorders
CA2722466A1 (en) 2008-04-29 2009-11-05 Tariq Ghayur Dual variable domain immunoglobulins and uses thereof
CA2725666A1 (en) 2008-06-03 2009-12-10 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
AU2009256250B2 (en) 2008-06-03 2013-05-30 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
GB2468629B (en) * 2008-06-08 2011-10-26 Tarig Sayed Mustafa Arbab Method, composition, device for the treatment of amylase malfunctions/inactivity in association with saccharides (mainly polysaccharides) based diseases
GB2465814B (en) * 2008-06-19 2011-10-26 Tarig Sayed Mustafa Arbab Method,composition and device for the treatment of enzymes and saccharides disorders
NZ590074A (en) 2008-07-08 2012-12-21 Abbott Lab Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
WO2011000924A1 (en) 2009-07-03 2011-01-06 Abbott Products Gmbh Spray-dried amylase, pharmaceutical preparations comprising the same and use
US8784884B2 (en) * 2009-09-17 2014-07-22 Stephen Perrett Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
KR20140015139A (ko) 2009-10-15 2014-02-06 애브비 인코포레이티드 이원 가변 도메인 면역글로불린 및 이의 용도
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
CA2807014A1 (en) 2010-08-03 2012-02-09 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
TW201211252A (en) 2010-08-26 2012-03-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
CN111187676A (zh) 2011-12-29 2020-05-22 诺维信公司 具有脂肪酶变体的洗涤剂组合物
UY34558A (es) 2011-12-30 2013-07-31 Abbvie Inc Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17
GB201212934D0 (en) * 2012-07-20 2012-09-05 Dupont Nutrition Biosci Aps Method
GB201212932D0 (en) * 2012-07-20 2012-09-05 Dupont Nutrition Biosci Aps Method
CN103045559B (zh) * 2012-10-23 2014-05-14 浙江工业大学 疏绵状嗜热丝孢菌脂肪酶突变体、编码基因及其应用
AU2013337775B2 (en) 2012-11-01 2017-03-30 Abbvie Inc. Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof
WO2014068083A1 (en) 2012-11-01 2014-05-08 Novozymes A/S Method for removal of dna
CN105324396A (zh) 2013-03-15 2016-02-10 艾伯维公司 针对IL-1β和/或IL-17的双重特异性结合蛋白
US9672331B2 (en) * 2013-12-17 2017-06-06 Alltech, Inc. Systems and methods for computer models of animal feed
US10537122B2 (en) 2013-12-17 2020-01-21 Alltech, Inc. Systems and methods for adjusting animal feed
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
BR112020024491A2 (pt) * 2018-06-05 2021-03-02 Novozymes Bioag A/S métodos de aplicação foliar de uma composição, de controle de pragas de plantas em uma planta ou parte da planta e/ou indução de resistência a uma praga de plantas em uma planta ou parte da planta, de controle ou prevenção de danos por pragas em um material de propagação da planta, uma planta, parte de uma planta e/ou órgão da planta, de controle ou prevenção de danos de uma praga de lepidópteros em uma planta e de controle ou prevenção de danos de uma praga de insetos em uma planta.
WO2023225459A2 (en) 2022-05-14 2023-11-23 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
DK173590D0 (da) * 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5869438A (en) * 1990-09-13 1999-02-09 Novo Nordisk A/S Lipase variants
US5892013A (en) * 1990-09-13 1999-04-06 Novo Nordisk A/S Lipase variants
US6495357B1 (en) * 1995-07-14 2002-12-17 Novozyme A/S Lipolytic enzymes
EP1017794A1 (en) * 1997-02-06 2000-07-12 Novo Nordisk A/S Polypeptide-polymer conjugates having added and/or removed attachment groups
TR200101497T2 (tr) * 1998-11-27 2001-11-21 Novozymes A/S Lipolitik enzim varyantları
RU2268065C2 (ru) * 1999-03-17 2006-01-20 Зольвай Фармасьютиклз Гмбх Лекарственное средство, предназначенное для лечения диабета
CA2366843A1 (en) * 1999-03-31 2000-10-12 Jesper Vind Lipase variant
WO2000060063A1 (en) * 1999-03-31 2000-10-12 Novozymes A/S Lipase variant
AR032392A1 (es) * 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
DE10260903A1 (de) * 2002-12-20 2004-07-08 Henkel Kgaa Neue Perhydrolasen
WO2004111216A2 (en) * 2003-06-19 2004-12-23 Novozymes A/S Phospholipase variants

Also Published As

Publication number Publication date
KR20080017025A (ko) 2008-02-25
ZA200710643B (en) 2008-11-26
TW200738256A (en) 2007-10-16
WO2006136159A3 (en) 2007-04-12
AR053634A1 (es) 2007-05-09
MX2007015472A (es) 2008-04-17
BRPI0612274A2 (pt) 2016-09-06
JP2008546394A (ja) 2008-12-25
NZ563693A (en) 2010-08-27
EP1896577A2 (en) 2008-03-12
WO2006136159A2 (en) 2006-12-28
CA2612648A1 (en) 2006-12-28
US20090047266A1 (en) 2009-02-19
CN101208429A (zh) 2008-06-25
AU2006261442A1 (en) 2006-12-28
IL187511A0 (en) 2008-03-20
RU2007149045A (ru) 2009-07-10

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