JP2014507141A5 - - Google Patents

Download PDF

Info

Publication number
JP2014507141A5
JP2014507141A5 JP2013553423A JP2013553423A JP2014507141A5 JP 2014507141 A5 JP2014507141 A5 JP 2014507141A5 JP 2013553423 A JP2013553423 A JP 2013553423A JP 2013553423 A JP2013553423 A JP 2013553423A JP 2014507141 A5 JP2014507141 A5 JP 2014507141A5
Authority
JP
Japan
Prior art keywords
dna
chromosome
primer
sample
base pairs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013553423A
Other languages
English (en)
Japanese (ja)
Other versions
JP6153874B2 (ja
JP2014507141A (ja
Filing date
Publication date
Priority claimed from US13/110,685 external-priority patent/US8825412B2/en
Application filed filed Critical
Priority claimed from US13/300,235 external-priority patent/US10017812B2/en
Publication of JP2014507141A publication Critical patent/JP2014507141A/ja
Publication of JP2014507141A5 publication Critical patent/JP2014507141A5/ja
Application granted granted Critical
Publication of JP6153874B2 publication Critical patent/JP6153874B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013553423A 2011-02-09 2011-11-18 非侵襲的出生前倍数性呼び出しのための方法 Active JP6153874B2 (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201161462972P 2011-02-09 2011-02-09
US61/462,972 2011-02-09
US201161448547P 2011-03-02 2011-03-02
US61/448,547 2011-03-02
US201161516996P 2011-04-12 2011-04-12
US61/516,996 2011-04-12
US13/110,685 2011-05-18
US13/110,685 US8825412B2 (en) 2010-05-18 2011-05-18 Methods for non-invasive prenatal ploidy calling
US201161571248P 2011-06-23 2011-06-23
US61/571,248 2011-06-23
US201161542508P 2011-10-03 2011-10-03
US61/542,508 2011-10-03
US13/300,235 US10017812B2 (en) 2010-05-18 2011-11-18 Methods for non-invasive prenatal ploidy calling
PCT/US2011/061506 WO2012108920A1 (en) 2011-02-09 2011-11-18 Methods for non-invasive prenatal ploidy calling
US13/300,235 2011-11-18

Publications (3)

Publication Number Publication Date
JP2014507141A JP2014507141A (ja) 2014-03-27
JP2014507141A5 true JP2014507141A5 (OSRAM) 2015-01-15
JP6153874B2 JP6153874B2 (ja) 2017-06-28

Family

ID=46638881

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013553423A Active JP6153874B2 (ja) 2011-02-09 2011-11-18 非侵襲的出生前倍数性呼び出しのための方法

Country Status (10)

Country Link
US (16) US10017812B2 (OSRAM)
EP (1) EP2673729B1 (OSRAM)
JP (1) JP6153874B2 (OSRAM)
CN (1) CN103608818B (OSRAM)
AU (1) AU2011358564B9 (OSRAM)
BR (1) BR112013020220B1 (OSRAM)
CA (1) CA2824387C (OSRAM)
IL (1) IL227842A0 (OSRAM)
RU (1) RU2671980C2 (OSRAM)
WO (1) WO2012108920A1 (OSRAM)

Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US8532930B2 (en) * 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US8515679B2 (en) * 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US20070027636A1 (en) * 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
WO2009105531A1 (en) * 2008-02-19 2009-08-27 Gene Security Network, Inc. Methods for cell genotyping
US20110092763A1 (en) * 2008-05-27 2011-04-21 Gene Security Network, Inc. Methods for Embryo Characterization and Comparison
US20110178719A1 (en) * 2008-08-04 2011-07-21 Gene Security Network, Inc. Methods for Allele Calling and Ploidy Calling
AU2010242073C1 (en) 2009-04-30 2015-12-24 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA2786565C (en) 2010-01-19 2017-04-25 Verinata Health, Inc. Partition defined detection methods
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
EP2513341B1 (en) 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
EP2848704B1 (en) 2010-01-19 2018-08-29 Verinata Health, Inc Sequencing methods for prenatal diagnoses
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
EP2670863B1 (en) 2011-01-31 2018-06-27 H. Hoffnabb-La Roche Ag Methods of identifying multiple epitopes in cells
US11560585B2 (en) 2011-01-31 2023-01-24 Roche Sequencing Solutions, Inc. Methods of identifying multiple epitopes in cells
CA2824387C (en) 2011-02-09 2019-09-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA3252077A1 (en) 2011-02-24 2025-03-20 The Chinese University Of Hong Kong Molecular testing of multiple pregnancies
RS57837B1 (sr) 2011-04-12 2018-12-31 Verinata Health Inc Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9228233B2 (en) 2011-10-17 2016-01-05 Good Start Genetics, Inc. Analysis methods
GB2497838A (en) 2011-10-19 2013-06-26 Nugen Technologies Inc Compositions and methods for directional nucleic acid amplification and sequencing
AU2013209499B2 (en) 2012-01-20 2018-05-10 Sequenom, Inc. Diagnostic processes that factor experimental conditions
CA2862552A1 (en) * 2012-01-26 2013-08-01 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
CA3209140A1 (en) 2012-04-19 2013-10-24 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
KR101705959B1 (ko) * 2012-05-23 2017-02-10 비지아이 다이어그노시스 씨오., 엘티디. 쌍둥이의 타입을 확인하는 방법과 시스템
US9193992B2 (en) * 2012-06-05 2015-11-24 Agilent Technologies, Inc. Method for determining ploidy of a cell
JP6181751B2 (ja) 2012-06-18 2017-08-16 ニューゲン テクノロジーズ， インコーポレイテッド 望まれない核酸配列のネガティブ選択のための組成物および方法
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
JP6392222B2 (ja) 2012-07-24 2018-09-19 ナテラ， インコーポレイテッド 高度多重ｐｃｒ法および組成物
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP4036247B1 (en) 2012-09-04 2024-04-10 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014093330A1 (en) 2012-12-10 2014-06-19 Clearfork Bioscience, Inc. Methods for targeted genomic analysis
CN105190656B (zh) * 2013-01-17 2018-01-16 佩索纳里斯公司 用于遗传分析的方法和系统
US20140242581A1 (en) * 2013-01-23 2014-08-28 Reproductive Genetics And Technology Solutions, Llc Compositions and methods for genetic analysis of embryos
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10844424B2 (en) 2013-02-20 2020-11-24 Bionano Genomics, Inc. Reduction of bias in genomic coverage measurements
CN105229168B (zh) 2013-02-20 2020-07-17 生物纳米基因有限公司 纳米流体中分子的表征
US9235808B2 (en) 2013-03-14 2016-01-12 International Business Machines Corporation Evaluation of predictions in the absence of a known ground truth
EP2971159B1 (en) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Methods for analyzing nucleic acids
US20140274738A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
WO2014143989A1 (en) * 2013-03-15 2014-09-18 Medical College Of Wisconsin, Inc. Fetal well being surveillance using fetal specific cell free dna
LT2981921T (lt) 2013-04-03 2023-02-27 Sequenom, Inc. Neinvazinio genetinių variacijų vertinimo būdai ir procesai
WO2014190286A2 (en) 2013-05-24 2014-11-27 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140371078A1 (en) * 2013-06-17 2014-12-18 Verinata Health, Inc. Method for determining copy number variations in sex chromosomes
KR102784584B1 (ko) 2013-06-21 2025-03-19 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
WO2015026967A1 (en) * 2013-08-20 2015-02-26 Natera, Inc. Methods of using low fetal fraction detection
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10964409B2 (en) 2013-10-04 2021-03-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN111863131A (zh) 2013-10-07 2020-10-30 塞昆纳姆股份有限公司 用于非侵入性评估染色体改变的方法和过程
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
EP3068883B1 (en) 2013-11-13 2020-04-29 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
SG10201804519RA (en) 2013-12-28 2018-07-30 Guardant Health Inc Methods and systems for detecting genetic variants
CN104745679B (zh) * 2013-12-31 2018-06-15 杭州贝瑞和康基因诊断技术有限公司 一种无创检测egfr基因突变的方法及试剂盒
CN106661612A (zh) 2014-01-27 2017-05-10 通用医疗公司 制备用于测序的核酸的方法
CN106164295B (zh) 2014-02-25 2020-08-11 生物纳米基因公司 减小基因组覆盖测量中的偏差
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
CN103901217A (zh) * 2014-03-21 2014-07-02 靖江市人民医院 大豆过氧化物酶免疫生物芯片及在唐氏综合症产前筛查血清学标志物检测中的应用
EP3957749A1 (en) 2014-04-21 2022-02-23 Natera, Inc. Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US10301671B2 (en) * 2014-05-06 2019-05-28 Baylor College Of Medicine Methods of linearly amplifying whole genome of a single cell
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US20160145684A1 (en) * 2014-06-27 2016-05-26 Genotox Laboratories Methods of detecting synthetic urine and matching a urine sample to a subject
CN104156631B (zh) * 2014-07-14 2017-07-18 天津华大基因科技有限公司 染色体三倍体检验方法
EP3656875B1 (en) 2014-07-18 2021-09-22 Illumina, Inc. Non-invasive prenatal diagnosis
EP3175000B1 (en) 2014-07-30 2020-07-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6793112B2 (ja) * 2014-08-01 2020-12-02 アリオサ ダイアグノスティックス インコーポレイテッドＡｒｉｏｓａ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． 胎児コピー数変異の統計的尤度を提供するアッセイ方法および胎児染色体異数性の尤度決定のためのアッセイ方法
WO2016025818A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
US20160053301A1 (en) * 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
WO2016038929A1 (ja) * 2014-09-11 2016-03-17 富士フイルム株式会社 胎児染色体の異数性の有無を検出する方法
