KR920006360A - 스쿠알렌 합성효소 억제제 - Google Patents

스쿠알렌 합성효소 억제제 Download PDF

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Publication number
KR920006360A
KR920006360A KR1019910015822A KR910015822A KR920006360A KR 920006360 A KR920006360 A KR 920006360A KR 1019910015822 A KR1019910015822 A KR 1019910015822A KR 910015822 A KR910015822 A KR 910015822A KR 920006360 A KR920006360 A KR 920006360A
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KR
South Korea
Prior art keywords
compound
pharmaceutically acceptable
atcc
compound according
formula
Prior art date
Application number
KR1019910015822A
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English (en)
Inventor
디. 버그스트롬 제임스
후앙 리유안
날린 마리
씨. 오니시 자넬
에프. 빌스 제랄드
에프. 바티잘 케니스
듀프레슨 클라우드
티. 디에쯔 마리아
Original Assignee
제임스 에프. 너턴
머크 앤드 캄파니, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US07/582,452 external-priority patent/US5102907A/en
Priority claimed from US07/582,303 external-priority patent/US5026554A/en
Application filed by 제임스 에프. 너턴, 머크 앤드 캄파니, 인코포레이티드 filed Critical 제임스 에프. 너턴
Publication of KR920006360A publication Critical patent/KR920006360A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

스쿠알렌 합성효소 억제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(I)의 화합물 또는 이의 약학적으로 허용가능한 염.
    상기식에서, Z1, Z2및 Z3는 각각 독립적으로, a) H, b) C1-5알킬 및 c) i)페닐 및 ii) 메틸, 메톡시, 할로겐(Cl, Br, I, F)또는 하이드록시로 치환된 페닐로 구성된 그룹의 한 구성원으로 치환된 C1-5알킬로 구성된 그룹으로부터 선택된다.
  2. 제1항에 있어서, 일반식(I)의 상대적 배위가 다음과 같은 화합물 또는 이의 약학적으로 허용가능한 염.
    상기식에서, Z1, Z2및 Z3는 각각 -CH2또는 -H이다.
  3. 제1항에 있어서, 일반식(I)의 절대적 배위가 다음과 같은 화합물 또는 이의 약학적으로 허용가능한 염.
    상기식에서, Z1, Z2및 Z3는 각각 -CH3또는 -H이다.
  4. 비독성의 치료학적 유효한 양의 제1항의 화합물 및 약학적으로 허용 가능한 담체를 함유하는 약학적 조성물.
  5. 콜레스테롤 과다증 환자에게서 콜레스테롤 과다증을 치료하는데 유용한 약제 제조를 위한 제1항에 따른 화합물의 용도.
  6. 스쿠알렌 합성효소가 억제되어야할 환자에게서 스쿠알렌 합성효소를 억제하는데 유용한 약제 제조를 위한 제1항에 따른 화합물의 용도.
  7. 항진균적 유효량의 제1항의 화합물을 진균생장이 방제되어야할 영역에 적용하여 진균 생육을 억제하기 위한 제1항에 따른 화합물의 용도.
  8. 회수가능량의 제1항의 화합물을 생산할 수 있는 MF 5465(ATCC 74011) 또는 이의 활성 돌연변이의 생물학적으로 순순한 배양물.
  9. 회수가능량의 제1항의 화합물을 생산할 수 있는 MF 5465(ATCC 74011) 또는 이의 활성 돌연변이제 배양물.
  10. 제1항의 화합물 형성에 적합한 조건하에서, MF 5465(ATCC 74011) 또는 이의 활성 돌연변이체를 배양하고 이 화합물을 회수함을 특징으로 하여, 제1항의 화합물을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910015822A 1990-09-13 1991-09-11 스쿠알렌 합성효소 억제제 KR920006360A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US58245390A 1990-09-13 1990-09-13
US07/582,452 US5102907A (en) 1990-09-13 1990-09-13 Novel squalene synthetase inhibitors
US07/582453 1990-09-13
US07/582,303 US5026554A (en) 1990-09-13 1990-09-13 Method of inhibiting fungal growth using squalene synthetase inhibitors
US07/582,303 1990-09-13
US07/582452 1990-09-13

Publications (1)

Publication Number Publication Date
KR920006360A true KR920006360A (ko) 1992-04-27

