|
FR2640638B1
(fr)
|
1988-12-20 |
1991-02-15 |
Commissariat Energie Atomique |
Bioreacteur et dispositif pour la culture de cellules animales
|
|
WO1991018088A1
(en)
|
1990-05-23 |
1991-11-28 |
The United States Of America, Represented By The Secretary, United States Department Of Commerce |
Adeno-associated virus (aav)-based eucaryotic vectors
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5252479A
(en)
|
1991-11-08 |
1993-10-12 |
Research Corporation Technologies, Inc. |
Safe vector for gene therapy
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US6268213B1
(en)
|
1992-06-03 |
2001-07-31 |
Richard Jude Samulski |
Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy
|
|
US5693531A
(en)
|
1993-11-24 |
1997-12-02 |
The United States Of America As Represented By The Department Of Health And Human Services |
Vector systems for the generation of adeno-associated virus particles
|
|
ATE386131T1
(de)
|
1994-04-13 |
2008-03-15 |
Univ Rockefeller |
Aav-vermittelte überbringung von dna in zellen des nervensystems
|
|
US20020159979A1
(en)
|
1994-06-06 |
2002-10-31 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US5658785A
(en)
|
1994-06-06 |
1997-08-19 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5856152A
(en)
|
1994-10-28 |
1999-01-05 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV vector and methods of use therefor
|
|
US5625048A
(en)
|
1994-11-10 |
1997-04-29 |
The Regents Of The University Of California |
Modified green fluorescent proteins
|
|
EP0796339A1
(en)
|
1994-12-06 |
1997-09-24 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant aav vectors
|
|
US5652224A
(en)
|
1995-02-24 |
1997-07-29 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism
|
|
US5741657A
(en)
|
1995-03-20 |
1998-04-21 |
The Regents Of The University Of California |
Fluorogenic substrates for β-lactamase and methods of use
|
|
US6281010B1
(en)
|
1995-06-05 |
2001-08-28 |
The Trustees Of The University Of Pennsylvania |
Adenovirus gene therapy vehicle and cell line
|
|
US5756283A
(en)
|
1995-06-05 |
1998-05-26 |
The Trustees Of The University Of Pennsylvania |
Method for improved production of recombinant adeno-associated viruses for gene therapy
|
|
US5741683A
(en)
|
1995-06-07 |
1998-04-21 |
The Research Foundation Of State University Of New York |
In vitro packaging of adeno-associated virus DNA
|
|
US5688676A
(en)
|
1995-06-07 |
1997-11-18 |
Research Foundation Of State University Of New York |
In vitro packaging of adeno-associated virus DNA
|
|
US6676935B2
(en)
|
1995-06-27 |
2004-01-13 |
Cell Genesys, Inc. |
Tissue specific adenoviral vectors
|
|
US6197293B1
(en)
|
1997-03-03 |
2001-03-06 |
Calydon, Inc. |
Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
|
|
CA2230655C
(en)
|
1995-08-30 |
2008-06-17 |
Genzyme Corporation |
Chromatographic purification of adenovirus and aav
|
|
US6265389B1
(en)
|
1995-08-31 |
2001-07-24 |
Alkermes Controlled Therapeutics, Inc. |
Microencapsulation and sustained release of oligonucleotides
|
|
US5846528A
(en)
|
1996-01-18 |
1998-12-08 |
Avigen, Inc. |
Treating anemia using recombinant adeno-associated virus virions comprising an EPO DNA sequence
|
|
US5858351A
(en)
|
1996-01-18 |
1999-01-12 |
Avigen, Inc. |
Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
US5952221A
(en)
|
1996-03-06 |
1999-09-14 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a first and second nucleic acid sequence
|
|
US7026468B2
(en)
|
1996-07-19 |
2006-04-11 |
Valentis, Inc. |
Process and equipment for plasmid purification
|
|
US6083716A
(en)
|
1996-09-06 |
2000-07-04 |
The Trustees Of The University Of Pennsylvania |
Chimpanzee adenovirus vectors
|
|
IL128779A0
(en)
|
1996-09-06 |
2000-01-31 |
Univ Pennsylvania |
Method for recombinant adeno-associated virus-directed gene therapy
|
|
AU722375B2
(en)
|
1996-09-06 |
2000-08-03 |
Trustees Of The University Of Pennsylvania, The |
Methods using cre-lox for production of recombinant adeno-associated viruses
|
|
US5866552A
(en)
|
1996-09-06 |
1999-02-02 |
The Trustees Of The University Of Pennsylvania |
Method for expressing a gene in the absence of an immune response
|
|
US20020037867A1
(en)
|
1999-02-26 |
2002-03-28 |
James M. Wilson |
Method for recombinant adeno-associated virus-directed gene therapy
|
|
CA2264482A1
(en)
|
1996-09-06 |
1998-03-12 |
The Trustees Of The University Of Pennsylvania |
An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase
|
|
AU4645697A
(en)
|
1996-09-11 |
1998-04-02 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Aav4 vector and uses thereof
|
|
US7732129B1
(en)
|
1998-12-01 |
2010-06-08 |
Crucell Holland B.V. |
Method for the production and purification of adenoviral vectors
|
|
BR9713368A
(pt)
|
1996-11-20 |
2001-09-18 |
Introgen Therapeutics Inc |
Processo melhorado para a produção e a purificação de vetores adenovirais
|
|
CA2270285A1
(en)
|
1996-12-18 |
1998-06-25 |
Targeted Genetics Corporation |
Aav split-packaging genes and cell lines comprising such genes for use in the production of recombinant aav vectors
|
|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
|
US6710036B2
(en)
|
1997-07-25 |
2004-03-23 |
Avigen, Inc. |
Induction of immune response to antigens expressed by recombinant adeno-associated virus
|
|
US6251677B1
(en)
|
1997-08-25 |
2001-06-26 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV virus and methods of use thereof
|
|
US6989264B2
(en)
|
1997-09-05 |
2006-01-24 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
CA2304131A1
(en)
|
1997-09-19 |
1999-04-01 |
James M. Wilson |
Method for gene transfer using bcl2 and compositions useful therein
|
|
WO1999014354A1
(en)
|
1997-09-19 |
1999-03-25 |
The Trustees Of The University Of The Pennsylvania |
Methods and vector constructs useful for production of recombinant aav
|
|
AU9397098A
(en)
|
1997-09-19 |
1999-04-12 |
Trustees Of The University Of Pennsylvania, The |
Methods and cell line useful for production of recombinant adeno-associated viruses
|
|
US6642051B1
(en)
|
1997-10-21 |
2003-11-04 |
Targeted Genetics Corporation |
Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
|
|
IT1297074B1
(it)
|
1997-11-21 |
1999-08-03 |
Angeletti P Ist Richerche Bio |
Forme ormone-dipendenti delle proteine rep del virus adeno-associato (aav-2), sequenze di dna codificanti per esse, vettori che le
|
|
AU759573B2
(en)
|
1997-12-23 |
2003-04-17 |
Crucell Holland B.V. |
Adeno-associated virus and adenovirus chimeric recombinant viruses useful for the integration of foreign genetic information into the chromosomal DNA of target cells
|
|
US6410300B1
(en)
|
1998-01-12 |
2002-06-25 |
The University Of North Carolina At Chapel Hill |
Methods and formulations for mediating adeno-associated virus (AAV) attachment and infection and methods for purifying AAV
|
|
AU2882899A
(en)
|
1998-02-26 |
1999-09-15 |
Trustees Of The University Of Pennsylvania, The |
Stable protection from dystrophic sarcolemmal degeneration and restoration of the sarcoglycan complex
|
|
US6953690B1
(en)
|
1998-03-20 |
2005-10-11 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6521426B1
(en)
|
1998-04-08 |
2003-02-18 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Preparation of recombinant adenovirus carrying a rep gene of adeno-associated virus
|
|
FR2778413B1
(fr)
|
1998-05-07 |
2000-08-04 |
Immunotech Sa |
Nouveaux reactifs et methode de lyse des erythrocytes
|
|
WO1999058700A1
(en)
|
1998-05-11 |
1999-11-18 |
Ariad Gene Therapeutics, Inc. |
Multiviral compositions and uses thereof
|
|
US6436392B1
(en)
|
1998-05-20 |
2002-08-20 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors
|
|
EP1849872A1
(en)
|
1998-05-20 |
2007-10-31 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors and uses thereof
|
|
WO1999061643A1
(en)
|
1998-05-27 |
1999-12-02 |
University Of Florida |
Method of preparing recombinant adeno-associated virus compositions by using an iodixananol gradient
|
|
JP2002516345A
(ja)
|
1998-05-27 |
2002-06-04 |
セル ジェネシス インコーポレイテッド |
第viii因子活性のアデノ随伴ウイルスベクター媒介性発現
|
|
AU762220B2
(en)
|
1998-05-28 |
2003-06-19 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
AAV5 vector and uses thereof
|
|
US6984517B1
(en)
|
1998-05-28 |
2006-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector and uses thereof
|
|
GB2338236B
(en)
|
1998-06-13 |
2003-04-09 |
Aea Technology Plc |
Microbiological cell processing
|
|
US6900049B2
(en)
|
1998-09-10 |
2005-05-31 |
Cell Genesys, Inc. |
Adenovirus vectors containing cell status-specific response elements and methods of use thereof
|
|
US6416992B1
(en)
|
1998-10-13 |
2002-07-09 |
Avigen, Inc. |
Compositions and methods for producing recombinant adeno-associated virus
|
|
US6200560B1
(en)
|
1998-10-20 |
2001-03-13 |
Avigen, Inc. |
Adeno-associated virus vectors for expression of factor VIII by target cells
|
|
AU764130B2
(en)
|
1998-10-27 |
2003-08-14 |
Crucell Holland B.V. |
Improved AAV vector production
|
|
US6759237B1
(en)
|
1998-11-05 |
2004-07-06 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
|
|
US6689600B1
(en)
|
1998-11-16 |
2004-02-10 |
Introgen Therapeutics, Inc. |
Formulation of adenovirus for gene therapy
|
|
US6759050B1
(en)
|
1998-12-03 |
2004-07-06 |
Avigen, Inc. |
Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
|
|
US6225113B1
(en)
|
1998-12-04 |
