IT1274658B - Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine - Google Patents

Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine

Info

Publication number
IT1274658B
IT1274658B ITMI950383A ITMI950383A IT1274658B IT 1274658 B IT1274658 B IT 1274658B IT MI950383 A ITMI950383 A IT MI950383A IT MI950383 A ITMI950383 A IT MI950383A IT 1274658 B IT1274658 B IT 1274658B
Authority
IT
Italy
Prior art keywords
penicillins
cephalosporins
production
improved enzymatic
enzymatic procedure
Prior art date
Application number
ITMI950383A
Other languages
English (en)
Inventor
Maurizio Zenoni
Original Assignee
Acs Dobfar Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acs Dobfar Spa filed Critical Acs Dobfar Spa
Publication of ITMI950383A0 publication Critical patent/ITMI950383A0/it
Priority to ITMI950383A priority Critical patent/IT1274658B/it
Priority to EP95120490A priority patent/EP0730035A1/en
Priority to CA002167118A priority patent/CA2167118A1/en
Priority to ES96101581T priority patent/ES2146332T3/es
Priority to AT96101581T priority patent/ATE191932T1/de
Priority to DE69607778T priority patent/DE69607778T2/de
Priority to PT96101581T priority patent/PT730036E/pt
Priority to DK96101581T priority patent/DK0730036T3/da
Priority to EP96101581A priority patent/EP0730036B1/en
Priority to CA002168923A priority patent/CA2168923C/en
Priority to ZA961015A priority patent/ZA961015B/xx
Priority to ZA961014A priority patent/ZA961014B/xx
Priority to JP8030699A priority patent/JPH08242884A/ja
Priority to JP8036837A priority patent/JPH08256789A/ja
Priority to CN96102535A priority patent/CN1144274A/zh
Priority to KR1019960004720A priority patent/KR100449193B1/ko
Priority to BR9600830A priority patent/BR9600830A/pt
Priority to KR1019960004719A priority patent/KR960031621A/ko
Priority to UA96020754A priority patent/UA44709C2/uk
Priority to CN96102555A priority patent/CN1087350C/zh
Priority to AU45799/96A priority patent/AU699930B2/en
Priority to BR9600835A priority patent/BR9600835A/pt
Priority to AU45798/96A priority patent/AU4579896A/en
Publication of ITMI950383A1 publication Critical patent/ITMI950383A1/it
Application granted granted Critical
Publication of IT1274658B publication Critical patent/IT1274658B/it
Priority to GR20000401585T priority patent/GR3033900T3/el
Priority to RU2002109387/13A priority patent/RU2002109387A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase
ITMI950383A 1995-02-28 1995-02-28 Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine IT1274658B (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ITMI950383A IT1274658B (it) 1995-02-28 1995-02-28 Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
EP95120490A EP0730035A1 (en) 1995-02-28 1995-12-22 Improved enzymatic process for producing penicillins and cephalosporins
CA002167118A CA2167118A1 (en) 1995-02-28 1996-01-12 Enzymatic process for producing penicillins and cephalosporins
ES96101581T ES2146332T3 (es) 1995-02-28 1996-02-05 Procedimiento para la sintesis enzimatica de antibioticos beta-lactama en presencia de un inhibidor de enzima.
AT96101581T ATE191932T1 (de) 1995-02-28 1996-02-05 Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitor
DE69607778T DE69607778T2 (de) 1995-02-28 1996-02-05 Verfahren zur enzymatischen Synthese von beta-laktam Antibiotika in Anwesenheit von einem Enzyminhibitor
PT96101581T PT730036E (pt) 1995-02-28 1996-02-05 Processo para a sintese enzimatica de antibioticos beta-lactamicos na presenca de um inibidor da enzima
DK96101581T DK0730036T3 (da) 1995-02-28 1996-02-05 Fremgangsmåde til enzymatisk syntese af Beta-lactamantibiotika i nærvær af en enzyminhibitor
EP96101581A EP0730036B1 (en) 1995-02-28 1996-02-05 Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor
CA002168923A CA2168923C (en) 1995-02-28 1996-02-06 Process for the enzymatic synthesis of .beta.-lactam antibiotics in the presence of an enzyme inhibitor
ZA961015A ZA961015B (en) 1995-02-28 1996-02-08 Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an ezyme inhibitor
ZA961014A ZA961014B (en) 1995-02-28 1996-02-08 Enzymatic process for producing penicillins and cephalosporins
JP8030699A JPH08242884A (ja) 1995-02-28 1996-02-19 ペニシリン及びセファロスポリンの酵素製造法
JP8036837A JPH08256789A (ja) 1995-02-28 1996-02-23 β−ラクタム抗生物質の酵素阻害剤の存在下での酵素合成法
CN96102535A CN1144274A (zh) 1995-02-28 1996-02-26 制备青霉素和头孢菌素的改进的酶催化方法
CN96102555A CN1087350C (zh) 1995-02-28 1996-02-27 酶抑制剂存在下酶法合成β－内酰胺抗生素的方法
BR9600830A BR9600830A (pt) 1995-02-28 1996-02-27 Processo para a produção de uma penicilina ou cefalosporina composição farmacêutica e enzima acilase penicilina
KR1019960004719A KR960031621A (ko) 1995-02-28 1996-02-27 페니실린과 세팔로스포린을 제조하기 위한 개선된 효소공정
UA96020754A UA44709C2 (uk) 1995-02-28 1996-02-27 Спосіб oдержання пеніциліну чи цефалоспорину
KR1019960004720A KR100449193B1 (ko) 1995-02-28 1996-02-27 효소억제제의존재하에서의β-락탐항생제의효소적합성방법
AU45799/96A AU699930B2 (en) 1995-02-28 1996-02-28 Process for enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor
BR9600835A BR9600835A (pt) 1995-02-28 1996-02-28 Processo para preparar penicilinas ou cefalosporinas e composiç o farmacêutica que as contêm
AU45798/96A AU4579896A (en) 1995-02-28 1996-02-28 Improved enzymatic process for producing penicillins and cephalosporins
GR20000401585T GR3033900T3 (en) 1995-02-28 2000-07-05 Process for the enzymatic synthesis of beta-lactam antibiotics in the presence of an enzyme inhibitor
RU2002109387/13A RU2002109387A (ru) 1995-02-28 2002-04-10 Способ ферментативного синтеза бета-лактамовых антибиотиков в присутствии ингибитора фермента

