ES467562A1 - Un procedimiento para la preparacion de nuevos derivados de 1-azabiciclo (3.2.0) hept-2-en-2-carboxilico - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 1-azabiciclo (3.2.0) hept-2-en-2-carboxilico

Info

Publication number
ES467562A1
ES467562A1 ES467562A ES467562A ES467562A1 ES 467562 A1 ES467562 A1 ES 467562A1 ES 467562 A ES467562 A ES 467562A ES 467562 A ES467562 A ES 467562A ES 467562 A1 ES467562 A1 ES 467562A1
Authority
ES
Spain
Prior art keywords
salts
same
compounds
composition containing
medical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467562A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9366/77A external-priority patent/GB1601688A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES467562A1 publication Critical patent/ES467562A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1.Un procedimiento para la preparación de nuevos derivados del 1-azabiciclo {3.2.0} hep-2-en-2-carboxílico de fórmula: **(Fórmula-01)** donde W representa un dirradical de fórmula: **(Fórmula-02)** o una sal de los mismos; cuyo procedimiento comprende cultivar una cepa productora de Streptomyces olivaceus o Treptomyces gaddenensis hasta que se ha producido una cantidad sustancial de dicho compuesto del medio de cultivo, y, si se desea, someter una mezcla de las sales obtenidas a separación cromatográfica sobre Diaion HP 20 o sobre una resina cromatográficamente equivalente.
ES467562A 1977-03-05 1978-03-03 Un procedimiento para la preparacion de nuevos derivados de 1-azabiciclo (3.2.0) hept-2-en-2-carboxilico Expired ES467562A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9366/77A GB1601688A (en) 1977-03-05 1977-03-05 6-(1-hydroxyethyl)-7-oxo 1-aza bicyclo (3,2,0)-hept-2-ene-2-carboxylic acid derivatives and their use in pharmaceutical compositions
GB3283677 1977-08-05

Publications (1)

Publication Number Publication Date
ES467562A1 true ES467562A1 (es) 1980-05-16

Family

ID=26242889

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467562A Expired ES467562A1 (es) 1977-03-05 1978-03-03 Un procedimiento para la preparacion de nuevos derivados de 1-azabiciclo (3.2.0) hept-2-en-2-carboxilico

Country Status (11)

Country Link
JP (1) JPS53116396A (es)
AU (1) AU525142B2 (es)
CH (1) CH641805A5 (es)
DE (1) DE2808563A1 (es)
DK (1) DK98478A (es)
ES (1) ES467562A1 (es)
FR (1) FR2401162A1 (es)
IE (1) IE46736B1 (es)
IT (1) IT7848280A0 (es)
NL (1) NL7802356A (es)
SE (1) SE7802462L (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162323A (en) * 1977-04-18 1979-07-24 Merck & Co., Inc. Antibiotic N-acetyl-dehydro-thienamycin
DE2966446D1 (en) * 1978-09-09 1984-01-05 Beecham Group Plc Beta-lactam compounds, their preparation and use
DE3164021D1 (en) * 1980-01-25 1984-07-19 Beecham Group Plc Beta-lactam containing compounds, their preparation and use
IN155384B (es) * 1980-05-14 1985-01-19 Pfizer
JP4977670B2 (ja) * 2008-09-11 2012-07-18 啓司 関口 生花整形器

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143713C (da) * 1975-11-21 1982-03-08 Merck & Co Inc Fremgangsmaade til fremstilling af et antibiotisk stof n-acetyl-thienamycin og salte deraf
DK143712C (da) * 1975-11-21 1982-03-22 Merck & Co Inc Fremgangsmaade til fremstilling af de antibiotiske stoffer 890a1 og 890a3
NL7704040A (nl) * 1976-04-28 1977-11-01 Merck & Co Inc Werkwijze voor het bereiden van nieuwe anti- biotica.

Also Published As

Publication number Publication date
FR2401162A1 (fr) 1979-03-23
SE7802462L (sv) 1978-09-06
IT7848280A0 (it) 1978-03-03
JPS53116396A (en) 1978-10-11
FR2401162B1 (es) 1980-08-29
AU525142B2 (en) 1982-10-21
IE46736B1 (en) 1983-09-07
DK98478A (da) 1978-09-06
IE780443L (en) 1978-09-05
DE2808563A1 (de) 1978-09-07
CH641805A5 (en) 1984-03-15
NL7802356A (nl) 1978-09-07
AU3384178A (en) 1979-09-06

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