2001-05-01 |
Genvec, Inc. |
Use of trans-activation and cis-activation to modulate the persistence of expression of a transgene in an at least E4-deficient adenovirus
|
|
US6387368B1
(en)
|
1999-02-08 |
2002-05-14 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV virus and methods of use thereof
|
|
DE19905501B4
(de)
|
1999-02-10 |
2005-05-19 |
MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie |
Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
|
|
US6509150B1
(en)
|
1999-03-05 |
2003-01-21 |
Universite De Nantes |
Compositions and methods for recombinant Adeno-Associated Virus production
|
|
US6258595B1
(en)
|
1999-03-18 |
2001-07-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
JP4693244B2
(ja)
|
1999-03-18 |
2011-06-01 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組換えアデノ随伴ウイルスのヘルパー無しの生産のための組成物および方法
|
|
CA2368194A1
(en)
|
1999-04-30 |
2000-11-09 |
University Of Florida |
Adeno-associated virus-delivered ribozyme compositions and methods of use
|
|
CA2375098A1
(en)
|
1999-06-02 |
2000-12-14 |
Trustees Of The University Of Pennsylvania |
Compositions and methods useful for production of recombinant viruses which require helper viruses
|
|
JP4969002B2
(ja)
|
1999-06-08 |
2012-07-04 |
ユニバーシテイ・オブ・アイオワ・リサーチ・フアウンデーシヨン |
rAAV形質導入を増加するための化合物および方法
|
|
AU781478B2
(en)
|
1999-08-20 |
2005-05-26 |
Johns Hopkins University School Of Medicine, The |
Methods and compositions for the construction and use of fusion libraries
|
|
WO2001023001A2
(en)
|
1999-09-29 |
2001-04-05 |
The Trustees Of The University Of Pennsylvania |
Rapid peg-modification
|
|
US6365394B1
(en)
|
1999-09-29 |
2002-04-02 |
The Trustees Of The University Of Pennsylvania |
Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus
|
|
EP1224313A1
(en)
|
1999-10-07 |
2002-07-24 |
University of Iowa Research Foundation |
Adeno-associated viruses and uses thereof
|
|
US7241447B1
(en)
|
1999-10-07 |
2007-07-10 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors and uses thereof
|
|
WO2001032711A2
(en)
|
1999-10-21 |
2001-05-10 |
Board Of Trustees Of The University Of Arkansas |
Adeno-associated virus aav rep78 major regulatory protein, mutants thereof and uses thereof
|
|
WO2001036623A2
(en)
|
1999-11-05 |
2001-05-25 |
Avigen, Inc. |
Ecdysone-inducible adeno-associated virus expression vectors
|
|
AU1775901A
(en)
|
1999-11-17 |
2001-05-30 |
Avigen, Inc. |
Recombinant adeno-associated virus virions for the treatment of lysosomal disorders
|
|
US20010049144A1
(en)
|
1999-12-10 |
2001-12-06 |
Victor Rivera |
Methods for high level expression of genes in primates
|
|
AU4565401A
(en)
|
2000-03-14 |
2001-09-24 |
Thomas Jefferson University |
Production of chimeric capsid vectors
|
|
US7638120B2
(en)
|
2000-03-14 |
2009-12-29 |
Thomas Jefferson University |
High transgene expression of a pseudotyped adeno-associated virus type
|
|
US6468524B1
(en)
|
2000-03-22 |
2002-10-22 |
The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
AAV4 vector and uses thereof
|
|
US6855314B1
(en)
|
2000-03-22 |
2005-02-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector for transducing brain cells and lung cells
|
|
US7048920B2
(en)
|
2000-03-24 |
2006-05-23 |
Cell Genesys, Inc. |
Recombinant oncolytic adenovirus for human melanoma
|
|
PT1309726E
(pt)
|
2000-03-30 |
2010-03-08 |
Whitehead Biomedical Inst |
Mediadores de interferência por rna específicos de sequência de rna
|
|
GB0009887D0
(en)
|
2000-04-20 |
2000-06-07 |
Btg Int Ltd |
Cytotoxic agents
|
|
AU2001257611A1
(en)
|
2000-04-28 |
2001-11-12 |
Avigen, Inc. |
Polynucleotides for use in recombinant adeno-associated virus virion production
|
|
CA2406743A1
(en)
|
2000-04-28 |
2001-11-08 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
|
|
US20030013189A1
(en)
|
2000-04-28 |
2003-01-16 |
Wilson James M. |
Compositions and methods useful for non-invasive delivery of therapeutic molecules to the bloodstream
|
|
AU6808001A
(en)
|
2000-05-23 |
2001-12-03 |
Neurologix Inc |
Glutamic acid decarboxylase (gad) based delivery systems
|
|
AU2001268373A1
(en)
|
2000-06-13 |
2001-12-24 |
The Children's Hospital Of Philadelphia |
Methods for administering recombinant adeno-associated virus virions to humans previously exposed to adeno-associated virus
|
|
US7045299B2
(en)
|
2000-07-18 |
2006-05-16 |
Takeda Pharmaceutical Company Limited |
Physiologically active peptide and use thereof
|
|
US6329181B1
(en)
|
2000-08-07 |
2001-12-11 |
Neurologix, Inc. |
Helper functions for recombinant vector production
|
|
US6593123B1
(en)
|
2000-08-07 |
2003-07-15 |
Avigen, Inc. |
Large-scale recombinant adeno-associated virus (rAAV) production and purification
|
|
AU2001294096A1
(en)
|
2000-08-17 |
2002-02-25 |
Uichi Ikeda |
Adeno-associated virus-mediated delivery of angiogenic factors
|
|
DE10066104A1
(de)
|
2000-09-08 |
2003-01-09 |
Medigene Ag |
Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung
|
|
FR2813891B1
(fr)
|
2000-09-14 |
2005-01-14 |
Immunotech Sa |
Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications
|
|
GB0024550D0
(enExample)
|
2000-10-06 |
2000-11-22 |
Oxford Biomedica Ltd |
|
|
JP2002153278A
(ja)
|
2000-11-22 |
2002-05-28 |
Hisamitsu Pharmaceut Co Inc |
ウイルスベクターの製造に用いられる細胞、その製法およびその細胞を用いたウイルスベクターの製造方法
|
|
WO2002070719A2
(en)
|
2001-01-19 |
2002-09-12 |
Trustees Of The University Of Pennsylvania |
Regulatable gene expression system
|
|
FR2821624B1
(fr)
|
2001-03-01 |
2004-01-02 |
Sod Conseils Rech Applic |
Nouveau polynucleotide utilisable pour moduler la proliferation des cellules cancereuses
|
|
US7588757B2
(en)
|
2001-03-14 |
2009-09-15 |
Genzyme Corporation |
Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
|
|
US20030147853A1
(en)
|
2001-03-14 |
2003-08-07 |
Mcclelland Alan |
Recombinant adeno-associated virus-mediated gene transfer via retroductal infusion of virions
|
|
CA2450470C
(en)
|
2001-06-22 |
2012-08-28 |
The Trustees Of The University Of Pennsylvania |
Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
|
|
US20040136963A1
(en)
|
2001-06-22 |
2004-07-15 |
The Trustees Of The University Of Pennsylvania |
Simian adenovirus vectors and methods of use
|
|
EP1900815B1
(en)
|
2001-07-12 |
2016-09-07 |
University of Massachusetts |
In vivo production of small interfering RNAs that mediate gene silencing
|
|
CA2921821A1
(en)
|
2001-07-12 |
2003-01-23 |
University Of Massachusetts |
In vivo production of small interfering rnas that mediate gene silencing
|
|
US8241622B2
(en)
|
2001-07-13 |
2012-08-14 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences
|
|
EP1279740A1
(en)
|
2001-07-26 |
2003-01-29 |
Vrije Universiteit Brussel |
Recombinant vector derived from adeno-associated virus for gene therapy
|
|
AU2002349877B2
(en)
|
2001-08-08 |
2007-10-11 |
The Trustees Of The University Of Pennsylvania |
Method for purification of viral vectors having proteins which bind sialic acid
|
|
US20030092161A1
(en)
|
2001-09-19 |
2003-05-15 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for production of recombinant viruses, and uses therefor
|
|
EP2428569B1
(en)
|
2001-09-28 |
2018-05-23 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Microrna molecules
|
|
US6723551B2
(en)
|
2001-11-09 |
2004-04-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
CA2467959C
(en)
|
2001-11-09 |
2009-03-10 |
Robert M. Kotin |
Production of adeno-associated virus in insect cells
|
|
NZ618298A
(en)
|
2001-11-13 |
2015-04-24 |
Univ Pennsylvania |
A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
|
|
EP1944043A1
(en)
|
2001-11-21 |
2008-07-16 |
The Trustees of the University of Pennsylvania |
Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
|
|
BR0214350A
(pt)
|
2001-11-21 |
2005-05-10 |
Univ Pennsylvania |
Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso
|
|
EP1453537A1
(en)
|
2001-12-12 |
2004-09-08 |
FH Faulding & Co. Limited |
Composition for viral preservation
|
|
PT2573170T
(pt)
|
2001-12-17 |
2018-03-26 |
Univ Pennsylvania |
Sequências de um vírus adenoassociado (aav) de serotipo 9, vetor contendo as mesmas, e suas utilizações
|
|
JP4810062B2
(ja)
|
2001-12-17 |
2011-11-09 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
アデノ随伴ウイルス(aav)血清型8の配列
|
|
AU2002359786A1
(en)
|
2001-12-19 |
2003-07-09 |
Hiroaki Mizukami |
Adeno-associated virus-mediated delivery of gdnf to skeletal muscles
|
|
WO2003062462A2
(en)
|
2002-01-16 |
2003-07-31 |
Dynal Biotech Asa |
Method for isolating nucleic acids and protein from a single sample
|
|
EP2348119B1
(en)
|
2002-02-01 |
2017-04-26 |
Oxford BioMedica (UK) Limited |
Multicistronic lentiviral vector
|
|
US20030180756A1
(en)
|
2002-03-21 |
2003-09-25 |
Yang Shi |
Compositions and methods for suppressing eukaryotic gene expression
|
|
GB0208390D0
(en)
|
2002-04-11 |
2002-05-22 |
Univ London |
Adeno-associated virus producer system
|
|
US20030198620A1
(en)
|
2002-04-16 |
2003-10-23 |
Keiya Ozawa |
Method of treating amino acid metabolic disorders using recombinant adeno-associated virus virions
|
|
ES2280694T3
(es)
|
2002-04-29 |
2007-09-16 |
The Trustees Of The University Of Pennsylvania |
Metodo para la extraccion directa y la amplificacion de virus integrados del adn celular de tejidos.
|
|
MXPA04010603A
(es)
|
2002-04-30 |
2004-12-13 |
Oncolytics Biotech Inc |
Metodos mejorados de purificacion viral.
