MX2020009004A - Derivados de acido nucleico bloqueado-acido dicarboxilico y proceso para su preparacion. - Google Patents

Derivados de acido nucleico bloqueado-acido dicarboxilico y proceso para su preparacion.

Info

Publication number
MX2020009004A
MX2020009004A MX2020009004A MX2020009004A MX2020009004A MX 2020009004 A MX2020009004 A MX 2020009004A MX 2020009004 A MX2020009004 A MX 2020009004A MX 2020009004 A MX2020009004 A MX 2020009004A MX 2020009004 A MX2020009004 A MX 2020009004A
Authority
MX
Mexico
Prior art keywords
dicarboxylic acid
lna
acid derivatives
sup
preparation
Prior art date
Application number
MX2020009004A
Other languages
English (en)
Inventor
Kurt Puentener
Christoph Rosenbohm
Filippo Sladojevich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2020009004A publication Critical patent/MX2020009004A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invención comprende derivados de ANB-ácido dicarboxílico de fórmula I o sales de los mismos, en donde R1 es una nucleobase o una nucleobase modificada, R2 es un grupo protector de hidroxilo y n es un número entero de 1 a 5. Los derivados de ANB-ácido dicarboxílico de la fórmula I se pueden usar en soportes sólidos precargados de la fórmula III y que sirven como material de partida adecuado para la síntesis de oligonucleótidos.
MX2020009004A 2018-03-14 2019-03-12 Derivados de acido nucleico bloqueado-acido dicarboxilico y proceso para su preparacion. MX2020009004A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18161687 2018-03-14
PCT/EP2019/056068 WO2019175126A1 (en) 2018-03-14 2019-03-12 Lna-dicarboxylic acid derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
MX2020009004A true MX2020009004A (es) 2020-10-05

Family

ID=61655630

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020009004A MX2020009004A (es) 2018-03-14 2019-03-12 Derivados de acido nucleico bloqueado-acido dicarboxilico y proceso para su preparacion.

Country Status (12)

Country Link
US (1) US20200407392A1 (es)
EP (1) EP3765473A1 (es)
JP (1) JP2021516673A (es)
KR (1) KR20200131232A (es)
CN (1) CN111836822A (es)
AU (1) AU2019235331A1 (es)
BR (1) BR112020014494A2 (es)
CA (1) CA3092235A1 (es)
IL (1) IL277066B2 (es)
MX (1) MX2020009004A (es)
SG (1) SG11202008232QA (es)
WO (1) WO2019175126A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018215049A1 (en) 2017-05-23 2018-11-29 F. Hoffmann-La Roche Ag Process for galnac oligonucleotide conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9021625D0 (en) 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides
US20040033973A1 (en) * 2002-08-16 2004-02-19 Muthiah Manoharan Compounds and oligomeric compounds comprising novel nucleobases
DK2708541T3 (en) 2003-11-13 2015-02-23 Isis Pharmaceuticals Inc 5,6-dihydroxy-isoindole derivatives as linkers for oligomeric solid phase synthesis
WO2006029023A2 (en) 2004-09-02 2006-03-16 Isis Pharmaceuticals, Inc. Polymeric beads for oligonucleotide synthesis
US8541569B2 (en) * 2008-09-06 2013-09-24 Chemgenes Corporation Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
JP6237237B2 (ja) * 2012-02-17 2017-11-29 味の素株式会社 塩基部保護オリゴヌクレオチド
EP4219516A3 (en) * 2012-07-13 2024-01-10 Wave Life Sciences Ltd. Chiral control
JP6429264B2 (ja) * 2013-11-12 2018-11-28 学校法人東京理科大学 ボラノホスフェート化合物、及び核酸オリゴマー

Also Published As

Publication number Publication date
IL277066B2 (en) 2023-09-01
AU2019235331A1 (en) 2020-08-06
US20200407392A1 (en) 2020-12-31
JP2021516673A (ja) 2021-07-08
EP3765473A1 (en) 2021-01-20
BR112020014494A2 (pt) 2020-12-01
IL277066A (en) 2020-10-29
WO2019175126A1 (en) 2019-09-19
CN111836822A (zh) 2020-10-27
SG11202008232QA (en) 2020-09-29
IL277066B1 (en) 2023-05-01
KR20200131232A (ko) 2020-11-23
CA3092235A1 (en) 2019-09-19

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