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI950383A IT1274658B (it) 1995-02-28 1995-02-28 Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine

Publications (3)

Publication Number Publication Date
ITMI950383A0 ITMI950383A0 (it) 1995-02-28
ITMI950383A1 ITMI950383A1 (it) 1996-08-28
IT1274658B true IT1274658B (it) 1997-07-18

Family

ID=11370726

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI950383A IT1274658B (it) 1995-02-28 1995-02-28 Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine

Country Status (9)

Country Link
EP (1) EP0730035A1 (it)
JP (1) JPH08242884A (it)
KR (1) KR960031621A (it)
CN (1) CN1144274A (it)
AU (1) AU4579896A (it)
BR (1) BR9600830A (it)
CA (1) CA2167118A1 (it)
IT (1) IT1274658B (it)
ZA (2) ZA961014B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2163997B2 (es) * 1999-10-22 2004-07-01 Universidad Complutense De Madrid Procedimiento para la inmovilizacion de una nueva penicilina v acilasa de "streptomyces lavendulae" para la obtencion de acido 6-aminopenicilanico.
ITMI20030042A1 (it) * 2003-01-14 2004-07-15 Univ Degli Studi Trieste Processo di sintesi enzimatica di antibiotici b lattamici.
KR101203287B1 (ko) * 2004-12-27 2012-11-20 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 세파클로르의 합성 방법
US20170101660A1 (en) * 2015-10-07 2017-04-13 Gwangju Institute Of Science And Technology Enzyme-immobilized porous membrane and preparation method of antibiotics using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1347665A (en) * 1971-08-20 1974-02-20 Toyo Jozo Kk Process for the production of cephalexin
IT1045797B (it) * 1973-12-20 1980-06-10 Snam Progetti Procedimento per la sintesi enzimatica di penicilline e cefalosporine semisintetiche mediante una acilasi insolubile
CZ381392A3 (en) * 1990-07-04 1993-12-15 Novo Nordisk As Process for preparing beta-lactams
IT1243800B (it) * 1990-08-28 1994-06-28 Sclavo Spa Procedimento migliorato per la preparazione di cefalosporine
SK63894A3 (en) * 1991-12-19 1995-03-08 Novo Nordisk As Method of preparation of beta-lactam antibiotic
ATE154526T1 (de) * 1992-04-16 1997-07-15 Merck Patent Gmbh Aktivierte trägermaterialien, ihre herstellung und verwendung
DE4333213A1 (de) * 1993-09-29 1995-03-30 Merck Patent Gmbh Immobilisierte Proteinase K

Also Published As

Publication number Publication date
JPH08242884A (ja) 1996-09-24
EP0730035A1 (en) 1996-09-04
ITMI950383A0 (it) 1995-02-28
ITMI950383A1 (it) 1996-08-28
AU4579896A (en) 1996-09-05
BR9600830A (pt) 1997-12-30
KR960031621A (ko) 1996-09-17
CA2167118A1 (en) 1996-08-29
CN1144274A (zh) 1997-03-05
ZA961015B (en) 1996-08-20
ZA961014B (en) 1996-08-29

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