ATE347616T1 - Ribonukleinsäurederivate - Google Patents
RibonukleinsäurederivateInfo
- Publication number
- ATE347616T1 ATE347616T1 AT00929665T AT00929665T ATE347616T1 AT E347616 T1 ATE347616 T1 AT E347616T1 AT 00929665 T AT00929665 T AT 00929665T AT 00929665 T AT00929665 T AT 00929665T AT E347616 T1 ATE347616 T1 AT E347616T1
- Authority
- AT
- Austria
- Prior art keywords
- substituent
- sample
- ribonuclic
- acid derivatives
- rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Turbine Rotor Nozzle Sealing (AREA)
- Window Of Vehicle (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9910158.6A GB9910158D0 (en) | 1999-04-30 | 1999-04-30 | Isolation of nucleic acid |
GBGB9910157.8A GB9910157D0 (en) | 1999-04-30 | 1999-04-30 | Polynucleotides |
GBGB9910154.5A GB9910154D0 (en) | 1999-04-30 | 1999-04-30 | Polynucleotides |
GBGB9910156.0A GB9910156D0 (en) | 1999-04-30 | 1999-04-30 | Polynucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE347616T1 true ATE347616T1 (de) | 2006-12-15 |
Family
ID=27451902
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00929665T ATE347616T1 (de) | 1999-04-30 | 2000-05-02 | Ribonukleinsäurederivate |
AT00929666T ATE421583T1 (de) | 1999-04-30 | 2000-05-02 | Isolierung von nukleinsäuren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00929666T ATE421583T1 (de) | 1999-04-30 | 2000-05-02 | Isolierung von nukleinsäuren |
Country Status (6)
Country | Link |
---|---|
US (4) | US6794140B1 (de) |
EP (2) | EP1196631B1 (de) |
AT (2) | ATE347616T1 (de) |
AU (4) | AU4588000A (de) |
DE (2) | DE60041442D1 (de) |
WO (4) | WO2000075302A2 (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1196631B1 (de) | 1999-04-30 | 2006-12-06 | Cyclops Genome Sciences Limited | Ribonukleinsäurederivate |
US6677120B2 (en) * | 2001-03-30 | 2004-01-13 | Isis Pharmaceuticals, Inc. | Building blocks for the solution phase synthesis of oligonucleotides |
US20060009409A1 (en) * | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
ATE443133T1 (de) | 2002-02-01 | 2009-10-15 | Life Technologies Corp | Oligonukleotidzusammensetzungen mit verbesserter effizienz |
US20040005568A1 (en) * | 2002-07-03 | 2004-01-08 | Stojanovic Milan N. | Movement of multi-enzymatic nanoassemblies on recognition landscapes |
US20040072226A1 (en) * | 2002-07-03 | 2004-04-15 | Stojanovic Milan N. | Movement of multi-enzymatic nanoassemblies on recognition landscapes |
GB0217963D0 (en) * | 2002-08-02 | 2002-09-11 | Cyclops Genome Sciences Ltd | Purification of nucleic acids |
DE10315581B4 (de) * | 2003-04-05 | 2007-06-28 | Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto | Verfahren zur Qualitätsbestimmung von RNA-Proben |
JP2006527993A (ja) * | 2003-07-23 | 2006-12-14 | シクロプス ゲノム サイエンス リミテッド | クリーンアップビーズ |
GB0317199D0 (en) | 2003-07-23 | 2003-08-27 | Cyclops Genome Sciences Ltd | Clean-up beads |
DE10344819B4 (de) * | 2003-09-26 | 2017-06-29 | Sartorius Stedim Biotech Gmbh | Adsorptionsmembranen, Verfahren zur Herstellung derselben und Vorrichtungen, welche die Adsorptionsmembranen umfassen |
EP1809744B1 (de) | 2004-11-05 | 2018-06-06 | QIAGEN North American Holdings, Inc. | Zusammensetzungen und verfahren zur reinigung von nukleinsäuren aus stabilisierungsreagenzien |
WO2006138145A1 (en) | 2005-06-14 | 2006-12-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
WO2007145940A2 (en) * | 2006-06-05 | 2007-12-21 | The University Of North Carolina At Chapel Hill | High-throughput rna structure analysis |
CA2691066C (en) * | 2007-02-09 | 2018-07-31 | Northwestern University | Particles for detecting intracellular targets |
