JP5825754B2 - Ａｐｏｂの発現を調節するための化合物および方法 - Google Patents

Ａｐｏｂの発現を調節するための化合物および方法 Download PDF

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JP5825754B2
JP5825754B2 JP2009510131A JP2009510131A JP5825754B2 JP 5825754 B2 JP5825754 B2 JP 5825754B2 JP 2009510131 A JP2009510131 A JP 2009510131A JP 2009510131 A JP2009510131 A JP 2009510131A JP 5825754 B2 JP5825754 B2 JP 5825754B2
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certain embodiments
short antisense
antisense compound
seq
nucleotides
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JP2009536038A (ja
Inventor
ブハノト サンジャイ
ブハノト サンジャイ
エス．ゲアリ リチャルド
エス．ゲアリ リチャルド
ムクカイ ロベルト
ムクカイ ロベルト
ピー．モニア ブレトト
ピー．モニア ブレトト
ピー．セトフ プニト
ピー．セトフ プニト
エム．シウコウスキ アンドレウ
エム．シウコウスキ アンドレウ
イー．スワイゼ エリク
イー．スワイゼ エリク
ワンセウイクズ エドワルド
ワンセウイクズ エドワルド
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
Isis Pharmaceuticals Inc
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Priority claimed from PCT/US2007/061183 external-priority patent/WO2007090071A2/en
Application filed by Ionis Pharmaceuticals Inc, Isis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of JP2009536038A publication Critical patent/JP2009536038A/ja
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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JP2009510131A 2006-05-05 2007-05-07 Ａｐｏｂの発現を調節するための化合物および方法 Active JP5825754B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US74663106P 2006-05-05 2006-05-05
US60/746,631 2006-05-05
US74705906P 2006-05-11 2006-05-11
US60/747,059 2006-05-11
US80566006P 2006-06-23 2006-06-23
US60/805,660 2006-06-23
US86455406P 2006-11-06 2006-11-06
US60/864,554 2006-11-06
PCT/US2007/061183 WO2007090071A2 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs
USPCT/US2007/061183 2007-01-27
PCT/US2007/068403 WO2007131238A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob

Related Child Applications (1)

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JP2013184285A Division JP2014033674A (ja) 2006-05-05 2013-09-05 Ａｐｏｂの発現を調節するための化合物および方法

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JP2009536038A JP2009536038A (ja) 2009-10-08
JP5825754B2 true JP5825754B2 (ja) 2015-12-02

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JP2009510132A Pending JP2009536222A (ja) 2006-05-05 2007-05-07 Ｐｃｓｋ９の発現を調節するための化合物および方法
JP2009510136A Pending JP2009536039A (ja) 2006-05-05 2007-05-07 Ｇｃｃｒの発現を調節するための化合物および方法
JP2009510131A Active JP5825754B2 (ja) 2006-05-05 2007-05-07 Ａｐｏｂの発現を調節するための化合物および方法
JP2009510130A Active JP5731115B2 (ja) 2006-05-05 2007-05-07 遺伝子発現を調節するための化合物および方法
JP2009510134A Expired - Fee Related JP5372745B2 (ja) 2006-05-05 2007-05-07 Ｓｇｌｔ２の発現を調節するための化合物および方法
JP2013184285A Pending JP2014033674A (ja) 2006-05-05 2013-09-05 Ａｐｏｂの発現を調節するための化合物および方法
JP2015248195A Active JP6272290B2 (ja) 2006-05-05 2015-12-21 Ａｐｏｂの発現を調節するための化合物および方法

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JP2009510132A Pending JP2009536222A (ja) 2006-05-05 2007-05-07 Ｐｃｓｋ９の発現を調節するための化合物および方法
JP2009510136A Pending JP2009536039A (ja) 2006-05-05 2007-05-07 Ｇｃｃｒの発現を調節するための化合物および方法

