KR20230145206A - 조절성 폴리뉴클레오티드 - Google Patents

조절성 폴리뉴클레오티드 Download PDF

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Publication number
KR20230145206A
KR20230145206A KR1020237032829A KR20237032829A KR20230145206A KR 20230145206 A KR20230145206 A KR 20230145206A KR 1020237032829 A KR1020237032829 A KR 1020237032829A KR 20237032829 A KR20237032829 A KR 20237032829A KR 20230145206 A KR20230145206 A KR 20230145206A
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South Korea
Prior art keywords
artificial sequence
rna
synthetic oligonucleotide
description
regulatory polynucleotide
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KR1020237032829A
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English (en)
Korean (ko)
Inventor
진자오 호우
마티유 이. 논넨마커
펑청 주
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보이저 테라퓨틱스, 인크.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
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    • C12N2330/00—Production
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
KR1020237032829A 2014-11-14 2015-11-13 조절성 폴리뉴클레오티드 Ceased KR20230145206A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201462079590P 2014-11-14 2014-11-14
US62/079,590 2014-11-14
US201562212004P 2015-08-31 2015-08-31
US62/212,004 2015-08-31
US201562234477P 2015-09-29 2015-09-29
US62/234,477 2015-09-29
PCT/US2015/060564 WO2016077689A1 (en) 2014-11-14 2015-11-13 Modulatory polynucleotides
KR1020177012955A KR102584655B1 (ko) 2014-11-14 2015-11-13 조절성 폴리뉴클레오티드

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KR20230145206A true KR20230145206A (ko) 2023-10-17

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KR1020237032829A Ceased KR20230145206A (ko) 2014-11-14 2015-11-13 조절성 폴리뉴클레오티드

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US (4) US10570395B2 (enExample)
EP (2) EP3907287A1 (enExample)
JP (3) JP6863891B2 (enExample)
KR (2) KR102584655B1 (enExample)
CN (5) CN107207556B (enExample)
AU (3) AU2015346164B2 (enExample)
BR (1) BR112017010088A2 (enExample)
CA (1) CA2975583C (enExample)
DK (1) DK3218386T3 (enExample)
ES (1) ES2878451T3 (enExample)
IL (2) IL284949B2 (enExample)
MX (3) MX2017006217A (enExample)
RU (2) RU2749882C2 (enExample)
SG (2) SG11201703419UA (enExample)
WO (1) WO2016077689A1 (enExample)
ZA (1) ZA202004557B (enExample)

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