WO2016042830A1 (ja) * 2014-09-16 2016-03-24 富士フイルム株式会社 胎児染色体の解析方法
JP6802154B2 (ja) * 2014-09-18 2020-12-16 イラミーナ インコーポレーテッド 核酸シーケンシングデータを解析するための方法およびシステム
US10612080B2 (en) 2014-09-22 2020-04-07 Roche Molecular Systems, Inc. Digital PCR for non-invasive prenatal testing
EP3224595A4 (en) 2014-09-24 2018-06-13 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
JP2016067268A (ja) * 2014-09-29 2016-05-09 富士フイルム株式会社 胎児の染色体異数性の非侵襲的判別方法
CA3002133A1 (en) * 2014-10-17 2016-04-21 Good Start Genetics, Inc. Pre-implantation genetic screening and aneuploidy detection
JP6280657B2 (ja) * 2014-10-30 2018-02-14 株式会社東芝 遺伝子型推定装置、方法、及びプログラム
WO2016070131A1 (en) 2014-10-30 2016-05-06 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
CN107110849B (zh) * 2014-12-19 2019-07-26 豪夫迈·罗氏有限公司 在选定的细胞亚群中鉴别多个表位的方法
WO2016112073A1 (en) 2015-01-06 2016-07-14 Good Start Genetics, Inc. Screening for structural variants
GB201502447D0 (en) 2015-02-13 2015-04-01 Univ Liverpool Method and apparatus for sample analysis
EP3279339B1 (en) 2015-03-31 2020-08-26 FUJIFILM Corporation Method for determining gene state of fetus
CN106148323B (zh) * 2015-04-22 2021-03-05 北京贝瑞和康生物技术有限公司 一种用于构建alk基因融合突变检测文库的方法和试剂盒
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
CN108431233B (zh) 2015-11-11 2022-04-01 分析生物科学有限公司 Dna文库的高效率构建
CN117174167A (zh) 2015-12-17 2023-12-05 夸登特健康公司 通过分析无细胞dna确定肿瘤基因拷贝数的方法
AU2017218149B2 (en) * 2016-02-12 2020-09-03 Regeneron Pharmaceuticals, Inc. Methods and systems for detection of abnormal karyotypes
JP7280044B2 (ja) 2016-04-15 2023-05-23 ナテラ， インコーポレイテッド 肺癌の検出方法
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
AU2017290809A1 (en) * 2016-07-01 2018-12-13 Natera, Inc. Compositions and methods for detection of nucleic acid mutations
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
AU2017315769B2 (en) 2016-08-25 2024-02-01 Resolution Bioscience, Inc. Methods for the detection of genomic copy changes in DNA samples
US11854666B2 (en) 2016-09-29 2023-12-26 Myriad Women's Health, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
CN109790570B (zh) * 2016-09-30 2023-09-15 富士胶片株式会社 获取来源于脊椎动物的单细胞的碱基序列信息的方法
WO2018064629A1 (en) * 2016-09-30 2018-04-05 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10451544B2 (en) 2016-10-11 2019-10-22 Genotox Laboratories Methods of characterizing a urine sample
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
IL319365A (en) 2017-01-24 2025-05-01 Sequenom Inc Methods and processes for assessing genetic variations
CN110520045A (zh) * 2017-02-03 2019-11-29 斯特里克公司 带防腐剂的采样管
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
PT3596233T (pt) 2017-03-17 2022-08-22 Sequenom Inc Métodos e processos para avaliação de mosaicismo genético
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
RU2657769C1 (ru) * 2017-05-31 2018-06-15 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова" Министерства здравоохранения Российской Федерации Способ прогнозирования наличия хромосомных аномалий в эмбрионах удовлетворительного и плохого качества на основании оценки транскрипционного профиля в кумулюсных клетках в программе экстракорпорального оплодотворения
CN110945136A (zh) 2017-06-20 2020-03-31 威斯康星州立大学医学院 使用总无细胞dna评估移植并发症风险
PL3649258T3 (pl) * 2017-07-07 2022-10-03 Nipd Genetics Public Company Limited Multipleksowa analiza równoległa ze wzbogaceniem sekwencji docelowych do oznaczania próbek dna płodowego
EP3655954A1 (en) * 2017-07-18 2020-05-27 Congenica Ltd. Screening system and method
HRP20210826T1 (hr) * 2017-07-26 2021-07-09 Trisomytest, S.R.O. Postupak neinvazivnog prenatalnog otkrivanja fetalnog kromosoma aneuploidija iz majčine krvi na temelju bayes mreže
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
JP2021500883A (ja) 2017-10-27 2021-01-14 ジュノ ダイアグノスティックス，インク． 超微量リキッドバイオプシーのためのデバイス、システム、および方法
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
CA3095030A1 (en) 2018-03-30 2019-10-03 Juno Diagnostics, Inc. Deep learning-based methods, devices, and systems for prenatal testing
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020010255A1 (en) 2018-07-03 2020-01-09 Natera, Inc. Methods for detection of donor-derived cell-free dna
CN109493919B (zh) * 2018-10-31 2023-04-14 中国石油大学(华东) 基于条件概率的基因型指派方法
EP3891301A4 (en) * 2018-12-05 2022-11-23 William Marsh Rice University QUANTIFICATION OF FOREIGN DNA IN LOW-VOLUME BLOOD SAMPLES USING SNP PROFILING
US20220056534A1 (en) 2018-12-17 2022-02-24 Natera, Inc. Methods for analysis of circulating cells
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
WO2020214547A1 (en) 2019-04-15 2020-10-22 Natera, Inc. Improved liquid biopsy using size selection
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
CA3143759A1 (en) * 2019-06-21 2020-12-24 Coopersurgical, Inc. Systems and methods for determining genome ploidy
AU2020296108B2 (en) 2019-06-21 2023-08-03 Coopersurgical, Inc. Systems and methods for determining pattern of inheritance in embryos
CN114945987A (zh) 2019-11-05 2022-08-26 佩索纳里斯公司 从单一样品预估肿瘤纯度
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
US12305242B2 (en) 2020-04-24 2025-05-20 The Johns Hopkins University Methods and related aspects for quantitative polymerase chain reaction to determine fractional abundance
CA3180334A1 (en) 2020-05-29 2021-12-02 Natera, Inc. Methods for detection of donor-derived cell-free dna
EP4165184A4 (en) * 2020-06-10 2024-09-04 Bonadea Diagnostics, LLC SEQUENCE CONVERSION REACTION
CN111951890B (zh) * 2020-08-13 2022-03-22 北京博昊云天科技有限公司 染色体和单基因病同步产前筛查的设备、试剂盒和分析系统
EP4225912A1 (en) * 2020-10-05 2023-08-16 Twist Bioscience Corporation Hybridization methods and reagents
CN116157869A (zh) * 2020-12-02 2023-05-23 伊鲁米纳软件公司 用于检测遗传改变的系统和方法
BR112023016896A2 (pt) 2021-02-25 2023-11-21 Natera Inc Métodos para detecção de dna livre de células derivadas de doador em receptores de transplantes de múltiplos órgãos
JP2024511980A (ja) 2021-03-18 2024-03-18 ナテラ， インコーポレイテッド 移植拒絶反応の判定方法
CN117597456A (zh) 2021-04-22 2024-02-23 纳特拉公司 用于确定肿瘤生长的速度的方法
JP2024528932A (ja) 2021-08-02 2024-08-01 ナテラ， インコーポレイテッド 妊娠中の女性における新生物を検出するための方法
CN118613594A (zh) 2021-09-01 2024-09-06 纳特拉公司 用于非侵入性产前测试的方法
WO2023059654A1 (en) 2021-10-05 2023-04-13 Personalis, Inc. Customized assays for personalized cancer monitoring
WO2023129936A1 (en) * 2021-12-29 2023-07-06 AiOnco, Inc. System and method for text-based biological information processing with analysis refinement
JP2025502843A (ja) 2022-01-04 2025-01-28 ナテラ， インコーポレイテッド がん検出及びモニタリングのための方法
EP4540410A2 (en) 2022-06-15 2025-04-23 Natera, Inc. Methods for determination and monitoring of transplant rejection by measuring rna
AU2023300533A1 (en) 2022-06-29 2025-01-16 Natera, Inc. Compositions and methods for identification of chromosomal microdeletions
JP2025533814A (ja) 2022-10-06 2025-10-09 ナテラ， インコーポレイテッド 妊娠中の移植レシピエントにおける移植拒絶反応を評価する非侵襲的方法
WO2024076484A1 (en) 2022-10-06 2024-04-11 Natera, Inc. Methods for determination and monitoring of xenotransplant rejection by measuring nucleic acids or proteins derived from the xenotransplant
EP4599086A1 (en) 2022-10-06 2025-08-13 Natera, Inc. Nucleic acid analysis of perfusion or flush fluids
CN116240274A (zh) * 2022-11-10 2023-06-09 武汉蓝沙医学检验实验室有限公司 无需父本对妊娠胎儿进行亲子鉴定的方法
AU2024218990A1 (en) 2023-02-07 2025-08-21 Natera, Inc. Method for identifying kidney allograft rejection genes in urine and utility of making those measurements
CN117965744B (zh) * 2023-12-12 2024-10-11 东莞博奥木华基因科技有限公司 一种基于多重pcr捕获技术检测胎儿样本倍性和母源细胞污染的试剂盒、引物和方法

Family Cites Families (626)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957654A (en) 1974-02-27 1976-05-18 Becton, Dickinson And Company Plasma separator with barrier to eject sealant
US4040785A (en) 1976-10-18 1977-08-09 Technicon Instruments Corporation Lysable blood preservative composition
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4935342A (en) 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
WO1989004838A1 (en) 1987-11-25 1989-06-01 Immunex Corporation Interleukin-1 receptors
US5319071A (en) 1987-11-25 1994-06-07 Immunex Corporation Soluble interleukin-1 receptors
IE61148B1 (en) 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
US5153117A (en) 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US5350683A (en) 1990-06-05 1994-09-27 Immunex Corporation DNA encoding type II interleukin-1 receptors
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5645988A (en) 1991-05-08 1997-07-08 The United States Of America As Represented By The Department Of Health And Human Services Methods of identifying drugs with selective effects against cancer cells
US5262329A (en) 1991-06-13 1993-11-16 Carver Jr Edward L Method for improved multiple species blood analysis
ES2091976T3 (es) 1991-06-20 1996-11-16 Hoffmann La Roche Metodos perfeccionados para la amplificacion del acido nucleico.
