DK1692139T3 - 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer - Google Patents
5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomererInfo
- Publication number
- DK1692139T3 DK1692139T3 DK04811142.1T DK04811142T DK1692139T3 DK 1692139 T3 DK1692139 T3 DK 1692139T3 DK 04811142 T DK04811142 T DK 04811142T DK 1692139 T3 DK1692139 T3 DK 1692139T3
- Authority
- DK
- Denmark
- Prior art keywords
- linkers
- dihydroxy
- oligomers
- solid phase
- phase synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52017903P | 2003-11-13 | 2003-11-13 | |
US53047703P | 2003-12-16 | 2003-12-16 | |
US56464904P | 2004-04-21 | 2004-04-21 | |
PCT/US2004/038325 WO2005049621A1 (en) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1692139T3 true DK1692139T3 (da) | 2013-03-11 |
Family
ID=34623783
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12199177.2T DK2708541T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese |
DK04811142.1T DK1692139T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12199177.2T DK2708541T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP1692139B1 (da) |
DK (2) | DK2708541T3 (da) |
ES (2) | ES2403937T3 (da) |
WO (1) | WO2005049621A1 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
US7888324B2 (en) | 2001-08-01 | 2011-02-15 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
CA2505801A1 (en) * | 2002-11-13 | 2004-05-27 | Rosanne Crooke | Antisense modulation of apolipoprotein b expression |
US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
US20050287558A1 (en) | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
JP5731115B2 (ja) | 2006-05-05 | 2015-06-10 | アイシス ファーマシューティカルズ, インコーポレーテッド | 遺伝子発現を調節するための化合物および方法 |
CA2682082A1 (en) | 2007-03-24 | 2008-10-02 | Genzyme Corporation | Administering antisense oligonucleotides complementary to human apolipoprotein b |
US9107933B2 (en) | 2009-03-16 | 2015-08-18 | Isis Pharmaceuticals, Inc. | Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III |
JP5360763B2 (ja) | 2009-10-21 | 2013-12-04 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
JP6028979B2 (ja) * | 2012-01-30 | 2016-11-24 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
EP2666794A1 (en) | 2012-05-23 | 2013-11-27 | Nitto Denko Corporation | Solid-phase support for oligonucleotide synthesis and oligonucleotide synthesis method |
TN2016000441A1 (en) | 2014-05-13 | 2018-04-04 | Novartis Ag | Compounds and compositions for inducing chondrogenesis. |
JP6537338B2 (ja) | 2015-04-24 | 2019-07-03 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
US11542294B2 (en) | 2017-03-29 | 2023-01-03 | Roche Innovation Center Copenhagen A/S | Rapid unylinker cleavage |
MX2020009004A (es) | 2018-03-14 | 2020-10-05 | Hoffmann La Roche | Derivados de acido nucleico bloqueado-acido dicarboxilico y proceso para su preparacion. |
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US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
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DE3329892A1 (de) | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
USRE34069E (en) | 1983-08-18 | 1992-09-15 | Biosyntech Gmbh | Process for the preparation of oligonucleotides |
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US5955600A (en) | 1996-12-27 | 1999-09-21 | Isis Pharmaceuticals, Inc. | Method for the synthesis of nucleotide or oligonucleotide phosphoramidites |
DE19811096A1 (de) | 1997-04-30 | 1998-11-05 | Schaeffler Waelzlager Ohg | Synchronisiervorrichtung |
US6114519A (en) | 1997-10-15 | 2000-09-05 | Isis Pharmaceuticals, Inc. | Synthesis of sulfurized oligonucleotides |
US6242591B1 (en) | 1997-10-15 | 2001-06-05 | Isis Pharmaceuticals, Inc. | Synthesis of sulfurized 2'-substituted oligonucleotides |
US6020475A (en) | 1998-02-10 | 2000-02-01 | Isis Pharmeuticals, Inc. | Process for the synthesis of oligomeric compounds |
US6111086A (en) | 1998-02-27 | 2000-08-29 | Scaringe; Stephen A. | Orthoester protecting groups |
US6274725B1 (en) | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
US6335439B1 (en) | 1998-06-11 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Method of preparing phosphoramidites |
US6465628B1 (en) | 1999-02-04 | 2002-10-15 | Isis Pharmaceuticals, Inc. | Process for the synthesis of oligomeric compounds |
US6147200A (en) | 1999-08-19 | 2000-11-14 | Isis Pharmaceuticals, Inc. | 2'-O-acetamido modified monomers and oligomers |
TWI263640B (en) * | 2001-12-19 | 2006-10-11 | Bristol Myers Squibb Co | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
US20040152905A1 (en) * | 2003-01-31 | 2004-08-05 | Guzaev Andrei P. | Universal building blocks and support media for synthesis of oligonucleotides and their analogs |
KR101595393B1 (ko) | 2014-05-22 | 2016-02-18 | 엘지전자 주식회사 | 정보 제공 시스템 및 그 방법 |
-
2004
- 2004-11-15 EP EP04811142A patent/EP1692139B1/en active Active
- 2004-11-15 DK DK12199177.2T patent/DK2708541T3/da active
- 2004-11-15 WO PCT/US2004/038325 patent/WO2005049621A1/en active Application Filing
- 2004-11-15 ES ES04811142T patent/ES2403937T3/es active Active
- 2004-11-15 EP EP12199177.2A patent/EP2708541B1/en active Active
- 2004-11-15 ES ES12199177.2T patent/ES2535033T3/es active Active
- 2004-11-15 DK DK04811142.1T patent/DK1692139T3/da active
Also Published As
Publication number | Publication date |
---|---|
ES2535033T3 (es) | 2015-05-04 |
EP1692139A1 (en) | 2006-08-23 |
EP2708541B1 (en) | 2015-01-28 |
EP1692139B1 (en) | 2013-02-13 |
DK2708541T3 (da) | 2015-02-23 |
ES2403937T3 (es) | 2013-05-22 |
EP2708541A1 (en) | 2014-03-19 |
WO2005049621A1 (en) | 2005-06-02 |
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