KR930023466A - Novel macrolide antibiotics and microorganisms producing them - Google Patents
Novel macrolide antibiotics and microorganisms producing them Download PDFInfo
- Publication number
- KR930023466A KR930023466A KR1019920007972A KR920007972A KR930023466A KR 930023466 A KR930023466 A KR 930023466A KR 1019920007972 A KR1019920007972 A KR 1019920007972A KR 920007972 A KR920007972 A KR 920007972A KR 930023466 A KR930023466 A KR 930023466A
- Authority
- KR
- South Korea
- Prior art keywords
- geri
- streptomyces
- macrolide antibiotics
- macrolide antibiotic
- microorganisms producing
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title claims abstract description 7
- 244000005700 microbiome Species 0.000 title 1
- NMCJUPSZVLSVGC-WYHDPXJESA-N GERI-155 Chemical compound O[C@@H]1[C@@H](OC)C[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)/C=C/C(=O)O[C@H](C)[C@@H](CO[C@H]2[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O2)OC)[C@@H]2O[C@@H]2CCC(=O)[C@@](C)(O)C[C@@H]1C NMCJUPSZVLSVGC-WYHDPXJESA-N 0.000 claims abstract 9
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 235000015097 nutrients Nutrition 0.000 claims abstract 2
- 241001154589 Streptomyces sp. KCTC 0041BP Species 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 206010034133 Pathogen resistance Diseases 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 241000187180 Streptomyces sp. Species 0.000 abstract 1
- 230000000844 anti-bacterial Effects 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 description 3
- 229940064005 Antibiotic throat preparations Drugs 0.000 description 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 description 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 description 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 description 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003115 biocidal Effects 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229940079866 intestinal antibiotics Drugs 0.000 description 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 description 1
Abstract
본 발명은, 특히 그람 양성균과 기존의 항생물질 내성균주에 대해 강력한 항균활성을 갖는 다음의 구조식으로 표시되는 마크롤라이드계 항생물질 GERI-155와 그의 유도체를 제공하는 것이며, 이 GERI-155를 생산하는 균주인 스트렙토마이세스에스피. GER-155를 제공한다. 또한 본 발명은, 스트렙토마이세스에스피, GERI-155를 영양배지에서 배양하여서 GERI-155를 생산하는 방법을 제공하는 것이다.The present invention is to provide macrolide antibiotic GERI-155 and its derivatives represented by the following structural formulas which have strong antibacterial activity, particularly against Gram-positive bacteria and existing antibiotic-resistant strains, and produce this GERI-155. Streptomyces sp. Provide GER-155. The present invention also provides a method for producing GERI-155 by culturing Streptomyces sp, GERI-155 in a nutrient medium.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
제1도는 본 발명에 따른 마크롤라이드계 항생물질의 자외선 흡수 스팩트럼 결과를 나타낸 것이고, 제2도는 본 발명에 따른 마크롤라이드계 항생물질의 적외선 흡수 스펙트럼 결과를 나타낸 것이며, 제3도는 본 발명에 따른 마퀘롤라이드계 항생물질의 탄소 핵자기 공명 흡수 스팩트럼 결과를 나타낸 것이다.1 shows the ultraviolet absorption spectrum results of the macrolide antibiotics according to the present invention, and FIG. 2 shows the infrared absorption spectrum results of the macrolide antibiotics according to the present invention, and FIG. The carbon nuclear magnetic resonance absorption spectrum of the marquelide-based antibiotics is shown.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019920007972A KR0184752B1 (en) | 1992-05-12 | 1992-05-12 | A novel macrolide antibiotics and micro-organism producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019920007972A KR0184752B1 (en) | 1992-05-12 | 1992-05-12 | A novel macrolide antibiotics and micro-organism producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR930023466A true KR930023466A (en) | 1993-12-18 |
| KR0184752B1 KR0184752B1 (en) | 1999-04-01 |
Family
ID=19332961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920007972A KR0184752B1 (en) | 1992-05-12 | 1992-05-12 | A novel macrolide antibiotics and micro-organism producing it |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR0184752B1 (en) |
-
1992
- 1992-05-12 KR KR1019920007972A patent/KR0184752B1/en not_active IP Right Cessation
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