IE780443L - Antibiotic from streptomycete - Google Patents

Antibiotic from streptomycete

Info

Publication number
IE780443L
IE780443L IE780443A IE44378A IE780443L IE 780443 L IE780443 L IE 780443L IE 780443 A IE780443 A IE 780443A IE 44378 A IE44378 A IE 44378A IE 780443 L IE780443 L IE 780443L
Authority
IE
Ireland
Prior art keywords
compounds
salts
formulae
streptomycete
antibiotic
Prior art date
Application number
IE780443A
Other versions
IE46736B1 (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9366/77A external-priority patent/GB1601688A/en
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IE780443L publication Critical patent/IE780443L/en
Publication of IE46736B1 publication Critical patent/IE46736B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The novel derivatives are compounds of the formulae I and II and their salts. These compounds are prepared by culturing Streptomyces olivaceus or Streptomyces gedanensis and recovering the compounds formed and/or their salts from the culture medium. Microorganisms preferred for the culture are the strains ATCC 31126 and 31365. The novel compounds of the formulae I and II and their salts exhibit antibacterial action and are employed as active component in medicaments, on their own or in combination with other antibiotics, preferably in the form of an individual, isolated salt. <IMAGE> [FR2401162A1]
IE443/78A 1977-03-05 1978-03-03 6-(1-hydroxyethyl)-7-oxo-1-aza bicyclo (3,2,0)-hept-2-ene-2-carboxylic acid derivatives and their use in pharmaceutical compositions IE46736B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9366/77A GB1601688A (en) 1977-03-05 1977-03-05 6-(1-hydroxyethyl)-7-oxo 1-aza bicyclo (3,2,0)-hept-2-ene-2-carboxylic acid derivatives and their use in pharmaceutical compositions
GB3283677 1977-08-05

Publications (2)

Publication Number Publication Date
IE780443L true IE780443L (en) 1978-09-05
IE46736B1 IE46736B1 (en) 1983-09-07

Family

ID=26242889

Family Applications (1)

Application Number Title Priority Date Filing Date
IE443/78A IE46736B1 (en) 1977-03-05 1978-03-03 6-(1-hydroxyethyl)-7-oxo-1-aza bicyclo (3,2,0)-hept-2-ene-2-carboxylic acid derivatives and their use in pharmaceutical compositions

Country Status (11)

Country Link
JP (1) JPS53116396A (en)
AU (1) AU525142B2 (en)
CH (1) CH641805A5 (en)
DE (1) DE2808563A1 (en)
DK (1) DK98478A (en)
ES (1) ES467562A1 (en)
FR (1) FR2401162A1 (en)
IE (1) IE46736B1 (en)
IT (1) IT7848280A0 (en)
NL (1) NL7802356A (en)
SE (1) SE7802462L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162323A (en) * 1977-04-18 1979-07-24 Merck & Co., Inc. Antibiotic N-acetyl-dehydro-thienamycin
DE2966446D1 (en) * 1978-09-09 1984-01-05 Beecham Group Plc Beta-lactam compounds, their preparation and use
DE3164021D1 (en) * 1980-01-25 1984-07-19 Beecham Group Plc Beta-lactam containing compounds, their preparation and use
IN155384B (en) * 1980-05-14 1985-01-19 Pfizer
JP4977670B2 (en) * 2008-09-11 2012-07-18 啓司 関口 Fresh flower shaping device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143713C (en) * 1975-11-21 1982-03-08 Merck & Co Inc PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC SUBSTANCE N-ACETYL-THIENAMYCINE AND SALTS THEREOF
DK143712C (en) * 1975-11-21 1982-03-22 Merck & Co Inc PROCEDURE FOR PREPARING ANTIBIOTIC SUBSTANCES 890A1 AND 890A3
NL7704040A (en) * 1976-04-28 1977-11-01 Merck & Co Inc PROCEDURE FOR PREPARING NEW ANTI-BIOTICS.

Also Published As

Publication number Publication date
JPS53116396A (en) 1978-10-11
CH641805A5 (en) 1984-03-15
IE46736B1 (en) 1983-09-07
ES467562A1 (en) 1980-05-16
DE2808563A1 (en) 1978-09-07
AU3384178A (en) 1979-09-06
SE7802462L (en) 1978-09-06
DK98478A (en) 1978-09-06
FR2401162A1 (en) 1979-03-23
AU525142B2 (en) 1982-10-21
IT7848280A0 (en) 1978-03-03
NL7802356A (en) 1978-09-07
FR2401162B1 (en) 1980-08-29

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