|
|
NZ561656A
(en)
|
2002-05-01 |
2009-03-31 |
Univ Florida |
Improved rAAV expression systems for genetic modification of specific capsid proteins
|
|
CA2524569C
(en)
|
2002-05-03 |
2013-10-22 |
Duke University |
A method of regulating gene expression
|
|
WO2003097797A2
(en)
|
2002-05-14 |
2003-11-27 |
Merck & Co., Inc. |
Methods of adenovirus purification
|
|
US7419817B2
(en)
|
2002-05-17 |
2008-09-02 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. |
Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
|
|
WO2003104413A2
(en)
|
2002-06-05 |
2003-12-18 |
University Of Florida |
Production of pseudotyped recombinant aav virions
|
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
|
US20040241854A1
(en)
|
2002-08-05 |
2004-12-02 |
Davidson Beverly L. |
siRNA-mediated gene silencing
|
|
WO2004020605A2
(en)
|
2002-08-29 |
2004-03-11 |
The Board Of Trustees Of The Leland Stanford Junior University |
Circular nucleic acid vectors, and methods for making and using the same
|
|
WO2004027030A2
(en)
|
2002-09-18 |
2004-04-01 |
Isis Pharmaceuticals, Inc. |
Efficient reduction of target rna’s by single- and double-stranded oligomeric compounds
|
|
EP1418185A1
(en)
|
2002-11-11 |
2004-05-12 |
Aventis Pharma Deutschland GmbH |
Use of EDG2 receptor in an animal model of heart failure
|
|
US7169612B2
(en)
|
2002-11-11 |
2007-01-30 |
Sanofi-Aventis Deutschland Gmbh |
Use of EDG2 receptor in an animal model of heart failure
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US7618948B2
(en)
|
2002-11-26 |
2009-11-17 |
Medtronic, Inc. |
Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
|
|
US20080318210A1
(en)
|
2003-08-27 |
2008-12-25 |
Rosetta Genomics |
Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof
|
|
WO2005017127A2
(en)
|
2003-02-21 |
2005-02-24 |
The Penn State Research Foundation |
Rna interference compositions and methods
|
|
US7510872B2
(en)
|
2003-02-26 |
2009-03-31 |
Nationwide Children's Hospital |
Recombinant adeno-associated virus production
|
|
WO2004083441A2
(en)
|
2003-03-19 |
2004-09-30 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Random peptide library displayed on aav vectors
|
|
WO2004108922A2
(en)
|
2003-04-25 |
2004-12-16 |
The Trustees Of The University Of Pennsylvania |
Use of aav comprising a capsid protein from aav7 or aav8 for the delivery of genes encoding apoprotein a or e genes to the liver
|
|
WO2004101787A1
(ja)
|
2003-05-14 |
2004-11-25 |
Japan Science And Technology Agency |
ハンチンチン遺伝子の発現抑制
|
|
US8927269B2
(en)
|
2003-05-19 |
2015-01-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Avian adenoassociated virus and uses thereof
|
|
PT1625210E
(pt)
|
2003-05-21 |
2011-03-15 |
Genzyme Corp |
Métodos para produzir preparações de vírions de aav recombinantes substancialmente livres de capsídeos vazios
|
|
EP1486567A1
(en)
|
2003-06-11 |
2004-12-15 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Improved adeno-associated virus (AAV) vector for gene therapy
|
|
JP4888876B2
(ja)
|
2003-06-13 |
2012-02-29 |
田平 武 |
アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
|
|
EP2657248B1
(en)
|
2003-06-19 |
2017-03-22 |
Genzyme Corporation |
AAV virions with decreased immunoreactivity and uses therefor
|
|
US7291498B2
(en)
|
2003-06-20 |
2007-11-06 |
The Trustees Of The University Of Pennsylvania |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
|
|
WO2005001103A2
(en)
|
2003-06-20 |
2005-01-06 |
The Trustees Of The University Of Pennsylvania |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
WO2005012537A2
(en)
|
2003-07-25 |
2005-02-10 |
Genvec, Inc. |
Adenoviral vector-based vaccines
|
|
CA2533701A1
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
|
EP3760234B1
(en)
|
2003-09-12 |
2023-11-01 |
University of Massachusetts |
Rna interference for the treatment of gain-of-function disorders
|
|
US20050064489A1
(en)
|
2003-09-24 |
2005-03-24 |
Zhang Fang Liang |
Engineered U6 and H1 promoters
|
|
HUE035567T2
(en)
|
2003-09-30 |
2018-05-28 |
Univ Pennsylvania |
Adeno-associated virus (AAV) clusters, sequences, vectors and applications containing them
|
|
US7962316B2
(en)
|
2003-10-27 |
2011-06-14 |
Merck Sharp & Dohme Corp. |
Method of designing siRNAs for gene silencing
|
|
NZ550284A
(en)
|
2004-03-05 |
2009-04-30 |
Benitec Ltd |
Multiple promoter expression cassettes for simultaneous delivery of RNAi agents
|
|
WO2006078279A2
(en)
|
2004-04-28 |
2006-07-27 |
The Trustees Of The University Of Pennsylvania |
Sequential delivery of immunogenic molecules via adenovirus and adeno-associated virus-mediated administrations
|
|
DK3290513T3
(da)
|
2004-06-01 |
2022-12-12 |
Genzyme Corp |
Sammensætninger og fremgangsmåder til forhindring af aav-vektoraggregering
|
|
JP4838255B2
(ja)
|
2004-10-05 |
2011-12-14 |
ジェンザイム・コーポレーション |
階段状カニューレ
|
|
US7901921B2
(en)
|
2004-10-22 |
2011-03-08 |
Oncolytics Biotech Inc. |
Viral purification methods
|
|
AU2005307737C1
(en)
|
2004-11-18 |
2013-08-29 |
The Board Of Trustees Of The University Of Illinois |
Multicistronic siRNA constructs to inhibit tumors
|
|
CN1286981C
(zh)
|
2004-11-30 |
2006-11-29 |
华中科技大学同济医学院附属同济医院 |
表达人类cyp2j2反义基因的重组腺相关病毒及其制备方法
|
|
US20060229268A1
(en)
|
2004-12-16 |
2006-10-12 |
Alsgen, Llc |
Small interference RNA (siRNA) molecules for modulating superoxide dismutase (SOD)
|
|
AU2006210443B2
(en)
|
2005-02-03 |
2011-01-27 |
Benitec, Inc. |
RNAi expression constructs
|
|
US8614101B2
(en)
|
2008-05-20 |
2013-12-24 |
Rapid Pathogen Screening, Inc. |
In situ lysis of cells in lateral flow immunoassays
|
|
US7625570B1
(en)
|
2005-03-10 |
2009-12-01 |
The Regents Of The University Of California |
Methods for purifying adeno-associated virus
|
|
WO2006130201A1
(en)
|
2005-03-14 |
2006-12-07 |
Board Of Regents, The University Of Texas System |
Antigene oligomers inhibit transcription
|
|
WO2006102072A2
(en)
|
2005-03-23 |
2006-09-28 |
The Trustees Of The University Of Pennsylvania |
Use of a pa131 polypeptide in treatment of atherosclerosis
|
|
EP1866422B1
(en)
|
2005-04-07 |
2016-04-06 |
The Trustees of The University of Pennsylvania |
Method of increasing the function of an aav vector
|
|
US8283151B2
(en)
|
2005-04-29 |
2012-10-09 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
|
|
PL2420256T3
(pl)
|
2005-05-02 |
2016-12-30 |
|
Terapia genowa dla zaburzeń neurometabolicznych
|
|
EP2239328A3
(en)
|
2005-08-18 |
2011-01-05 |
Alnylam Pharmaceuticals Inc. |
Methods and compositions for treating neurological disease
|
|
CA2619882C
(en)
|
2005-08-23 |
2015-05-26 |
The Regents Of The University Of California |
Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
|
|
EP1857552A1
(en)
|
2006-05-20 |
2007-11-21 |
Cargill Incorporated |
Thermostable xylose isomerase enzyme
|
|
PT3272872T
(pt)
|
2005-10-20 |
2020-06-26 |
Uniqure Ip Bv |
Vetores aav melhorados produzidos em células de insetos
|
|
RU2448974C2
(ru)
|
2005-11-01 |
2012-04-27 |
Элнилэм Фармасьютикалз, Инк. |
РНКи-ИНГИБИРОВАНИЕ РЕПЛИКАЦИИ ВИРУСА ГРИППА
|
|
JP5066095B2
(ja)
|
2005-11-17 |
2012-11-07 |
ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム |
染色体dnaに標的化されるオリゴマーによる遺伝子発現の調節
|
|
EP1979485A2
(en)
|
2006-01-31 |
2008-10-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Self-complementary parvoviral vectors, and methods for making and using the same
|
|
US7588772B2
(en)
|
2006-03-30 |
2009-09-15 |
Board Of Trustees Of The Leland Stamford Junior University |
AAV capsid library and AAV capsid proteins
|
|
CA3024953A1
(en)
*
|
2006-04-03 |
2007-10-11 |
Roche Innovation Center Copenhagen A/S |
Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
|
|
DK2012822T3
(da)
|
2006-04-28 |
2010-05-25 |
Univ Pennsylvania |
Modificeret adenovirushexonprotein og anvendelser deraf
|
|
EP2018421B1
(en)
|
2006-04-28 |
2012-12-19 |
The Trustees of the University of Pennsylvania |
Scalable production method for aav
|
|
EP2016174A2
(en)
|
2006-04-28 |
2009-01-21 |
The Trustees of the University of Pennsylvania |
Modified aav vectors having reduced capsid immunogenicity and use thereof
|
|
US20080003565A1
(en)
|
2006-05-02 |
2008-01-03 |
Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services |
Viral nucleic acid microarray and method of use
|
|
JP5551432B2
(ja)
|
2006-05-25 |
2014-07-16 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
遺伝子不活性化のための方法と組成物
|
|
AU2007261806B2
(en)
|
2006-06-21 |
2013-08-15 |
Uniqure Ip B.V. |
Vectors with modified initiation codon for the translation of AAV-Rep78 useful for production of AAV in insect cells
|
|
AU2007275010B2
(en)
|
2006-07-21 |
2013-06-20 |
California Institute Of Technology |
Targeted gene delivery for dendritic cell vaccination
|
|
ES2385679T3
(es)
|
2006-08-24 |
2012-07-30 |
Virovek, Inc. |
Expresión de células de insecto de genes con marcos de lectura abiertos superpuestos, métodos y composiciones de éstos
|
|
EP3146982B1
(en)
|
2006-10-03 |
2019-08-21 |
Genzyme Corporation |
Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders
|
|
US8895309B2
(en)
|
2006-11-29 |
2014-11-25 |
Nationwide Children's Hospital |
Myostatin inhibition for enhancing muscle and/or improving muscle function
