KR100222606B1 - Process for preparation of beta-lactams - Google Patents

Process for preparation of beta-lactams Download PDF

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Publication number
KR100222606B1
KR100222606B1 KR1019930700004A KR930700004A KR100222606B1 KR 100222606 B1 KR100222606 B1 KR 100222606B1 KR 1019930700004 A KR1019930700004 A KR 1019930700004A KR 930700004 A KR930700004 A KR 930700004A KR 100222606 B1 KR100222606 B1 KR 100222606B1
Authority
KR
South Korea
Prior art keywords
beta
lactams
preparation
lactam
concentration
Prior art date
Application number
KR1019930700004A
Other languages
English (en)
Inventor
Svend Gunnar Kaasgaard
Ulla Veitland
Original Assignee
Dsm Gist B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Gist B V filed Critical Dsm Gist B V
Application granted granted Critical
Publication of KR100222606B1 publication Critical patent/KR100222606B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
KR1019930700004A 1990-07-04 1993-01-04 Process for preparation of beta-lactams KR100222606B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90610045 1990-07-04

Publications (1)

Publication Number Publication Date
KR100222606B1 true KR100222606B1 (en) 1999-10-01

Family

ID=8205872

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700004A KR100222606B1 (en) 1990-07-04 1993-01-04 Process for preparation of beta-lactams

Country Status (17)

Country Link
US (1) US5525483A (ko)
EP (1) EP0537255B1 (ko)
JP (1) JP3115593B2 (ko)
KR (1) KR100222606B1 (ko)
AT (1) ATE317912T1 (ko)
AU (1) AU8208691A (ko)
CA (1) CA2086250C (ko)
CZ (1) CZ381392A3 (ko)
DE (1) DE69133509T2 (ko)
ES (1) ES2258260T3 (ko)
FI (1) FI925988A0 (ko)
NO (1) NO307710B1 (ko)
PT (1) PT98205B (ko)
RU (1) RU2136759C1 (ko)
SK (1) SK381392A3 (ko)
WO (1) WO1992001061A1 (ko)
ZA (1) ZA915142B (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0618979A1 (en) * 1991-12-19 1994-10-12 Gist-Brocades B.V. AN IMPROVED METHOD FOR THE PREPARATION OF CERTAIN $g(b)-LACTAM ANTIBIOTICS
NZ247464A (en) * 1992-04-24 1994-12-22 Lilly Co Eli Preparation of 2-amino-acetamidocephalosporin derivatives, the 2-acetamido group substituted in the 2-position by a c5-6 cyclic hydrocarbon or a c5-heterocycle
WO1994017800A1 (en) * 1993-02-15 1994-08-18 Gist-Brocades B.V. AN IMPROVED β-LACTAM ANTIBIOTIC COMPOSITION
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
JPH0719083U (ja) * 1993-09-20 1995-04-04 株式会社江崎製作所 自動二輪車のヘッドパイプ
AUPM543894A0 (en) * 1994-05-04 1994-05-26 Commonwealth Scientific And Industrial Research Organisation An adjuvant
AU2881595A (en) * 1994-06-10 1996-01-05 Gist-Brocades B.V. Improved acylation method for penicillins and cephalosporins
AU3163295A (en) * 1994-07-18 1996-02-16 Gist-Brocades B.V. Process for preparation of beta -lactams at constantly high concentration of reactants
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
IT1274658B (it) * 1995-02-28 1997-07-18 Acs Dobfar Spa Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
DK0730036T3 (da) * 1995-02-28 2000-07-24 Acs Dobfar Spa Fremgangsmåde til enzymatisk syntese af Beta-lactamantibiotika i nærvær af en enzyminhibitor
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
DE69626842D1 (de) * 1995-12-08 2003-04-24 Dsm Nv Verfahren zur herstellung eines anitibiotkums
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
NL1006266C2 (nl) * 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
CN101448842A (zh) 2006-05-19 2009-06-03 帝斯曼知识产权资产管理有限公司 一种用于结晶头孢羟氨苄的方法
EP2121960B1 (en) 2007-03-09 2011-06-01 DSM IP Assets B.V. Process for the preparation of beta-lactam compounds
CN103635586A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 结晶头孢氧哌唑中间体、其制备方法及其制药用途
CN103635585A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 用青霉素g酰化酶制备3’-硫代头孢菌素的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079305A (en) * 1959-09-24 1963-02-26 Bayer Ag Process for the enzymatic acylation of 6-aminopenicillanic acid
US3152050A (en) * 1962-12-27 1964-10-06 American Home Prod Enzymatic process for preparing penicillins
JPS5417030B2 (ko) * 1972-12-06 1979-06-27
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
DE3507403A1 (de) * 1985-03-02 1986-09-04 Hoechst Ag, 6230 Frankfurt Enzymatische semisynthese von ss-lactamantibiotika
ATE138690T1 (de) * 1988-04-26 1996-06-15 Gist Brocades Nv Verfahren zur enzymatischen herstellung von beta- lactamen
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.

Also Published As

Publication number Publication date
CA2086250C (en) 2001-05-29
NO307710B1 (no) 2000-05-15
EP0537255A1 (en) 1993-04-21
JPH05507623A (ja) 1993-11-04
WO1992001061A1 (en) 1992-01-23
FI925988A (fi) 1992-12-31
ZA915142B (en) 1992-05-27
NO930006L (no) 1993-01-04
JP3115593B2 (ja) 2000-12-11
FI925988A0 (fi) 1992-12-31
RU2136759C1 (ru) 1999-09-10
CA2086250A1 (en) 1992-01-05
ATE317912T1 (de) 2006-03-15
AU8208691A (en) 1992-02-04
CZ381392A3 (en) 1993-12-15
NO930006D0 (no) 1993-01-04
PT98205A (pt) 1992-05-29
US5525483A (en) 1996-06-11
DE69133509T2 (de) 2006-08-24
SK381392A3 (en) 1995-11-08
ES2258260T3 (es) 2006-08-16
EP0537255B1 (en) 2006-02-15
DE69133509D1 (de) 2006-04-20
PT98205B (pt) 1998-12-31

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