US5569582A (en) 1991-07-15 1996-10-29 Institute Of Molecular Biology & Technology Rapid amplification and detection of nucleic acids
IL103935A0 (en) 1991-12-04 1993-05-13 Du Pont Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification
US5856097A (en) 1992-03-04 1999-01-05 The Regents Of The University Of California Comparative genomic hybridization (CGH)
GB9305984D0 (en) 1993-03-23 1993-05-12 Royal Free Hosp School Med Predictive assay
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
NZ271318A (en) 1993-07-05 1998-08-26 North Gen Hospital Nhs Trust Leukocyte cell preparations stabilised with heavy metal compounds
WO1995006137A1 (en) 1993-08-27 1995-03-02 Australian Red Cross Society Detection of genes
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5716776A (en) 1994-03-04 1998-02-10 Mark H. Bogart Enrichment by preferential mitosis of fetal lymphocytes from a maternal blood sample
US5891734A (en) 1994-08-01 1999-04-06 Abbott Laboratories Method for performing automated analysis
US6025128A (en) 1994-09-29 2000-02-15 The University Of Tulsa Prediction of prostate cancer progression by analysis of selected predictive parameters
US6479235B1 (en) 1994-09-30 2002-11-12 Promega Corporation Multiplex amplification of short tandem repeat loci
PE64396A1 (es) 1995-01-23 1997-01-28 Hoffmann La Roche Proteina accesoria del receptor de la interleucina 1
US5648220A (en) 1995-02-14 1997-07-15 New England Medical Center Hospitals, Inc. Methods for labeling intracytoplasmic molecules
DE69620596T2 (de) 1995-05-19 2002-11-21 Abbott Laboratories, Abbott Park Nachweis von nukleinsäuren mit breitem dynamikbereich unter verwendung von aggregat-primer-reihen
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5736033A (en) 1995-12-13 1998-04-07 Coleman; Charles M. Separator float for blood collection tubes with water swellable material
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
AU2324997A (en) 1996-03-15 1997-10-01 Penn State Research Foundation, The Detection of extracellular tumor-associated nucleic acid in blood plasma or ser um using nucleic acid amplification assays
ES2347854T5 (es) 1996-03-26 2014-07-24 Michael S. Kopreski Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer
US6108635A (en) 1996-05-22 2000-08-22 Interleukin Genetics, Inc. Integrated disease information system
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5860917A (en) 1997-01-15 1999-01-19 Chiron Corporation Method and apparatus for predicting therapeutic outcomes
US5824467A (en) 1997-02-25 1998-10-20 Celtrix Pharmaceuticals Methods for predicting drug response
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20010051341A1 (en) 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
ATE280177T1 (de) 1997-03-20 2004-11-15 Hoffmann La Roche Modifizierte primer
ATE364718T1 (de) 1997-04-01 2007-07-15 Solexa Ltd Verfahren zur vervielfältigung von nukleinsäure
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US20020119478A1 (en) 1997-05-30 2002-08-29 Diagen Corporation Methods for detection of nucleic acid sequences in urine
US5994148A (en) 1997-06-23 1999-11-30 The Regents Of University Of California Method of predicting and enhancing success of IVF/ET pregnancy
US6013444A (en) * 1997-09-18 2000-01-11 Oligotrail, Llc DNA bracketing locus compatible standards for electrophoresis
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6124120A (en) 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
ATE301195T1 (de) 1998-01-23 2005-08-15 Immunex Corp Acpl dna und polypeptide
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6406671B1 (en) 1998-12-05 2002-06-18 Becton, Dickinson And Company Device and method for separating components of a fluid sample
ATE347616T1 (de) 1999-04-30 2006-12-15 Cyclops Genome Sciences Ltd Ribonukleinsäurederivate
US6180349B1 (en) 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number
US7058517B1 (en) 1999-06-25 2006-06-06 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
US6964847B1 (en) 1999-07-14 2005-11-15 Packard Biosciences Company Derivative nucleic acids and uses thereof
GB9917307D0 (en) 1999-07-23 1999-09-22 Sec Dep Of The Home Department Improvements in and relating to analysis of DNA
NZ531466A (en) 1999-07-23 2005-06-24 Sec Dep Home Dept Use of single nucleotide polymorphisms (SNPs) to identify individuals in forensic investigations
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6251604B1 (en) 1999-08-13 2001-06-26 Genopsys, Inc. Random mutagenesis and amplification of nucleic acid
WO2001034844A1 (en) 1999-11-10 2001-05-17 Ligochem, Inc. Method for isolating dna from a proteinaceous medium and kit for performing method
US20030148301A1 (en) 1999-12-10 2003-08-07 Toshiya Aono Method of detecting nucleotide polymorphism
US6221603B1 (en) 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
EP1990428B1 (en) 2000-02-07 2010-12-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7510834B2 (en) 2000-04-13 2009-03-31 Hidetoshi Inoko Gene mapping method using microsatellite genetic polymorphism markers
GB0009179D0 (en) 2000-04-13 2000-05-31 Imp College Innovations Ltd Non-invasive prenatal diagnosis
AU2001274869A1 (en) 2000-05-20 2001-12-03 The Regents Of The University Of Michigan Method of producing a dna library using positional amplification
JP2004511210A (ja) 2000-05-23 2004-04-15 バリアジェニックス　インコーポレーテッド 配列変動を検出する、ｄｎａを遺伝分析するための方法
US20030009295A1 (en) 2001-03-14 2003-01-09 Victor Markowitz System and method for retrieving and using gene expression data from multiple sources
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
US20020006622A1 (en) 2000-06-07 2002-01-17 Allan Bradley Novel compositions and methods for array-based nucleic acid hybridization
US7058616B1 (en) 2000-06-08 2006-06-06 Virco Bvba Method and system for predicting resistance of a disease to a therapeutic agent using a neural network
GB0016742D0 (en) 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
AU2002246612B2 (en) 2000-10-24 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
US20020107640A1 (en) 2000-11-14 2002-08-08 Ideker Trey E. Methods for determining the true signal of an analyte
EP1368369A4 (en) 2000-11-15 2006-02-22 Hoffmann La Roche METHODS AND REAGENTS FOR IDENTIFYING RARE EMBRYONIC CELLS IN THE MATERNAL CIRCULATORY SYSTEM
WO2002044411A1 (en) 2000-12-01 2002-06-06 Rosetta Inpharmatics, Inc. Use of profiling for detecting aneuploidy
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
US20020182622A1 (en) 2001-02-01 2002-12-05 Yusuke Nakamura Method for SNP (single nucleotide polymorphism) typing
JP2002300894A (ja) 2001-02-01 2002-10-15 Inst Of Physical & Chemical Res 一塩基多型タイピング方法
WO2002070751A1 (en) 2001-03-02 2002-09-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pcr method
JP4276843B2 (ja) 2001-03-23 2009-06-10 芳之 金井 モノヌクレオソーム及びその製造方法、ヌクレオソームに特異的な抗体の測定方法、自己免疫病診断方法、ヌクレオソームｄｎａ製造方法、ｄｎａプレート、ｄｎａプレート製造方法、並びに抗ｄｎａ抗体測定法
US6489135B1 (en) 2001-04-17 2002-12-03 Atairgintechnologies, Inc. Determination of biological characteristics of embryos fertilized in vitro by assaying for bioactive lipids in culture media
FR2824144B1 (fr) 2001-04-30 2004-09-17 Metagenex S A R L Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
WO2002087431A1 (en) 2001-05-01 2002-11-07 Structural Bioinformatics, Inc. Diagnosing inapparent diseases from common clinical tests using bayesian analysis
AU2002305436A1 (en) 2001-05-09 2002-11-18 Virginia Commonwealth University Multiple sequencible and ligatible structures for genomic analysis
US20040126760A1 (en) 2001-05-17 2004-07-01 Natalia Broude Novel compositions and methods for carrying out multple pcr reactions on a single sample
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
IL159482A0 (en) 2001-06-22 2004-06-01 Univ Geneve Method for detecting diseases caused by chromosomal imbalances
WO2003010537A1 (en) 2001-07-24 2003-02-06 Curagen Corporation Family based tests of association using pooled dna and snp markers
ATE502119T1 (de) 2001-07-25 2011-04-15 Oncomedx Inc Verfahren zur bewertung pathologischer krankheitszustände unter verwendung extrazellulärer rna
US7297778B2 (en) 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
WO2003019141A2 (en) 2001-08-23 2003-03-06 Immunivest Corporation Analysis of circulating tumor cells, fragments, and debris
US6807491B2 (en) 2001-08-30 2004-10-19 Hewlett-Packard Development Company, L.P. Method and apparatus for combining gene predictions using bayesian networks
US6927028B2 (en) 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
AUPR749901A0 (en) 2001-09-06 2001-09-27 Monash University Method of identifying chromosomal abnormalities and prenatal diagnosis
US7153656B2 (en) 2001-09-11 2006-12-26 Los Alamos National Security, Llc Nucleic acid sequence detection using multiplexed oligonucleotide PCR
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US20040014067A1 (en) 2001-10-12 2004-01-22 Third Wave Technologies, Inc. Amplification methods and compositions
WO2003031646A1 (en) 2001-10-12 2003-04-17 The University Of Queensland Multiple genetic marker selection and amplification
US7297485B2 (en) 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US6617137B2 (en) 2001-10-15 2003-09-09 Molecular Staging Inc. Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
JP4229237B2 (ja) 2001-12-11 2009-02-25 株式会社ネーテック 血液細胞分離システム
US7198897B2 (en) 2001-12-19 2007-04-03 Brandeis University Late-PCR
ATE340871T1 (de) 2001-12-24 2006-10-15 Wolfgang Prof Holzgreve Verfahren zur nicht-invasiven diagnose von transplantationen und transfusionen
US20040115629A1 (en) 2002-01-09 2004-06-17 Panzer Scott R Molecules for diagnostics and therapeutics
US20030211522A1 (en) 2002-01-18 2003-11-13 Landes Gregory M. Methods for fetal DNA detection and allele quantitation
CA2474982A1 (en) 2002-02-01 2003-08-07 Rosetta Inpharmatics Llc Computer systems and methods for identifying genes and determining pathways associated with traits
US7736892B2 (en) 2002-02-25 2010-06-15 Kansas State University Research Foundation Cultures, products and methods using umbilical cord matrix cells
CA2477611A1 (en) 2002-03-01 2003-09-12 Ravgen, Inc. Rapid analysis of variations in a genome
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20060229823A1 (en) 2002-03-28 2006-10-12 Affymetrix, Inc. Methods and computer software products for analyzing genotyping data
US7211191B2 (en) 2004-09-30 2007-05-01 Thermogenesis Corp. Blood component separation method and apparatus
