JP4460205B2 - シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法 - Google Patents

シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法 Download PDF

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JP4460205B2
JP4460205B2 JP2001567699A JP2001567699A JP4460205B2 JP 4460205 B2 JP4460205 B2 JP 4460205B2 JP 2001567699 A JP2001567699 A JP 2001567699A JP 2001567699 A JP2001567699 A JP 2001567699A JP 4460205 B2 JP4460205 B2 JP 4460205B2
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solution
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JP2003531118A5 (OSRAM
JP2003531118A (ja
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ジェフリー・エイ・ローブル
リチャード・ビー・サルスキー
デイビッド・ジェイ・オージェリ
デイビッド・アール・マグニン
ローレンス・ジー・ハマン
デイビッド・エイ・ビテベナー
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Bristol Myers Squibb Co
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
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  • Diabetes (AREA)
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  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
JP2001567699A 2000-03-10 2001-03-05 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法 Expired - Lifetime JP4460205B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18855500P 2000-03-10 2000-03-10
US60/188,555 2000-03-10
PCT/US2001/007151 WO2001068603A2 (en) 2000-03-10 2001-03-05 Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl iv, processes for their preparation, and their use

Related Child Applications (1)

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JP2010006181A Division JP5427047B2 (ja) 2000-03-10 2010-01-14 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法

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JP2003531118A JP2003531118A (ja) 2003-10-21
JP2003531118A5 JP2003531118A5 (OSRAM) 2010-03-04
JP4460205B2 true JP4460205B2 (ja) 2010-05-12

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JP2001567699A Expired - Lifetime JP4460205B2 (ja) 2000-03-10 2001-03-05 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法
JP2010006181A Expired - Lifetime JP5427047B2 (ja) 2000-03-10 2010-01-14 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法
JP2012263345A Pending JP2013040219A (ja) 2000-03-10 2012-11-30 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法
JP2013249334A Expired - Lifetime JP5953292B2 (ja) 2000-03-10 2013-12-02 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法
JP2015092196A Expired - Lifetime JP5951843B2 (ja) 2000-03-10 2015-04-28 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法

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JP2010006181A Expired - Lifetime JP5427047B2 (ja) 2000-03-10 2010-01-14 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法
JP2012263345A Pending JP2013040219A (ja) 2000-03-10 2012-11-30 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法
JP2013249334A Expired - Lifetime JP5953292B2 (ja) 2000-03-10 2013-12-02 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法
JP2015092196A Expired - Lifetime JP5951843B2 (ja) 2000-03-10 2015-04-28 シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法

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US (2) US6395767B2 (OSRAM)
EP (4) EP1559710B1 (OSRAM)
JP (5) JP4460205B2 (OSRAM)
KR (2) KR100758407B1 (OSRAM)
CN (2) CN1213028C (OSRAM)
AR (1) AR027634A1 (OSRAM)
AT (1) ATE396176T1 (OSRAM)
AU (2) AU2001245466B2 (OSRAM)
BE (2) BE2010C008I2 (OSRAM)
BR (1) BRPI0109115B8 (OSRAM)
CA (1) CA2402894C (OSRAM)
CO (1) CO5280198A1 (OSRAM)
CY (3) CY1108273T1 (OSRAM)
CZ (3) CZ304355B6 (OSRAM)
DE (3) DE60134122D1 (OSRAM)
DK (1) DK1261586T3 (OSRAM)
EG (1) EG25854A (OSRAM)
ES (4) ES2456667T3 (OSRAM)
FR (2) FR10C0010I2 (OSRAM)
HK (1) HK1049330B (OSRAM)
HU (5) HU230347B1 (OSRAM)
IL (4) IL151372A0 (OSRAM)
LU (2) LU91650I2 (OSRAM)
MX (1) MXPA02008837A (OSRAM)
MY (1) MY124512A (OSRAM)
NL (1) NL300436I1 (OSRAM)
NO (3) NO324227B1 (OSRAM)
NZ (1) NZ520821A (OSRAM)
PE (1) PE20020771A1 (OSRAM)
PL (1) PL207041B1 (OSRAM)
PT (1) PT1261586E (OSRAM)
RU (1) RU2286986C2 (OSRAM)
SG (1) SG152030A1 (OSRAM)
TW (2) TWI258468B (OSRAM)
UY (2) UY26613A1 (OSRAM)
WO (1) WO2001068603A2 (OSRAM)
ZA (1) ZA200206816B (OSRAM)

Cited By (1)

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JP2015134830A (ja) * 2000-03-10 2015-07-27 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ シクロプロピル縮合ピロリジン骨格を有するジペプチジルペプチダーゼｉｖの阻害剤及び方法

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US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US6573287B2 (en) * 2001-04-12 2003-06-03 Bristo-Myers Squibb Company 2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
CN1723196A (zh) * 2001-06-27 2006-01-18 史密丝克莱恩比彻姆公司 作为二肽酶抑制剂的氟代吡咯烷
EP1399433B1 (en) * 2001-06-27 2007-08-22 Smithkline Beecham Corporation Fluoropyrrolidines as dipeptidyl peptidase inhibitors
US7196201B2 (en) * 2001-06-27 2007-03-27 Smithkline Beecham Corporation Pyrrolidines as dipeptidyl peptidase inhibitors
AU2002348276A1 (en) * 2001-11-16 2003-06-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
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US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
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GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
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US7405234B2 (en) * 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7378385B2 (en) * 2002-08-08 2008-05-27 University Of Cincinnati Role for GLP-1 to mediate responses to disparate stressors
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