KR960031621A - 페니실린과 세팔로스포린을 제조하기 위한 개선된 효소공정 - Google Patents

페니실린과 세팔로스포린을 제조하기 위한 개선된 효소공정 Download PDF

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KR960031621A
KR960031621A KR1019960004719A KR19960004719A KR960031621A KR 960031621 A KR960031621 A KR 960031621A KR 1019960004719 A KR1019960004719 A KR 1019960004719A KR 19960004719 A KR19960004719 A KR 19960004719A KR 960031621 A KR960031621 A KR 960031621A
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penicillin
cephalosporin
atom
amide
immobilized
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KR1019960004719A
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체노니 마우리치오
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마르코 팔치아니
에이씨에스 도브파 에스. 피. 에이.
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Publication of KR960031621A publication Critical patent/KR960031621A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
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  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

6-아미노 페니실란산 또는 7-아미노 세팔로스포란산을 아즐락톤 중합체에 부동화된 페니실린 아실라아제 효소의 존재하에 수성 매질 속에서 아미드와 반응시켜 페니실린 또는 세팔로스포린을 제조하는 방법이 기재되어 있다.

Description

페니실린과 세팔로스포린을 제조하기 위한 개선된 효소공정
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 일반식(Ⅳ) 또는 (V)의 6-아미노-페니실란산 또는 7-아미노-세팔로스포란산과 일반식(Ⅲ)의 아미드 또는 이의 염을 산(Ⅳ) 또는 (V) 1몰 당 아미드(Ⅲ) 1.5 내지 3몰의 몰비로 부동화 페니실린 아실라아제 효소의 존재하에 수성 매질속에서 -5℃ 내지 +35℃의 온도에서 반응시켜 일반식(I) 또는 (Ⅱ)의 페니실린 또는 세팔로스포린을 제조하는 방법에 있어서, 페니실린 아실라아제 효소가 아즐락톤 중합체에 부동화되어 있음을 특징으로 하는 방법.
    상기 식에서, X는 S 또는 CH2이고, R은 임의로 치환된 6원 환 탄화수소이며, R1은 수소원자, 할로겐원자, 메틸 그룹, 메톡시 그룹, C1내지 C4의 알케닐 그룹, 또는 산소원자, 황원자 또는 질소원자를 통해 유기 라디칼에 결합된 메틸렌 그룹이고, R2와 R3은 서로 독립적으로 수소 또는 직쇄 또는 측쇄의 탄소수 1 내지 3의 알킬그룹이다.
  2. 제1항에 있어서, 아미드(Ⅲ)이 D-페닐글리신 아미드 또는 이와 유기산 또는 무기산과의 염임을 특징으로 하는 방법.
  3. 제1항 또는 제2항의 방법에 의해 제조된 페니실린 또는 세팔로스포린과 약제학적으로 허용되는 담체 또는 희석제를 포함하는 약제학적 조성물.
  4. 아즐락톤 중합체에 부동화된 효소 페니실린 아실라아제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960004719A 1995-02-28 1996-02-27 페니실린과 세팔로스포린을 제조하기 위한 개선된 효소공정 KR960031621A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI950383A IT1274658B (it) 1995-02-28 1995-02-28 Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
ITMI95A000383 1995-02-28

Publications (1)

Publication Number Publication Date
KR960031621A true KR960031621A (ko) 1996-09-17

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KR1019960004719A KR960031621A (ko) 1995-02-28 1996-02-27 페니실린과 세팔로스포린을 제조하기 위한 개선된 효소공정

Country Status (9)

Country Link
EP (1) EP0730035A1 (ko)
JP (1) JPH08242884A (ko)
KR (1) KR960031621A (ko)
CN (1) CN1144274A (ko)
AU (1) AU4579896A (ko)
BR (1) BR9600830A (ko)
CA (1) CA2167118A1 (ko)
IT (1) IT1274658B (ko)
ZA (2) ZA961015B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2163997B2 (es) * 1999-10-22 2004-07-01 Universidad Complutense De Madrid Procedimiento para la inmovilizacion de una nueva penicilina v acilasa de "streptomyces lavendulae" para la obtencion de acido 6-aminopenicilanico.
ITMI20030042A1 (it) * 2003-01-14 2004-07-15 Univ Degli Studi Trieste Processo di sintesi enzimatica di antibiotici b lattamici.
JP5022913B2 (ja) * 2004-12-27 2012-09-12 ディーエスエム シノケム ファーマシューティカルズ ネザーランズ ビー．ヴイ． セファクロルの合成方法
US20170101660A1 (en) * 2015-10-07 2017-04-13 Gwangju Institute Of Science And Technology Enzyme-immobilized porous membrane and preparation method of antibiotics using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE404928B (sv) * 1971-08-20 1978-11-06 Toyo Jozo Kk Framstellning av cefalexin med hjelp av acylerande enzym
IT1045797B (it) * 1973-12-20 1980-06-10 Snam Progetti Procedimento per la sintesi enzimatica di penicilline e cefalosporine semisintetiche mediante una acilasi insolubile
WO1992001061A1 (en) * 1990-07-04 1992-01-23 Novo Nordisk A/S PROCESS FOR PREPARATION OF β-LACTAMS
IT1243800B (it) * 1990-08-28 1994-06-28 Sclavo Spa Procedimento migliorato per la preparazione di cefalosporine
DE618979T1 (de) * 1991-12-19 1995-05-18 Novonordisk As Verbesserte methode zur herstellung von bestimmten -g(b)-lactam-antibiotika.
DE4310964A1 (de) * 1992-04-16 1993-10-21 Merck Patent Gmbh Aktivierte Trägermaterialien, ihre Herstellung und Verwendung
DE4333213A1 (de) * 1993-09-29 1995-03-30 Merck Patent Gmbh Immobilisierte Proteinase K

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Publication number Publication date
ITMI950383A0 (it) 1995-02-28
ZA961015B (en) 1996-08-20
ITMI950383A1 (it) 1996-08-28
ZA961014B (en) 1996-08-29
CN1144274A (zh) 1997-03-05
EP0730035A1 (en) 1996-09-04
AU4579896A (en) 1996-09-05
IT1274658B (it) 1997-07-18
CA2167118A1 (en) 1996-08-29
JPH08242884A (ja) 1996-09-24
BR9600830A (pt) 1997-12-30

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