GB760403A - Improvements in or relating to enteric coatings - Google Patents

Improvements in or relating to enteric coatings

Info

Publication number
GB760403A
GB760403A GB28392/53A GB2839253A GB760403A GB 760403 A GB760403 A GB 760403A GB 28392/53 A GB28392/53 A GB 28392/53A GB 2839253 A GB2839253 A GB 2839253A GB 760403 A GB760403 A GB 760403A
Authority
GB
United Kingdom
Prior art keywords
film
forming substance
cellulose
phthalate
propylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28392/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB760403A publication Critical patent/GB760403A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2873—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A coating composition for medicaments (see Group VI) comprises a film-forming substance having uniformly dispersed therein a finely-divided mineral solid which is inert to the film-forming substance and which is present in amount sufficient to prevent the film from cracking and crazing upon ageing, i.e. 10-150 per cent by weight based on the weight of the film-forming substance. The film-forming substance may be a dicarboxylic acid ester of cellulose containing free carboxyl groups such as cellulose acetate phthalate and cellulose propionate phthalate, or a cellulose ether. Specified mineral solids include talc, fuller's earth, diatomaceous earth, calamine, bentonite, pumice and insoluble sodium metaphosphate. Plasticizers, such as propylene glycol, triacetin, tripropionin, ethyl acid adipate and butyl acid phthalate, and edible surface-active agents, such as lecithin and sorbitan monooleate, may also be present. In an example erythromycin tablets are coated with a composition comprising cellulose acetate phthalate. talc, anhydrous alcohol, anhydrous acetone, propylene glycol and sorbitan monooleate, Specification 526,276,[Group IV], is referred to.ALSO:An enteric coating composition comprises an enteric film-forming substance having uniformly dispersed therein a finely divided mineral solid which is inert to the film-forming substance and which is present in an amount sufficient to prevent the film from cracking and crazing upon ageing, i.e. 10-150 per cent by weight based on the weight of the film-forming substance. The film-forming substance may be a dicarboxylic acid ester of cellulose containing free carboxyl groups such as cellulose acetate phthalate and cellulose propionate phthalate, polyvinyl acetate, polyvinylphthalate, a cellulose ether, a copolymer of an aliphatic dibasic unsaturated acid and a vinyl compound, shellac, zein, balsam tolu or a higher fatty acid. Specified mineral solids include talc, fuller's earth, diatomaceous earth, calamine, bentonite, pumice and insoluble sodium metaphosphate. Plasticizers, such as propylene glycol, triacetin, tripropionin, ethyl acid adipate and butyl acid phthalate and edible surface active agents such as lecithin and sorbitan monooleate may also be present. Medicaments which may be coated include antibiotics such as erythromycin, ammonium chloride, sodium salicylate, diethylstilboestrol, gentian violet, barbiturates; anti-epileptics, acriflavine and ferrous sulphate. These materials may be coated by known methods. In an example erythromycin tablets are coated with a composition comprising cellulose acetate phthalate, talc, anhydrous alcohol anhydrous acetone, propylene glycol and sorbitan mono-oleate. Specification 526,276 is referred to.
GB28392/53A 1952-10-16 1953-10-14 Improvements in or relating to enteric coatings Expired GB760403A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US760403XA 1952-10-16 1952-10-16

Publications (1)

Publication Number Publication Date
GB760403A true GB760403A (en) 1956-10-31

Family

ID=22129569

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28392/53A Expired GB760403A (en) 1952-10-16 1953-10-14 Improvements in or relating to enteric coatings

Country Status (2)

