NO307710B1 - Fremgangsmåte ved fremstilling av <beta>-laktamer - Google Patents

Fremgangsmåte ved fremstilling av <beta>-laktamer

Info

Publication number
NO307710B1
NO307710B1 NO930006A NO930006A NO307710B1 NO 307710 B1 NO307710 B1 NO 307710B1 NO 930006 A NO930006 A NO 930006A NO 930006 A NO930006 A NO 930006A NO 307710 B1 NO307710 B1 NO 307710B1
Authority
NO
Norway
Prior art keywords
beta
lactams
preparation
lactam
concentration
Prior art date
Application number
NO930006A
Other languages
English (en)
Other versions
NO930006D0 (no
NO930006L (no
Inventor
Svend Gunnar Kaasgaard
Ulla Veitland
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of NO930006D0 publication Critical patent/NO930006D0/no
Publication of NO930006L publication Critical patent/NO930006L/no
Publication of NO307710B1 publication Critical patent/NO307710B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
NO930006A 1990-07-04 1993-01-04 Fremgangsmåte ved fremstilling av <beta>-laktamer NO307710B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90610045 1990-07-04
PCT/DK1991/000188 WO1992001061A1 (en) 1990-07-04 1991-07-03 PROCESS FOR PREPARATION OF β-LACTAMS

Publications (3)

Publication Number Publication Date
NO930006D0 NO930006D0 (no) 1993-01-04
NO930006L NO930006L (no) 1993-01-04
NO307710B1 true NO307710B1 (no) 2000-05-15

Family

ID=8205872

Family Applications (1)

Application Number Title Priority Date Filing Date
NO930006A NO307710B1 (no) 1990-07-04 1993-01-04 Fremgangsmåte ved fremstilling av <beta>-laktamer

Country Status (17)

Country Link
US (1) US5525483A (no)
EP (1) EP0537255B1 (no)
JP (1) JP3115593B2 (no)
KR (1) KR100222606B1 (no)
AT (1) ATE317912T1 (no)
AU (1) AU8208691A (no)
CA (1) CA2086250C (no)
CZ (1) CZ381392A3 (no)
DE (1) DE69133509T2 (no)
ES (1) ES2258260T3 (no)
FI (1) FI925988A (no)
NO (1) NO307710B1 (no)
PT (1) PT98205B (no)
RU (1) RU2136759C1 (no)
SK (1) SK381392A3 (no)
WO (1) WO1992001061A1 (no)
ZA (1) ZA915142B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL170842B1 (pl) * 1991-12-19 1997-01-31 Gist Brocades Bv Sposób wytwarzania antybiotyków ß -laktamowych PL PL PL
ES2135446T3 (es) * 1992-04-24 1999-11-01 Lilly Co Eli Procedimiento para la preparacion de cefalosporinas.
WO1994017800A1 (en) * 1993-02-15 1994-08-18 Gist-Brocades B.V. AN IMPROVED β-LACTAM ANTIBIOTIC COMPOSITION
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
JPH0719083U (ja) * 1993-09-20 1995-04-04 株式会社江崎製作所 自動二輪車のヘッドパイプ
AUPM543894A0 (en) * 1994-05-04 1994-05-26 Commonwealth Scientific And Industrial Research Organisation An adjuvant
US5753458A (en) * 1994-06-10 1998-05-19 Gist-Brocades B.V. Acylation method for penicillins and cephalosporins
US6048708A (en) * 1994-07-18 2000-04-11 Gist-Brocades B.V. Process for preparation of β-lactams at constantly high concentration of reactants
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
DK0730036T3 (da) * 1995-02-28 2000-07-24 Acs Dobfar Spa Fremgangsmåde til enzymatisk syntese af Beta-lactamantibiotika i nærvær af en enzyminhibitor
IT1274658B (it) * 1995-02-28 1997-07-18 Acs Dobfar Spa Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
ES2195024T3 (es) * 1995-12-08 2003-12-01 Dsm Ip Assets Bv Procedimiento para la preparacion de antibioticos.
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
NL1006266C2 (nl) * 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
KR101420451B1 (ko) 2006-05-19 2014-07-16 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 세파드록실의 결정화 방법
ES2365831T3 (es) 2007-03-09 2011-10-11 Dsm Ip Assets B.V. Proceso para preparar compuestos beta-lactámicos.
EP2723882B1 (en) 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase
EP2723881A2 (en) 2011-06-23 2014-04-30 DSM Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079305A (en) * 1959-09-24 1963-02-26 Bayer Ag Process for the enzymatic acylation of 6-aminopenicillanic acid
US3152050A (en) * 1962-12-27 1964-10-06 American Home Prod Enzymatic process for preparing penicillins
JPS5417030B2 (no) * 1972-12-06 1979-06-27
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
DE3507403A1 (de) * 1985-03-02 1986-09-04 Hoechst Ag, 6230 Frankfurt Enzymatische semisynthese von ss-lactamantibiotika
DE68926548T2 (de) * 1988-04-26 1996-09-26 Gist Brocades Nv Verfahren zur enzymatischen Herstellung von beta-Lactamen
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.

Also Published As

Publication number Publication date
WO1992001061A1 (en) 1992-01-23
DE69133509T2 (de) 2006-08-24
PT98205B (pt) 1998-12-31
ES2258260T3 (es) 2006-08-16
KR100222606B1 (en) 1999-10-01
FI925988A0 (fi) 1992-12-31
SK381392A3 (en) 1995-11-08
FI925988A (fi) 1992-12-31
NO930006D0 (no) 1993-01-04
DE69133509D1 (de) 2006-04-20
CZ381392A3 (en) 1993-12-15
RU2136759C1 (ru) 1999-09-10
CA2086250A1 (en) 1992-01-05
AU8208691A (en) 1992-02-04
PT98205A (pt) 1992-05-29
NO930006L (no) 1993-01-04
JP3115593B2 (ja) 2000-12-11
ATE317912T1 (de) 2006-03-15
CA2086250C (en) 2001-05-29
EP0537255B1 (en) 2006-02-15
US5525483A (en) 1996-06-11
JPH05507623A (ja) 1993-11-04
EP0537255A1 (en) 1993-04-21
ZA915142B (en) 1992-05-27

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