EP2142671A2 (de) * | 2007-03-30 | 2010-01-13 | Qiagen GmbH | Modifizierte polynukleotide mit riboseringen |
WO2008134077A1 (en) * | 2007-04-30 | 2008-11-06 | Archemix Corp. | Metabolic profile directed aptamer medicinal chemistry |
CA2689923A1 (en) * | 2007-05-30 | 2008-12-11 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
CN102014919B (zh) | 2008-03-03 | 2015-02-25 | 托斯克公司 | 减少毒性的甲氨蝶呤佐剂及其使用方法 |
US20110053226A1 (en) * | 2008-06-13 | 2011-03-03 | Riboxx Gmbh | Method for enzymatic synthesis of chemically modified rna |
MX2011005429A (es) | 2008-11-24 | 2011-06-21 | Univ Northwestern | Composiciones de nanoparticulas de arn polivalentes. |
US20100233270A1 (en) * | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
SG2014011381A (en) | 2009-02-13 | 2014-06-27 | Chem Inc X | Methods of creating and screening dna-encoded libraries |
EP2272976A1 (de) * | 2009-07-06 | 2011-01-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur Differenzierung von Polynucleotid-Strängen |
US20120185176A1 (en) | 2009-09-30 | 2012-07-19 | Natera, Inc. | Methods for Non-Invasive Prenatal Ploidy Calling |
CA2779099C (en) | 2009-10-30 | 2021-08-10 | Northwestern University | Templated nanoconjugates |
EP2333102A1 (de) * | 2009-12-14 | 2011-06-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur Identifizierung von RNA-Liganden |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
EP2854058A3 (de) | 2010-05-18 | 2015-10-28 | Natera, Inc. | Verfahren zur nichtinvasiven pränatalen Ploidiezuordnung |
US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
EP2388324A1 (de) | 2010-05-20 | 2011-11-23 | Siemens Healthcare Diagnostics Inc. | Kontrollmaterial für Nukleinsäureteste |
FR2968302B1 (fr) | 2010-12-06 | 2012-11-30 | Biomerieux Sa | Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits |
CN103608466B (zh) | 2010-12-22 | 2020-09-18 | 纳特拉公司 | 非侵入性产前亲子鉴定方法 |
CN103608818B (zh) | 2011-02-09 | 2017-12-08 | 纳特拉公司 | 非侵入性产前倍性识别装置 |
SG10201605812YA (en) * | 2011-09-07 | 2016-09-29 | Chem Inc X | Methods for tagging dna-encoded libraries |
WO2013040499A1 (en) | 2011-09-14 | 2013-03-21 | Northwestern University | Nanoconjugates able to cross the blood-brain barrier |
US9040675B2 (en) | 2012-04-30 | 2015-05-26 | General Electric Company | Formulations for nucleic acid stabilization on solid substrates |
US9040679B2 (en) | 2012-04-30 | 2015-05-26 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
US9044738B2 (en) | 2012-04-30 | 2015-06-02 | General Electric Company | Methods and compositions for extraction and storage of nucleic acids |
US9480966B2 (en) | 2012-04-30 | 2016-11-01 | General Electric Company | Substrates and methods for collection, stabilization and elution of biomolecules |
SG10201907347YA (en) | 2012-07-13 | 2019-09-27 | X Chem Inc | Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases |
FR2994184B1 (fr) | 2012-08-02 | 2017-12-08 | Biomerieux Sa | Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits |
WO2014093688A1 (en) * | 2012-12-12 | 2014-06-19 | 1Massachusetts Institute Of Technology | Compositions and methods for functional nucleic acid delivery |
US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
EP3055413B1 (de) | 2013-10-07 | 2020-01-08 | The University of North Carolina at Chapel Hill | Nachweis chemischer modifikationen in nukleinsäuren |
EP3561075A1 (de) | 2014-04-21 | 2019-10-30 | Natera, Inc. | Nachweis von mutationen in tumorbiopsien und in zellfreie proben |
PT3134506T (pt) | 2014-04-25 | 2019-10-31 | Translate Bio Inc | Métodos de purificação de rna mensageiro |
EP3209403A4 (de) * | 2014-10-24 | 2018-09-12 | Abbott Molecular Inc. | Anreicherung von kleinen nukleinsäuren |
