MX2019006920A - Derivados de la espiropiperidina. - Google Patents

Derivados de la espiropiperidina.

Info

Publication number
MX2019006920A
MX2019006920A MX2019006920A MX2019006920A MX2019006920A MX 2019006920 A MX2019006920 A MX 2019006920A MX 2019006920 A MX2019006920 A MX 2019006920A MX 2019006920 A MX2019006920 A MX 2019006920A MX 2019006920 A MX2019006920 A MX 2019006920A
Authority
MX
Mexico
Prior art keywords
compounds
spiropiperidine
fatty acid
methods
acid synthase
Prior art date
Application number
MX2019006920A
Other languages
English (en)
Inventor
Mcwherter Melody
L Hudkins Robert
B Whitman David
A Zificsak Craig
L Zulli Allison
Original Assignee
89Bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 89Bio Ltd filed Critical 89Bio Ltd
Publication of MX2019006920A publication Critical patent/MX2019006920A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

En la presente se describen compuestos de espiropiperidina de acuerdo con la Fórmula l que han demostrado actividad como inhibidores de ácido graso sintasa. En la presente también se describen composiciones farmacéuticas que contienen los compuestos de espiropiperidina descritos, y métodos para tratar enfermedades mediadas por ácido graso sintasas, mediante la administración de uno o más de los compuestos o formulaciones farmacéuticas descritas en la presente. En la presente también se describen métodos para sintetizar los compuestos descritos, incluyendo los compuestos de espiropiperidina descritos y los productos intermedios sintéticos que son útiles en tales síntesis. (Ver fórmula).
MX2019006920A 2016-12-14 2017-12-14 Derivados de la espiropiperidina. MX2019006920A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662434167P 2016-12-14 2016-12-14
PCT/US2017/066422 WO2018112204A1 (en) 2016-12-14 2017-12-14 Spiropiperidine derivatives

Publications (1)

Publication Number Publication Date
MX2019006920A true MX2019006920A (es) 2019-11-28

Family

ID=62559235

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019006920A MX2019006920A (es) 2016-12-14 2017-12-14 Derivados de la espiropiperidina.

Country Status (7)

Country Link
US (2) US11046707B2 (es)
EP (1) EP3554637A4 (es)
JP (2) JP7162591B2 (es)
CA (1) CA3046805A1 (es)
IL (1) IL267145B (es)
MX (1) MX2019006920A (es)
WO (1) WO2018112204A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113431448B (zh) 2016-04-08 2022-06-14 J·P·希瓦利埃 用于锁定可移动面板的锁定系统
EP3554637A4 (en) * 2016-12-14 2020-05-20 89Bio Ltd. SPIROPIPERID DERIVATIVES
HU231333B1 (hu) * 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698566A (en) * 1993-02-12 1997-12-16 Merck & Co., Inc. Nitrogen-containing spirocycles
WO2007011809A1 (en) 2005-07-19 2007-01-25 Merck & Co., Inc. Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors
TW200804393A (en) * 2005-11-14 2008-01-16 Solvay Pharm Gmbh Novel N-sulfamoyl-N'-benzopyranpiperidines for medical use
BRPI0618539A2 (pt) 2005-11-14 2011-09-06 Solvay Pharm Gmbh n-sulfamoil-n'-benzopiranopiperidinas para utilização médica
JP5271917B2 (ja) * 2007-01-12 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション スピロクロマノン誘導体
PE20081559A1 (es) 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
CA2712897A1 (en) * 2008-01-30 2009-08-06 Pharmacopeia, Inc. Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
EP2307422B1 (en) * 2008-07-04 2014-03-26 Msd K.K. Novel spirochromanone carboxylic acids
JPWO2012161119A1 (ja) * 2011-05-20 2014-07-31 興和株式会社 新規なスピロピペリジン誘導体及びこれを含有する医薬
CN103304571B (zh) * 2012-03-06 2018-02-16 凯惠科技发展(上海)有限公司 螺环化合物、其制备方法、中间体、药物组合物和应用
EP3554637A4 (en) * 2016-12-14 2020-05-20 89Bio Ltd. SPIROPIPERID DERIVATIVES

Also Published As

Publication number Publication date
JP7162591B2 (ja) 2022-10-28
IL267145A (en) 2019-08-29
US11878982B2 (en) 2024-01-23
CA3046805A1 (en) 2018-06-21
WO2018112204A1 (en) 2018-06-21
US20200031840A1 (en) 2020-01-30
US20210284651A1 (en) 2021-09-16
EP3554637A4 (en) 2020-05-20
IL267145B (en) 2022-01-01
JP2022166192A (ja) 2022-11-01
US11046707B2 (en) 2021-06-29
JP2020511412A (ja) 2020-04-16
EP3554637A1 (en) 2019-10-23

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