DK1692139T3 - 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer - Google Patents

5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer

Info

Publication number
DK1692139T3
DK1692139T3 DK04811142.1T DK04811142T DK1692139T3 DK 1692139 T3 DK1692139 T3 DK 1692139T3 DK 04811142 T DK04811142 T DK 04811142T DK 1692139 T3 DK1692139 T3 DK 1692139T3
Authority
DK
Denmark
Prior art keywords
linkers
dihydroxy
oligomers
solid phase
phase synthesis
Prior art date
Application number
DK04811142.1T
Other languages
English (en)
Inventor
Ravikumar Vasulinga
Wang Zhiwei
Raju Krishna Kumar
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DK1692139T3 publication Critical patent/DK1692139T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK04811142.1T 2003-11-13 2004-11-15 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer DK1692139T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52017903P 2003-11-13 2003-11-13
US53047703P 2003-12-16 2003-12-16
US56464904P 2004-04-21 2004-04-21
PCT/US2004/038325 WO2005049621A1 (en) 2003-11-13 2004-11-15 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis

Publications (1)

Publication Number Publication Date
DK1692139T3 true DK1692139T3 (da) 2013-03-11

Family

ID=34623783

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12199177.2T DK2708541T3 (da) 2003-11-13 2004-11-15 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese
DK04811142.1T DK1692139T3 (da) 2003-11-13 2004-11-15 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK12199177.2T DK2708541T3 (da) 2003-11-13 2004-11-15 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese

Country Status (4)

Country Link
EP (2) EP1692139B1 (da)
DK (2) DK2708541T3 (da)
ES (2) ES2403937T3 (da)
WO (1) WO2005049621A1 (da)

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US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7888324B2 (en) 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
CA2505801A1 (en) * 2002-11-13 2004-05-27 Rosanne Crooke Antisense modulation of apolipoprotein b expression
US7511131B2 (en) 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
JP5731115B2 (ja) 2006-05-05 2015-06-10 アイシス ファーマシューティカルズ， インコーポレーテッド 遺伝子発現を調節するための化合物および方法
CA2682082A1 (en) 2007-03-24 2008-10-02 Genzyme Corporation Administering antisense oligonucleotides complementary to human apolipoprotein b
US9107933B2 (en) 2009-03-16 2015-08-18 Isis Pharmaceuticals, Inc. Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III
JP5360763B2 (ja) 2009-10-21 2013-12-04 日東電工株式会社 核酸固相合成用リンカー及び担体
JP6028979B2 (ja) * 2012-01-30 2016-11-24 日東電工株式会社 核酸固相合成用リンカー及び担体
EP2666794A1 (en) 2012-05-23 2013-11-27 Nitto Denko Corporation Solid-phase support for oligonucleotide synthesis and oligonucleotide synthesis method
TN2016000441A1 (en) 2014-05-13 2018-04-04 Novartis Ag Compounds and compositions for inducing chondrogenesis.
JP6537338B2 (ja) 2015-04-24 2019-07-03 日東電工株式会社 核酸固相合成用リンカー及び担体
US11542294B2 (en) 2017-03-29 2023-01-03 Roche Innovation Center Copenhagen A/S Rapid unylinker cleavage
MX2020009004A (es) 2018-03-14 2020-10-05 Hoffmann La Roche Derivados de acido nucleico bloqueado-acido dicarboxilico y proceso para su preparacion.

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Also Published As

Publication number Publication date
ES2535033T3 (es) 2015-05-04
EP1692139A1 (en) 2006-08-23
EP2708541B1 (en) 2015-01-28
EP1692139B1 (en) 2013-02-13
DK2708541T3 (da) 2015-02-23
ES2403937T3 (es) 2013-05-22
EP2708541A1 (en) 2014-03-19
WO2005049621A1 (en) 2005-06-02

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