|
|
WO2008067398A2
(en)
|
2006-11-29 |
2008-06-05 |
University Of Iowa Research Foundation |
Alternative export pathways for vector expressed rna interference
|
|
US8071752B2
(en)
|
2007-01-29 |
2011-12-06 |
City Of Hope |
Multi-targeting short interfering RNAs
|
|
WO2008097503A2
(en)
|
2007-02-02 |
2008-08-14 |
Biogen Idec Ma Inc. |
Use of semaphorin 6a for promoting myelination and oligodendrocyte differentiation
|
|
US9725485B2
(en)
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
US9611302B2
(en)
|
2007-04-09 |
2017-04-04 |
University Of Florida Research Foundation, Inc. |
High-transduction-efficiency RAAV vectors, compositions, and methods of use
|
|
HRP20161150T1
(hr)
|
2007-04-09 |
2016-11-18 |
University Of Florida Research Foundation, Inc. |
PRIPRAVCI rAAV VEKTORA KOJI IMAJU TIROZIN-MODIFICIRANE CAPSID PROTEINE I POSTUPCI ZA UPORABU
|
|
WO2008128251A1
(en)
|
2007-04-17 |
2008-10-23 |
The Children's Hospital Of Philadelphia |
Humanized viral vectors and methods of use thereof
|
|
WO2008134646A2
(en)
|
2007-04-26 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna interference suppression of neurodegenerative diseases and methods of use thereof
|
|
WO2008145400A2
(en)
|
2007-05-31 |
2008-12-04 |
Medigene Ag |
Mutated structural protein of a parvovirus
|
|
EP2012122A1
(en)
|
2007-07-06 |
2009-01-07 |
Medigene AG |
Mutated parvovirus structural proteins as vaccines
|
|
EP2530152B1
(en)
|
2007-05-31 |
2017-12-27 |
University of Iowa Research Foundation |
Reduction of off-target RNA interference toxicity
|
|
JP5480132B2
(ja)
|
2007-06-15 |
2014-04-23 |
ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション |
Drosha媒介性のマイクロrnaプロセッシングを標的するための癌原性all−1融合タンパク質
|
|
US8841437B2
(en)
|
2008-06-20 |
2014-09-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Precursor miRNA loop-modulated target regulation
|
|
RU2491344C2
(ru)
|
2007-06-29 |
2013-08-27 |
Ф.Хоффманн-Ля Рош Аг |
Промотор
|
|
WO2009006450A1
(en)
*
|
2007-06-29 |
2009-01-08 |
Boston Biomedical, Inc. |
Bacteria-mediated gene modulation via microrna machinery
|
|
CA3002933A1
(en)
|
2007-07-14 |
2009-01-22 |
Beverly L. Davidson |
Methods and compositions for treating brain diseases
|
|
EP2019143A1
(en)
|
2007-07-23 |
2009-01-28 |
Genethon |
CNS gene delivery using peripheral administration of AAV vectors
|
|
CA2694406C
(en)
|
2007-07-26 |
2019-03-26 |
Amsterdam Molecular Therapeutics (Amt) B.V. |
Baculoviral vectors comprising repeated coding sequences with differential codon biases
|
|
US20100286378A1
(en)
*
|
2007-08-27 |
2010-11-11 |
Boston Biomedical, Inc. |
Composition of Asymmetric RNA Duplex As MicroRNA Mimetic or Inhibitor
|
|
WO2009030025A1
(en)
|
2007-09-04 |
2009-03-12 |
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health |
Porcine adeno-associated viruses
|
|
ES2426091T3
(es)
|
2007-09-19 |
2013-10-21 |
Uniqure Ip B.V. |
Uso de maquinaria de replicación de AAV para producción de proteína mejorada
|
|
EP2205740A2
(en)
|
2007-10-02 |
2010-07-14 |
Rxi Pharmaceuticals Corp. |
Tripartite rnai constructs
|
|
CA2701639A1
(en)
|
2007-10-04 |
2009-04-09 |
Board Of Regents, The University Of Texas System |
Modulating gene expression with agrna and gapmers targeting antisense transcripts
|
|
EP2186283A4
(en)
|
2007-10-18 |
2011-03-09 |
Lg Electronics Inc |
METHOD AND SYSTEM FOR TRANSMITTING AND RECEIVING SIGNALS
|
|
KR101614362B1
(ko)
|
2007-11-28 |
2016-04-22 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
유인원 아과 b 아데노바이러스 sadv-28,27,-29,-32,-33, 및 -35 및 그것의 사용
|
|
DK2220241T3
(en)
|
2007-11-28 |
2017-01-09 |
Univ Pennsylvania |
Adenovirus comprising a simian adenovirus E-SAdV-39-capsidhexonprotein and uses thereof
|
|
JP5758124B2
(ja)
|
2007-11-28 |
2015-08-05 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
サルサブファミリーCアデノウイルスSAdV−40、−31および−34ならびにそれらの用途
|
|
CA2710953A1
(en)
|
2007-12-28 |
2009-07-09 |
The Regents Of The University Of California |
Methods and compositions for increasing gene expression
|
|
US8133488B2
(en)
|
2008-01-18 |
2012-03-13 |
Genentech, Inc. |
Methods and compositions for targeting polyubiquitin
|
|
EP2242840B1
(en)
|
2008-01-29 |
2019-07-24 |
Applied Genetic Technologies Corporation |
Recombinant adeno-associated virus production using bhk cells in suspension
|
|
US10131904B2
(en)
|
2008-02-11 |
2018-11-20 |
Rxi Pharmaceuticals Corporation |
Modified RNAi polynucleotides and uses thereof
|
|
AU2009215987B2
(en)
|
2008-02-19 |
2015-01-22 |
Uniqure Ip B.V. |
Optimisation of expression of parvoviral rep and cap proteins in insect cells
|
|
EP2250255A2
(en)
|
2008-03-04 |
2010-11-17 |
The Trustees of the University of Pennsylvania |
Simian adenoviruses sadv-36,-42.1, -42.2, and -44 and uses thereof
|
|
WO2009137006A2
(en)
|
2008-04-30 |
2009-11-12 |
The University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
WO2009134681A2
(en)
|
2008-04-30 |
2009-11-05 |
The Trustees Of The University Of Pennsylvania |
Aav7 viral vectors for targeted delivery of rpe cells
|
|
WO2010011404A2
(en)
|
2008-05-20 |
2010-01-28 |
Eos Neuroscience, Inc. |
Vectors for delivery of light-sensitive proteins and methods of use
|
|
JP5689413B2
(ja)
|
2008-05-21 |
2015-03-25 |
ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン |
平滑末端を有する5’三リン酸オリゴヌクレオチドおよびその使用
|
|
EP2299812B1
(en)
|
2008-05-27 |
2017-07-12 |
Yale University |
Targeting tgf-beta as a therapy for alzheimer's disease
|
|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
US8222221B2
(en)
|
2008-06-04 |
2012-07-17 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small RNA targeting of gene promoters
|
|
WO2009151620A2
(en)
|
2008-06-13 |
2009-12-17 |
Cornell Research Foundation, Inc. Wmc |
Pain treatment using erk2 inhibitors
|
|
US20110171262A1
(en)
|
2008-06-17 |
2011-07-14 |
Andrew Christian Bakker |
Parvoviral capsid with incorporated gly-ala repeat region
|
|
WO2010002851A1
(en)
|
2008-06-30 |
2010-01-07 |
Alnylam Pharmaceuticals, Inc. |
Silencing and rig-1 activation by dual function oligonucleotides
|
|
US8945885B2
(en)
|
2008-07-03 |
2015-02-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Minicircle DNA vector preparations and methods of making and using the same
|
|
WO2010011346A1
(en)
|
2008-07-24 |
2010-01-28 |
Rxi Pharmaceuticals Corporation |
Rnai constructs and uses therof
|
|
WO2010014857A2
(en)
|
2008-07-30 |
2010-02-04 |
University Of Massachusetts |
Chromosome therapy
|
|
CA2753338A1
(en)
|
2008-09-22 |
2010-03-25 |
Rxi Pharmaceuticals Corporation |
Neutral nanotransporters
|
|
CA2738969A1
(en)
|
2008-09-29 |
2010-04-01 |
Amsterdam Molecular Therapeutics (Amt) B.V. |
Porphobilinogen deaminase gene therapy
|
|
CN104689316A
(zh)
|
2008-10-22 |
2015-06-10 |
弗·哈夫曼-拉罗切有限公司 |
轴突变性的调节
|
|
EP2774985B1
(en)
|
2008-10-31 |
2016-12-14 |
The Trustees Of The University Of Pennsylvania |
Simian adenovirus SAdV-43 and uses thereof
|
|
US9415121B2
(en)
|
2008-12-19 |
2016-08-16 |
Nationwide Children's Hospital |
Delivery of MECP2 polynucleotide using recombinant AAV9
|
|
ES2634118T3
(es)
|
2009-02-11 |
2017-09-26 |
The University Of North Carolina At Chapel Hill |
Vectores de virus modificados y métodos para fabricar y utilizar los mismos
|
|
CN102341406B
(zh)
|
2009-03-04 |
2016-06-08 |
德国癌症研究中心 |
组装活化蛋白(aap)及其用于制备基本上由vp3组成的细小病毒颗粒的应用
|
|
AU2010227419A1
(en)
|
2009-03-27 |
2011-10-20 |
Proyecto De Biomedicina Cima, S.L. |
Methods and compositions for the treatment of cirrhosis and liver fibrosis
|
|
US10920244B2
(en)
|
2009-04-30 |
2021-02-16 |
The Trustees Of The University Of Pennsylvania |
Compositions for targeting conducting airway cells comprising adeno-associated virus constructs
|
|
EP2772542B1
(en)
|
2009-05-28 |
2016-12-28 |
Deutsches Krebsforschungszentrum |
Modified AAV capsid polypeptides
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
WO2010138675A1
(en)
|
2009-05-29 |
2010-12-02 |
The Trustees Of The University Of Pennsylvania |
Simian adenovirus 41 and uses thereof
|
|
US20120142764A1
(en)
|
2009-06-05 |
2012-06-07 |
Dai-Wu Seol |
Multi-Cistronic shRNA Expression Cassette for Suppressing Single or Multiple Target Genes
|
|
HUE054940T2
(hu)
|
2009-06-16 |
2021-10-28 |
Genzyme Corp |
Javított eljárások rekombináns AAV-vektorok tisztítására
|
|
CA2767225A1
(en)
|
2009-07-06 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for enhancing production of a biological product
|
|
CA2767231A1
(en)
|
2009-07-06 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
Cell-based bioprocessing
|
|
EP2453735B1
(en)
|
2009-07-15 |
2015-07-08 |
Calimmune Inc. |
Dual Vector for Inhibition of Human Immunodeficiency Virus
|
|
EP2292781A1
(en)
|
2009-08-17 |
2011-03-09 |
Genethon |
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
|
|
WO2011038187A1
(en)
|
2009-09-25 |
2011-03-31 |
The Trustees Of The University Of Pennsylvania |
Controlled adeno-associated virus (aav) diversification and libraries prepared therefrom
|
|
MX2012005450A
(es)
|
2009-11-09 |
2012-08-15 |
Genepod Therapeutics Ab |
Constructo de vector virico novedoso para sintesis dopa continua optimizada especificamente de neuronas in vivo.