US7241281B2 (en) 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
US20040096874A1 (en) 2002-04-11 2004-05-20 Third Wave Technologies, Inc. Characterization of CYP 2D6 genotypes
US20030235848A1 (en) 2002-04-11 2003-12-25 Matt Neville Characterization of CYP 2D6 alleles
CA2484360A1 (en) 2002-05-02 2003-11-13 The University Of North Carolina At Chapel Hill In vitro mutagenesis, phenotyping, and gene mapping
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US20040009518A1 (en) 2002-05-14 2004-01-15 The Chinese University Of Hong Kong Methods for evaluating a disease condition by nucleic acid detection and fractionation
US20040229231A1 (en) 2002-05-28 2004-11-18 Frudakis Tony N. Compositions and methods for inferring ancestry
AU2003229397B2 (en) 2002-05-31 2009-04-23 Genetic Technologies Limited Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood
WO2003106623A2 (en) 2002-06-13 2003-12-24 New York University Early noninvasive prenatal test for aneuploidies and heritable conditions
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US7097976B2 (en) 2002-06-17 2006-08-29 Affymetrix, Inc. Methods of analysis of allelic imbalance
US20050009069A1 (en) 2002-06-25 2005-01-13 Affymetrix, Inc. Computer software products for analyzing genotyping
EP1573037A4 (en) 2002-06-28 2007-05-09 Orchid Cellmark Inc METHODS AND COMPOSITIONS FOR ANALYZING WEAKENED SAMPLES USING UNIQUE NUCLEOTIDE POLYMORPHISMS PANELS
EP1388812A1 (en) 2002-07-04 2004-02-11 Ronald E. Dr. Kates Method for training a learning-capable system
JP4116856B2 (ja) 2002-10-02 2008-07-09 富士フイルム株式会社 １塩基多型の検出方法
US7459273B2 (en) 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
AU2003285861A1 (en) 2002-10-07 2004-05-04 University Of Medicine And Dentistry Of New Jersey High throughput multiplex dna sequence amplifications
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
WO2004044225A2 (en) 2002-11-11 2004-05-27 Affymetrix, Inc. Methods for identifying dna copy number changes
EP3000899A1 (en) 2002-12-04 2016-03-30 Applied Biosystems, LLC Multiplex amplification of polynucleotides
EP1583904B1 (de) 2003-01-02 2013-10-02 Wobben Properties GmbH Windturbinenrotorblatt mit verringerter schallemission
WO2004065617A2 (en) 2003-01-17 2004-08-05 The Trustees Of Boston University Haplotype analysis
WO2004065628A1 (en) 2003-01-21 2004-08-05 Guoliang Fu Quantitative multiplex detection of nucleic acids
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
EP1594950A4 (en) 2003-01-29 2007-07-25 454 Corp PRODUCT FOR THE PREPARATION OF SIMPLE STRANDED DNA BANKS
EP1599608A4 (en) 2003-03-05 2007-07-18 Genetic Technologies Ltd Identification of fetal DNA and fetal cell marker in maternal plasma or serum
US20040209299A1 (en) 2003-03-07 2004-10-21 Rubicon Genomics, Inc. In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA
US20040197832A1 (en) 2003-04-03 2004-10-07 Mor Research Applications Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
EP1627075A4 (en) 2003-05-09 2006-09-20 Univ Tsinghua METHODS AND PREPARATIONS FOR OPTIMIZING MULTIPLEX PCR STARTERS
CA2525956A1 (en) 2003-05-28 2005-01-06 Pioneer Hi-Bred International, Inc. Plant breeding method
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
EP1660680B1 (en) 2003-07-31 2009-03-11 Sequenom, Inc. Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
AU2003263660A1 (en) 2003-08-29 2005-03-16 Pantarhei Bioscience B.V. Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood
EP2354253A3 (en) 2003-09-05 2011-11-16 Trustees of Boston University Method for non-invasive prenatal diagnosis
US20050053950A1 (en) 2003-09-08 2005-03-10 Enrique Zudaire Ubani Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons
ATE415495T1 (de) * 2003-09-22 2008-12-15 Trisogen Biotechnology Ltd Par Zum nachweis einer änderung einer locus- kopienzahl geeignete verfahren
WO2005028645A1 (ja) 2003-09-24 2005-03-31 Kyushu Tlo Company, Limited ＭＤＲ１遺伝子の５’制御領域におけるＳＮＰｓ
WO2005030999A1 (en) 2003-09-25 2005-04-07 Dana-Farber Cancer Institute, Inc Methods to detect lineage-specific cells
CA2541706C (en) 2003-10-08 2014-02-18 The Trustees Of Boston University Methods for prenatal diagnosis of chromosomal abnormalities
CA2482097C (en) 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
DE60328193D1 (de) 2003-10-16 2009-08-13 Sequenom Inc Nicht invasiver Nachweis fötaler genetischer Merkmale
US20050221341A1 (en) 2003-10-22 2005-10-06 Shimkets Richard A Sequence-based karyotyping
WO2005044086A2 (en) 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
US20050164252A1 (en) 2003-12-04 2005-07-28 Yeung Wah Hin A. Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell
EP1706488B1 (en) 2004-01-12 2013-07-24 Roche NimbleGen, Inc. Method of performing pcr amplification on a microarray
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US20100216151A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US7035740B2 (en) 2004-03-24 2006-04-25 Illumina, Inc. Artificial intelligence and global normalization methods for genotyping
JP4437050B2 (ja) 2004-03-26 2010-03-24 株式会社日立製作所 診断支援システム、診断支援方法および診断支援サービスの提供方法
US7805282B2 (en) * 2004-03-30 2010-09-28 New York University Process, software arrangement and computer-accessible medium for obtaining information associated with a haplotype
EP1732951B1 (en) 2004-03-31 2009-12-02 Adnagen AG Monoclonal antibodies with specificity for fetal erythroid cells
US7414118B1 (en) 2004-04-14 2008-08-19 Applied Biosystems Inc. Modified oligonucleotides and applications thereof
US7468249B2 (en) 2004-05-05 2008-12-23 Biocept, Inc. Detection of chromosomal disorders
WO2005121946A2 (en) 2004-06-02 2005-12-22 New England Biolabs, Inc. Inferring function from shotgun sequencing data
US7709194B2 (en) 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
EP1819734A2 (en) 2004-06-14 2007-08-22 The Board Of Trustees Of The University Of Illinois Antibodies binding to cd34+/cd36+ fetal but not to adult cells
EP1786924A4 (en) 2004-07-06 2008-10-01 Genera Biosystems Pty Ltd METHOD FOR DETECTING ANEUPLOIDIA
BRPI0513382A (pt) 2004-07-14 2008-05-06 Wyeth Corp composições e processos de purificação de glicoproteìna associada à mielina (mag)
DE102004036285A1 (de) 2004-07-27 2006-02-16 Advalytix Ag Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe
EP1784508B1 (en) 2004-08-09 2012-10-03 Generation Biotech, LLC Method for nucleic acid isolation and amplification
EP1789786A4 (en) 2004-08-18 2008-02-13 Abbott Molecular Inc DETERMINING DATA QUALITY AND / OR SEGMENTAL ANEUMS USING A COMPUTER SYSTEM
JP4810164B2 (ja) 2004-09-03 2011-11-09 富士フイルム株式会社 核酸分離精製方法
US8024128B2 (en) 2004-09-07 2011-09-20 Gene Security Network, Inc. System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data
US20060088574A1 (en) 2004-10-25 2006-04-27 Manning Paul B Nutritional supplements
US20060088870A1 (en) 2004-10-22 2006-04-27 Finkelstein Sydney D Topographic genotyping for determining the diagnosis, malignant potential, and biologic behavior of pancreatic cysts and related conditions
US20060134662A1 (en) 2004-10-25 2006-06-22 Pratt Mark R Method and system for genotyping samples in a normalized allelic space
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
WO2006055761A1 (en) 2004-11-17 2006-05-26 Mosaic Reproductive Health And Genetics, Llc Methods of determining human egg competency
US8389578B2 (en) 2004-11-24 2013-03-05 Adamas Pharmaceuticals, Inc Composition and method for treating neurological disease
US20070042384A1 (en) 2004-12-01 2007-02-22 Weiwei Li Method for isolating and modifying DNA from blood and body fluids
ES2311958T3 (es) * 2005-02-11 2009-02-16 Smartgene Gmbh Procedimiento y sistema informatico para validar datos de secuenciacion de adn.
WO2006091979A2 (en) 2005-02-25 2006-08-31 The Regents Of The University Of California Full karyotype single cell chromosome analysis
US20060234264A1 (en) 2005-03-14 2006-10-19 Affymetrix, Inc. Multiplex polynucleotide synthesis
US7618777B2 (en) 2005-03-16 2009-11-17 Agilent Technologies, Inc. Composition and method for array hybridization
US7645576B2 (en) 2005-03-18 2010-01-12 The Chinese University Of Hong Kong Method for the detection of chromosomal aneuploidies
CA2894337C (en) 2005-03-18 2018-08-28 The Chinese University Of Hong Kong Markers for prenatal diagnosis of trisomy 18
US8642264B2 (en) * 2005-03-24 2014-02-04 Zoragen Biotechnologies Llp Method of quantifying target and reference nucleic acid
JP2008538496A (ja) 2005-04-12 2008-10-30 ４５４ ライフ サイエンシーズ コーポレイション ウルトラディープ配列決定を用いて配列変異体を決定するための方法
US20060228721A1 (en) 2005-04-12 2006-10-12 Leamon John H Methods for determining sequence variants using ultra-deep sequencing
AU2006251937A1 (en) 2005-05-27 2006-11-30 John Wayne Cancer Institute Use of free circulating DNA for diagnosis, prognosis, and treatment of cancer
WO2007117256A1 (en) 2005-05-31 2007-10-18 Applera Corporation Multiplexed amplification of short nucleic acids
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
CA2615323A1 (en) 2005-06-06 2007-12-21 454 Life Sciences Corporation Paired end sequencing
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
WO2007011903A2 (en) 2005-07-15 2007-01-25 Applera Corporation Analyzing messenger rna and micro rna in the same reaction mixture
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
RU2290078C1 (ru) 2005-07-25 2006-12-27 Евгений Владимирович Новичков Способ прогнозирования рецидива серозного рака яичников
US8515679B2 (en) 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US20070027636A1 (en) 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US8532930B2 (en) * 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US20070178501A1 (en) 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
WO2007018601A1 (en) 2005-08-02 2007-02-15 Rubicon Genomics, Inc. Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction
WO2007030680A2 (en) 2005-09-07 2007-03-15 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as axl inhibitors
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0523276D0 (en) 2005-11-15 2005-12-21 London Bridge Fertility Chromosomal analysis by molecular karyotyping
JP6121642B2 (ja) 2005-11-26 2017-04-26 ナテラ， インコーポレイテッド 予測を行うための、遺伝子データを清浄化し、そして、そのデータを使用するためのシステムおよび方法
WO2007070280A2 (en) 2005-12-02 2007-06-21 The General Hospital Corporation Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility
WO2007070482A2 (en) 2005-12-14 2007-06-21 Xueliang Xia Microarray-based preimplantation genetic diagnosis of chromosomal abnormalities
DK1966394T3 (da) 2005-12-22 2012-10-29 Keygene Nv Forbedrede strategier til transkriptprofilering under anvendelse af high throughput-sekventeringsteknologier
SI2385143T1 (sl) 2006-02-02 2016-11-30 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Neinvazivni genetski presejalni test ploda z digitalno analizo
WO2007092538A2 (en) * 2006-02-07 2007-08-16 President And Fellows Of Harvard College Methods for making nucleotide probes for sequencing and synthesis
US9012184B2 (en) 2006-02-08 2015-04-21 Illumina Cambridge Limited End modification to prevent over-representation of fragments
ATE508209T1 (de) 2006-02-28 2011-05-15 Univ Louisville Res Found Erkennung von chromosomabnormalitäten im fötus mit hilfe der tandem-einzelnukleotid- polymorphismen
US8609338B2 (en) 2006-02-28 2013-12-17 University Of Louisville Research Foundation, Inc. Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
US20100184043A1 (en) 2006-02-28 2010-07-22 University Of Louisville Research Foundation Detecting Genetic Abnormalities
WO2007106523A2 (en) 2006-03-13 2007-09-20 Veridex, Llc Propagation of primary cells
US20070231823A1 (en) 2006-03-23 2007-10-04 Mckernan Kevin J Directed enrichment of genomic DNA for high-throughput sequencing
US20080038733A1 (en) 2006-03-28 2008-02-14 Baylor College Of Medicine Screening for down syndrome
JP2009072062A (ja) 2006-04-07 2009-04-09 Institute Of Physical & Chemical Research 核酸の５’末端を単離するための方法およびその適用
WO2007121276A2 (en) 2006-04-12 2007-10-25 Biocept, Inc. Enrichment of circulating fetal dna
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US7901884B2 (en) 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US8679741B2 (en) 2006-05-31 2014-03-25 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
US7981609B2 (en) 2006-06-09 2011-07-19 The Brigham And Women's Hospital, Inc. Methods for identifying and using SNP panels
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2061801A4 (en) 2006-06-14 2009-11-11 Living Microsystems Inc DIAGNOSIS OF FETAL ANOMALIES BY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS
EP2029778B1 (en) 2006-06-14 2018-05-02 Verinata Health, Inc Diagnosis of fetal abnormalities
CN101675169B (zh) 2006-06-14 2018-01-02 维里纳塔健康公司 使用样品拆分和dna标签进行稀有细胞分析
EP2366801B1 (en) 2006-06-14 2016-10-19 Verinata Health, Inc Methods for the diagnosis of fetal abnormalities
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
WO2008111990A1 (en) 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
EP2035540A2 (en) 2006-06-15 2009-03-18 Stratagene System for isolating biomolecules from a sample
WO2007147063A2 (en) 2006-06-16 2007-12-21 Sequenom, Inc. Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample
US20080182244A1 (en) 2006-08-04 2008-07-31 Ikonisys, Inc. Pre-Implantation Genetic Diagnosis Test
WO2008024827A2 (en) * 2006-08-22 2008-02-28 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Design and selection of genetic targets for sequence resolved organism detection and identification
EP2057282A4 (en) 2006-08-24 2010-10-27 Univ Massachusetts Medical MAPPING GENOMIC INTERACTIONS
WO2008143627A2 (en) 2006-09-14 2008-11-27 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
US20080085836A1 (en) 2006-09-22 2008-04-10 Kearns William G Method for genetic testing of human embryos for chromosome abnormalities, segregating genetic disorders with or without a known mutation and mitochondrial disorders following in vitro fertilization (IVF), embryo culture and embryo biopsy
EP2094838A1 (en) 2006-10-16 2009-09-02 Cellula, Inc. Methods and compositions for differential expansion of fetal cells in maternal blood and their use
WO2008051928A2 (en) 2006-10-23 2008-05-02 The Salk Institute For Biological Studies Target-oriented whole genome amplification of nucliec acids
KR100825367B1 (ko) 2006-11-07 2008-04-28 전남대학교산학협력단 표지자로서 미토콘드리아 유전자 과변이부위를 이용하는조혈모세포이식 후 생착능 평가방법 및 키트
US20110045462A1 (en) 2006-11-14 2011-02-24 The Regents Of The University Of California Digital analysis of gene expression
ATE527385T1 (de) 2006-11-16 2011-10-15 Genentech Inc Mit tumoren assoziierte genetische variationen
WO2008059578A1 (en) 2006-11-16 2008-05-22 Olympus Corporation Multiplex pcr method
WO2008079374A2 (en) 2006-12-21 2008-07-03 Wang Eric T Methods and compositions for selecting and using single nucleotide polymorphisms
WO2008081451A2 (en) 2007-01-03 2008-07-10 Monaliza Medical Ltd. Methods and kits for analyzing genetic material of a fetus
US20080164204A1 (en) 2007-01-08 2008-07-10 Mehdi Hatamian Valve for facilitating and maintaining separation of fluids and materials
PT2121977T (pt) 2007-01-11 2017-08-18 Erasmus Univ Medical Center Captura da conformação cromossómica circular (4c)
EP2121983A2 (en) 2007-02-02 2009-11-25 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
US20100129792A1 (en) 2007-02-06 2010-05-27 Gerassimos Makrigiorgos Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions
US8173370B2 (en) 2007-02-08 2012-05-08 Sequenom, Inc. Nucleic acid-based tests for RHD typing, gender determination and nucleic acid quantification
CN101790731B (zh) 2007-03-16 2013-11-06 纳特拉公司 用于清除遗传数据干扰并确定染色体拷贝数的系统和方法
US8617816B2 (en) 2007-03-16 2013-12-31 454 Life Sciences, A Roche Company System and method for detection of HIV drug resistant variants
US8652780B2 (en) 2007-03-26 2014-02-18 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
JP5262230B2 (ja) 2007-03-28 2013-08-14 独立行政法人理化学研究所 新規多型検出法
ITTO20070307A1 (it) 2007-05-04 2008-11-05 Silicon Biosystems Spa Metodo e dispositivo per la diagnosi prenatale non-invasiva
US20080293589A1 (en) 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
KR20100038330A (ko) 2007-05-31 2010-04-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 입체구조적 방해 및 효소 관련 신호 증폭 기반의 고 특이성 및 고 민감도 검출
WO2008151110A2 (en) 2007-06-01 2008-12-11 The University Of North Carolina At Chapel Hill Molecular diagnosis and typing of lung cancer variants
WO2008157264A2 (en) 2007-06-15 2008-12-24 Sequenom, Inc. Combined methods for the detection of chromosomal aneuploidy
US20100273159A1 (en) 2007-06-20 2010-10-28 Taag-Genetics S.A. Nested Multiplex Amplification Method for Identification of Multiple Biological Entities
US20090023190A1 (en) 2007-06-20 2009-01-22 Kai Qin Lao Sequence amplification with loopable primers
AU2008272421B2 (en) 2007-07-03 2014-09-04 Genaphora Ltd. Chimeric primers for improved nucleic acid amplification reactions
WO2009009769A2 (en) 2007-07-11 2009-01-15 Artemis Health, Inc. Diagnosis of fetal abnormalities using nucleated red blood cells
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
KR102222378B1 (ko) 2007-07-23 2021-03-04 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
KR101376359B1 (ko) 2007-08-01 2014-03-27 다나-파버 캔서 인스티튜트 인크. 표적 서열 강화
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
EP2191276B1 (en) 2007-08-03 2013-11-20 DKFZ Deutsches Krebsforschungszentrum Method for prenatal diagnosis using exosomes and cd24 as a marker
WO2009032779A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for the size-specific seperation of nucleic acid from a sample
ATE549419T1 (de) 2007-08-29 2012-03-15 Sequenom Inc Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
US8748100B2 (en) 2007-08-30 2014-06-10 The Chinese University Of Hong Kong Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
JP5707132B2 (ja) 2007-09-07 2015-04-22 フルイダイム コーポレイション コピー数変動の決定、方法およびシステム
US20090081678A1 (en) 2007-09-21 2009-03-26 Streck, Inc. Nucleic acid isolation in preserved whole blood
CA2697640C (en) 2007-09-21 2016-06-21 Katholieke Universiteit Leuven Tools and methods for genetic tests using next generation sequencing
US20100326218A1 (en) 2007-09-27 2010-12-30 Michael Boeckh Identifying a subject with an increased risk of invasive mold infection
ATE509123T1 (de) 2007-10-16 2011-05-15 Hoffmann La Roche Hochauflösende hochdurchsatz-hla-genotypisierung mittels klonaler sequenzierung
US20100086914A1 (en) 2008-10-03 2010-04-08 Roche Molecular Systems, Inc. High resolution, high throughput hla genotyping by clonal sequencing
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
WO2009064897A2 (en) 2007-11-14 2009-05-22 Chronix Biomedical Detection of nucleic acid sequence variations in circulating nucleic acid in bovine spongiform encephalopathy
WO2009064789A2 (en) 2007-11-15 2009-05-22 The Johns Hopkins University Methods for detecting and monitoring circulating cancer stem cells
AU2008329833B2 (en) 2007-11-30 2014-04-17 Global Life Sciences Solutions Usa Llc Method for isolation of genomic DNA, RNA and proteins from a single sample
US20100216145A1 (en) 2007-12-10 2010-08-26 Mor Research Application Ltd. Assay for Detecting Circulating Free Nucleic Acids
FR2925480B1 (fr) 2007-12-21 2011-07-01 Gervais Danone Sa Procede d'enrichissement d'une eau en oxygene par voie electrolytique, eau ou boisson enrichie en oxygene et utilisations
EP2077337A1 (en) 2007-12-26 2009-07-08 Eppendorf Array Technologies SA Amplification and detection composition, method and kit
WO2009092035A2 (en) 2008-01-17 2009-07-23 Sequenom, Inc. Methods and compositions for the analysis of biological molecules
EP3699291B1 (en) 2008-01-17 2024-08-07 Sequenom, Inc. Single molecule nucleic acid sequence analysis processes and compositions
ES2936256T3 (es) 2008-02-01 2023-03-15 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas
EP2245198A1 (en) 2008-02-04 2010-11-03 Massachusetts Institute of Technology Selection of nucleic acids by solution hybridization to oligonucleotide baits
WO2009105531A1 (en) 2008-02-19 2009-08-27 Gene Security Network, Inc. Methods for cell genotyping
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
US20090307180A1 (en) 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
WO2009145828A2 (en) 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
ES2586457T3 (es) 2008-04-03 2016-10-14 Cb Biotechnologies, Inc. Reacción en cadena de la polimerasa múltiple de rescate de amplicón para amplificación de dianas múltiples
US20110092763A1 (en) 2008-05-27 2011-04-21 Gene Security Network, Inc. Methods for Embryo Characterization and Comparison
EP2128169A1 (de) 2008-05-30 2009-12-02 Qiagen GmbH Verfahren zur Isolierung von kurzkettigen Nukleinsäuren
MX2011000794A (es) 2008-07-21 2011-02-24 Becton Dickinson Co Dispositivo de separacion de fase por densidad.
