SG11201505272QA - Age-related macular degeneration treatment - Google Patents

Age-related macular degeneration treatment

Info

Publication number
SG11201505272QA
SG11201505272QA SG11201505272QA SG11201505272QA SG11201505272QA SG 11201505272Q A SG11201505272Q A SG 11201505272QA SG 11201505272Q A SG11201505272Q A SG 11201505272QA SG 11201505272Q A SG11201505272Q A SG 11201505272QA SG 11201505272Q A SG11201505272Q A SG 11201505272QA
Authority
SG
Singapore
Prior art keywords
age
macular degeneration
related macular
degeneration treatment
treatment
Prior art date
Application number
SG11201505272QA
Inventor
David Suhy
Tin Mao
Shih-Chu Kao
Original Assignee
Benitec Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benitec Biopharma Ltd filed Critical Benitec Biopharma Ltd
Publication of SG11201505272QA publication Critical patent/SG11201505272QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21047Alternative-complement-pathway C3/C5 convertase (3.4.21.47), i.e. properdin factor B
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • C12N2310/141MicroRNAs, miRNAs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3519Fusion with another nucleic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
    • C12N2310/531Stem-loop; Hairpin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00Production
    • C12N2330/50Biochemical production, i.e. in a transformed host cell
    • C12N2330/51Specially adapted vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
SG11201505272QA 2013-01-08 2014-01-08 Age-related macular degeneration treatment SG11201505272QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361750086P 2013-01-08 2013-01-08
PCT/AU2014/000007 WO2014107763A1 (en) 2013-01-08 2014-01-08 Age-related macular degeneration treatment

Publications (1)

Publication Number Publication Date
SG11201505272QA true SG11201505272QA (en) 2015-08-28

Family

ID=51166430

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201705518SA SG10201705518SA (en) 2013-01-08 2014-01-08 Age-Related Macular Degeneration Treatment
SG11201505272QA SG11201505272QA (en) 2013-01-08 2014-01-08 Age-related macular degeneration treatment

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201705518SA SG10201705518SA (en) 2013-01-08 2014-01-08 Age-Related Macular Degeneration Treatment

Country Status (13)

