ATE427990T1 - Verbesserte reinigungsmethode fur viren - Google Patents
Verbesserte reinigungsmethode fur virenInfo
- Publication number
- ATE427990T1 ATE427990T1 AT03724692T AT03724692T ATE427990T1 AT E427990 T1 ATE427990 T1 AT E427990T1 AT 03724692 T AT03724692 T AT 03724692T AT 03724692 T AT03724692 T AT 03724692T AT E427990 T1 ATE427990 T1 AT E427990T1
- Authority
- AT
- Austria
- Prior art keywords
- cleaning method
- improved virus
- virus cleaning
- improved
- virus
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
- C12N2720/12222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
- C12N2720/12234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
- C12N2720/12251—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37727302P | 2002-04-30 | 2002-04-30 | |
US44317603P | 2003-01-29 | 2003-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE427990T1 true ATE427990T1 (de) | 2009-04-15 |
Family
ID=29406789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03724692T ATE427990T1 (de) | 2002-04-30 | 2003-04-28 | Verbesserte reinigungsmethode fur viren |
Country Status (17)
Country | Link |
---|---|
US (3) | US7223585B2 (de) |
EP (1) | EP1501921B2 (de) |
JP (1) | JP2005523722A (de) |
AR (1) | AR039783A1 (de) |
AT (1) | ATE427990T1 (de) |
AU (1) | AU2003229159B2 (de) |
BR (1) | BR0309659A (de) |
CA (1) | CA2482512C (de) |
DE (1) | DE60327069D1 (de) |
DK (1) | DK1501921T4 (de) |
ES (1) | ES2323454T5 (de) |
HK (1) | HK1070670A1 (de) |
IL (1) | IL164551A (de) |
MX (1) | MXPA04010603A (de) |
NZ (1) | NZ535944A (de) |
TW (1) | TWI317378B (de) |
WO (1) | WO2003093463A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0309659A (pt) | 2002-04-30 | 2005-02-22 | Oncolytics Biotech Inc | Método para produzir vìrus de uma cultura de células, composição, e, método para produzir reovìrus infeccioso |
JP4558652B2 (ja) * | 2003-06-20 | 2010-10-06 | マイクロビクス・バイオシステムズ・インコーポレイテツド | ウイルス生産の改善 |
US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
US8373381B2 (en) | 2005-04-22 | 2013-02-12 | GM Global Technology Operations LLC | DC/DC-less coupling of matched batteries to fuel cells |
US10260049B2 (en) | 2005-08-01 | 2019-04-16 | Virocure, Inc. | Attenuated reovirus |
US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
ES2377356T3 (es) * | 2006-04-20 | 2012-03-26 | Wyeth Llc | Procedimiento de purificación para el aislamiento del virus purificado de la estomatitis vesicular de un cultivo celular |
US20080131955A1 (en) * | 2006-11-30 | 2008-06-05 | Canon U.S. Life Sciences, Inc. | Method of Separating Target DNA from Mixed DNA |
US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
EP2334328A4 (de) * | 2008-09-24 | 2012-08-29 | Medimmune Llc | Verfahren zur reinigung von viren |
BR112012026095A2 (pt) | 2010-04-14 | 2015-09-15 | Emd Millipore Corp | métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos. |
CN103347535B (zh) | 2010-12-02 | 2015-11-25 | 昂科利蒂克斯生物科技公司 | 液体病毒制剂 |
EA201390812A1 (ru) | 2010-12-02 | 2013-11-29 | Онколитикс Байотек Инк. | Лиофилизированные вирусные составы |
JP6029651B2 (ja) * | 2011-04-29 | 2016-11-24 | オンコリティクス バイオテク,インコーポレーテッド | ゲル浸透クロマトグラフィーを使用してウイルスを精製する方法 |
DK2970920T3 (en) | 2013-03-15 | 2018-08-06 | Childrens Hospital Philadelphia | SCALABLE MANUFACTURING PROCESS FOR MANUFACTURING RECOMBINANT LENTIVIRAL VECTORS IN SERUM-FREE SUSPENSION CELL CULTURE SYSTEM |
FR3014901B1 (fr) | 2013-12-17 | 2017-06-09 | Genethon | Procede de purification de virus ou vecteurs viraux enveloppes |
WO2015106951A1 (en) * | 2014-01-14 | 2015-07-23 | Koninklijke Philips N.V. | Organic light emitting diode |
WO2016130569A1 (en) * | 2015-02-09 | 2016-08-18 | Mj Biologics, Inc. | A composition comprising pedv antigens and methods for making and using the composition |
WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
CN107106689A (zh) | 2014-11-05 | 2017-08-29 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
SG11201703419UA (en) | 2014-11-14 | 2017-05-30 | Voyager Therapeutics Inc | Modulatory polynucleotides |
MX2017006216A (es) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela). |
EP3230441A4 (de) | 2014-12-12 | 2018-10-03 | Voyager Therapeutics, Inc. | Zusammensetzungen und verfahren zur herstellung von scaav |
