KR880008972A - 카르복실산 유도체 - Google Patents

카르복실산 유도체 Download PDF

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Publication number
KR880008972A
KR880008972A KR1019880000538A KR880000538A KR880008972A KR 880008972 A KR880008972 A KR 880008972A KR 1019880000538 A KR1019880000538 A KR 1019880000538A KR 880000538 A KR880000538 A KR 880000538A KR 880008972 A KR880008972 A KR 880008972A
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KR
South Korea
Prior art keywords
compound
formula
salt
hydrogen
pharmaceutically acceptable
Prior art date
Application number
KR1019880000538A
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English (en)
Inventor
이쯔오 유키다
히로시 하타나카
쿠미코 니타
세이지 하시모토
마사쿠니 오쿠하라
히데츄구 무라이
마사시 하시모토
Original Assignee
후지사와 도모기찌로
후지사와 야꾸힝 고오교오 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878701618A external-priority patent/GB8701618D0/en
Priority claimed from GB878715931A external-priority patent/GB8715931D0/en
Application filed by 후지사와 도모기찌로, 후지사와 야꾸힝 고오교오 가부시기가이샤 filed Critical 후지사와 도모기찌로
Publication of KR880008972A publication Critical patent/KR880008972A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음.

Description

카르복실산 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 식 (I)의 화합물 또는 그들의 약학적 허용염 :
    여기에서 R1은 수소, 저급알킬 또는 아릴임.
  2. 제1항에 있어서, R1이 메틸인 화합물.
  3. 스트렙토 마이시스 속에 속하는 식 (Ia) 생산균주를 영양기질 중에서 배양하고, 얻어진 배양 브로쓰로부터 화합물(Ia) 또는 그들의 염을 회수하는 단계로 구성된 식 (Ia)의 화합물 또는 그들의 염을 제조하는 방법.
    여기에서 R1 a은 수소 또는 메틸임.
  4. (a) 식 II의 화합물 또는 그들의 염을 가수분해하여 식 (I)의 화합물 또는 그들의 염을 산출하거나 (b) 식 III의 화합물 또는 그들의 염을 가수분해하여 식 (I) 화합물 또는 그들의 염을 산출하는 것을 특징으로 하는 식 (I)의 화합물 또는 그들의 염을 제조하는 방법.
    상기식에서 R1은 수소, 저급알킬 또는 아릴이며, R1와 R3는 각각 보호된 카르복시이며 R4는 하이드록시 카르바모일이고 X는 할로겐이며 R5는 카르복시 또는 보호된 카르복시이며 Y는 할로겐 또는 하이드록시임.
  5. 카르바 페냄항생제 또는 그들의 약학적 허용 염 및 식 (I)의 화합물 또는 그들의 약학적 허용염과 약학적 허용담체를 함유하고 있는 항균성 조성물.
    상기식에서 R1은 수소, 저급알킬 또는 아릴임.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880000538A 1987-01-26 1988-01-25 카르복실산 유도체 KR880008972A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB878701618A GB8701618D0 (en) 1987-01-26 1987-01-26 Carboxylic acid derivatives
JP8701618 1987-01-26
GB878715931A GB8715931D0 (en) 1987-07-07 1987-07-07 Carboxylic acid derivatives
JP8715931 1987-07-07

Publications (1)

Publication Number Publication Date
KR880008972A true KR880008972A (ko) 1988-09-13

Family

ID=26291837

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880000538A KR880008972A (ko) 1987-01-26 1988-01-25 카르복실산 유도체

Country Status (7)

Country Link
US (1) US5061730A (ko)
EP (1) EP0276947B1 (ko)
JP (1) JPS6419047A (ko)
KR (1) KR880008972A (ko)
DE (1) DE3864841D1 (ko)
ES (1) ES2037819T3 (ko)
GR (1) GR3002821T3 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1161947B1 (en) * 1991-02-01 2005-06-08 Daiichi Suntory Pharma Co., Ltd. Oral antibacterial compositions and method for the improvement of gastrointestinal absorption of penem or carbapenem antibiotics
AU762991B2 (en) 1998-03-13 2003-07-10 Burnham Institute, The Molecules that home to various selected organs or tissues
US6174687B1 (en) 1999-02-26 2001-01-16 The Burnham Institute Methods of identifying lung homing molecules using membrane dipeptidase
GB0116142D0 (en) * 2001-07-02 2001-08-22 Astrazeneca Ab Method
EP1448563A1 (en) * 2001-11-16 2004-08-25 Ranbaxy Laboratories, Ltd. Process for the preparation of crystalline imipenem

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048301A1 (en) * 1980-09-24 1982-03-31 Merck & Co. Inc. 2-(Cyclopropane-carboxamido)-2-alkenoic acids, their esters and salts, and antibacterial compositions comprising the same and a thienamycin-type compound
US4757066A (en) * 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
JPH01272553A (ja) * 1988-04-22 1989-10-31 Fujisawa Pharmaceut Co Ltd カルボン酸誘導体

Also Published As

Publication number Publication date
US5061730A (en) 1991-10-29
JPS6419047A (en) 1989-01-23
DE3864841D1 (de) 1991-10-24
EP0276947A3 (en) 1989-03-29
EP0276947A2 (en) 1988-08-03
EP0276947B1 (en) 1991-09-18
GR3002821T3 (en) 1993-01-25
ES2037819T3 (es) 1993-07-01

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