Country Link
US (2) US10000753B2 (en)
EP (1) EP2943571A4 (en)
JP (1) JP2016507514A (en)
KR (1) KR20150103280A (en)
CN (1) CN105143450A (en)
AU (1) AU2014205036A1 (en)
CA (1) CA2897342A1 (en)
HK (1) HK1218656A1 (en)
IL (1) IL239836A0 (en)
MX (1) MX2015008697A (en)
RU (1) RU2015133252A (en)
SG (2) SG10201705518SA (en)
WO (1) WO2014107763A1 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015033343A1 (en) 2013-09-03 2015-03-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions and methods for expressing recombinant polypeptides
SG11201604692UA (en) * 2013-12-12 2016-07-28 Alnylam Pharmaceuticals Inc Complement component irna compositions and methods of use thereof
IL234638A0 (en) 2014-09-14 2014-12-02 Yeda Res & Dev Nmda receptor antagonists for treating gaucher disease
EP3218484A4 (en) 2014-11-14 2018-05-30 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
RU2749882C2 (en) * 2014-11-14 2021-06-18 Вояджер Терапьютикс, Инк. Modulating polynucleotides
EP4218771A1 (en) 2015-03-27 2023-08-02 Yeda Research and Development Co. Ltd Methods of treating motor neuron diseases
EP3294280A1 (en) 2015-05-11 2018-03-21 Yeda Research and Development Co., Ltd. Citrin inhibitors for the treatment of cancer
KR20180063881A (en) 2015-07-16 2018-06-12 바이오카인 테라퓨틱스 리미티드 Compositions and methods for the treatment of cancer
EP3405024B1 (en) 2016-01-21 2022-12-28 The State of Israel - Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) Parthenocarpic plants and methods of producing same
US20190046497A1 (en) 2016-02-14 2019-02-14 Yeda Research And Development Co., Ltd. Methods of modulating protein exocytosis and uses of same in therapy
CN109073660B (en) * 2016-02-29 2022-10-28 麦恩泰科特有限公司 Predictive markers useful for the treatment of wet age-related macular degeneration
RU2758488C2 (en) 2016-05-18 2021-10-28 Вояджер Терапьютикс, Инк. Modulating polynucleotides
JP7220080B2 (en) 2016-05-18 2023-02-09 ボイジャー セラピューティクス インコーポレイテッド Compositions and methods for treating Huntington's disease
IL247368A0 (en) 2016-08-18 2016-11-30 Yeda Res & Dev Diagnostic and therapeutic uses of exosomes
KR102495222B1 (en) * 2016-12-14 2023-02-09 베니텍 아이피 홀딩스 아이엔씨. Treatment of Ophthalmopharyngeal Dystrophy (OPMD) and Uses Thereof
TW201827596A (en) * 2016-12-23 2018-08-01 日商協和醱酵麒麟有限公司 Nucleic acid inhibiting expression of complement factor B
WO2018141025A1 (en) * 2017-02-03 2018-08-09 Benitec Biopharma Limited Reagents for treatment of ocular diseases and conditions associated with neovascularisation and use thereof
WO2018204803A1 (en) 2017-05-05 2018-11-08 Voyager Therapeutics, Inc. Compositions and methods of treating huntington's disease
WO2018204786A1 (en) 2017-05-05 2018-11-08 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
IL252151A0 (en) 2017-05-07 2017-07-31 Fainzilber Michael Methods of treating psychiatric stress disorders
US11541072B2 (en) * 2017-06-27 2023-01-03 Massachusetts Eye And Ear Infirmary AAV-CRISPR/Cas9 genome editing of VEGFR2 for treating ocular diseases
IL253642A0 (en) 2017-07-24 2017-09-28 Seger Rony Combination therapy for the treatment of cancer
BR112020005103A2 (en) * 2017-09-15 2020-09-24 Commonwealth Scientific And Industrial Research Organisation rna molecule, chimeric ribonucleic acid (rna) molecule, isolated and / or exogenous polynucleotide, vector, host cell, polynucleotide, non-human organism, method, method for producing a non-human organism, extract of a host cell, composition, method to downwardly regulate the level and / or activity of a target RNA molecule in an organism, method to control a non-human organism, method to treat a disease in an individual, RNA molecule, use of an RNA molecule and kit
AU2018336128B2 (en) 2017-09-19 2023-01-05 Tropic Biosciences UK Limited Modifying the specificity of plant non-coding RNA molecules for silencing gene expression
EP3704252A1 (en) 2017-11-01 2020-09-09 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof
IL255664A0 (en) 2017-11-14 2017-12-31 Shachar Idit Hematopoietic stem cells with improved properties
IL262658A (en) 2018-10-28 2020-04-30 Memorial Sloan Kettering Cancer Center Prevention of age related clonal hematopoiesis and diseases associated therewith
GB201903520D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
GB201903521D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd No title
GB201903519D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
IL268111A (en) 2019-07-16 2021-01-31 Fainzilber Michael Methods of treating pain
CA3153727A1 (en) * 2019-09-10 2021-03-18 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Treatment methods for eye disorders
IL270306A (en) 2019-10-30 2021-05-31 Yeda Res & Dev Prevention and treatment of pre-myeloid and myeloid malignancies
EP4096647A1 (en) 2020-01-30 2022-12-07 Yeda Research and Development Co. Ltd Treating acute liver disease with tlr-mik inhibitors
WO2022079719A1 (en) 2020-10-15 2022-04-21 Yeda Research And Development Co. Ltd. Method of treating myeloid malignancies
KR20230132472A (en) 2020-12-18 2023-09-15 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Composition for use in the treatment of CHD2 haploid dysfunction and method for determining the same
IL304068A (en) 2020-12-28 2023-08-01 1E Therapeutics Ltd P21 mrna targeting dnazymes
IL304047A (en) 2020-12-28 2023-08-01 1E Therapeutics Ltd P21 mrna target areas for silencing
GB202103256D0 (en) 2021-03-09 2021-04-21 Tropic Biosciences Uk Ltd Method for silencing genes
EP4337197A1 (en) 2021-05-10 2024-03-20 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Pharmaceutical compositions for treating neurological conditions
EP4396346A1 (en) * 2021-09-02 2024-07-10 Silence Therapeutics GmbH Nucleic acids for inhibiting expression of complement factor b (cfb) in a cell
CA3234612A1 (en) 2021-10-14 2023-04-20 Weedout Ltd. Methods of weed control
IL312399A (en) 2021-10-29 2024-06-01 Alnylam Pharmaceuticals Inc Complement factor b (cfb) irna compositions and methods of use thereof
WO2024149907A2 (en) 2023-01-13 2024-07-18 Laverock Therapeutics Limited Novel polynucleotides, cells and methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517864B2 (en) 2001-05-18 2009-04-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US7148342B2 (en) * 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
US7309487B2 (en) 2004-02-09 2007-12-18 George Inana Methods and compositions for detecting and treating retinal diseases
EP2363483A3 (en) 2004-03-05 2014-07-16 Benitec, Inc. Multiple promoter expression cassettes for simultaneous delivery of RNAi agents
CA2559161C (en) * 2004-03-12 2013-06-11 Alnylam Pharmaceuticals, Inc. Irna agents targeting vegf
US8282921B2 (en) * 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
CN101180394B (en) 2005-02-03 2013-01-09 贝尼泰克有限公司 Rnai expression constructs
WO2006116756A1 (en) 2005-04-28 2006-11-02 Benitec, Limited. Multiple-rnai expression cassettes for simultaneous delivery of rnai agents related to heterozygotic expression patterns
AU2006315102A1 (en) 2005-11-21 2007-05-24 Johnson & Johnson Research Pty Limited Multitargeting interfering RNAs having two active strands and methods for their design and use
GB0608838D0 (en) 2006-05-04 2006-06-14 Novartis Ag Organic compounds
HUE040417T2 (en) * 2007-05-04 2019-03-28 Marina Biotech Inc Amino acid lipids and uses thereof
WO2008154482A2 (en) * 2007-06-08 2008-12-18 Sirnaomics, Inc. Sirna compositions and methods of use in treatment of ocular diseases
US8283331B2 (en) * 2007-10-09 2012-10-09 Children's Medical Center Corporation Methods to regulate miRNA processing by targeting Lin-28
US8470792B2 (en) 2008-12-04 2013-06-25 Opko Pharmaceuticals, Llc. Compositions and methods for selective inhibition of VEGF
WO2012015775A2 (en) 2010-07-28 2012-02-02 Dharmacon, Inc. Sirna targeting vegfa and methods for treatment in vivo
US9220716B2 (en) 2011-07-26 2015-12-29 Children's Medical Center Corporation Methods and compositions for the treatment of proliferative vascular disorders
AU2013225619A1 (en) 2012-02-29 2014-10-16 Benitec Biopharma Limited Pain treatment