EP3368054A4 (de) | 2015-10-28 | 2019-07-03 | Voyager Therapeutics, Inc. | Regulierbare expression unter verwendung des adeno-assoziierten virus (aav) |
US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
KR102392236B1 (ko) | 2016-05-18 | 2022-05-03 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
SG11201809643UA (en) | 2016-05-18 | 2018-12-28 | Voyager Therapeutics Inc | Compositions and methods of treating huntington's disease |
EP3831281A1 (de) | 2016-08-30 | 2021-06-09 | The Regents of The University of California | Verfahren für biomedizinisches targeting und freisetzung sowie vorrichtungen und systeme zur ausführung davon |
CA3061652A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (als) |
EP3619308A4 (de) | 2017-05-05 | 2021-01-27 | Voyager Therapeutics, Inc. | Zusammensetzungen und verfahren zur behandlung von morbus huntington |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
KR20200044793A (ko) | 2017-08-03 | 2020-04-29 | 보이저 테라퓨틱스, 인크. | Aav의 전달을 위한 조성물 및 방법 |
JP7502991B2 (ja) | 2017-10-16 | 2024-06-19 | ボイジャー セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症(als)の治療 |
WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
EP3762500A1 (de) | 2018-03-06 | 2021-01-13 | Voyager Therapeutics, Inc. | Aus insektenzelle hergestellte teilweise selbstkomplementäre aav-genome |
EP3793615A2 (de) | 2018-05-16 | 2021-03-24 | Voyager Therapeutics, Inc. | Gerichtete entwicklung von aav zur verbesserung des tropismus für zns |
US20210207167A1 (en) | 2018-05-16 | 2021-07-08 | Voyager Therapeutics, Inc. | Aav serotypes for brain specific payload delivery |
EP3818161A1 (de) | 2018-07-02 | 2021-05-12 | Voyager Therapeutics, Inc. | Behandlung von amyotropher lateralsklerose und rückenmarksassoziierten erkrankungen |
CA3107462A1 (en) | 2018-07-24 | 2020-01-30 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
EP3861113A1 (de) | 2018-10-04 | 2021-08-11 | Voyager Therapeutics, Inc. | Verfahren zur messung des titers und der potenz von viralen vektorpartikeln |
SG11202107645RA (en) | 2019-01-18 | 2021-08-30 | Voyager Therapeutics Inc | Methods and systems for producing aav particles |
US20220243225A1 (en) | 2019-04-29 | 2022-08-04 | Voyager Therapeutics, Inc. | SYSTEMS AND METHODS FOR PRODUCING BACULOVIRAL INFECTED INSECT CELLS (BIICs) IN BIOREACTORS |
US20220290182A1 (en) | 2019-08-09 | 2022-09-15 | Voyager Therapeutics, Inc. | Cell culture medium for use in producing gene therapy products in bioreactors |
WO2021041485A1 (en) | 2019-08-26 | 2021-03-04 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
EP4192514A1 (de) | 2020-08-06 | 2023-06-14 | Voyager Therapeutics, Inc. | Zellkulturmedium zur verwendung bei der herstellung von gentherapieprodukten in bioreaktoren |
EP4301768A2 (de) | 2021-03-03 | 2024-01-10 | Voyager Therapeutics, Inc. | Kontrollierte expression von viralen proteinen |
WO2022187548A1 (en) | 2021-03-03 | 2022-09-09 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
WO2024054983A1 (en) | 2022-09-08 | 2024-03-14 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
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US4721675A (en) | 1982-02-01 | 1988-01-26 | Abbott Laboratories | Production of hepatitis A virus in vitro utilizing a persistently virus infected cell culture system |
JPS6344532A (ja) | 1986-08-11 | 1988-02-25 | Biseibutsu Kagaku Kenkyusho:Kk | 豚のレオウイルス感染症ワクチン |
US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5658779A (en) * | 1992-03-20 | 1997-08-19 | Ligochem, Inc. | Method of adsorbing viruses from fluid compositions |
DZ1706A1 (fr) | 1992-08-07 | 2002-02-17 | Merck & Co Inc | Vaccin contre le virus de l'hepatite a. |
FR2696748B1 (fr) * | 1992-10-14 | 1994-12-30 | Pasteur Merieux Serums Vacc | Procédé de préparation d'antigènes et de vaccins de l'hépatite A (HAV). |
US5614413A (en) * | 1993-07-01 | 1997-03-25 | The Uab Research Foundation | Encapsidated recombinant poliovirus nucleic acid and methods of making and using same |
US6686200B1 (en) * | 1993-08-31 | 2004-02-03 | Uab Research Foundation | Methods and compositions for the large scale production of recombinant adeno-associated virus |
HRP950097A2 (en) | 1994-03-08 | 1997-06-30 | Merck & Co Inc | Hepatitis a virus culture process |