|
|
CA2781332C
(en)
|
2009-11-19 |
2018-09-04 |
National University Corporation Okayama University |
System for increasing gene expression and vector comprising the system
|
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
|
WO2011088081A1
(en)
|
2010-01-12 |
2011-07-21 |
The University Of North Carolina At Chapel Hill |
Restrictive inverted terminal repeats for viral vectors
|
|
EP2531604B1
(en)
|
2010-02-05 |
2017-04-05 |
The University of North Carolina At Chapel Hill |
Compositions and methods for enhanced parvovirus transduction
|
|
WO2011101869A1
(en)
*
|
2010-02-22 |
2011-08-25 |
Transgene Biotek Ltd. |
Adeno-associated virus 2/8 - micro rna-101 therapy for liver cancer
|
|
EP2545165B1
(en)
|
2010-03-11 |
2020-07-29 |
uniQure IP B.V. |
Mutated rep encoding sequences for use in aav production
|
|
US9546112B2
(en)
|
2010-03-22 |
2017-01-17 |
Association Institut De Myologie |
Methods of increasing efficiency of vector penetration of target tissue
|
|
US9315825B2
(en)
|
2010-03-29 |
2016-04-19 |
The Trustees Of The University Of Pennsylvania |
Pharmacologically induced transgene ablation system
|
|
WO2011126808A2
(en)
|
2010-03-29 |
2011-10-13 |
The Trustees Of The University Of Pennsylvania |
Pharmacologically induced transgene ablation system
|
|
WO2011122950A1
(en)
|
2010-04-01 |
2011-10-06 |
Amsterdam Molecular Therapeutics (Amt) Ip B.V. |
Monomeric duplex aav vectors
|
|
JP5963743B2
(ja)
|
2010-04-23 |
2016-08-03 |
ユニバーシティ オブ マサチューセッツ |
Cnsターゲティングaavベクターおよびその使用方法
|
|
CA2833912C
(en)
|
2010-04-23 |
2021-09-21 |
University Of Massachusetts |
Aav-based treatment of cholesterol-related disorders
|
|
WO2011133874A1
(en)
|
2010-04-23 |
2011-10-27 |
University Of Massachusetts |
Multicistronic expression constructs
|
|
US9839696B2
(en)
|
2010-04-30 |
2017-12-12 |
City Of Hope |
Recombinant adeno-associated vectors for targeted treatment
|
|
US8927514B2
(en)
|
2010-04-30 |
2015-01-06 |
City Of Hope |
Recombinant adeno-associated vectors for targeted treatment
|
|
AU2011285909B2
(en)
|
2010-08-02 |
2016-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
|
|
WO2012018881A2
(en)
|
2010-08-03 |
2012-02-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for the regulation of rna
|
|
US8808684B2
(en)
|
2010-09-10 |
2014-08-19 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Epidermal growth factor receptor (EGFR) and methods of use in adenoviral-associated virus type 6 (AAV6) transduction
|
|
CN101972476B
(zh)
*
|
2010-09-14 |
2012-12-19 |
中国人民解放军第二军医大学 |
利用MicroRNA-155的核酸疫苗佐剂及其构建方法
|
|
US9102943B2
(en)
|
2010-10-05 |
2015-08-11 |
Takara Bio Inc. |
Method for producing virus vector
|
|
US8663624B2
(en)
|
2010-10-06 |
2014-03-04 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
JP5704361B2
(ja)
|
2010-10-27 |
2015-04-22 |
学校法人自治医科大学 |
神経系細胞への遺伝子導入のためのアデノ随伴ウイルスビリオン
|
|
EP2637702A4
(en)
|
2010-11-11 |
2014-11-26 |
Univ Miami |
METHODS, COMPOSITIONS, CELLS AND KITS FOR TREATING ISCHEMIC INJURIES
|
|
AU2011332025B2
(en)
|
2010-11-23 |
2015-06-25 |
The Trustees Of The University Of Pennsylvania |
Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof
|
|
ES2739804T3
(es)
|
2011-02-12 |
2020-02-04 |
Univ Iowa Res Found |
Compuestos terapéuticos
|
|
SG10201601110VA
(en)
|
2011-02-17 |
2016-03-30 |
Univ Pennsylvania |
Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer
|
|
WO2012115980A1
(en)
|
2011-02-22 |
2012-08-30 |
California Institute Of Technology |
Delivery of proteins using adeno-associated virus (aav) vectors
|
|
GB201103062D0
(en)
|
2011-02-22 |
2011-04-06 |
Isis Innovation |
Method
|
|
EP2500434A1
(en)
|
2011-03-12 |
2012-09-19 |
Association Institut de Myologie |
Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
|
|
JP6007463B2
(ja)
|
2011-04-18 |
2016-10-12 |
国立研究開発法人国立精神・神経医療研究センター |
薬剤送達粒子及びその製造方法
|
|
EP2699688A1
(en)
|
2011-04-20 |
2014-02-26 |
The Trustees Of The University Of Pennsylvania |
Regimens and compositions for aav-mediated passive immunization of airborne pathogens
|
|
US9226976B2
(en)
|
2011-04-21 |
2016-01-05 |
University Of Massachusetts |
RAAV-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
|
|
MX349138B
(es)
|
2011-04-22 |
2017-07-13 |
Univ California |
Variones de virus adeno-asociados con capside variante y sus metodos de uso.
|
|
WO2012149646A1
(en)
*
|
2011-05-05 |
2012-11-08 |
Sunnybrook Research Institute |
Mirna inhibitors and their uses
|
|
WO2012158757A1
(en)
|
2011-05-16 |
2012-11-22 |
The Trustees Of The University Of Pennsylvania |
Proviral plasmids for production of recombinant adeno-associated virus
|
|
WO2012159006A2
(en)
|
2011-05-18 |
2012-11-22 |
University Of Florida Research Foundation, Inc. |
Polypeptides and vectors for targeting her2/neu expressing cells and uses thereof
|
|
WO2012168003A1
(en)
|
2011-06-06 |
2012-12-13 |
Biocartis S.A. |
Selective lysis of cells by ionic surfactants
|
|
CA3106285A1
(en)
|
2011-07-25 |
2013-01-31 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of dux4
|
|
ES2623780T3
(es)
|
2011-07-27 |
2017-07-12 |
Genethon |
Sistemas de expresión de baculovirus mejorados
|
|
US8852911B2
(en)
|
2011-08-04 |
2014-10-07 |
The Regents Of The University Of California |
Method of producing dicer
|
|
US20130129668A1
(en)
|
2011-09-01 |
2013-05-23 |
The Regents Of The University Of California |
Diagnosis and treatment of arthritis using epigenetics
|
|
CA2847604A1
(en)
|
2011-09-08 |
2013-03-14 |
Uniqure Ip B.V. |
Removal of contaminating viruses from aav preparations
|
|
US9464322B2
(en)
|
2011-09-09 |
2016-10-11 |
University Of Kentucky Research Foundation |
Methods for diagnosing and treating alzheimer's disease (AD) using the molecules that stabilize intracellular calcium (Ca2+) release
|
|
WO2013036889A1
(en)
|
2011-09-09 |
2013-03-14 |
University Of Washington |
Retrograde transport peptide and use of same for delivery to central nervous system
|
|
EP2758433B1
(en)
|
2011-09-19 |
2017-10-18 |
Axon Neuroscience SE |
Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
|
|
EP2771455B1
(en)
|
2011-10-28 |
2016-10-05 |
The University of North Carolina At Chapel Hill |
Cell line for production of adeno-associated virus
|
|
AU2012340567B2
(en)
|
2011-11-22 |
2017-11-23 |
The Children's Hospital Of Philadelphia |
Virus vectors for highly efficient transgene delivery
|
|
WO2013078199A2
(en)
|
2011-11-23 |
2013-05-30 |
Children's Medical Center Corporation |
Methods for enhanced in vivo delivery of synthetic, modified rnas
|
|
US9611305B2
(en)
|
2012-01-06 |
2017-04-04 |
Mayo Foundation For Medical Education And Research |
Treating cardiovascular or renal diseases
|
|
WO2013113696A1
(en)
|
2012-01-30 |
2013-08-08 |
Vib Vzw |
Means and method for diagnosis and treatment of alzheimer's disease
|
|
EP2814513B1
(en)
|
2012-02-14 |
2017-12-20 |
The Regents of The University of California |
Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions
|
|
RU2653444C2
(ru)
|
2012-02-17 |
2018-05-08 |
Дзе Чилдрен'З Хоспитал Оф Филадельфия |
Композиции вектора aav и способы переноса генов в клетки, органы и ткани
|
|
WO2013122605A1
(en)
|
2012-02-17 |
2013-08-22 |
Evernote Corporation |
Site memory processing
|
|
US20150148405A1
(en)
|
2012-02-21 |
2015-05-28 |
The Johns Hopkins University |
Expression Construct for a Lin28-Resistant Let-7 Precursor MicroRNA
|
|
EP2820159B1
(en)
|
2012-02-29 |
2019-10-23 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating huntington's disease
|
|
HUE054087T2
(hu)
|
2012-04-18 |
2021-09-28 |
Childrens Hospital Philadelphia |
Készítmények és eljárások nagy hatékonyságú géntranszferre AAV kapszidvariánsok alkalmazásával
|
|
EP2660325A3
(en)
|
2012-05-02 |
2014-02-12 |
Christian Medical College |
AAV vectors and corresponding nucleotide sequences and methods
|
|
US9163259B2
(en)
|
2012-05-04 |
2015-10-20 |
Novartis Ag |
Viral vectors for the treatment of retinal dystrophy
|
|
BR112014027724B1
(pt)
|
2012-05-08 |
2022-05-03 |
Merck Sharp & Dohme Corp. E Alectos Therapeutics Inc |
Composto, e, composição farmacêutica
|
|
WO2013170078A1
(en)
|
2012-05-09 |
2013-11-14 |
Oregon Health & Science University |
Adeno associated virus plasmids and vectors
|
|
US10294281B2
(en)
|
2012-05-15 |
2019-05-21 |
University Of Florida Research Foundation, Incorporated |
High-transduction-efficiency rAAV vectors, compositions, and methods of use
|
|
TWI698240B
(zh)
|
2012-05-15 |
2020-07-11 |
澳大利亞商艾佛蘭屈澳洲私營有限公司 |
使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
|
|
IN2014KN02672A
(enExample)
|
2012-05-18 |
2015-05-08 |
Univ Iowa Res Found |
|
|
WO2013173702A2
(en)
|
2012-05-18 |
2013-11-21 |
The Trustees Of The University Of Pennsylvania |
Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof
|
|
WO2013177367A2
(en)
|
2012-05-23 |
2013-11-28 |
The Johns Hopkins University |
Compounds and methods of use thereof for treating neurodegenerative disorders
|
|
EP2871239B1
(en)
|
2012-07-06 |
2018-08-29 |
Takara Bio Inc. |
Cell capable of producing adeno-associated virus vector
|
|
JP6366581B2
(ja)
|
2012-07-06 |
2018-08-08 |
ユニバーシティー オブ アイオワ リサーチ ファウンデーション |
改変されたアデノ随伴ウイルスベクター組成物
|
|
EP2875133B1
(en)
*
|
2012-07-17 |
2018-01-10 |
Université de Genève |
Nucleic acids for down-regulation of gene expression
|
|
US20150252384A1
(en)
|
2012-08-01 |
2015-09-10 |
National Children's Hospital |
Intrathecal delivery of recombinant adeno-associated virus 9
|
|
JP2015529685A
(ja)
|
2012-09-17 |
2015-10-08 |
ザ・リサーチ・インスティテュート・アット・ネイションワイド・チルドレンズ・ホスピタルThe Research Institute Atnationwide Children’S Hospital |
筋萎縮性側索硬化症の処置のための組成物および方法
|
|
PL2900686T3
(pl)
|
2012-09-28 |
2021-01-25 |
The University Of North Carolina At Chapel Hill |
Wektory aav ukierunkowane na oligodendrocyty
|
|
AU2013204200B2
(en)
|
2012-10-11 |
2016-10-20 |
Brandeis University |
Treatment of amyotrophic lateral sclerosis
|
|
US9733237B2
(en)
|
2012-10-31 |
2017-08-15 |
The Trustees Of Columbia University In The City Of New York |
Methods for identifying candidates for the treatment of neurodegenerative diseases
|
|
AU2013359199C1
(en)
|
2012-12-12 |
2021-06-17 |
Massachusetts Institute Of Technology |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
CN104937100B
(zh)
|
2012-12-25 |
2020-04-03 |
宝生物工程株式会社 |
Aav 变体
|
|
EP3521420A1
(en)
|
2013-01-08 |
2019-08-07 |
Genzyme Corporation |
Use of inos inhibitors to increase viral yield in culture
|
|
US10000753B2
(en)
|
2013-01-08 |
2018-06-19 |
Benitec Biopharma Limited |
Age-related macular degeneration treatment
|
|
US9066966B2
(en)
*
|
2013-02-01 |
2015-06-30 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia
|
|
DK2954051T3
(da)
|
2013-02-08 |
2019-07-08 |
Univ Pennsylvania |
Modificeret kapsid til genoverførsel til behandling af nethinden
|
|
US9726009B2
(en)
|
2013-03-12 |
2017-08-08 |
Halliburton Energy Services, Inc. |
Wellbore servicing tools, systems and methods utilizing near-field communication
|
|
AU2014244167A1
(en)
|
2013-03-13 |
2015-10-08 |
The Children's Hospital Of Philadelphia |
Adeno-associated virus vectors and methods of use thereof
|
|
WO2014144844A1
(en)
|
2013-03-15 |
2014-09-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
tRNA DERIVED SMALL RNAs (tsRNAs) INVOLVED IN CELL VIABILITY
|
|
US9447433B2
(en)
|
2013-03-15 |
2016-09-20 |
The University Of North Carolina At Chapel Hill |
Synthetic adeno-associated virus inverted terminal repeats
|
|
CA2904156C
(en)
|
2013-03-15 |
2023-01-10 |
The Children's Hospital Of Philadelphia |
Vectors comprising stuffer/filler polynucleotide sequences and methods of use
|
|
CA3174963A1
(en)
|
2013-04-08 |
2014-10-16 |
University Of Iowa Research Foundation |
Chimeric adeno-associated virus/ bocavirus parvovirus vector
|
|
EP2792742A1
(en)
|
2013-04-17 |
2014-10-22 |
Universitätsklinikum Hamburg-Eppendorf (UKE) |
Gene-therapy vectors for treating cardiomyopathy
|
|
DK2986635T3
(en)
|
2013-04-18 |
2019-01-28 |
Fond Telethon |
EFFECTIVE DELIVERY OF BIG GENES THROUGH DUAL-AAV VECTORS
|
|
WO2014172669A1
(en)
|
2013-04-20 |
2014-10-23 |
Research Institute At Nationwide Children's Hospital |
Recombinant adeno-associated virus delivery of exon 2-targeted u7snrna polynucleotide constructs
|
|
US9719106B2
(en)
|
2013-04-29 |
2017-08-01 |
The Trustees Of The University Of Pennsylvania |
Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
|
|
CN115120746A
(zh)
|
2013-05-15 |
2022-09-30 |
明尼苏达大学董事会 |
腺相关病毒介导的基因向中枢神经系统转移
|
|
WO2014186746A1
(en)
|
2013-05-16 |
2014-11-20 |
University Of Florida Research Foundation, Inc. |
HAIRPIN mRNA ELEMENTS AND METHODS FOR THE REGULATION OF PROTEIN TRANSLATION
|
|
CA2907799A1
(en)
|
2013-05-31 |
2014-12-04 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
WO2014201308A1
(en)
|
2013-06-12 |
2014-12-18 |
Washington University |
Endothelial-targeted adenoviral vectors, methods and uses therefor
|
|
US20160122727A1
(en)
|
2013-06-13 |
2016-05-05 |
Shire Human Genetic Therapies, Inc. |
Messenger rna based viral production
|
|
SI3024498T1
(sl)
|
2013-07-22 |
2020-07-31 |
The Children's Hospital Of Philadelphia |
Različica AAV in sestavki, postopki in uporabe za prenos genov v celice, organe in tkiva
|
|
RU2664471C2
(ru)
|
2013-07-26 |
2018-08-17 |
Юниверсити Оф Айова Рисерч Фаундейшн |
Способы и композиции для лечения болезней мозга
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
EP4219727A3
(en)
|
2013-08-27 |
2023-09-06 |
Research Institute at Nationwide Children's Hospital |
Products and methods for treatment of amyotrophic lateral sclerosis
|
|
EP3039129B1
(en)
|
2013-08-30 |
2018-06-27 |
Amgen Inc. |
High titer recombinant aav vector production in adherent and suspension cells
|
|
EP3044318B1
(en)
|
2013-09-13 |
2019-05-01 |
California Institute of Technology |
Selective recovery
|
|
EP3049527A4
(en)
|
2013-09-26 |
2017-08-16 |
University of Florida Research Foundation, Inc. |
Synthetic combinatorial aav capsid library for targeted gene therapy
|
|
WO2015044292A1
(en)
|
2013-09-26 |
2015-04-02 |
Universitat Autonoma De Barcelona |
Gene therapy compositions for use in the prevention and/or treatment of non-alcoholic fatty liver disease
|
|
EP3459965B1
(en)
|
2013-10-11 |
2020-12-02 |
Massachusetts Eye & Ear Infirmary |
Methods of predicting ancestral virus sequences and uses thereof
|
|
WO2015060722A1
(en)
|
2013-10-24 |
2015-04-30 |
Uniqure Ip B.V. |
Aav-5 pseudotyped vector for gene therapy for neurological diseases
|
|
WO2015069647A1
(en)
|
2013-11-05 |
2015-05-14 |
The Research Institute At Nationwide Children's Hospital |
COMPOSITIONS AND METHODS FOR INHIBITING NF- kB AND SOD-1 TO TREAT AMYOTROPHIC LATERAL SCLEROSIS
|
|
US20160272687A1
(en)
|
2013-11-08 |
2016-09-22 |
The Board Of Trustees Of The University Of Arkansas |
Adeno-associated virus "x" oncogene
|
|
EP3068905A4
(en)
|
2013-11-11 |
2017-07-05 |
Sangamo BioSciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
CN105934515B
(zh)
|
2013-11-26 |
2020-08-04 |
美国政府(由卫生和人类服务部的部长所代表) |
用于治疗糖原贮积病的腺相关病毒载体
|
|
EP3075849B1
(en)
|
2013-11-29 |
2019-03-13 |
Takara Bio Inc. |
Method for quantifying adeno-associated virus
|
|
SG11201604505QA
(en)
|
2013-12-03 |
2016-07-28 |
Agency Science Tech & Res |
Tailed Mirtron Effectors For RNAi-Mediated Gene Silencing
|
|
US9732345B2
(en)
|
2013-12-09 |
2017-08-15 |
Baylor College Of Medicine |
Hippo and dystrophin complex signaling in cardiomyocyte renewal
|
|
AU2014362245A1
(en)
|
2013-12-12 |
2016-06-16 |
Massachusetts Institute Of Technology |
Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders
|
|
GB201322798D0
(en)
|
2013-12-20 |
2014-02-05 |
Oxford Biomedica Ltd |
Production system
|
|
US20150197809A1
(en)
|
2014-01-13 |
2015-07-16 |
Trustees Of Boston University |
Methods and assays relating to huntingtons disease and parkinson's disease
|
|
GB201401707D0
(en)
|
2014-01-31 |
2014-03-19 |
Sec Dep For Health The |
Adeno-associated viral vectors
|
|
GB201403684D0
(en)
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
US10072251B2
(en)
|
2014-02-19 |
2018-09-11 |
University Of Massachusetts |
Recombinant AAVS having useful transcytosis properties
|
|
RU2016136989A
(ru)
|
2014-02-19 |
2018-03-22 |
Ф.Хоффманн-Ля Рош Аг |
Шаттл для гематоэнцефалического барьера
|
|
WO2015124546A1
(en)
|
2014-02-19 |
2015-08-27 |
Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii- Cnic |
Aav vectors for the treatment of ischemic and non-ischemic heart disease
|
|
US20170007720A1
(en)
|
2014-02-21 |
2017-01-12 |
University Of Florida Research Foundation, Inc. |
Methods and compositions for gene delivery to on bipolar cells
|
|
EP3110974A4
(en)
|
2014-02-24 |
2018-01-24 |
Celgene Corporation |
Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders
|
|
EP3113787B1
(en)
|
2014-03-04 |
2019-12-04 |
University of Florida Research Foundation, Inc. |
Improved raav vectors and methods for transduction of photoreceptors and rpe cells
|
|
AU2015226911B2
(en)
|
2014-03-07 |
2018-03-01 |
The Arizona Board Of Regents On Behalf Of The University Of Arizona |
Non-narcotic CRMP2 peptides targeting sodium channels for chronic pain
|
|
PL3117005T3
(pl)
|
2014-03-10 |
2024-11-04 |
Uniqure Ip B.V. |
Dodatkowo ulepszone wektory aav produkowane w komórkach owadzich
|
|
US10280418B2
(en)
|
2014-03-18 |
2019-05-07 |
Univeristy Of Massachusetts |
RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
|
|
PL3757214T3
(pl)
|
2014-04-01 |
2022-09-12 |
Biogen Ma Inc. |
Kompozycje do modulowania ekspresji sod-1
|
|