EP3220895B1 (de) | 2014-11-21 | 2022-08-31 | Northwestern University | Sequenzspezifische zelluläre aufnahme von sphärischen nukleinsäurenanopartikelkonjugaten |
EP3294885B1 (de) | 2015-05-08 | 2020-07-01 | CureVac Real Estate GmbH | Verfahren zur herstellung von rna |
WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
DE202016009003U1 (de) | 2015-05-29 | 2021-05-28 | Curevac Real Estate Gmbh | Zusammensetzung umfassend in vitro transkribierte RNA erhältlich durch ein Verfahren zur Herstellung und Reinigung von RNA mit mindestens einem Schritt mit einer tangentialen Flussfiltration |
EP3302784B1 (de) | 2015-06-05 | 2021-10-06 | W.R. Grace & Co.-Conn. | Adsorbierende klärmittel für bioprozesstechnik und verfahren zur herstellung und verwendung davon |
CN108473932B (zh) | 2015-09-09 | 2022-07-15 | 集联健康有限公司 | 用于样品收集、稳定化和保存的系统、方法和装置 |
US10214739B2 (en) * | 2015-10-30 | 2019-02-26 | Axagarius Gmbh & Co. Kg | RNA binding solution |
US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
CA3037192A1 (en) * | 2016-11-07 | 2018-05-11 | nanoSUR LLC | Post-transcriptionally chemically modified double strand rnas |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
JP2018134392A (ja) | 2017-01-10 | 2018-08-30 | ドローブリッジ ヘルス,インコーポレイテッド | サンプル収集のためのデバイス、システム、及び方法 |
AU2018225348A1 (en) * | 2017-02-21 | 2019-07-18 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
EA202090752A1 (ru) * | 2017-06-16 | 2020-06-15 | Борис Славинович ФАРБЕР | Комбинаторные производные олигонуклеотидов рнк |
MX2020003695A (es) | 2017-11-30 | 2020-08-03 | Arrakis Therapeutics Inc | Fotosondas de union a acido nucleico y usos de las mismas. |
FR3078977B1 (fr) * | 2018-03-16 | 2023-03-17 | Biomerieux Sa | Procede d'extraction d'acides nucleiques |
WO2019200228A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
EP4396348A2 (de) * | 2021-08-31 | 2024-07-10 | Nanosur LLC | Modifizierte dsrna-zusammensetzungen mit hohem molekulargewicht |
WO2023101963A2 (en) * | 2021-11-30 | 2023-06-08 | Northwestern University | Compositions for inhibiting dipeptide repeat protein-ribosomal rna interaction and uses thereof |
WO2024167836A1 (en) * | 2023-02-06 | 2024-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and modifications for reducing innate immune responses to rna |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588718A (en) * | 1984-03-28 | 1986-05-13 | The Upjohn Company | Carboxy containing ester prodrugs of corticosteroids |
US5681726A (en) * | 1988-09-19 | 1997-10-28 | Stratagene | Method of double stranded DNA synthesis |
US5859221A (en) * | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
US5872232A (en) * | 1990-01-11 | 1999-02-16 | Isis Pharmaceuticals Inc. | 2'-O-modified oligonucleotides |
US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
US5660985A (en) * | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
JPH0813274B2 (ja) * | 1990-08-13 | 1996-02-14 | アイシス・ファーマシューティカルス・インコーポレーテッド | 遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド |
US5426180A (en) | 1991-03-27 | 1995-06-20 | Research Corporation Technologies, Inc. | Methods of making single-stranded circular oligonucleotides |
US6235887B1 (en) * | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
ATE181557T1 (de) | 1993-02-24 | 1999-07-15 | Jui H Wang | Zusammensetzungen und methoden zur anwendung von reaktiven antiviralen polymeren |
AU8088694A (en) * | 1993-10-27 | 1995-05-22 | Ribozyme Pharmaceuticals, Inc. | 2'-amido and 2'-peptido modified oligonucleotides |
US5700642A (en) * | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
