KR102461102B1 - 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도 - Google Patents

림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도 Download PDF

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KR102461102B1
KR102461102B1 KR1020217025289A KR20217025289A KR102461102B1 KR 102461102 B1 KR102461102 B1 KR 102461102B1 KR 1020217025289 A KR1020217025289 A KR 1020217025289A KR 20217025289 A KR20217025289 A KR 20217025289A KR 102461102 B1 KR102461102 B1 KR 102461102B1
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닐스 론베르그
모한 스리니바산
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A—HUMAN NECESSITIES
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
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KR1020217025289A 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도 Active KR102461102B1 (ko)

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KR1020227037107A KR20220150417A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261667058P 2012-07-02 2012-07-02
US61/667,058 2012-07-02
KR1020207017392A KR102290633B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
PCT/US2013/048999 WO2014008218A1 (en) 2012-07-02 2013-07-02 Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof

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KR1020207017392A Division KR102290633B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도

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KR20210102485A KR20210102485A (ko) 2021-08-19
KR102461102B1 true KR102461102B1 (ko) 2022-10-31

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KR1020217025289A Active KR102461102B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020207017392A Active KR102290633B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020227037107A Ceased KR20220150417A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020157002360A Active KR102126596B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020237038493A Ceased KR20230159625A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020247038243A Pending KR20240168469A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도

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KR1020207017392A Active KR102290633B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020227037107A Ceased KR20220150417A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020157002360A Active KR102126596B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020237038493A Ceased KR20230159625A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020247038243A Pending KR20240168469A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도

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DK2439273T3 (da) * 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
PT1907424E (pt) * 2005-07-01 2015-10-09 Squibb & Sons Llc Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
MA33208B1 (fr) 2009-03-25 2012-04-02 Genentech Inc Anticorps anti-fgfr3 et procédés d'utilisation de ceux-ci
EP3812387A1 (en) 2011-07-21 2021-04-28 Sumitomo Dainippon Pharma Oncology, Inc. Heterocyclic protein kinase inhibitors
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
UA117466C2 (uk) 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19
US10344088B2 (en) 2013-03-15 2019-07-09 Glaxosmithkline Intellectual Property Development Limited Antigen binding proteins
CA2908380A1 (en) 2013-04-09 2014-10-16 Boston Biomedical, Inc. Methods for treating cancer
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