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US20110178719A1 (en) 2008-08-04 2011-07-21 Gene Security Network, Inc. Methods for Allele Calling and Ploidy Calling
CN102203287B (zh) 2008-08-26 2017-09-19 弗卢迪格姆公司 增加样本和/或靶通量的测定方法
DE102008045705A1 (de) 2008-09-04 2010-04-22 Macherey, Nagel Gmbh & Co. Kg Handelsgesellschaft Verfahren zur Gewinnung von kurzer RNA sowie Kit hierfür
US8586310B2 (en) 2008-09-05 2013-11-19 Washington University Method for multiplexed nucleic acid patch polymerase chain reaction
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP3770255A1 (en) 2008-09-16 2021-01-27 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2324131A4 (en) 2008-09-17 2013-02-27 Ge Healthcare Bio Sciences PROCESS FOR ISOLATING SMALL RNA
CA2737643C (en) 2008-09-20 2020-10-06 Hei-Mun Fan Noninvasive diagnosis of fetal aneuploidy by sequencing
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
WO2010042831A2 (en) 2008-10-10 2010-04-15 Swedish Health Services Diagnosis, prognosis and treatment of glioblastoma multiforme
WO2010045617A2 (en) 2008-10-17 2010-04-22 University Of Louisville Research Foundation Detecting genetic abnormalities
CN102272327B (zh) 2008-11-07 2015-11-25 赛昆塔公司 通过序列分析监测状况的方法
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
CN102325901A (zh) 2008-12-22 2012-01-18 赛卢拉有限公司 检测等位基因、基因组和转录物组的方法和基因型分析谱
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
WO2010088288A2 (en) 2009-01-28 2010-08-05 Fluidigm Corporation Determination of copy number differences by amplification
WO2010087985A2 (en) 2009-01-28 2010-08-05 Yale University Novel markers for detection of complications resulting from in utero encounters
DK3290530T3 (da) 2009-02-18 2020-12-07 Streck Inc Konservering af cellefrie nukleinsyrer
CN102428190B (zh) 2009-03-27 2014-02-26 生命技术公司 用于检测等位基因变体的方法、组合物和试剂盒
US20100285537A1 (en) 2009-04-02 2010-11-11 Fluidigm Corporation Selective tagging of short nucleic acid fragments and selective protection of target sequences from degradation
SG174617A1 (en) 2009-04-02 2011-10-28 Fluidigm Corp Multi-primer amplification method for barcoding of target nucleic acids
EP2414545B1 (en) 2009-04-03 2017-01-11 Sequenom, Inc. Nucleic acid preparation compositions and methods
WO2010118016A2 (en) 2009-04-06 2010-10-14 The Johns Hopkins University Digital quantification of dna methylation
US20120115140A1 (en) 2009-04-29 2012-05-10 Js Genetics Inc. Molecular Diagnosis of Fragile X Syndrome Associated with FMR1 Gene
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US8481699B2 (en) 2009-07-14 2013-07-09 Academia Sinica Multiplex barcoded Paired-End ditag (mbPED) library construction for ultra high throughput sequencing
WO2011015944A2 (en) 2009-08-06 2011-02-10 Cedars-Sinai Medical Center Use of free dna as an early predictor of severity in acute pancreatitis
US8563242B2 (en) 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
CN101643904B (zh) 2009-08-27 2011-04-27 北京北方微电子基地设备工艺研究中心有限责任公司 深硅刻蚀装置和深硅刻蚀设备的进气系统
WO2011032078A1 (en) 2009-09-11 2011-03-17 Health Reseach Inc. Detection of x4 strains of hiv-1 by heteroduplex tracking assay
WO2011035870A1 (en) 2009-09-22 2011-03-31 Roche Diagnostics Gmbh Determination of kir haplotypes associated with disease
CA2773186A1 (en) 2009-09-24 2011-03-31 Qiagen Gaithersburg, Inc. Compositions, methods, and kits for isolating and analyzing nucleic acids using an anion exchange material
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA2778926C (en) 2009-10-26 2018-03-27 Lifecodexx Ag Means and methods for non-invasive diagnosis of chromosomal aneuploidy
HUE061110T2 (hu) 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából
GB2488289A (en) 2009-11-06 2012-08-22 Univ Leland Stanford Junior Non-invasive diagnosis of graft rejection in organ transplant patients
EP3103883A1 (en) 2009-11-09 2016-12-14 Streck, Inc. Stabilization of rna in and extracting from intact cells within a blood sample
JP2013511991A (ja) 2009-11-25 2013-04-11 クアンタライフ， インコーポレイテッド 遺伝子材料を検出する方法および組成物
WO2011071353A2 (ko) 2009-12-07 2011-06-16 Jeon Min-Yong 원심분리관
MA33899B1 (fr) 2009-12-08 2013-01-02 Hemaquest Pharmaceuticals Inc Procedes et regimes a faible dose pour des troubles des globules rouges
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US8574842B2 (en) 2009-12-22 2013-11-05 The Board Of Trustees Of The Leland Stanford Junior University Direct molecular diagnosis of fetal aneuploidy
EP2516680B1 (en) 2009-12-22 2016-04-06 Sequenom, Inc. Processes and kits for identifying aneuploidy
CA2786916A1 (en) 2010-01-15 2011-07-21 The University Of British Columbia Multiplex amplification for the detection of nucleic acid variations
EP2848704B1 (en) 2010-01-19 2018-08-29 Verinata Health, Inc Sequencing methods for prenatal diagnoses
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US20120270739A1 (en) 2010-01-19 2012-10-25 Verinata Health, Inc. Method for sample analysis of aneuploidies in maternal samples
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
WO2011094646A1 (en) 2010-01-28 2011-08-04 Medical College Of Wisconsin, Inc. Methods and compositions for high yield, specific amplification
US8574832B2 (en) 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
US8940487B2 (en) 2010-02-09 2015-01-27 UmiTaq Bio Methods and compositions for universal detection of nucleic acids
ES2544288T3 (es) 2010-02-26 2015-08-28 Life Technologies Corporation Fast PCR para la genotipificación de STR
AU2011223789A1 (en) 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
EP2551356B1 (en) 2010-03-24 2017-06-14 Toppan Printing Co., Ltd. Method for detecting target base sequence using competitive primer
WO2011140510A2 (en) 2010-05-06 2011-11-10 Bioo Scientific Corporation Oligonucleotide ligation, barcoding and methods and compositions for improving data quality and throughput using massively parallel sequencing
CA2796822C (en) 2010-05-07 2021-10-05 The Board Of Trustees Of The Leland Standford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
EP2569453B1 (en) 2010-05-14 2015-12-16 Fluidigm Corporation Nucleic acid isolation methods
EP2569447A4 (en) 2010-05-14 2013-11-27 Fluidigm Corp ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US20190309358A1 (en) 2010-05-18 2019-10-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20220356526A1 (en) 2010-05-18 2022-11-10 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20130196862A1 (en) 2010-05-18 2013-08-01 Natera, Inc. Informatics Enhanced Analysis of Fetal Samples Subject to Maternal Contamination
US20190284623A1 (en) 2010-05-18 2019-09-19 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
WO2013052557A2 (en) 2011-10-03 2013-04-11 Natera, Inc. Methods for preimplantation genetic diagnosis by sequencing
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20140206552A1 (en) 2010-05-18 2014-07-24 Natera, Inc. Methods for preimplantation genetic diagnosis by sequencing
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20130123120A1 (en) 2010-05-18 2013-05-16 Natera, Inc. Highly Multiplex PCR Methods and Compositions
US20110301854A1 (en) 2010-06-08 2011-12-08 Curry Bo U Method of Determining Allele-Specific Copy Number of a SNP
US20120190557A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Risk calculation for evaluation of fetal aneuploidy
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
EP2426217A1 (en) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Analytical methods for cell free nucleic acids and applications
WO2012042374A2 (en) 2010-10-01 2012-04-05 Anssi Jussi Nikolai Taipale Method of determining number or concentration of molecules
JP2012085556A (ja) 2010-10-18 2012-05-10 Shinya Watanabe 乳がんの診断方法
CN103534591B (zh) 2010-10-26 2016-04-06 利兰·斯坦福青年大学托管委员会 通过测序分析进行的非侵入性胎儿遗传筛选
CN103328654B (zh) 2010-10-27 2017-07-11 哈佛学院院长等 立足点引物双链体的组合物及其使用方法
US9163329B2 (en) 2010-11-12 2015-10-20 Agilent Technologies, Inc. RNA labeling method
KR101891847B1 (ko) 2010-11-30 2018-08-24 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
EP2649199A2 (en) 2010-12-07 2013-10-16 Stanford University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale
CN118086471A (zh) 2010-12-17 2024-05-28 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
WO2012083250A2 (en) 2010-12-17 2012-06-21 Celula, Inc. Methods for screening and diagnosing genetic conditions
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
BR112013016708B1 (pt) 2010-12-30 2021-08-17 Foundation Medicine, Inc Otimização de análise multigene de amostras de tumor
US20120190021A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
CA2824387C (en) * 2011-02-09 2019-09-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP3760731A1 (en) 2011-02-09 2021-01-06 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9290815B2 (en) 2011-02-21 2016-03-22 Qiagen Gmbh Method for quantifying human DNA
GB2488358A (en) 2011-02-25 2012-08-29 Univ Plymouth Enrichment of foetal DNA in maternal plasma
WO2012122374A2 (en) 2011-03-08 2012-09-13 Children's Medical Center Corporation Non-invasive methods for diagnosing chronic organ transplant rejection
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
RS57837B1 (sr) 2011-04-12 2018-12-31 Verinata Health Inc Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama
CN103843001B (zh) 2011-04-14 2017-06-09 考利达基因组股份有限公司 复杂核酸序列数据的处理和分析
AU2012242847B2 (en) 2011-04-15 2017-01-19 The Johns Hopkins University Safe sequencing system
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US9957558B2 (en) 2011-04-28 2018-05-01 Life Technologies Corporation Methods and compositions for multiplex PCR
CA2834218C (en) 2011-04-29 2021-02-16 Sequenom, Inc. Quantification of a minority nucleic acid species using inhibitory oligonucleotides
US8945844B2 (en) 2011-07-11 2015-02-03 Samsung Electronics Co., Ltd. Method of amplifying target nucleic acid with reduced amplification bias and method for determining relative amount of target nucleic acid in sample
US20130024127A1 (en) 2011-07-19 2013-01-24 John Stuelpnagel Determination of source contributions using binomial probability calculations
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
AU2012304328B2 (en) 2011-09-09 2017-07-20 The Board Of Trustees Of The Leland Stanford Junior University Methods for obtaining a sequence
JP5536729B2 (ja) 2011-09-20 2014-07-02 株式会社ソニー・コンピュータエンタテインメント 情報処理装置、アプリケーション提供システム、アプリケーション提供サーバ、アプリケーション提供方法、および情報処理方法
CN113388606A (zh) 2011-09-26 2021-09-14 凯杰有限公司 用于分离细胞外核酸的快速方法
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013049892A1 (en) 2011-10-07 2013-04-11 Murdoch Childrens Research Institute Diagnostic assay for tissue transplantation status
WO2013078470A2 (en) 2011-11-22 2013-05-30 MOTIF, Active Multiplex isolation of protein-associated nucleic acids
WO2013086464A1 (en) 2011-12-07 2013-06-13 The Broad Institute, Inc. Markers associated with chronic lymphocytic leukemia prognosis and progression
WO2013086352A1 (en) 2011-12-07 2013-06-13 Chronix Biomedical Prostate cancer associated circulating nucleic acid biomarkers
CA2859528C (en) 2011-12-16 2020-10-27 Basf Agrochemical Products B.V. Methods and compositions for analyzing ahasl genes in wheat
US20130190653A1 (en) 2012-01-25 2013-07-25 Angel Gabriel Alvarez Ramos Device for blood collection from the placenta and the umbilical cord
JP2015508655A (ja) 2012-02-14 2015-03-23 コーネル ユニバーシティー 組み合わせたヌクレアーゼ反応、連結反応、およびポリメラーゼ反応を用いて核酸配列、発現、またはコピー変化を相対的に定量するための方法
WO2013128281A1 (en) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Method for attaching a counter sequence to a nucleic acid sample
WO2013130848A1 (en) 2012-02-29 2013-09-06 Natera, Inc. Informatics enhanced analysis of fetal samples subject to maternal contamination
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
