DK2708541T3 - 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese - Google Patents
5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese Download PDFInfo
- Publication number
- DK2708541T3 DK2708541T3 DK12199177.2T DK12199177T DK2708541T3 DK 2708541 T3 DK2708541 T3 DK 2708541T3 DK 12199177 T DK12199177 T DK 12199177T DK 2708541 T3 DK2708541 T3 DK 2708541T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- volume
- acetonitrile
- alkyl
- oligonucleotide
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Claims (12)
1. Forbindelse med formlen:
hvor R1 er aryl, cycloalkyl, umættet cycloalkyl, alkyl, umættet alkyl, heterocyclyl, umættet heterocyclyl, heteroaryl eller acyl, hvor R1 eventuelt er substitueret med én eller flere substituenter.
2. Forbindelsen ifølge krav 1 med formlen:
3. Forbindelsen ifølge krav 1, hvor R1 yderligere er substitueret med fra 1 til 5 substituenter.
4. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er aryl, der eventuelt er yderligere substitueret.
5. Forbindelsen ifølge et hvilket som helst af kravene 1 eller 3-4, hvor R1 er phenyl eller naphthyl, der eventuelt er yderligere substitueret.
6. Forbindelsen ifølge et hvilket som helst af kravene 1 eller 3-4, hvor R1 er phenyl eller naphthyl, der er usubstitueret eller substitueret med fra 1 til ca. 5 medlemmer af gruppen bestående af F, Cl, Br, I, NO2, C1-C12 alkyl eller CF3.
7. Forbindelsen ifølge et hvilket som helst af kravene 1 eller 3-5, hvor R1 er phenyl eller naphthyl, der er usubstitueret.
8. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er heterocyclyl, og R1 eventuelt er yderligere substitueret.
9. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er pyridiyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, furanyl, thiophenyl, thiazolyl, pyrrolyl eller imidazolyl og R1 eventuelt er yderligere substitueret.
10. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er pyridyl, furanyl eller thiophenyl og R1 eventuelt er yderligere substitueret.
11. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er pyridiyl, furanyl, eller thiophenyl, og R1 ikke er yderligere substitueret.
12. Forbindelsen ifølge krav 1 eller krav 3, hvor R1 er N-alkyl-morpholinyl, N-alkyl-piperidinyl eller Ν,Ν'-dialkylpiperazinyl, og R1 eventuelt er yderligere substitueret.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52017903P | 2003-11-13 | 2003-11-13 | |
US53047703P | 2003-12-16 | 2003-12-16 | |
US56464904P | 2004-04-21 | 2004-04-21 | |
EP04811142A EP1692139B1 (en) | 2003-11-13 | 2004-11-15 | 5,6 -dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2708541T3 true DK2708541T3 (da) | 2015-02-23 |
Family
ID=34623783
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04811142.1T DK1692139T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer |
DK12199177.2T DK2708541T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindolderivater som linkere til oligomer-fastfasesyntese |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04811142.1T DK1692139T3 (da) | 2003-11-13 | 2004-11-15 | 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP1692139B1 (da) |
DK (2) | DK1692139T3 (da) |
ES (2) | ES2535033T3 (da) |
WO (1) | WO2005049621A1 (da) |
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US7888324B2 (en) | 2001-08-01 | 2011-02-15 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
WO2004044181A2 (en) * | 2002-11-13 | 2004-05-27 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein b expression |
US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
US20050287558A1 (en) | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
KR101441700B1 (ko) | 2006-05-05 | 2014-09-18 | 아이시스 파마수티컬즈 인코포레이티드 | Pcsk9 발현을 조절하는 화합물 및 방법 |
JP2010522245A (ja) | 2007-03-24 | 2010-07-01 | ゲンザイム コーポレイション | ヒトアポリポタンパク質bと相補的なアンチセンスオリゴヌクレオチドの投与 |
WO2010107838A1 (en) | 2009-03-16 | 2010-09-23 | Isis Pharmaceuticals, Inc. | Targeting apolipoprotein b for the reduction of apolipoprotein c-iii |
JP5360763B2 (ja) | 2009-10-21 | 2013-12-04 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
JP6028979B2 (ja) * | 2012-01-30 | 2016-11-24 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
EP2666794A1 (en) | 2012-05-23 | 2013-11-27 | Nitto Denko Corporation | Solid-phase support for oligonucleotide synthesis and oligonucleotide synthesis method |
MA39972A (fr) | 2014-05-13 | 2015-11-19 | Choi Ha Soon | Composés et compositions d'induction de la chondrogenèse |
JP6537338B2 (ja) | 2015-04-24 | 2019-07-03 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
WO2018177881A1 (en) | 2017-03-29 | 2018-10-04 | Roche Innovation Center Copenhagen A/S | Unylinker rapid cleavage |
JP2021516673A (ja) | 2018-03-14 | 2021-07-08 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Lna−ジカルボン酸誘導体およびその調製のための方法 |
US20230203474A1 (en) * | 2021-12-27 | 2023-06-29 | Industrial Technology Research Institute | Compound, solid carrier including the same and method for preparing nucleic acid |
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-
2004
- 2004-11-15 EP EP04811142A patent/EP1692139B1/en active Active
- 2004-11-15 DK DK04811142.1T patent/DK1692139T3/da active
- 2004-11-15 ES ES12199177.2T patent/ES2535033T3/es active Active
- 2004-11-15 EP EP12199177.2A patent/EP2708541B1/en active Active
- 2004-11-15 DK DK12199177.2T patent/DK2708541T3/da active
- 2004-11-15 WO PCT/US2004/038325 patent/WO2005049621A1/en active Application Filing
- 2004-11-15 ES ES04811142T patent/ES2403937T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
EP1692139B1 (en) | 2013-02-13 |
EP2708541B1 (en) | 2015-01-28 |
EP1692139A1 (en) | 2006-08-23 |
WO2005049621A1 (en) | 2005-06-02 |
EP2708541A1 (en) | 2014-03-19 |
DK1692139T3 (da) | 2013-03-11 |
ES2535033T3 (es) | 2015-05-04 |
ES2403937T3 (es) | 2013-05-22 |
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