JP7559059B2 - 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 - Google Patents

免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 Download PDF

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JP7559059B2
JP7559059B2 JP2022520000A JP2022520000A JP7559059B2 JP 7559059 B2 JP7559059 B2 JP 7559059B2 JP 2022520000 A JP2022520000 A JP 2022520000A JP 2022520000 A JP2022520000 A JP 2022520000A JP 7559059 B2 JP7559059 B2 JP 7559059B2
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cancer
methyl
compound
amino
pyrido
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JP2022549375A5 (cg-RX-API-DMAC10.html
JP2022549375A (ja
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リィ，ジンウェイ
ウー，リアンシン
ヤオ，ウェンチン
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Incyte Corp
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022520000A 2019-09-30 2020-09-29 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 Active JP7559059B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962908317P 2019-09-30 2019-09-30
US62/908,317 2019-09-30
PCT/US2020/053190 WO2021067217A1 (en) 2019-09-30 2020-09-29 Pyrido[3,2-d]pyrimidine compounds as immunomodulators

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JP2022549375A JP2022549375A (ja) 2022-11-24
JP2022549375A5 JP2022549375A5 (cg-RX-API-DMAC10.html) 2023-10-05
JP7559059B2 true JP7559059B2 (ja) 2024-10-01

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US (2) US11401279B2 (cg-RX-API-DMAC10.html)
EP (1) EP4037773A1 (cg-RX-API-DMAC10.html)
JP (1) JP7559059B2 (cg-RX-API-DMAC10.html)
KR (1) KR20220075382A (cg-RX-API-DMAC10.html)
CN (1) CN115175734B (cg-RX-API-DMAC10.html)
AR (1) AR120109A1 (cg-RX-API-DMAC10.html)
AU (1) AU2020357514A1 (cg-RX-API-DMAC10.html)
BR (1) BR112022005826A2 (cg-RX-API-DMAC10.html)
CA (1) CA3155852A1 (cg-RX-API-DMAC10.html)
CL (1) CL2022000787A1 (cg-RX-API-DMAC10.html)
CO (1) CO2022005378A2 (cg-RX-API-DMAC10.html)
CR (1) CR20220190A (cg-RX-API-DMAC10.html)
EC (1) ECSP22034236A (cg-RX-API-DMAC10.html)
IL (1) IL291471B2 (cg-RX-API-DMAC10.html)
MX (1) MX2022003578A (cg-RX-API-DMAC10.html)
PE (1) PE20221038A1 (cg-RX-API-DMAC10.html)
PH (1) PH12022550754A1 (cg-RX-API-DMAC10.html)
TW (1) TWI879811B (cg-RX-API-DMAC10.html)
WO (1) WO2021067217A1 (cg-RX-API-DMAC10.html)

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ES2906460T3 (es) 2016-05-06 2022-04-18 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
EP3464279B1 (en) 2016-05-26 2021-11-24 Incyte Corporation Heterocyclic compounds as immunomodulators
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US20180057486A1 (en) 2016-08-29 2018-03-01 Incyte Corporation Heterocyclic compounds as immunomodulators
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EP3810610A1 (en) 2018-05-18 2021-04-28 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
CN117304191A (zh) 2018-07-05 2023-12-29 因赛特公司 作为a2a/a2b抑制剂的稠合吡嗪衍生物
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
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TW202115059A (zh) 2019-08-09 2021-04-16 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之鹽
JP7559059B2 (ja) 2019-09-30 2024-10-01 インサイト・コーポレイション 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物
EP4058461A1 (en) 2019-11-11 2022-09-21 Incyte Corporation Salts and crystalline forms of a pd-1/pd-l1 inhibitor
EP4174066A4 (en) * 2020-06-17 2024-06-19 Abbisko Therapeutics Co., Ltd. Immunosuppressant, and preparation method therefor and use thereof
US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
IL302590A (en) 2020-11-06 2023-07-01 Incyte Corp Process for preparing PD-1/PD-L1 inhibitor and salts and crystalline forms thereof
EP4491617A4 (en) * 2022-03-07 2026-02-25 Abbisko Therapeutics Co Ltd HOLOSYMETRIC BIPHENYL DERIVATIVE, ITS PREPARATION PROCESS AND ITS USE
CN117384088A (zh) * 2023-09-27 2024-01-12 上海凌凯医药科技有限公司 一种3-硝基吡啶甲腈类化合物以及3-氨基-吡啶甲酰胺类化合物的制备方法
US20250186450A1 (en) 2023-12-06 2025-06-12 Incyte Corporation COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS
CN120204228B (zh) * 2025-04-17 2026-01-30 重庆医科大学附属第一医院 化合物或其盐在制备癌症治疗药物中的用途

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