Country Link
DE (1) DE1043588B (en)
GB (1) GB760403A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2992166A (en) * 1957-11-05 1961-07-11 Cilag Chemie Diagnostic composition
US3080318A (en) * 1958-03-13 1963-03-05 Xerox Corp Three-component xerographic toner
US3080250A (en) * 1958-03-13 1963-03-05 Xerox Corp Self-tackifying xerographic toner
US3080251A (en) * 1958-03-13 1963-03-05 Xerox Corp Method of xerographic development
US3265630A (en) * 1958-12-22 1966-08-09 Ncr Co Encapsulating lipophilic material by coacervation
US3317394A (en) * 1955-12-22 1967-05-02 Haessle Ab Medicinal tablet and a method for its preparation
EP0244380A2 (en) * 1986-04-30 1987-11-04 Aktiebolaget Hässle Pharmaceutical formulations of acid labile substances for oral use
EP0247983A2 (en) * 1986-04-30 1987-12-02 Aktiebolaget Hässle New pharmaceutical preparation for oral use
DE4100920A1 (en) * 1991-01-15 1992-07-16 Degussa ACTIVE SUBSTANCE PREPARATION FOR ORAL ADMINISTRATION TO Ruminants
US5599556A (en) * 1991-12-31 1997-02-04 Abbott Laboratories Prolamine coatings for taste masking
CN116570572A (en) * 2023-05-23 2023-08-11 曲阜贝斯迪生物医药有限公司 Gastric-soluble film coating premix and preparation method thereof

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3317394A (en) * 1955-12-22 1967-05-02 Haessle Ab Medicinal tablet and a method for its preparation
US2992166A (en) * 1957-11-05 1961-07-11 Cilag Chemie Diagnostic composition
US3080318A (en) * 1958-03-13 1963-03-05 Xerox Corp Three-component xerographic toner
US3080250A (en) * 1958-03-13 1963-03-05 Xerox Corp Self-tackifying xerographic toner
US3080251A (en) * 1958-03-13 1963-03-05 Xerox Corp Method of xerographic development
US3265630A (en) * 1958-12-22 1966-08-09 Ncr Co Encapsulating lipophilic material by coacervation
EP0567201A2 (en) * 1986-04-30 1993-10-27 Aktiebolaget Hässle Vehicles for oral administration of a specific pharmaceutically active acid labile substance
EP0567201A3 (en) * 1986-04-30 1995-06-07 Haessle Ab Vehicles for oral administration of a specific pharmaceutically active acid labile substance.
EP0247983A3 (en) * 1986-04-30 1988-10-19 Aktiebolaget Hassle New pharmaceutical preparation for oral use
EP0244380A3 (en) * 1986-04-30 1988-10-19 Aktiebolaget Hassle Pharmaceutical formulations of acid labile substances for oral use
EP0247983A2 (en) * 1986-04-30 1987-12-02 Aktiebolaget Hässle New pharmaceutical preparation for oral use
EP0496437A2 (en) * 1986-04-30 1992-07-29 Aktiebolaget Hässle Use of specific core material and layers to obtain pharmaceutical formulations stable to discolouration of omeprazole
EP0496437A3 (en) * 1986-04-30 1992-09-02 Aktiebolaget Haessle Use of specific core material and layers to obtain pharmaceutical formulations stable to discolouration of omeprazole
EP0502556A1 (en) * 1986-04-30 1992-09-09 Aktiebolaget Hässle Use of specific core material and layers to obtain pharmaceutical formulations stable to discolouration of acid labile compounds
EP0565210A2 (en) * 1986-04-30 1993-10-13 Aktiebolaget Hässle Vehicles for oral adminstration of pharmaceutically active acide labile substances
EP0244380A2 (en) * 1986-04-30 1987-11-04 Aktiebolaget Hässle Pharmaceutical formulations of acid labile substances for oral use
EP0565210A3 (en) * 1986-04-30 1995-06-07 Haessle Ab
DE4100920A1 (en) * 1991-01-15 1992-07-16 Degussa ACTIVE SUBSTANCE PREPARATION FOR ORAL ADMINISTRATION TO Ruminants
US5279832A (en) * 1991-01-15 1994-01-18 Degussa Ag Active-substance preparation for oral administration, especially to ruminants
US5599556A (en) * 1991-12-31 1997-02-04 Abbott Laboratories Prolamine coatings for taste masking
US5609909A (en) * 1991-12-31 1997-03-11 Abbott Laboratories Prolamine coatings for taste masking
CN116570572A (en) * 2023-05-23 2023-08-11 曲阜贝斯迪生物医药有限公司 Gastric-soluble film coating premix and preparation method thereof

Also Published As

Publication number Publication date
DE1043588B (en) 1958-11-13

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