MX2018007129A - Formas solidas de ester etilico del acido (2r,4s)-5-(bifenil-4-il) -4-[(3-carboxipropionil)amino]-2-metil-pentanoico, sus sales y un metodo de preparacion. - Google Patents
Formas solidas de ester etilico del acido (2r,4s)-5-(bifenil-4-il) -4-[(3-carboxipropionil)amino]-2-metil-pentanoico, sus sales y un metodo de preparacion.Info
- Publication number
- MX2018007129A MX2018007129A MX2018007129A MX2018007129A MX2018007129A MX 2018007129 A MX2018007129 A MX 2018007129A MX 2018007129 A MX2018007129 A MX 2018007129A MX 2018007129 A MX2018007129 A MX 2018007129A MX 2018007129 A MX2018007129 A MX 2018007129A
- Authority
- MX
- Mexico
- Prior art keywords
- sacubitril
- formula
- salts
- salt
- solid forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a formas sólidas del ácido libre de sacubitrilo de fórmula 1, especialmente una forma cristalina, incl. un método para eliminar impurezas químicas del ácido libre en bruto de sacubitrilo que se caracteriza por el uso de sales de sacubitrilo que cristalizan bien con las aminas de fórmula 9, donde R1, R2, R3 representan independientemente hidrógeno o un alquilo C1-C7, preferiblemente la sal con ciclohexilamina, terc-butilamina o iso-propilamina. La invención también se refiere a un sólido novedoso, forma cristalina de sacubitrilo (8) - hemisolvato de la sal de potasio de sacubitrilo, incl. métodos de preparación directos, altamente eficaces e industrialmente útiles de una forma sólida de ácido libre de sacubitrilo y sus sales farmacéuticamente aplicables, especialmente la sal de sodio cristalina de fórmula 5, sal de calcio de sacubitrilo de fórmula 6 y el hemisolvato de la sal de potasio de sacubitrilo de fórmula 8.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ2015-891A CZ2015891A3 (cs) | 2015-12-11 | 2015-12-11 | Krystalická forma draselné soli ethylesteru (2R,4S)-5-(bifenyl-4-yl)-4-[(3-karboxypropionyl)amino]-2-methylpentanové kyseliny a průmyslově použitelný způsob její přípravy |
CZ2015-896A CZ2015896A3 (cs) | 2015-12-14 | 2015-12-14 | Pevné formy ethyl esteru (2R,4S)-5-(bifenyl-4-yl)-4-[3-karboxypropionyl)amino]-2--methylpentanové kyseliny, její sole a způsob přípravy |
PCT/CZ2016/000130 WO2017097275A1 (en) | 2015-12-11 | 2016-12-12 | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018007129A true MX2018007129A (es) | 2018-11-09 |
Family
ID=57614098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018007129A MX2018007129A (es) | 2015-12-11 | 2016-12-12 | Formas solidas de ester etilico del acido (2r,4s)-5-(bifenil-4-il) -4-[(3-carboxipropionil)amino]-2-metil-pentanoico, sus sales y un metodo de preparacion. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP3386945A1 (es) |
BR (1) | BR112018011788A2 (es) |
CO (1) | CO2018005941A2 (es) |
MX (1) | MX2018007129A (es) |
WO (1) | WO2017097275A1 (es) |
ZA (1) | ZA201803749B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10683260B2 (en) * | 2016-09-07 | 2020-06-16 | Nanjing Noratech Pharmaceuticals Co., Ltd. | Crystalline form of sacubitril sodium salt |
US10857132B2 (en) | 2016-10-10 | 2020-12-08 | Laurus Labs Limited | Stable amorphous form of sacubitril valsartan trisodium complex and processes for preparation thereof |
JP7022747B2 (ja) | 2016-10-28 | 2022-02-18 | バイオコン・リミテッド | アモルファスサクビトリルバルサルタン三ナトリウムおよびその調製のためのプロセス |
CN107311909A (zh) * | 2017-06-22 | 2017-11-03 | 东南大学 | 一种lcz696杂质对照品的制备方法 |