WO2015157070A2
(en)
|
2014-04-09 |
2015-10-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating cystic fibrosis
|
|
EP2933335A1
(en)
|
2014-04-18 |
2015-10-21 |
Genethon |
A method of treating peripheral neuropathies and motor neuron diseases
|
|
WO2015164786A1
(en)
|
2014-04-25 |
2015-10-29 |
University Of Massachusetts |
Recombinant aav vectors useful for reducing immunity against transgene products
|
|
EP3134431B1
(en)
|
2014-04-25 |
2021-04-07 |
The Trustees Of The University Of Pennsylvania |
Ldlr variants and their use in compositions for reducing cholesterol levels
|
|
EP3139966B1
(en)
|
2014-05-08 |
2020-11-18 |
Sangamo Therapeutics, Inc. |
Compositions for use in treating huntington's disease
|
|
US20170088819A1
(en)
|
2014-05-16 |
2017-03-30 |
Vrije Universiteit Brussel |
Genetic correction of myotonic dystrophy type 1
|
|
ES2759317T3
(es)
|
2014-05-20 |
2020-05-08 |
Univ Iowa Res Found |
Compuestos terapéuticos para la enfermedad de Huntington
|
|
WO2015183667A1
(en)
|
2014-05-28 |
2015-12-03 |
The Regents Of The University Of California |
HYBRID tRNA/pre-miRNA MOLECULES AND METHODS OF USE
|
|
US10577627B2
(en)
|
2014-06-09 |
2020-03-03 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
US20150376612A1
(en)
|
2014-06-10 |
2015-12-31 |
The General Hospital Corporation |
CCCTC-Binding Factor (CTCF) RNA Interactome
|
|
US11207424B2
(en)
|
2014-06-13 |
2021-12-28 |
Mayo Foundation For Medical Education And Research |
Methods and materials for increasing viral vector infectivity
|
|
US10781459B2
(en)
|
2014-06-20 |
2020-09-22 |
University Of Florida Research Foundation, Incorporated |
Methods of packaging multiple adeno-associated virus vectors
|
|
US10526583B2
(en)
|
2014-07-02 |
2020-01-07 |
University Of Florida Research Foundation, Incorporated |
Compositions and methods for purifying recombinant adeno-associated virus
|
|
US10023846B2
(en)
|
2014-07-10 |
2018-07-17 |
Takara Bio Inc. |
Production method for non-enveloped virus particles
|
|
US9616090B2
(en)
|
2014-07-30 |
2017-04-11 |
Sangamo Biosciences, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
|
CA2955285C
(en)
|
2014-07-31 |
2023-09-26 |
Association Institut De Myologie |
Treatment of amyotrophic lateral sclerosis
|
|
WO2016019364A1
(en)
|
2014-08-01 |
2016-02-04 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for self-regulated inducible gene expression
|
|
WO2016040347A2
(en)
|
2014-09-08 |
2016-03-17 |
University Of Iowa Research Foundation |
Microrna inhibitor system and methods of use thereof
|
|
WO2016054554A1
(en)
|
2014-10-03 |
2016-04-07 |
University Of Massachusetts |
Heterologous targeting peptide grafted aavs
|
|
JP6842410B2
(ja)
|
2014-10-03 |
2021-03-17 |
ユニバーシティ オブ マサチューセッツ |
新規の高効率ライブラリーにより同定されるaavベクター
|
|
US10842886B2
(en)
|
2014-10-10 |
2020-11-24 |
Research Institute At Nationwide Children's Hospital |
Guided injections for AAV gene transfer to muscle
|
|
WO2016065001A1
(en)
|
2014-10-21 |
2016-04-28 |
University Of Massachusetts |
Recombinant aav variants and uses thereof
|
|
WO2016073693A2
(en)
|
2014-11-05 |
2016-05-12 |
Voyager Therapeutics, Inc. |
Aadc polynucleotides for the treatment of parkinson's disease
|
|
AU2015342997B2
(en)
|
2014-11-05 |
2021-11-18 |
Research Institute At Nationwide Children's Hospital |
Methods and materials for producing recombinant viruses in eukaryotic microalgae
|
|
CN114717264A
(zh)
|
2014-11-14 |
2022-07-08 |
沃雅戈治疗公司 |
治疗肌萎缩性侧索硬化(als)的组合物和方法
|
|
CA2975583A1
(en)
*
|
2014-11-14 |
2016-05-19 |
Voyager Therapeutics, Inc. |
Modulatory polynucleotides
|
|
CA2967393A1
(en)
|
2014-11-21 |
2016-05-26 |
The University Of North Carolina At Chapel Hill |
Aav vectors targeted to the central nervous system
|
|
WO2016081927A2
(en)
|
2014-11-21 |
2016-05-26 |
University Of Florida Research Foundation, Inc. |
Genome-modified recombinant adeno-associated virus vectors
|
|
US11021762B2
(en)
|
2014-11-28 |
2021-06-01 |
Uniqure Ip B.V. |
DNA impurities in a composition comprising a parvoviral virion
|
|
US11697825B2
(en)
|
2014-12-12 |
2023-07-11 |
Voyager Therapeutics, Inc. |
Compositions and methods for the production of scAAV
|
|
LT3237618T
(lt)
|
2014-12-24 |
2019-07-10 |
Uniqure Ip B.V. |
Rnri sukeltas hantingtino geno slopinimas
|
|
KR102618947B1
(ko)
|
2014-12-30 |
2023-12-27 |
유니버시티 오브 아이오와 리써치 파운데이션 |
뇌 질환을 치료하기 위한 방법 및 조성물
|
|
EP3245220B1
(en)
|
2015-01-14 |
2023-09-20 |
The University of North Carolina at Chapel Hill |
Methods and compositions for targeted gene transfer
|
|
MX2017009336A
(es)
|
2015-01-16 |
2017-11-15 |
Voyager Therapeutics Inc |
Polinucleótidos dirigidos al sistema nervioso central.
|
|
JP2018506530A
(ja)
|
2015-01-30 |
2018-03-08 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
脊柱軟膜下遺伝子送達システム
|
|
US20180030096A1
(en)
|
2015-02-03 |
2018-02-01 |
University Of Florida Research Foundation, Inc. |
Recombinant aav1, aav5, and aav6 capsid mutants and uses thereof
|
|
HK1247641A1
(zh)
|
2015-02-10 |
2018-09-28 |
Genzyme Corporation |
变体RNAi
|
|
LT3256594T
(lt)
|
2015-02-10 |
2022-02-10 |
Genzyme Corporation |
Patobulintas virusinių dalelių tiekimas į dryžuotąjį kūną ir smegenų žievę
|
|
EP3262162A4
(en)
|
2015-02-23 |
2018-08-08 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
EP3270960A4
(en)
|
2015-03-20 |
2018-08-08 |
Bluebird Bio, Inc. |
Vector formulations
|
|
CA2979065A1
(en)
|
2015-03-24 |
2016-09-29 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
HUE050441T2
(hu)
|
2015-04-03 |
2020-12-28 |
Univ Massachusetts |
Huntingtin-mRNS célzására szolgáló oligonukleotid-vegyületek
|
|
JP6892433B2
(ja)
|
2015-04-03 |
2021-06-23 |
ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts |
十分に安定化された非対称sirna
|
|
US10081659B2
(en)
|
2015-04-06 |
2018-09-25 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Adeno-associated vectors for enhanced transduction and reduced immunogenicity
|
|
TWI707951B
(zh)
|
2015-04-08 |
2020-10-21 |
美商健臻公司 |
過大腺相關載體之製造
|
|
ES2763551T3
(es)
|
2015-04-16 |
2020-05-29 |
Univ Emory |
Promotores y vectores recombinantes para la expresión de proteínas en el hígado y uso de los mismos
|
|
EP4491733A3
(en)
|
2015-04-23 |
2025-03-26 |
University of Massachusetts |
Modulation of aav vector transgene expression
|
|
WO2016172008A1
(en)
|
2015-04-24 |
2016-10-27 |
University Of Massachusetts |
Modified aav constructions and uses thereof
|
|
WO2016179038A1
(en)
|
2015-05-01 |
2016-11-10 |
Spark Therapeutics, Inc. |
ADENO-ASSOCIATED VIRUS-MEDIATED CRISPR-Cas9 TREATMENT OF OCULAR DISEASE
|
|
AU2016256894B2
(en)
|
2015-05-07 |
2020-11-26 |
Massachusetts Eye And Ear Infirmary |
Methods of delivering an agent to the eye
|
|
EP3294398A4
(en)
|
2015-05-11 |
2019-01-09 |
Alcyone Lifesciences, Inc. |
SYSTEM AND METHOD FOR THE ADMINISTRATION OF MEDICAMENTS
|
|
CA2985786A1
(en)
|
2015-05-12 |
2016-11-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Aav isolate and fusion protein comprising nerve growth factor signal peptide and parathyroid hormone
|
|
US20170067028A1
(en)
|
2015-05-15 |
2017-03-09 |
Douglas J. Ballon |
Radiolabeling of adeno associated virus
|
|
US10729790B2
(en)
|
2015-05-26 |
2020-08-04 |
Salk Institute For Biological Studies |
Motor neuron-specific expression vectors
|
|
IL322085A
(en)
|
2015-05-29 |
2025-09-01 |
Univ Pennsylvania |
Compositions and methods for reducing unfolded proteins
|
|
WO2016196507A1
(en)
|
2015-05-29 |
2016-12-08 |
University Of Iowa Research Foundation |
Methods of delivery of transgenes for treating brain diseases
|
|
WO2017004514A1
(en)
|
2015-07-02 |
2017-01-05 |
University Of Florida Research Foundation, Inc. |
Recombinant adeno-associated virus vectors to target medullary thyroid carcinoma
|
|
US20170007669A1
(en)
|
2015-07-07 |
2017-01-12 |
Mayo Foundation For Medical Education And Research |
Peptide-mediated delivery of active agents across the blood-brain barrier
|
|
EP3320101B1
(en)
|
2015-07-07 |
2021-08-11 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for expressing a polynucleotide of interest in the peripheral nervous system of a subject
|
|
WO2017015102A1
(en)
|
2015-07-17 |
2017-01-26 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for achieving high levels of transduction in human liver cells
|
|
CA2988471A1
(en)
|
2015-07-28 |
2017-02-02 |
University Of Massachusetts |
Transgenic expression of dnase i in vivo delivered by an adeno-associated virus vector
|
|
JP7166168B2
(ja)
|
2015-07-30 |
2022-11-07 |
マサチューセッツ アイ アンド イヤー インファーマリー |
祖先ウイルス配列およびその使用
|
|
US20190000940A1
(en)
|
2015-07-31 |
2019-01-03 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of aadc deficiency
|
|
US20180201937A1
(en)
|
2015-08-04 |
2018-07-19 |
The University Of Chicago |