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JP2009510130A Active JP5731115B2 (ja) 2006-05-05 2007-05-07 遺伝子発現を調節するための化合物および方法
JP2009510134A Expired - Fee Related JP5372745B2 (ja) 2006-05-05 2007-05-07 Ｓｇｌｔ２の発現を調節するための化合物および方法
JP2013184285A Pending JP2014033674A (ja) 2006-05-05 2013-09-05 Ａｐｏｂの発現を調節するための化合物および方法
JP2015248195A Active JP6272290B2 (ja) 2006-05-05 2015-12-21 Ａｐｏｂの発現を調節するための化合物および方法

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US (14) US20090292006A1 (enExample)
EP (10) EP2023940B1 (enExample)
JP (7) JP2009536222A (enExample)
KR (1) KR101441700B1 (enExample)
CN (1) CN103554205A (enExample)
AT (2) ATE513912T1 (enExample)
AU (4) AU2007257094B2 (enExample)
BR (1) BRPI0711429A2 (enExample)
CA (3) CA2651042A1 (enExample)
DK (5) DK2021472T3 (enExample)
ES (2) ES2471978T3 (enExample)
MX (1) MX2008014100A (enExample)
NO (1) NO20084738L (enExample)
PT (1) PT2015758E (enExample)
WO (9) WO2007131237A2 (enExample)

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US20060009410A1 (en) * 2002-11-13 2006-01-12 Crooke Rosanne M Effects of apolipoprotein B inhibition on gene expression profiles in animals
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US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
EP2096170B1 (en) * 2005-09-19 2011-08-10 Isis Pharmaceuticals, Inc. Modulation of glucagon receptor expression
JP5713377B2 (ja) 2005-12-28 2015-05-07 ザ スクリプス リサーチ インスティテュート 薬物標的としての天然アンチセンスおよび非コードｒｎａ転写物
US7764650B2 (en) 2006-03-02 2010-07-27 Intel Corporation Mobile station and method for fast roaming with integrity protection and source authentication using a common protocol
ES2569558T3 (es) 2006-04-03 2016-05-11 Roche Innovation Center Copenhagen A/S Composición farmacéutica que comprende oligonucleótidos antisentido anti-ARNmi
MX2008012219A (es) 2006-04-03 2008-10-02 Santaris Pharma As Composicion farmaceutica que comprende oligonucleotidos antisentido anti-miarn.
WO2007131237A2 (en) 2006-05-05 2007-11-15 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of ptp1b
WO2008011431A2 (en) * 2006-07-17 2008-01-24 Sirna Therapeutics Inc. Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina)
EP2410053B2 (en) 2006-10-18 2020-07-15 Ionis Pharmaceuticals, Inc. Antisense compounds
KR20090103894A (ko) 2006-11-27 2009-10-01 아이시스 파마수티컬즈 인코포레이티드 고콜레스테롤혈증을 치료하는 방법
US8093222B2 (en) 2006-11-27 2012-01-10 Isis Pharmaceuticals, Inc. Methods for treating hypercholesterolemia
US8470791B2 (en) * 2007-03-22 2013-06-25 Santaris Pharma A/S RNA antagonist compounds for the inhibition of Apo-B100 expression
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US20150344879A1 (en) 2015-12-03
KR20090034310A (ko) 2009-04-07
JP2009536039A (ja) 2009-10-08
WO2007131238A2 (en) 2007-11-15
JP6272290B2 (ja) 2018-01-31
EP2019692B1 (en) 2014-06-04
WO2007143317A2 (en) 2007-12-13
WO2007134014A3 (en) 2009-04-09
PT2015758E (pt) 2014-06-25
WO2007143315A2 (en) 2007-12-13
KR101441700B1 (ko) 2014-09-18
US8143230B2 (en) 2012-03-27
AU2007257093A1 (en) 2007-12-13
MX2008014100A (es) 2009-02-25
WO2007134014A2 (en) 2007-11-22
ES2471978T3 (es) 2014-06-27
US20090306179A1 (en) 2009-12-10
CA2651309C (en) 2019-06-11
EP2505646A1 (en) 2012-10-03
ES2386578T3 (es) 2012-08-23
WO2007146511A8 (en) 2009-04-02
US20090326042A1 (en) 2009-12-31
US20090318532A1 (en) 2009-12-24

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