KR102461102B1 - 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도 - Google Patents

림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도 Download PDF

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KR102461102B1
KR102461102B1 KR1020217025289A KR20217025289A KR102461102B1 KR 102461102 B1 KR102461102 B1 KR 102461102B1 KR 1020217025289 A KR1020217025289 A KR 1020217025289A KR 20217025289 A KR20217025289 A KR 20217025289A KR 102461102 B1 KR102461102 B1 KR 102461102B1
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닐스 론베르그
모한 스리니바산
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C—CHEMISTRY; METALLURGY
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KR1020217025289A 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도 Active KR102461102B1 (ko)

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KR1020227037107A KR20220150417A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도

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Application Number Priority Date Filing Date Title
US201261667058P 2012-07-02 2012-07-02
US61/667,058 2012-07-02
KR1020207017392A KR102290633B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
PCT/US2013/048999 WO2014008218A1 (en) 2012-07-02 2013-07-02 Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof

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KR1020207017392A Division KR102290633B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도

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KR102461102B1 true KR102461102B1 (ko) 2022-10-31

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KR1020217025289A Active KR102461102B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020227037107A Ceased KR20220150417A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020237038493A Ceased KR20230159625A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020157002360A Active KR102126596B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020207017392A Active KR102290633B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020247038243A Pending KR20240168469A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도

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KR1020227037107A Ceased KR20220150417A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020237038493A Ceased KR20230159625A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020157002360A Active KR102126596B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020207017392A Active KR102290633B1 (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도
KR1020247038243A Pending KR20240168469A (ko) 2012-07-02 2013-07-02 림프구 활성화 유전자-3 (lag-3)에 결합하는 항체의 최적화, 및 그의 용도

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CN109485727A (zh) * 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
KR101411165B1 (ko) * 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날항체
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
AU2010229994B2 (en) 2009-03-25 2016-08-18 Genentech, Inc. Anti-FGFR3 antibodies and methods using same
US9416132B2 (en) 2011-07-21 2016-08-16 Tolero Pharmaceuticals, Inc. Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
AR091649A1 (es) * 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
SI2970464T1 (sl) * 2013-03-15 2020-08-31 Glaxosmithkline Intellectual Propety Development Limited Anti-LAG-3 vezavni proteini
JP6433085B2 (ja) 2013-04-09 2018-12-05 ボストン バイオメディカル， インコーポレイテッド がんの処置に使用するための２−アセチルナフト［２，３−ｂ］フラン−４，９−ジオン
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