Inhibitors of cacna1a/alpha1a subunit internal ribosomal entry site (ires) and methods of treating spinocerebellar ataxia type 6
|
|
US10047377B2
(en)
|
2015-09-22 |
2018-08-14 |
Loyola University Of Chicago |
Methods for modulating KLHL1 levels, methods for modulating current activity in T-type calcium channels, molecules therefor, and methods for identifying molecules therefor
|
|
WO2017053753A1
(en)
|
2015-09-23 |
2017-03-30 |
Sangamo Biosciences, Inc. |
Htt repressors and uses thereof
|
|
CA2996420A1
(en)
|
2015-09-28 |
2017-04-06 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for antibody-evading virus vectors
|
|
AU2016335572B2
(en)
|
2015-10-09 |
2022-12-08 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treating Huntington's disease and related disorders
|
|
EP4567425A3
(en)
|
2015-10-09 |
2025-10-08 |
Genzyme Corporation |
Early post-transfection isolation of cells (epic) for biologics production
|
|
US10123969B2
(en)
|
2015-10-15 |
2018-11-13 |
Wisconsin Alumni Research Foundation |
Osmotic enhancement of drug/therapeutic delivery to the brain following infusion or injection into the cerebrospinal fluid
|
|
EP3364996B1
(en)
|
2015-10-22 |
2021-08-25 |
University of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
US12188037B2
(en)
|
2015-10-22 |
2025-01-07 |
University Of Florida Research Foundation, Incorporated |
Synthetic combinatorial AAV3 capsid library
|
|
DK3364997T5
(da)
|
2015-10-22 |
2024-09-30 |
Univ Massachusetts |
Aspartoacylase genterapi til behandling af canavans sygdom
|
|
CN116650668A
(zh)
|
2015-10-23 |
2023-08-29 |
衣阿华大学研究基金会 |
使用基因疗法以推迟疾病发生和发展同时提供认知保护来治疗神经变性疾病的方法
|
|
US20180230489A1
(en)
|
2015-10-28 |
2018-08-16 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
WO2017075119A1
(en)
|
2015-10-28 |
2017-05-04 |
The Trustees Of The Univeresity Of Pennsylvania |
Intrathecal administration of adeno-associated-viral vectors for gene therapy
|
|
WO2017079768A1
(en)
|
2015-11-08 |
2017-05-11 |
Genentech, Inc. |
Methods of screening for multispecific antibodies
|
|
US10633662B2
(en)
|
2015-11-10 |
2020-04-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for modulating AAV infection
|
|
WO2017096039A1
(en)
|
2015-12-01 |
2017-06-08 |
Spark Therapeutics, Inc. |
Scalable methods for producing recombinant adeno-associated viral (aav) vector in serum-free suspension cell culture system suitable for clinical use
|
|
US20170151416A1
(en)
|
2015-12-01 |
2017-06-01 |
Invivo Therapeutics Corporation |
Methods and Systems for Delivery of a Trail of a Therapeutic Substance into an Anatomical Space
|
|
EP3384034B1
(en)
|
2015-12-02 |
2020-07-08 |
The Board of Trustees of the Leland Stanford Junior University |
Novel recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
|
|
US10406244B2
(en)
|
2015-12-02 |
2019-09-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
AAV vectors with expanded packaging capacity
|
|
CA3004971A1
(en)
|
2015-12-03 |
2017-06-08 |
Universite D'evry Val D'essonne |
Compositions and methods for improving viral vector efficiency
|
|
EP3387118B1
(en)
|
2015-12-11 |
2022-04-06 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aavrh10
|
|
EP3387117B1
(en)
|
2015-12-11 |
2022-11-23 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aav8
|
|
WO2017100674A1
(en)
|
2015-12-11 |
2017-06-15 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aav1
|
|
CA3007495C
(en)
|
2015-12-11 |
2023-04-11 |
California Institute Of Technology |
Targeting peptides for directing adeno-associated viruses (aavs)
|
|
EP3387138B1
(en)
|
2015-12-11 |
2022-01-26 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aav9
|
|
CA3008013A1
(en)
|
2015-12-14 |
2017-06-22 |
The University Of North Carolina At Chapel Hill |
Modified capsid proteins for enhanced delivery of parvovirus vectors
|
|
WO2017112948A1
(en)
|
2015-12-24 |
2017-06-29 |
University Of Florida Research Foundation, Inc. |
Improved aav production using suspension adapted cells
|
|
WO2017122789A1
(ja)
|
2016-01-15 |
2017-07-20 |
学校法人自治医科大学 |
てんかん治療のためのアデノ随伴ウイルスビリオン
|
|
EP3411059A4
(en)
|
2016-02-02 |
2019-10-16 |
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METHOD FOR INCREASING THE EFFECTIVENESS OF THE SYSTEMIC DELIVERY OF AVV GENES TO THE CENTRAL NERVOUS SYSTEM
|
|
WO2017136202A1
(en)
|
2016-02-05 |
2017-08-10 |
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Injection of single-stranded or self-complementary adeno-associated virus 9 into the cerebrospinal fluid
|
|
WO2017139381A1
(en)
|
2016-02-08 |
2017-08-17 |
University Of Iowa Research Foundation |
Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
|
|
CN109415704B
(zh)
|
2016-02-16 |
2022-02-25 |
利兰斯坦福初级大学董事会 |
对先已存在的人中和抗体有抗性的新型重组腺相关病毒衣壳
|
|
WO2017147477A1
(en)
|
2016-02-26 |
2017-08-31 |
University Of Florida Research Foundation, Inc. |
Aav heparin mutants that display significantly improved eye and brain transduction
|
|
EP3957331A1
(en)
|
2016-03-03 |
2022-02-23 |
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Closed-ended linear duplex dna for non-viral gene transfer
|
|
WO2017155973A1
(en)
|
2016-03-07 |
2017-09-14 |
University Of Iowa Research Foundation |
Aav-mediated expression using a synthetic promoter and enhancer
|
|
AU2017234929B2
(en)
|
2016-03-18 |
2024-05-02 |
The Children's Hospital Of Philadelphia |
Therapeutic for treatment of diseases including the central nervous system
|
|
WO2017165859A1
(en)
|
2016-03-24 |
2017-09-28 |
Research Institute At Nationwide Children's Hospital |
Modified viral capsid proteins
|
|
EP3436476A4
(en)
|
2016-03-28 |
2020-04-29 |
The Regents of The University of California |
ANTI-RYK ANTIBODIES AND METHOD FOR USE THEREOF
|
|
LT3436593T
(lt)
|
2016-03-28 |
2023-03-10 |
Ultragenyx Pharmaceutical Inc. |
Adenoviruso šiluminio inaktyvavimo būdai
|
|
BR112018070250A2
(pt)
|
2016-03-30 |
2019-01-29 |
Spark Therapeutics Inc |
linhagem celular para proteína recombinante e/ou produção de vetores virais
|
|
WO2017173283A1
(en)
|
2016-03-31 |
2017-10-05 |
Spark Therapeutics, Inc. |
Column-based fully scalable raav manufacturing process
|
|
CN109661470A
(zh)
|
2016-04-15 |
2019-04-19 |
宾夕法尼亚州大学信托人 |
新型aav8突变衣壳和含有其的组合物
|
|
ES2989468T3
(es)
|
2016-04-16 |
2024-11-26 |
Univ Florida |
Métodos para mejorar la potencia biológica de virus adenoasociados recombinantes producidos en un sistema baculovírico
|
|
NZ744418A
(en)
|
2016-04-21 |
2025-10-31 |
Virovek Inc |
Aav production in insect cells, methods and compositions therefor
|
|
EP3235516B1
(en)
|
2016-04-22 |
2019-06-26 |
Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin |
Regulatable adeno-associated virus (aav) vector
|
|
WO2017190031A1
(en)
|
2016-04-28 |
2017-11-02 |
Indiana University Research And Technology Corporation |
Methods and compositions for resolving components of a virus preparation
|
|
WO2017189963A1
(en)
|
2016-04-29 |
2017-11-02 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
|
EP3452495B1
(en)
|
2016-05-03 |
2021-06-23 |
Children's Medical Research Institute |
Adeno-associated virus polynucleotides, polypeptides and virions
|
|
US11866462B2
(en)
|
2016-05-04 |
2024-01-09 |
Oregon Health & Science University |
Recombinant adeno-associated viral vectors
|
|
IL262784B2
(en)
|
2016-05-18 |
2023-10-01 |
Voyager Therapeutics Inc |
modulatory polynucleotides
|
|
SG11201809643UA
(en)
|
2016-05-18 |
2018-12-28 |
Voyager Therapeutics Inc |
Compositions and methods of treating huntington's disease
|
|
US10898585B2
(en)
|
2017-04-14 |
2021-01-26 |
Ptc Therapeutics .Inc. |
Gene therapy for AADC deficiency
|
|
EP3619310A4
(en)
|
2017-05-05 |
2021-01-27 |
Voyager Therapeutics, Inc. |
Modulatory polynucleotides
|
|
WO2018204786A1
(en)
|
2017-05-05 |
2018-11-08 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
MX2019013172A
(es)
|
2017-05-05 |
2020-09-07 |
Voyager Therapeutics Inc |
Composiciones y metodos para tratar la enfermedad de huntington.
|
|
EP3635121A1
(en)
|
2017-06-02 |
2020-04-15 |
Institut National de la Sante et de la Recherche Medicale (INSERM) |
Viral vector combining gene therapy and genome editing approaches for gene therapy of genetic disorders
|
|
GB201714027D0
(en)
|
2017-09-01 |
2017-10-18 |
Proqr Therapeutics Ii Bv |
Antisense oligonucleotides for the treatment of huntington's disease
|
|
WO2019079242A1
(en)
|
2017-10-16 |
2019-04-25 |
Voyager Therapeutics, Inc. |
TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
|
|
US11434502B2
(en)
|
2017-10-16 |
2022-09-06 |
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Treatment of amyotrophic lateral sclerosis (ALS)
|
|
JP7565218B2
(ja)
|
2018-07-02 |
2024-10-10 |
ボイジャー セラピューティクス インコーポレイテッド |
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|