WO2013138510A1 (en) 2012-03-13 2013-09-19 Patel Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
CA3209140A1 (en) 2012-04-19 2013-10-24 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
EP2653562A1 (en) 2012-04-20 2013-10-23 Institut Pasteur Anellovirus genome quantification as a biomarker of immune suppression
ES2905448T3 (es) 2012-05-10 2022-04-08 Massachusetts Gen Hospital Métodos para determinar una secuencia nucleotídica
WO2013177220A1 (en) 2012-05-21 2013-11-28 The Scripps Research Institute Methods of sample preparation
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
WO2013181651A1 (en) 2012-06-01 2013-12-05 Omega Bio-Tek, Inc. Selective nucleic acid fragment recovery
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
WO2014004726A1 (en) 2012-06-26 2014-01-03 Caifu Chen Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
CA2878246C (en) 2012-07-20 2022-01-11 Verinata Health, Inc. Detecting and classifying copy number variation in a cancer genome
JP6392222B2 (ja) 2012-07-24 2018-09-19 ナテラ， インコーポレイテッド 高度多重ｐｃｒ法および組成物
WO2014020564A1 (en) 2012-08-03 2014-02-06 Ferring B.V. Cell-free dna as a therapeutic target for female infertility and diagnostic marker
US10993418B2 (en) 2012-08-13 2021-05-04 Life Genetics Lab, Llc Method for measuring tumor burden in patient derived xenograft (PDX) mice
US10988803B2 (en) 2014-12-29 2021-04-27 Life Genetics Lab, Llc Multiplexed assay for quantitating and assessing integrity of cell-free DNA in biological fluids for cancer diagnosis, prognosis and surveillance
US20140051585A1 (en) 2012-08-15 2014-02-20 Natera, Inc. Methods and compositions for reducing genetic library contamination
US9500651B2 (en) 2012-08-15 2016-11-22 Université de Montréal Method for identifying novel minor histocompatibility antigens
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
CN105164509B (zh) 2012-08-28 2018-02-23 阿科尼生物系统公司 用于纯化核酸的方法和试剂盒
EP4036247B1 (en) 2012-09-04 2024-04-10 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20140065621A1 (en) 2012-09-04 2014-03-06 Natera, Inc. Methods for increasing fetal fraction in maternal blood
US20220411875A1 (en) 2012-10-03 2022-12-29 Natera, Inc. Methods for simultaneous amplification of target loci
US9669405B2 (en) 2012-10-22 2017-06-06 The Regents Of The University Of California Sterilizable photopolymer serum separator
EP3026124A1 (en) 2012-10-31 2016-06-01 Genesupport SA Non-invasive method for detecting a fetal chromosomal aneuploidy
JP2014118334A (ja) 2012-12-18 2014-06-30 Sumitomo Electric Ind Ltd 光ファイバ製造方法
EP2943590A4 (en) 2013-01-13 2017-02-15 Unitaq Bio Methods and compositions for pcr using blocked and universal primers
WO2014122288A1 (en) 2013-02-08 2014-08-14 Qiagen Gmbh Method for separating dna by size
US9982255B2 (en) 2013-03-11 2018-05-29 Kailos Genetics, Inc. Capture methodologies for circulating cell free DNA
GB2528205B (en) 2013-03-15 2020-06-03 Guardant Health Inc Systems and methods to detect rare mutations and copy number variation
KR20160004265A (ko) 2013-03-15 2016-01-12 이뮤코 쥐티아이 다이아그노스틱스, 아이엔씨. 무세포 dna를 이용하는 신장 상태의 평가를 위한 방법 및 조성물
US10385394B2 (en) 2013-03-15 2019-08-20 The Translational Genomics Research Institute Processes of identifying and characterizing X-linked disorders
US20140272956A1 (en) 2013-03-15 2014-09-18 Abbott Molecular Inc. Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits
WO2014143989A1 (en) 2013-03-15 2014-09-18 Medical College Of Wisconsin, Inc. Fetal well being surveillance using fetal specific cell free dna
GB201304810D0 (en) 2013-03-15 2013-05-01 Isis Innovation Assay
AU2014233373B2 (en) 2013-03-15 2019-10-24 Verinata Health, Inc. Generating cell-free DNA libraries directly from blood
EP3421613B1 (en) 2013-03-15 2020-08-19 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acid tumor markers
US10072298B2 (en) 2013-04-17 2018-09-11 Life Technologies Corporation Gene fusions and gene variants associated with cancer
SI3004388T2 (sl) 2013-05-29 2023-11-30 Chronix Biomedical Odkrivanje in kvantifikacija donorjeve brezcelične DNK v cirkulaciji prejemnikov presajenih organov
WO2015026873A1 (en) 2013-08-19 2015-02-26 Singular Bio, Inc. Assays for single molecule detection and use thereof
WO2015035177A1 (en) 2013-09-06 2015-03-12 Immucor Gti Diagnostics, Inc. Compositions and methods for diagnosis and prediction of solid organ graft rejection
US11694764B2 (en) 2013-09-27 2023-07-04 University Of Washington Method for large scale scaffolding of genome assemblies
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
WO2015069933A1 (en) 2013-11-06 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Circulating cell-free dna for diagnosis of transplant rejection
EP4130350A1 (en) 2013-11-07 2023-02-08 The Board of Trustees of the Leland Stanford Junior University Cell-free nucleic acids for the analysis of the human microbiome and components thereof
WO2015083004A1 (en) 2013-12-02 2015-06-11 Population Genetics Technologies Ltd. Method for evaluating minority variants in a sample
SG10201804519RA (en) 2013-12-28 2018-07-30 Guardant Health Inc Methods and systems for detecting genetic variants
PT3089822T (pt) 2013-12-30 2022-05-06 Atreca Inc Análise de ácidos nucleicos associados com células isoladas usando códigos de barras de ácido nucleico
CN106661612A (zh) 2014-01-27 2017-05-10 通用医疗公司 制备用于测序的核酸的方法
CN106029962A (zh) 2014-02-11 2016-10-12 豪夫迈·罗氏有限公司 靶向测序和uid过滤
US20170051343A1 (en) 2014-02-14 2017-02-23 The Board Of Regents Of The University Of Texas System Strand exchange hairpin primers that give high allelic discrimination
WO2015134552A1 (en) 2014-03-03 2015-09-11 Swift Biosciences, Inc. Enhanced adaptor ligation
US11767559B2 (en) 2014-03-14 2023-09-26 Caredx, Inc. Methods of monitoring immunosuppressive therapies in a transplant recipient
US9914973B2 (en) 2014-03-25 2018-03-13 Quest Diagnostics Investments Incorporated Detection of gene fusions by intragenic differential expression (IDE) using average cycle thresholds
WO2015164432A1 (en) 2014-04-21 2015-10-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3957749A1 (en) 2014-04-21 2022-02-23 Natera, Inc. Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples
CN107223159A (zh) 2014-05-09 2017-09-29 科戴克斯生命股份公司 源自特定细胞类型的dna的检测及相关方法
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US10400282B2 (en) 2014-06-27 2019-09-03 Inserm (Institut National De La Santéet De La Recherche Médicale) Methods employing circulating DNA and miRNA as biomarkers for female infertility
EP3164503B1 (en) 2014-07-03 2024-08-28 Agilent Technologies, Inc. Methods for non-invasive detection of transplant health or rejection
US10619163B2 (en) 2014-07-03 2020-04-14 Rhodx, Inc. Tagging and assessing a target sequence
WO2016009059A1 (en) 2014-07-17 2016-01-21 Qiagen Gmbh Method for isolating rna with high yield
GB201412834D0 (en) 2014-07-18 2014-09-03 Cancer Rec Tech Ltd A method for detecting a genetic variant
EP3656875B1 (en) 2014-07-18 2021-09-22 Illumina, Inc. Non-invasive prenatal diagnosis
PL3194612T3 (pl) 2014-08-22 2024-11-04 Resolution Bioscience, Inc. Metody ilościowej analizy genetycznej dna wolnego od komórek
ES2904909T3 (es) 2014-10-08 2022-04-06 Univ Cornell Método para la identificación y la cuantificación relativa de cambios en la expresión de secuencias de ácidos nucleicos, en variantes de corte y empalme, en la translocación, en el número de copias o en la metilación utilizando reacciones combinadas de nucleasa, de ligadura y de polimerasa con prevención de arrastre
WO2016063122A1 (en) 2014-10-20 2016-04-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for screening a subject for a cancer
EP3209403A4 (en) 2014-10-24 2018-09-12 Abbott Molecular Inc. Enrichment of small nucleic acids
CN107002130B (zh) 2014-11-11 2022-02-01 深圳华大基因研究院 多程测序
EP3224380A1 (en) 2014-11-25 2017-10-04 The Broad Institute Inc. Clonal haematopoiesis
EP3754027A1 (en) 2014-12-01 2020-12-23 The Broad Institute, Inc. Methods for altering or modulating spatial proximity between nucleic acids inside of a cell
GB201501907D0 (en) 2015-02-05 2015-03-25 Technion Res & Dev Foundation System and method for single cell genetic analysis
WO2016123698A1 (en) 2015-02-06 2016-08-11 Uti Limited Partnership Diagnostic assay for post-transplant assessment of potential rejection of donor organs
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
WO2016138080A1 (en) 2015-02-24 2016-09-01 Trustees Of Boston University Protection of barcodes during dna amplification using molecular hairpins
CN107208157B (zh) 2015-02-27 2022-04-05 贝克顿迪金森公司 用于条形编码核酸以用于测序的方法和组合物
WO2016160844A2 (en) 2015-03-30 2016-10-06 Cellular Research, Inc. Methods and compositions for combinatorial barcoding
KR101850437B1 (ko) 2015-04-14 2018-04-20 이원다이애그노믹스(주) 차세대 염기서열 분석기법을 이용한 장기 이식 거부 반응 예측 방법
EP3286326B1 (en) 2015-04-23 2025-01-22 Becton, Dickinson and Company Method for whole transcriptome amplification
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
JP2018514219A (ja) 2015-04-30 2018-06-07 メディカル カレッジ オブ ウィスコンシン インコーポレイテッド 無細胞ｄｎａを評価するための多重／最適化ミスマッチ増幅（ｍｏｍａ）−リアルタイムｐｃｒ
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
BR112017025873A2 (pt) 2015-06-01 2018-08-14 Gea Food Solutions Weert Bv método para revestir a cabeça de um pirulito com um material de revestimento
ES2906751T3 (es) 2015-06-05 2022-04-20 Qiagen Gmbh Método para separar el DNA por tamaño
US20160371428A1 (en) 2015-06-19 2016-12-22 Natera, Inc. Systems and methods for determining aneuploidy risk using sample fetal fraction
CN107922959A (zh) 2015-07-02 2018-04-17 阿瑞玛基因组学公司 混合物样品的精确分子去卷积
JP2018523469A (ja) 2015-07-10 2018-08-23 ウエストバージニア ユニバーシティＷｅｓｔ Ｖｉｒｇｉｎｉａ Ｕｎｉｖｅｒｓｉｔｙ 脳卒中および脳卒中重篤度のマーカー
WO2017009851A2 (en) 2015-07-16 2017-01-19 Pomvom Ltd. Coordinating communication and/or storage based on image analysis
GB201516047D0 (en) 2015-09-10 2015-10-28 Cancer Rec Tech Ltd Method
CN106544407B (zh) 2015-09-18 2019-11-08 广州华大基因医学检验所有限公司 确定受体cfDNA样本中供体来源cfDNA比例的方法
CN108138231A (zh) 2015-09-29 2018-06-08 路德维格癌症研究有限公司 分型和组装不连续基因组元件
CN108368542B (zh) 2015-10-19 2022-04-08 多弗泰尔基因组学有限责任公司 用于基因组组装、单元型定相以及独立于靶标的核酸检测的方法
WO2017070415A1 (en) 2015-10-22 2017-04-27 Cytosorbents Corporation Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins an potassium from biological fluids
SG11201803646YA (en) 2015-11-04 2018-05-30 Atreca Inc Combinatorial sets of nucleic acid barcodes for analysis of nucleic acids associated with single cells
EP3377647B1 (en) 2015-11-16 2020-03-11 Progenity, Inc. Nucleic acids and methods for detecting methylation status
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
WO2017091865A1 (en) 2015-12-03 2017-06-08 Alfred Health Monitoring treatment or progression of myeloma
CN105986030A (zh) 2016-02-03 2016-10-05 广州市基准医疗有限责任公司 甲基化dna检测方法
EP4574992A3 (en) 2016-03-22 2025-07-16 Myriad Women's Health, Inc. Combinatorial dna screening
US10781439B2 (en) 2016-03-30 2020-09-22 Covaris, Inc. Extraction of cfDNA from biological samples
WO2017165982A1 (en) 2016-04-01 2017-10-05 Uti Limited Partnership Plasma derived cell-free mitochondrial deoxyribonucleic acid
US11542547B2 (en) 2016-04-07 2023-01-03 Rutgers, The State University Of New Jersey Multiplex nucleic acid assay methods capable of detecting closely related alleles, and reagents therefor
EP3443066B1 (en) 2016-04-14 2024-10-02 Guardant Health, Inc. Methods for early detection of cancer
JP7280044B2 (ja) 2016-04-15 2023-05-23 ナテラ， インコーポレイテッド 肺癌の検出方法
BR112018072196A2 (pt) 2016-04-29 2019-02-12 Medical College Wisconsin Inc amplificação de incompatibilidade otimizada multiplexadas (moma) - número do alvo
MX2018013261A (es) 2016-04-29 2019-04-22 Medical College Wisconsin Inc Reacción de cadena de polimerasas para amplificación de discordancias optimizada multiplicada (moma)-en tiempo real para la valoración del bienestar fetal.