Family

ID=27416377

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910015822A KR920006360A (ko) 1990-09-13 1991-09-11 스쿠알렌 합성효소 억제제

Country Status (12)

Country Link
EP (1) EP0475706A1 (ko)
JP (1) JPH04360889A (ko)
KR (1) KR920006360A (ko)
AU (1) AU640520B2 (ko)
CA (1) CA2050739A1 (ko)
FI (1) FI914295A (ko)
IE (1) IE913221A1 (ko)
IL (1) IL99415A0 (ko)
MX (1) MX9100998A (ko)
NO (1) NO913612L (ko)
NZ (1) NZ239663A (ko)
PT (1) PT98901A (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97251A0 (en) * 1990-03-21 1992-05-25 Merck & Co Inc Antihypercholesterolemic 2,8-dioxabicyclo(3,2,1)octane derivatives,their preparation and pharmaceutical compositions containing them
IL101810A0 (en) * 1991-05-10 1992-12-30 Merck & Co Inc Cholesterol lowering dioxabicyclo(3.2.1)octane derivatives and pharmaceutical compositions containing them
US5256689A (en) * 1991-05-10 1993-10-26 Merck & Co., Inc. Cholesterol lowering compounds
US5506262A (en) * 1991-05-10 1996-04-09 Merck & Co., Inc. Cholesterol lowering compounds
AU2230292A (en) * 1991-07-16 1993-02-23 Glaxo Group Limited Cyclic ketal derivatives
EP0526936A3 (en) * 1991-08-02 1993-05-05 Merck & Co. Inc. Cholesterol-lowering agents
US5364948A (en) * 1991-08-02 1994-11-15 Merck & Co., Inc. Biologically active compounds isolated from aerobic fermentation of Trichoderma viride
GB2261373A (en) * 1991-11-15 1993-05-19 Merck & Co Inc Inhibitors of farnesyl protein transferase as anti-cancer agents
US5294627A (en) * 1992-08-27 1994-03-15 Merck & Co., Inc. Directed biosynthesis of biologically active compounds
US5726306A (en) * 1992-04-20 1998-03-10 Takeda Chemical Industries, Ltd. 4,1-benzoxazepin derivatives and their use
DE69332792T2 (de) * 1992-04-20 2004-01-15 Takeda Chemical Industries Ltd 4,1-Benzoxazepinderivate als Squalen-Synthetase Inhibitoren und ihre Verwendung zur Behandlung von Hypercholesterämie und als Fungizide
EP0568946A1 (en) * 1992-05-08 1993-11-10 Takeda Chemical Industries, Ltd. Compound TAN-1607A, its derivatives, their production, and use thereof
US5283256A (en) * 1992-07-22 1994-02-01 Merck & Co., Inc. Cholesterol-lowering agents
US5310949A (en) * 1992-09-02 1994-05-10 Merck & Co., Inc. Cholesterol lowering compounds
US5322855A (en) * 1992-10-19 1994-06-21 Merck & Co., Inc. Cholesterol lowering compounds
US5447717A (en) * 1993-02-25 1995-09-05 Merck & Co., Inc. Cholesterol-lowering agents
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97251A0 (en) * 1990-03-21 1992-05-25 Merck & Co Inc Antihypercholesterolemic 2,8-dioxabicyclo(3,2,1)octane derivatives,their preparation and pharmaceutical compositions containing them
JPH06504774A (ja) * 1991-01-09 1994-06-02 グラクソ、グループ、リミテッド 架橋環状ケタール誘導体
GB9100431D0 (en) * 1991-01-09 1991-02-20 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
NO913612L (no) 1992-03-16
CA2050739A1 (en) 1992-03-14
FI914295A0 (fi) 1991-09-12
IL99415A0 (en) 1992-08-18
PT98901A (pt) 1992-08-31
AU8386891A (en) 1992-03-19
NO913612D0 (no) 1991-09-12
FI914295A (fi) 1992-03-14
EP0475706A1 (en) 1992-03-18
NZ239663A (en) 1993-07-27
AU640520B2 (en) 1993-08-26
JPH04360889A (ja) 1992-12-14
MX9100998A (es) 1992-05-04
IE913221A1 (en) 1992-02-25

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