SI0757717T1 (sl) | 1994-05-16 | 2006-08-31 | Merck & Co Inc | Cepivo proti papilomavirusu |
US6146873A (en) | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
AR004464A1 (es) | 1994-11-14 | 1998-12-16 | Merck Sharp & Dohme | Un metodo para producir una proteina de capside de papilomavirus |
US6143548A (en) * | 1995-08-30 | 2000-11-07 | Genzyme Corporation | Chromatographic purification of adeno-associated virus (AAV) |
DE69737107T2 (de) * | 1996-11-20 | 2007-07-12 | Introgen Therapeutics Inc., Austin | Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren |
ES2283032T3 (es) | 1996-12-13 | 2007-10-16 | Schering Corporation | Metodos para purificar virus. |
TW570803B (en) | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
US6214333B1 (en) | 1997-07-08 | 2001-04-10 | Texas Heart Institute | Vasoprotective recombinant adenovirus vector containing a human TFPI gene |
US6110461A (en) | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
GB9804632D0 (en) | 1998-03-05 | 1998-04-29 | Cantab Pharma Res | Virus preparations and methods |
ES2312447T3 (es) | 2000-05-31 | 2009-03-01 | Novartis Vaccines And Diagnostics, Inc. | Procedimiento para la purificacion de particulas de replicon alfavirus. |
TWI289158B (en) * | 2000-08-10 | 2007-11-01 | Oncolytics Biotech Inc | Method of producing infectious reovirus |
EP2253701B1 (de) * | 2001-03-16 | 2014-08-13 | Oncolytics Biotech Inc. | Methode zur Extraktion von Virus aus einer Zellkultur |
BR0309659A (pt) | 2002-04-30 | 2005-02-22 | Oncolytics Biotech Inc | Método para produzir vìrus de uma cultura de células, composição, e, método para produzir reovìrus infeccioso |
US7901921B2 (en) * | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
-
2003
- 2003-04-28 BR BR0309659-9A patent/BR0309659A/pt not_active IP Right Cessation
- 2003-04-28 NZ NZ535944A patent/NZ535944A/en unknown
- 2003-04-28 ES ES03724692T patent/ES2323454T5/es not_active Expired - Lifetime
- 2003-04-28 JP JP2004501599A patent/JP2005523722A/ja active Pending
- 2003-04-28 CA CA2482512A patent/CA2482512C/en not_active Expired - Lifetime
- 2003-04-28 WO PCT/CA2003/000624 patent/WO2003093463A1/en active Application Filing
- 2003-04-28 AU AU2003229159A patent/AU2003229159B2/en not_active Expired
- 2003-04-28 AT AT03724692T patent/ATE427990T1/de not_active IP Right Cessation
- 2003-04-28 DE DE60327069T patent/DE60327069D1/de not_active Expired - Lifetime
- 2003-04-28 MX MXPA04010603A patent/MXPA04010603A/es active IP Right Grant
- 2003-04-28 DK DK03724692.3T patent/DK1501921T4/da active
- 2003-04-28 EP EP03724692A patent/EP1501921B2/de not_active Expired - Lifetime
- 2003-04-29 US US10/424,985 patent/US7223585B2/en not_active Expired - Lifetime
- 2003-04-29 AR ARP030101504A patent/AR039783A1/es unknown
- 2003-04-29 TW TW092109972A patent/TWI317378B/zh not_active IP Right Cessation
-
2004
- 2004-10-13 IL IL164551A patent/IL164551A/en active IP Right Grant
-
2005
- 2005-04-04 HK HK05102826.1A patent/HK1070670A1/xx not_active IP Right Cessation
-
2007
- 2007-04-17 US US11/736,479 patent/US8685734B2/en active Active
-
2014
- 2014-02-07 US US14/175,214 patent/US10167452B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
HK1070670A1 (en) | 2005-06-24 |
EP1501921A1 (de) | 2005-02-02 |
US20140178969A1 (en) | 2014-06-26 |
MXPA04010603A (es) | 2004-12-13 |
US20070269856A1 (en) | 2007-11-22 |
EP1501921B2 (de) | 2012-07-25 |
US20040005693A1 (en) | 2004-01-08 |
US10167452B2 (en) | 2019-01-01 |
NZ535944A (en) | 2007-11-30 |
EP1501921B1 (de) | 2009-04-08 |
BR0309659A (pt) | 2005-02-22 |
JP2005523722A (ja) | 2005-08-11 |
DE60327069D1 (de) | 2009-05-20 |
CA2482512C (en) | 2011-09-20 |
DK1501921T4 (da) | 2012-10-08 |
IL164551A (en) | 2010-05-17 |
ES2323454T5 (es) | 2012-11-14 |
AR039783A1 (es) | 2005-03-02 |
TW200401829A (en) | 2004-02-01 |
US8685734B2 (en) | 2014-04-01 |
DK1501921T3 (da) | 2009-06-22 |
ES2323454T3 (es) | 2009-07-16 |
TWI317378B (en) | 2009-11-21 |
IL164551A0 (en) | 2005-12-18 |
AU2003229159A1 (en) | 2003-11-17 |
AU2003229159B2 (en) | 2008-02-21 |
WO2003093463A1 (en) | 2003-11-13 |
US7223585B2 (en) | 2007-05-29 |
CA2482512A1 (en) | 2003-11-13 |
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