PL3658122T3 (pl) * | 2017-07-28 | 2021-10-18 | Synthon B.V. | Kompozycja farmaceutyczna zawierająca sakubitryl i walsartan |
CN109400493B (zh) * | 2017-08-15 | 2021-07-09 | 成都博腾药业有限公司 | 沙库比曲及其中间体的制备方法 |
CN107602410A (zh) * | 2017-09-13 | 2018-01-19 | 浙江三门恒康制药有限公司 | 沙库比曲钠盐的晶型ii及其制备方法 |
CN108530371B (zh) * | 2017-12-27 | 2020-09-01 | 浙江天宇药业股份有限公司 | 一种沙库比曲钠盐、沙库比曲游离酸与乙酸的共晶物、其晶型、晶型的制备方法及用途 |
CN108558693A (zh) * | 2018-04-24 | 2018-09-21 | 南京双科医药开发有限公司 | 一种沙库巴曲游离酸及其金属盐在药物制备中应用的方法 |
GB201810326D0 (en) * | 2018-06-22 | 2018-08-08 | Johnson Matthey Plc | Crystalline form of sacubitril, its preparation and use |
CN109912486B (zh) * | 2019-04-25 | 2022-09-27 | 东北制药集团股份有限公司 | 一种联苯甲基内酰胺化合物的制备方法 |
CN110878039A (zh) * | 2019-12-18 | 2020-03-13 | 株洲千金药业股份有限公司 | 一种沙库巴曲缬沙坦钠杂质的制备方法 |
CN115677521B (zh) * | 2022-11-16 | 2024-02-02 | 迪嘉药业集团股份有限公司 | 一种高纯度沙库巴曲钙的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5217996A (en) | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
MXPA04006917A (es) | 2002-01-17 | 2004-12-06 | Novartis Ag | Composiciones farmaceuticas que comprenden inhibidores de valsartan y endopeptidasa neutra. |
WO2007045663A2 (en) | 2005-10-19 | 2007-04-26 | Novartis Ag | Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure |
AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
EP1903027A1 (en) | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
CN101631765B (zh) | 2007-01-12 | 2014-10-01 | 诺华股份有限公司 | 用于制备5-联苯基-4-氨基-2-甲基戊酸的方法 |
AR070176A1 (es) | 2008-01-17 | 2010-03-17 | Novartis Ag | Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis |
PL2526088T3 (pl) | 2010-01-22 | 2016-01-29 | Novartis Ag | Produkty pośrednie inhibitorów obojętnej endopeptydazy oraz sposób ich wytwarzania |
BR112013004164A2 (pt) | 2010-08-23 | 2016-05-10 | Novartis Ag | processo para a preparação de intermediários para a produção de inibidores da nep |
WO2012025502A1 (en) | 2010-08-23 | 2012-03-01 | Novartis Ag | New process for the preparation of intermediates useful for the manufacture nep inhibitors |
AR092278A1 (es) | 2012-08-31 | 2015-04-08 | Novartis Ag | Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados |
JP2016530282A (ja) | 2013-08-26 | 2016-09-29 | ノバルティス アーゲー | 新規使用 |
CN105622452A (zh) * | 2014-08-27 | 2016-06-01 | 上海翰森生物医药科技有限公司 | Ahu-377结晶型游离酸及其制备方法和应用 |
WO2016029828A1 (zh) * | 2014-08-27 | 2016-03-03 | 上海翰森生物医药科技有限公司 | AHU-377结晶型游离酸、半钙盐、α﹣苯乙胺盐及其制备方法和应用 |
CN105461587A (zh) * | 2014-08-27 | 2016-04-06 | 上海翰森生物医药科技有限公司 | Ahu-377半钙盐晶型及其制备方法和应用 |
HUE046278T2 (hu) * | 2014-11-14 | 2020-02-28 | Zentiva Ks | Módszer AHU-377 gyógyszerészetben alkalmazható formáinak elõállítására, izolálására és tisztítására |
CN105837464A (zh) * | 2015-01-15 | 2016-08-10 | 四川海思科制药有限公司 | 沙库比曲钠的晶型及其制备方法和用途 |
-
2016
- 2016-12-12 EP EP16818971.0A patent/EP3386945A1/en not_active Withdrawn
- 2016-12-12 BR BR112018011788A patent/BR112018011788A2/pt not_active Application Discontinuation
- 2016-12-12 MX MX2018007129A patent/MX2018007129A/es unknown
- 2016-12-12 WO PCT/CZ2016/000130 patent/WO2017097275A1/en active Application Filing
-
2018
- 2018-06-06 ZA ZA2018/03749A patent/ZA201803749B/en unknown
- 2018-06-12 CO CONC2018/0005941A patent/CO2018005941A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO2018005941A2 (es) | 2018-07-10 |
WO2017097275A1 (en) | 2017-06-15 |
ZA201803749B (en) | 2019-04-24 |
BR112018011788A2 (pt) | 2018-12-04 |
EP3386945A1 (en) | 2018-10-17 |
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