JPS5620598A - Novel antibiotic and its preparation - Google Patents

Novel antibiotic and its preparation

Info

Publication number
JPS5620598A
JPS5620598A JP9560979A JP9560979A JPS5620598A JP S5620598 A JPS5620598 A JP S5620598A JP 9560979 A JP9560979 A JP 9560979A JP 9560979 A JP9560979 A JP 9560979A JP S5620598 A JPS5620598 A JP S5620598A
Authority
JP
Japan
Prior art keywords
methyl
formula
micromonospora
preparation
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9560979A
Other languages
Japanese (ja)
Other versions
JPH0227360B2 (en
Inventor
Yoshihiko Oka
Hitoshi Ishida
Mikio Morioka
Yozo Numazaki
Tsutomu Santo
Isao Takahashi
Koichi Tanaka
Taku Oosono
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Microbial Chemistry Research Foundation
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation, Yamanouchi Pharmaceutical Co Ltd filed Critical Microbial Chemistry Research Foundation
Priority to JP9560979A priority Critical patent/JPH0227360B2/en
Publication of JPS5620598A publication Critical patent/JPS5620598A/en
Priority to JP29311989A priority patent/JPH02257889A/en
Publication of JPH0227360B2 publication Critical patent/JPH0227360B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An aminoglycoside compound expressed by formula I (R1 and R4 are methyls or H; R2 is OH or H; R3 is amino or OH; R2 is OH when R4 is methyl, and H when R4 is H), or its acid addition salt.
EXAMPLE: 4"-C-methyl-3"-N-methylkanamycin A expressed by formula II.
USE: An antimicrobial agent having a wide range of activites against Gram-positive and Gram-negative bacteria.
PROCESS: A strain capable of producing gentamicin (or its variant), preferably Micromonospora sp.K-6993 or K-6993-Y-41 (FERM-P No.4304 or 4305), belonging to the genus Micromonospora is incubated in a culture medium containing kanamycin A or B at 28W32°C under neutral pH conditions for 3W7 days. The resulting antibiotic is then separated and purified.
COPYRIGHT: (C)1981,JPO&Japio
JP9560979A 1979-07-27 1979-07-27 SHINKIKOSEIBUTSUSHITSU Expired - Lifetime JPH0227360B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP9560979A JPH0227360B2 (en) 1979-07-27 1979-07-27 SHINKIKOSEIBUTSUSHITSU
JP29311989A JPH02257889A (en) 1979-07-27 1989-11-10 Production of novel antibiotic substance or its acid addition salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9560979A JPH0227360B2 (en) 1979-07-27 1979-07-27 SHINKIKOSEIBUTSUSHITSU

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP29311989A Division JPH02257889A (en) 1979-07-27 1989-11-10 Production of novel antibiotic substance or its acid addition salt

Publications (2)

Publication Number Publication Date
JPS5620598A true JPS5620598A (en) 1981-02-26
JPH0227360B2 JPH0227360B2 (en) 1990-06-15

Family

ID=14142285

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9560979A Expired - Lifetime JPH0227360B2 (en) 1979-07-27 1979-07-27 SHINKIKOSEIBUTSUSHITSU

Country Status (1)

Country Link
JP (1) JPH0227360B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100450607B1 (en) * 2002-07-11 2004-09-30 경동제약 주식회사 Process for preparing Galamin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100450607B1 (en) * 2002-07-11 2004-09-30 경동제약 주식회사 Process for preparing Galamin

Also Published As

Publication number Publication date
JPH0227360B2 (en) 1990-06-15

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