US6008334A (en) * | 1996-07-24 | 1999-12-28 | The Board Of Regents Of The University Of Oklahoma | Base-protected nucleotide analogs with protected thiol groups |
US5849902A (en) * | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
WO1999014346A2 (en) * | 1997-09-19 | 1999-03-25 | Sequitur, Inc. | SENSE mRNA THERAPY |
DE19801153A1 (de) | 1998-01-14 | 1999-07-15 | Jenne Andreas | Verfahren zur Selektion von Ribozymen, die Ribonucleinsäuren in trans an 2'-OH-Gruppen kovalent modifizieren können und durch dieses Verfahren erhältliche Ribozyme |
JP2002512794A (ja) | 1998-04-29 | 2002-05-08 | リボザイム・ファーマシューティカルズ・インコーポレーテッド | ヌクレオチド三リン酸およびリボザイム内へのそれらの取り込み |
DE69911793T2 (de) | 1998-07-28 | 2004-08-12 | Micromet Ag | Heterominikörper |
EP1196631B1 (de) | 1999-04-30 | 2006-12-06 | Cyclops Genome Sciences Limited | Ribonukleinsäurederivate |
US6720144B1 (en) * | 2001-06-21 | 2004-04-13 | Quest Diagnostics | Detection of clonal T-cell receptor-γ gene rearrangement by PCR/temporal temperature gradient gel electrophoresis (TTGE) |
GB0217963D0 (en) | 2002-08-02 | 2002-09-11 | Cyclops Genome Sciences Ltd | Purification of nucleic acids |
JP2006527993A (ja) | 2003-07-23 | 2006-12-14 | シクロプス ゲノム サイエンス リミテッド | クリーンアップビーズ |
-
2000
- 2000-05-02 EP EP00929665A patent/EP1196631B1/de not_active Expired - Lifetime
- 2000-05-02 AU AU45880/00A patent/AU4588000A/en not_active Abandoned
- 2000-05-02 DE DE60041442T patent/DE60041442D1/de not_active Expired - Fee Related
- 2000-05-02 WO PCT/GB2000/001684 patent/WO2000075302A2/en active Application Filing
- 2000-05-02 AT AT00929665T patent/ATE347616T1/de not_active IP Right Cessation
- 2000-05-02 US US10/031,636 patent/US6794140B1/en not_active Expired - Fee Related
- 2000-05-02 AT AT00929666T patent/ATE421583T1/de not_active IP Right Cessation
- 2000-05-02 AU AU47674/00A patent/AU4767400A/en not_active Abandoned
- 2000-05-02 DE DE60032235T patent/DE60032235T2/de not_active Expired - Lifetime
- 2000-05-02 WO PCT/GB2000/001687 patent/WO2000066605A2/en active Application Filing
- 2000-05-02 WO PCT/GB2000/001670 patent/WO2000075306A2/en active Application Filing
- 2000-05-02 WO PCT/GB2000/001683 patent/WO2001094626A1/en active IP Right Grant
- 2000-05-02 AU AU47673/00A patent/AU4767300A/en not_active Abandoned
- 2000-05-02 EP EP00929666A patent/EP1177281B1/de not_active Expired - Lifetime
- 2000-05-02 AU AU45890/00A patent/AU4589000A/en not_active Abandoned
-
2001
- 2001-10-26 US US10/011,495 patent/US6867290B2/en not_active Expired - Fee Related
-
2004
- 2004-04-08 US US10/820,423 patent/US7244568B2/en not_active Expired - Fee Related
-
2005
- 2005-02-14 US US11/057,808 patent/US20050272679A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU4767400A (en) | 2000-12-28 |
WO2000075306A3 (en) | 2001-05-17 |
US20050272679A1 (en) | 2005-12-08 |
DE60032235D1 (de) | 2007-01-18 |
AU4588000A (en) | 2000-12-28 |
DE60032235T2 (de) | 2007-11-15 |
US6794140B1 (en) | 2004-09-21 |
US7244568B2 (en) | 2007-07-17 |
WO2000066605A3 (en) | 2001-04-26 |
EP1196631A1 (de) | 2002-04-17 |
WO2000066605A2 (en) | 2000-11-09 |
WO2000075306A2 (en) | 2000-12-14 |
US6867290B2 (en) | 2005-03-15 |
US20030039985A1 (en) | 2003-02-27 |
AU4589000A (en) | 2000-11-17 |
ATE421583T1 (de) | 2009-02-15 |
WO2000075302A3 (en) | 2001-04-26 |
WO2000075302A2 (en) | 2000-12-14 |
EP1196631B1 (de) | 2006-12-06 |
EP1177281B1 (de) | 2009-01-21 |
DE60041442D1 (de) | 2009-03-12 |
WO2001094626A1 (en) | 2001-12-13 |
US20050074753A1 (en) | 2005-04-07 |
AU4767300A (en) | 2001-12-17 |
EP1177281A2 (de) | 2002-02-06 |
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