Also Published As

Publication number Publication date
HK1218656A1 (en) 2017-03-03
EP2943571A1 (en) 2015-11-18
CN105143450A (en) 2015-12-09
KR20150103280A (en) 2015-09-09
MX2015008697A (en) 2016-08-04
JP2016507514A (en) 2016-03-10
US10000753B2 (en) 2018-06-19
EP2943571A4 (en) 2016-11-30
WO2014107763A1 (en) 2014-07-17
CA2897342A1 (en) 2014-07-17
US20180320180A1 (en) 2018-11-08
US20160145611A1 (en) 2016-05-26
IL239836A0 (en) 2015-08-31
RU2015133252A (en) 2017-02-10
AU2014205036A1 (en) 2015-07-30
SG10201705518SA (en) 2017-08-30

Similar Documents

Publication Publication Date Title
HK1218656A1 (en) Age-related macular degeneration treatment
IL266651A (en) Implant
HK1222994A1 (en) Tobacco treatment
HK1217490A1 (en) Novel traps in the treatment of macular degeneration
HK1217452A1 (en) Prostamide-containing intraocular implant
GB201308131D0 (en) Ophthalmoscope
EP2945639A4 (en) Methods for treating cardiac conditions
HK1215164A1 (en) Treatment methods
HK1214093A1 (en) Tobacco treatment
SG10201708547YA (en) Compositions and methods for treating and preventing macular degeneration
GB201304872D0 (en) Treatment
GB201308244D0 (en) Soil treatment
GB201616158D0 (en) Age-related macular degeneration
HK1216391A1 (en) Combination treatment
PL2826522T3 (en) Pacemaker
GB201307310D0 (en) Treatment
PT2777699T (en) Diethylamine-2,5-dihydroxybenzenesulfonate for the treatment of age-related macular degeneration
GB2514124B (en) Turf Treatment
GB201321115D0 (en) Treatment
GB201309238D0 (en) Treatment
IL230230A0 (en) Implant
GB201322764D0 (en) Treating places
GB201310756D0 (en) Implant