EP3449014A1 (en) 2016-04-29 2019-03-06 The Medical College of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cancer
WO2017205540A1 (en) 2016-05-24 2017-11-30 The Translational Genomics Research Institute Molecular tagging methods and sequencing libraries
WO2017205826A1 (en) 2016-05-27 2017-11-30 Sequenom, Inc. Methods for detecting genetic variations
AU2017290809A1 (en) 2016-07-01 2018-12-13 Natera, Inc. Compositions and methods for detection of nucleic acid mutations
KR102610098B1 (ko) 2016-07-06 2023-12-04 가던트 헬쓰, 인크. 무세포 핵산의 프래그멘톰 프로파일링을 위한 방법
CA3033650A1 (en) 2016-08-17 2018-02-22 The Regents Of The University Of California A novel immunoprobe-based method to assess organ injury status through a biofluid-based cell-free dna (cfdna) assay
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US11512306B2 (en) 2016-10-19 2022-11-29 The Chinese University Of Hong Kong Gestational age assessment by methylation and size profiling of maternal plasma DNA
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
AU2017355464A1 (en) 2016-11-02 2019-05-30 The Medical College Of Wisconsin, Inc. Methods for assessing risk using total and specific cell-free DNA
CN110177874A (zh) 2016-11-02 2019-08-27 威斯康星州立大学医学院 用于使用错配扩增和统计方法来评估风险的方法
CN109906274B (zh) 2016-11-08 2023-08-25 贝克顿迪金森公司 用于细胞标记分类的方法
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
WO2018119422A1 (en) 2016-12-22 2018-06-28 Duke University Polycationic microfibers and methods of using the same
EP3571320B1 (en) 2017-01-17 2022-04-06 Life Technologies Corporation Compositions and methods for immune repertoire sequencing
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CA3067635A1 (en) 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. Transplant patient monitoring with cell-free dna
AU2018288835A1 (en) 2017-06-20 2020-01-16 The Medical College Of Wisconsin, Inc. Assessing conditions in transplant subjects using donor-specific cell-free DNA
CN110945136A (zh) 2017-06-20 2020-03-31 威斯康星州立大学医学院 使用总无细胞dna评估移植并发症风险
WO2019008408A1 (en) 2017-07-07 2019-01-10 INSERM (Institut National de la Santé et de la Recherche Médicale) METHODS FOR DETERMINING WHETHER A PATIENT SUFFERING FROM MYELOPROLIFERATIVE NEOPLASM IS AT RISK OF THROMBOSIS
WO2019006561A1 (en) 2017-07-07 2019-01-10 Mcmaster University RISK ASSESSMENT TOOL FOR PATIENTS WITH SEPSIS
CN107365769B (zh) 2017-07-25 2021-05-04 深圳华大智造科技股份有限公司 一种鼓泡状引物及其组成的试剂盒和应用
IL319255A (en) 2017-08-07 2025-04-01 Univ Johns Hopkins Methods and materials for cancer assessment and treatment
CN111183232A (zh) 2017-08-17 2020-05-19 泰诊断有限公司 确定不具有供体基因型的供体无细胞dna的方法
WO2019046817A1 (en) 2017-09-01 2019-03-07 Life Technologies Corporation COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING
IL273413B2 (en) 2017-09-18 2024-05-01 Santersus Ag Method and device for purification of blood from circulating cell free dna
US11091800B2 (en) 2017-09-20 2021-08-17 University Of Utah Research Foundation Size-selection of cell-free DNA for increasing family size during next-generation sequencing
KR20200116081A (ko) 2017-12-01 2020-10-08 주노 쎄러퓨티크스 인코퍼레이티드 유전자 조작된 세포의 투약 및 조절 방법
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
SG11202005474RA (en) 2017-12-15 2020-07-29 Acrannolife Genomics Pvt Ltd A non-invasive method for monitoring transplanted organ status in organ-transplant recipients
US20210071246A1 (en) 2018-01-12 2021-03-11 Natera, Inc. Novel primers and uses thereof
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
GB201819134D0 (en) 2018-11-23 2019-01-09 Cancer Research Tech Ltd Improvements in variant detection
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
WO2019217918A1 (en) 2018-05-10 2019-11-14 The Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-cancer risk assessment with non-cancer associated targets
US20210257048A1 (en) 2018-06-12 2021-08-19 Natera, Inc. Methods and systems for calling mutations
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020010255A1 (en) 2018-07-03 2020-01-09 Natera, Inc. Methods for detection of donor-derived cell-free dna
JP2021530231A (ja) 2018-07-17 2021-11-11 ナテラ， インコーポレイテッド ニューラルネットワークを使用して倍数性状態を呼び出すための方法およびシステム
CA3107983A1 (en) 2018-07-23 2020-01-30 Guardant Health, Inc. Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage
WO2020041449A1 (en) 2018-08-21 2020-02-27 Zymo Research Corporation Methods and compositions for tracking sample quality
WO2020076957A1 (en) 2018-10-09 2020-04-16 Tai Diagnostics, Inc. Cell lysis assay for cell-free dna analysis
CN113227468A (zh) 2018-11-21 2021-08-06 卡里乌斯公司 感染性疾病的检测和预测
US20220056534A1 (en) 2018-12-17 2022-02-24 Natera, Inc. Methods for analysis of circulating cells
EP3899033A4 (en) 2018-12-17 2022-10-19 The Medical College of Wisconsin, Inc. Assessing risk with total cell-free dna
WO2020206292A2 (en) 2019-04-03 2020-10-08 The Medical College Of Wisconsin, Inc. Assessing conditions in transplant subjects using donor-specific cell-free dna
JP2022526984A (ja) 2019-04-03 2022-05-27 ザ メディカル カレッジ オブ ウィスコンシン，インコーポレイテッド 無細胞ｄｎａでの移植患者の監視
WO2020206290A1 (en) 2019-04-03 2020-10-08 The Medical College Of Wisconsin, Inc. Methods for assessing risk using total cell-free dna
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
WO2020214547A1 (en) 2019-04-15 2020-10-22 Natera, Inc. Improved liquid biopsy using size selection
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
US20220340963A1 (en) 2019-09-20 2022-10-27 Natera, Inc. Methods for assessing graft suitability for transplantation
CA3180334A1 (en) 2020-05-29 2021-12-02 Natera, Inc. Methods for detection of donor-derived cell-free dna
WO2022015676A1 (en) 2020-07-13 2022-01-20 The Medical College Of Wisconsin, Inc. Methods for making treatment management decisions in transplant subjects and assessing transplant risks with threshold values
BR112023016896A2 (pt) 2021-02-25 2023-11-21 Natera Inc Métodos para detecção de dna livre de células derivadas de doador em receptores de transplantes de múltiplos órgãos
JP2024511980A (ja) 2021-03-18 2024-03-18 ナテラ， インコーポレイテッド 移植拒絶反応の判定方法
CN117597456A (zh) 2021-04-22 2024-02-23 纳特拉公司 用于确定肿瘤生长的速度的方法
JP2024528932A (ja) 2021-08-02 2024-08-01 ナテラ， インコーポレイテッド 妊娠中の女性における新生物を検出するための方法
CN118613594A (zh) 2021-09-01 2024-09-06 纳特拉公司 用于非侵入性产前测试的方法

Similar Documents

Publication Publication Date Title
JP2014507141A5 (OSRAM)
US20240060124A1 (en) Methods for amplification of cell-free dna using ligated adaptors and universal and inner target-specific primers for multiplexed nested pcr
US11326208B2 (en) Methods for nested PCR amplification of cell-free DNA
US10590482B2 (en) Amplification of cell-free DNA using nested PCR
CN102791881B (zh) 基于大小的基因组分析
JP6153874B2 (ja) 非侵襲的出生前倍数性呼び出しのための方法
JP6392222B2 (ja) 高度多重ｐｃｒ法および組成物
CN113614246B (zh) 用于鉴别肿瘤模型的方法和组合物
JP6045686B2 (ja) 胎児ゲノムにおける所定領域の塩基情報を確定する方法、システム及びコンピューター読み取り可能な記録媒体
WO2013053182A1 (zh) 检测核酸样本中预定事件的方法和系统以及捕获芯片
TW201122470A (en) Fetal genomic analysis from a maternal biological sample
JP2015522293A (ja) 多重化連続ライゲーションに基づく遺伝子変異体の検出
WO2018121468A1 (zh) 检测胎儿基因突变的方法、装置和试剂盒
CN110541025A (zh) 杜氏肌营养不良基因缺陷的检测方法、引物组合物及试剂盒
JP2025533814A (ja) 妊娠中の移植レシピエントにおける移植拒絶反応を評価する非侵襲的方法
TW201823472A (zh) 基於單倍型之通用非侵入性單基因疾病產前檢測
AU2015252046B2 (en) Methods for Non-Invasive Prenatal Ploidy Calling
CN110846394A (zh) 一种检测肺动脉高压病的alk1基因探针组及其应用
CN110669837A (zh) 一种检测肺动脉高压病的Caveolin-1基因探针组及其应用
CN110846397A (zh) 一种检测肺动脉高压病的smad9基因探针组及其应用