RU92016568A - Способ получения производных бета-лактамов - Google Patents

Способ получения производных бета-лактамов

Info

Publication number
RU92016568A
RU92016568A RU92016568/13A RU92016568A RU92016568A RU 92016568 A RU92016568 A RU 92016568A RU 92016568/13 A RU92016568/13 A RU 92016568/13A RU 92016568 A RU92016568 A RU 92016568A RU 92016568 A RU92016568 A RU 92016568A
Authority
RU
Russia
Prior art keywords
lactam derivatives
beta lactam
obtaining beta
beta
lactam
Prior art date
Application number
RU92016568/13A
Other languages
English (en)
Other versions
RU2136759C1 (ru
Inventor
Гуннар Косгорд Свенн
Вейтланд Улла
Original Assignee
Гист-Брокадс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гист-Брокадс Б.В. filed Critical Гист-Брокадс Б.В.
Priority claimed from PCT/DK1991/000188 external-priority patent/WO1992001061A1/en
Publication of RU92016568A publication Critical patent/RU92016568A/ru
Application granted granted Critical
Publication of RU2136759C1 publication Critical patent/RU2136759C1/ru

Links

Claims (1)

  1. Предложен способ синтеза производных бета-лактамов посредством ферментативной реакции исходного бета-лактама с соответствующим агентом ацилирования, причем сумма концентраций агента ацилирования и концентрации производного бета-лактама в реакционной смеси составляет более примерно 400 мМ.
RU92016568A 1990-07-04 1991-07-03 Способ получения производного бета-лактама RU2136759C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP90610045.8 1990-07-04
EP90610045 1990-07-04
EP90610045,8 1990-07-04
PCT/DK1991/000188 WO1992001061A1 (en) 1990-07-04 1991-07-03 PROCESS FOR PREPARATION OF β-LACTAMS

Publications (2)

Publication Number Publication Date
RU92016568A true RU92016568A (ru) 1996-07-10
RU2136759C1 RU2136759C1 (ru) 1999-09-10

Family

ID=8205872

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92016568A RU2136759C1 (ru) 1990-07-04 1991-07-03 Способ получения производного бета-лактама

Country Status (17)

Country Link
US (1) US5525483A (ru)
EP (1) EP0537255B1 (ru)
JP (1) JP3115593B2 (ru)
KR (1) KR100222606B1 (ru)
AT (1) ATE317912T1 (ru)
AU (1) AU8208691A (ru)
CA (1) CA2086250C (ru)
CZ (1) CZ381392A3 (ru)
DE (1) DE69133509T2 (ru)
ES (1) ES2258260T3 (ru)
FI (1) FI925988A0 (ru)
NO (1) NO307710B1 (ru)
PT (1) PT98205B (ru)
RU (1) RU2136759C1 (ru)
SK (1) SK381392A3 (ru)
WO (1) WO1992001061A1 (ru)
ZA (1) ZA915142B (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK63894A3 (en) * 1991-12-19 1995-03-08 Novo Nordisk As Method of preparation of beta-lactam antibiotic
ZA932809B (en) * 1992-04-24 1994-10-21 Lilly Co Eli Process for preparing cephalosporins.
WO1994017800A1 (en) * 1993-02-15 1994-08-18 Gist-Brocades B.V. AN IMPROVED β-LACTAM ANTIBIOTIC COMPOSITION
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
JPH0719083U (ja) * 1993-09-20 1995-04-04 株式会社江崎製作所 自動二輪車のヘッドパイプ
AUPM543894A0 (en) * 1994-05-04 1994-05-26 Commonwealth Scientific And Industrial Research Organisation An adjuvant
WO1995034675A1 (en) * 1994-06-10 1995-12-21 Gist-Brocades B.V. Improved acylation method for penicillins and cephalosporins
CN1095875C (zh) * 1994-07-18 2002-12-11 吉斯特·布罗卡迪斯股份有限公司 在恒定的高反应物浓度下制备β－内酰胺的方法
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
IT1274658B (it) * 1995-02-28 1997-07-18 Acs Dobfar Spa Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
DE69607778T2 (de) * 1995-02-28 2000-08-10 Acs Dobfar S.P.A., Tribiano Verfahren zur enzymatischen Synthese von beta-laktam Antibiotika in Anwesenheit von einem Enzyminhibitor
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
KR100455252B1 (ko) * 1995-12-08 2005-01-15 디에스엠 기스트 베.파우. 항생제제조방법
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
EP2024374A1 (en) 2006-05-19 2009-02-18 DSMIP Assets B.V. Process for the crystallisation of cefadroxil
EP2121960B1 (en) * 2007-03-09 2011-06-01 DSM IP Assets B.V. Process for the preparation of beta-lactam compounds
ES2729707T3 (es) 2011-06-23 2019-11-05 Centrient Pharmaceuticals Netherlands B V Proceso de preparación de cefalosporinas 3'-tiosustituidas empleando una penicilina G acilasa
EP2723881A2 (en) 2011-06-23 2014-04-30 DSM Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079305A (en) * 1959-09-24 1963-02-26 Bayer Ag Process for the enzymatic acylation of 6-aminopenicillanic acid
US3152050A (en) * 1962-12-27 1964-10-06 American Home Prod Enzymatic process for preparing penicillins
JPS5417030B2 (ru) * 1972-12-06 1979-06-27
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
DE3507403A1 (de) * 1985-03-02 1986-09-04 Hoechst Ag, 6230 Frankfurt Enzymatische semisynthese von ss-lactamantibiotika
DK198789A (da) * 1988-04-26 1989-10-27 Gist Brocades Nv Fremgangsmaade til enzymatisk fremstilling af beta-lactamer
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.

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